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Layout of proteins anchoring neurotransmitter receptors
The postsynaptic density (PSD) is a protein dense specialization attached to the postsynaptic membrane. PSDs were originally identified by electron microscopy
Postsynaptic_density
Mammalian protein found in Homo sapiens
PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (discs
DLG4
Biological junctions through which neurons' signals can be sent
Immediately behind the postsynaptic membrane is an elaborate complex of interlinked proteins called the postsynaptic density (PSD). Proteins in the PSD
Chemical_synapse
Protein-coding gene in the species Homo sapiens
enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". The Journal of Neuroscience. 19 (11): 4189–99
GRIN2B
Chemical substance that enables neurotransmission
Postsynaptic density Voltage- gated Ca++ channel Synaptic vesicle Neurotransmitter transporter Receptor Neurotransmitter Axon terminal Synaptic cleft Dendrite
Neurotransmitter
Protein involved in multiple prion diseases
plasticity. It was further found that Aβ-oligomers bind to PrPC at the postsynaptic density, indirectly overactivating the NMDA receptor via the Fyn enzyme,
Major_prion_protein
Protein-coding gene in humans
domain (SAM). Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other
SHANK3
Protein-coding gene in the species Homo sapiens
synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein
SHANK2
Protein in Homo sapiens
knockout mice die perinatally. SynGAP1 is shown to localize at the postsynaptic density on the dendritic spines of excitatory synapses. Cultured neurons
SYNGAP1
Part of an animal that coordinates actions and senses
proteins that cluster together to form a structure resembling a postsynaptic density (the signal-receiving part of a synapse). However, the function of
Nervous_system
Transmembrane protein family
PKA or SAP97 phosphorylation, receptors are then trafficked to the postsynaptic density (PSD). However, this process of trafficking to the PSD still remains
AMPA_receptor
American cell biologist (1918–2009)
cell membrane dynamics, and published extensively on the subject of postsynaptic density. Siekevitz was born on February 25, 1918, in Philadelphia to a working-class
Philip_Siekevitz
Protein
Neuroligins interact with other postsynaptic proteins to localize neurotransmitter receptors and channels in the postsynaptic density as the cell matures. Additionally
Neuroligin
Protein-coding gene in the species Homo sapiens
higher levels of the GluR1 subunit and increased miniature excitatory postsynaptic currents (mEPSCs) in addition to displaying deficiencies in long-term
Activity-regulated cytoskeleton-associated protein
Activity-regulated_cytoskeleton-associated_protein
Protein-coding gene in the species Homo sapiens
"SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density". The Journal of Biological Chemistry. 272 (18): 11943–51. doi:10
DLG1
Structure connecting neurons in the nervous system
close apposition with the membrane of the target (postsynaptic) cell. Both the presynaptic and postsynaptic sites contain extensive arrays of molecular machinery
Synapse
Protein-coding gene in the species Homo sapiens
receptor complex postsynaptic density basolateral plasma membrane synapse glutamatergic synapse extrinsic component of postsynaptic density membrane Biological
SCRIB
Protein-coding gene in humans
"SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density". J. Biol. Chem. 272 (18): 11943–51. doi:10.1074/jbc.272.18.11943
DLG3
Type of synapse
membrane of the postsynaptic cell, and thus increases the probability of triggering an action potential in that cell. The postsynaptic cell—a muscle cell
Excitatory_synapse
Class of enzymes
it cannot remain active. After LTP induction, CaMKII moves to the postsynaptic density (PSD). However, if the stimulation does not induce LTP, the translocation
Ca2+/calmodulin-dependent protein kinase II
Ca2+/calmodulin-dependent_protein_kinase_II
Protein-coding gene in the species Homo sapiens
kinase-associated protein, a postsynaptic density protein at excitatory synapses that interacts directly with postsynaptic density-95/synapse-associated protein
DLGAP1
Chaperone protein
neurodegenerative diseases such as Alzheimer's disease. During healthy ageing, the density of sigma-1 receptors has been seen to increase. However, in diseases such
Sigma-1_receptor
Protein and coding gene in humans
neurons, Homer1 is concentrated in postsynaptic structures and constitutes a major part of the postsynaptic density. EVH1 domain interacts with PPXXF motif
HOMER1
Protein-coding gene in humans
function in bringing together the Ras signalling complex at the postsynaptic density. It is known to have two isoforms, one of which binds PSD95 and S-SCAM
CNKSR2
Protein-coding gene in the species Homo sapiens
complex cytoplasm cytosol membrane plasma membrane cytoskeleton postsynaptic density cytoplasmic vesicle plasma membrane raft Biological process barbed-end
ADD2
Protein-coding gene in humans
presynapse postsynaptic density axon synaptic vesicle membrane cytoplasmic vesicle presynaptic membrane cell projection dendritic spine postsynaptic membrane
PRRT2
Protein-coding gene in the species Homo sapiens
CD, Petralia RS, Wang YX, McGee AW, Bredt DS, et al. (May 1999). "Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel
GRID2
Mammalian protein found in Homo sapiens
States B, et al. (Sep 1998). "Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP". Neuron. 21 (3): 581–591
GRIA2
Human enzyme
activity Cellular component cytoplasm cytosol centrosome membrane postsynaptic density plasma membrane microtubule organizing center cytoskeleton cytoplasmic
MIB1
Mammalian protein found in Homo sapiens
vesicle membrane postsynaptic membrane cell projection endoplasmic reticulum membrane membrane synaptic vesicle postsynaptic density axonal spine plasma
GRIA1
Persistent strengthening of synapses based on recent patterns of activity
and postsynaptic structures such as axonal bouton, dendritic spine and postsynaptic density. On the molecular level, an increase of the postsynaptic scaffolding
Long-term_potentiation
Protein-coding gene in the species Homo sapiens
granule lumen extracellular space nucleus postsynaptic density membrane cell junction synapse postsynaptic membrane Biological process epidermis development
FABP5
Glutamate receptor and ion channel protein found in nerve cells
dorsolateral prefrontal cortex, GluN2B are exclusively within the postsynaptic density, and mediate higher cognitive operations such as working memory.
NMDA_receptor
identified in aortic endothelial cells and cardiomyocytes. It is the main postsynaptic protein regulating the availability of calmodulin by binding to it in
Neurogranin
Small protrusion on a dendrite that receives input from a single axon
the spine contains an electron-dense region referred to as the "postsynaptic density" (PSD). The PSD directly apposes the active zone of its synapsing
Dendritic_spine
Human protein and coding gene
metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome". The
FMR1
Protein-coding gene in the species Homo sapiens
action. It slows maturation of some neurons and increases neuronal spine density. SRGAP2 may also be involved in the development of some cancers. SRGAP2
SRGAP2
Enclosing or separating membrane in organisms acting as selective semi-permeable barrier
different types of "supramembrane" structures such as caveolae, postsynaptic density, podosome, invadopodium, desmosome, hemidesmosome, focal adhesion
Biological_membrane
Protein-coding gene in the species Homo sapiens
found at the synapse, DISC1 is also likely to play a key role in postsynaptic density, however this novel role is not yet fully understood. The DISC1 protein
DISC1
Protein-coding gene in the species Homo sapiens
component cytoplasm microprocessor complex nucleolus nucleus nucleoplasm postsynaptic density Biological process regulation of stem cell proliferation primary
Microprocessor complex subunit DGCR8
Microprocessor_complex_subunit_DGCR8
Mammalian protein found in humans
component of membrane G protein-coupled receptor dimeric complex postsynaptic density membrane G protein-coupled receptor homodimeric complex plasma membrane
Metabotropic glutamate receptor 1
Metabotropic_glutamate_receptor_1
Protein and coding gene in humans
Cellular component basal part of cell cell junction postsynaptic membrane synapse postsynaptic density membrane cytoplasm cytosol plasma membrane cellular
HOMER3
Protein found in humans
neural cells, at certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by Cadherin-2. N-cadherins interact
Cadherin-2
Highly modified saliva containing zootoxins
Both elapids and viperids may carry numerous other types of toxins. Postsynaptic density Voltage- gated Ca++ channel Synaptic vesicle Neurotransmitter transporter
Snake_venom
Protein-coding gene in the species Homo sapiens
isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton". J. Biol. Chem. 276 (51): 48458–65. doi:10
DNM2
Protein-coding gene in the species Homo sapiens
1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science. 269 (5231): 1737–1740. Bibcode:1995Sci
GRIN2A
Protein-coding gene in the species Homo sapiens
projection cytoskeleton lamellipodium cytoplasm postsynaptic density actin cytoskeleton dendrite postsynaptic actin cytoskeleton glutamatergic synapse Biological
PPP1R9A
Protein-coding gene in the species Homo sapiens
downregulated by axotomy: its characteristic localization at the postsynaptic density of axosomatic synapse". The Journal of Neuroscience. 15 (7 Pt 2):
PJA2
Protein-coding gene in the species Homo sapiens
Sala C, Kim E, Craig AM, et al. (June 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light
DYNLL2
Overview of and topical guide to the human nervous system
neurons. Membrane potential Ion channel Voltage-gated ion channels Postsynaptic density Voltage- gated Ca++ channel Synaptic vesicle Neurotransmitter transporter
Outline of the human nervous system
Outline_of_the_human_nervous_system
Mammalian protein found in Homo sapiens
mitochondrion mitochondrial inner membrane extracellular exosome nucleus postsynaptic density mitochondrial crista extrinsic component of mitochondrial outer membrane
Prohibitin
Protein-coding gene in the species Homo sapiens
nuclear pore nucleoplasm dendrite nucleus cytoplasm cytosol host cell postsynaptic density glutamatergic synapse Biological process regulation of DNA recombination
Importin_subunit_alpha-5
Mammalian protein found in humans
Gq-coupled G protein-coupled receptor predominantly expressed on the postsynaptic sites of neurons. In humans, it is encoded by the GRM5 gene. The amino
Metabotropic glutamate receptor 5
Metabotropic_glutamate_receptor_5
Protein-coding gene in the species Homo sapiens
known as channel-associated protein of synapse-110 (chapsyn-110) or postsynaptic density protein 93 (PSD-93) is a protein that in humans is encoded by the
DLG2
Protein-coding gene in humans
membrane postsynaptic density integral component of plasma membrane excitatory synapse cell junction dendrite synaptic cleft terminal bouton postsynaptic density
GRIN1
Protein-coding gene in the species Homo sapiens
binding Cellular component membrane nucleus nucleoplasm cytosol postsynaptic density ribonucleoprotein complex Biological process mRNA splicing, via spliceosome
HNRPH2
Main receptor for most antipsychotic drugs
N-Propyldihydrexidine – analogue of the D1/D5 agonist dihydrexidine; Selective for postsynaptic D2 receptor over the presynaptic D2 autoreceptor. Piribedil – also D3
Dopamine_receptor_D2
Protein-coding gene in the species Homo sapiens
exosome cytoskeleton nucleus cytosol presynapse glutamatergic synapse postsynaptic density, intracellular component Biological process actin cytoskeleton reorganization
TNIK
Protein-coding gene in the species Homo sapiens
protein-containing complex binding Cellular component cell projection postsynaptic density plasma membrane dendritic spine photoreceptor outer segment synapse
MAP1B
Protein-coding gene in the species Homo sapiens
spindle microtubule extracellular exosome cytoskeleton cytoplasm postsynaptic density cytosol plasma membrane microtubule cytoskeleton axon Biological
MAP4
Ability of a synapse to strengthen or weaken over time according to its activity
and postsynaptic structures such as axonal bouton, dendritic spine and postsynaptic density. On the molecular level, an increase of the postsynaptic scaffolding
Synaptic_plasticity
Protein-coding gene in the species Homo sapiens
gene. DAP-4 is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with
DLGAP4
Protein-coding gene in the species Homo sapiens
peroxisomal membrane cell leading edge neuron projection postsynaptic density postsynaptic membrane membrane focal adhesion intracellular anatomical
ARF1
Faculty of mind to store and retrieve data
and postsynaptic structures such as axonal bouton, dendritic spine and postsynaptic density. On the molecular level, an increase of the postsynaptic scaffolding
Memory
Protein-coding gene in the species Homo sapiens
signal transduction gephyrin clustering involved in postsynaptic density assembly postsynaptic density protein 95 clustering learning regulation of AMPA
NRXN1
Topics referred to by the same term
composing that signal. Protein S deficiency Post-stroke depression Postsynaptic density, a specialization of the cytoskeleton at the synaptic junction Psychiatric
PSD
Protein found in humans
neuron projection synapse postsynaptic density membrane somatodendritic compartment cytosol cell surface postsynaptic density cerebellar mossy fiber Schaffer
CACNG2
Protein-coding gene in the species Homo sapiens
membrane plasma membrane nucleus lamellipodium cytoplasm nuclear speck postsynaptic density glutamatergic synapse cell projection Biological process intracellular
DGKZ
Mammalian protein found in Homo sapiens
cytosol dendrite cell projection intracellular anatomical structure postsynaptic density nuclear periphery neuron projection soma dendritic shaft cell body
Microtubule-associated protein 2
Microtubule-associated_protein_2
Protein-coding gene in the species Homo sapiens
growth cone Golgi apparatus intracellular membrane-bounded organelle postsynaptic density membrane plasma membrane axonal growth cone midbody ciliary membrane
PTCH1
Human gene and protein
FAM81A gene which is expressed in the postsynaptic density of the brain. It plays a pivotal role in forming postsynaptic protein agglomerations, essential
FAM81A
Protein-coding gene in humans
interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains". Journal of Cerebral
FYN
Protein-coding gene in the species Homo sapiens
Low-density lipoprotein receptor-related protein 4 (LRP-4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a protein that in
Low-density lipoprotein receptor-related protein 4
Low-density_lipoprotein_receptor-related_protein_4
Protein-coding gene in the species Homo sapiens
enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi:10.1523/JNEUROSCI
LIN7C
Cell surface receptor, part of the low-density lipoprotein receptor family
Low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), is a protein that in humans is encoded
Low-density lipoprotein receptor-related protein 8
Low-density_lipoprotein_receptor-related_protein_8
Protein-coding gene in the species Homo sapiens
membrane axon Schaffer collateral - CA1 synapse integral component of postsynaptic density membrane Biological process dorsal/ventral axon guidance negative
Netrin_receptor_DCC
Neuronal calcium sensory protein
levels Cellular component cytoplasm cytosol postsynaptic membrane Golgi apparatus membrane postsynaptic density intracellular membrane-bounded organelle
Neuronal_calcium_sensor-1
Protein found in humans
presynaptic active zone cytoplasmic component glutamatergic synapse postsynaptic density, intracellular component Biological process regulation of transcription
P120_catenin
Mammalian protein found in humans
membrane cell projection protein-containing complex chaperone complex postsynaptic density Biological process rRNA export from nucleus regulation of cell cycle
TSC1
Protein-coding gene in the species Homo sapiens
is one of the membrane-associated guanylate kinases localized at postsynaptic density in neuronal cells. These kinases are a family of signaling molecules
DLGAP2
Mitochondrial gene coding for a protein involved in the respiratory chain
glutamate receptor binding Cellular component respirasome membrane postsynaptic density integral component of membrane mitochondrion mitochondrial respiratory
MT-ND2
Protein-coding gene in the species Homo sapiens
(1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science. 269 (5231): 1737–40. Bibcode:1995Sci..
GRIN3A
Protein-coding gene in the species Homo sapiens
cytoplasm PML body centrosome postsynaptic membrane cell projection spindle pole nuclear body membrane postsynaptic density plasma membrane spindle dendritic
RGS14
Protein-coding gene in the species Homo sapiens
component integral component of membrane synaptic membrane membrane postsynaptic density plasma membrane inhibitory synapse dendrite presynaptic membrane
NPTN
Protein-coding gene in the species Homo sapiens
nucleoplasm extracellular matrix cytosol cytosolic small ribosomal subunit postsynaptic density synapse Biological process viral transcription SRP-dependent cotranslational
40S_ribosomal_protein_S18
Mammalian protein found in Homo sapiens
TSC1-TSC2 complex perinuclear region of cytoplasm lysosome nucleus postsynaptic density Biological process regulation of endocytosis protein localization
TSC2
Protein-coding gene in humans
membrane postsynaptic membrane membrane plasma membrane synapse cell junction dendrite acetylcholine-gated channel complex postsynaptic density soma integral
CHRNA3
Central nervous system stimulant
aminophylline, which are prescribed to relieve symptoms of asthma or COPD. Postsynaptic density Voltage- gated Ca++ channel Synaptic vesicle Neurotransmitter transporter
Caffeine
Protein-coding gene in humans
enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi:10.1523/JNEUROSCI
LIN7A
Mammalian protein found in Homo sapiens
activity Cellular component cytoplasm cytosol endosome plasma membrane postsynaptic density glutamatergic synapse Biological process regulation of neuron projection
PAK3
Protein-coding gene in the species Homo sapiens
"alpha-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells". FEBS Letters. 473 (2): 188–94.
Alpha-actinin-2
Protein-coding gene in the species Homo sapiens
integral component of presynaptic membrane integral component of postsynaptic density membrane Biological process cell differentiation blood vessel morphogenesis
Ephrin_B2
Protein-coding gene in the species Homo sapiens
endosome extracellular exosome mitochondrion lysosome endosome membrane postsynaptic density retromer, cargo-selective complex mitochondrion-derived vesicle neuron
VPS35
Protein-coding gene in the species Homo sapiens
protein kinase binding Cellular component cytosol Golgi apparatus postsynaptic density synaptic vesicle myelin sheath synapse synaptic vesicle membrane
Synapsin_I
Protein-coding gene in the species Homo sapiens
component axon terminus integral component of membrane postsynaptic membrane membrane postsynaptic density plasma membrane integral component of plasma membrane
Muscarinic acetylcholine receptor M1
Muscarinic_acetylcholine_receptor_M1
Protein-coding gene in the species Homo sapiens
small ribosomal subunit cytosol extracellular matrix nucleoplasm postsynaptic density synapse Biological process Notch signaling pathway SRP-dependent
40S_ribosomal_protein_S19
Protein-coding gene in the species Homo sapiens
synaptic vesicle membrane membrane cytoplasmic vesicle synaptic vesicle postsynaptic density glutamatergic synapse Biological process regulation of synaptic transmission
SYN3
Protein-coding gene in the species Homo sapiens
Petralia RS, Wang YX, McGee AW, Bredt DS, Wenthold RJ (May 1999). "Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel
GRID1
Human protein and coding gene
anatomical structure nucleoplasm clathrin-coated pit pseudopodium postsynaptic density Golgi membrane lysosomal membrane basolateral plasma membrane cytoplasmic
Arrestin_beta_1
Protein-coding gene in the species Homo sapiens
activity clathrin binding Cellular component cytosol synapse vesicle postsynaptic density cytoplasm intracellular membrane-bounded organelle presynapse Biological
Auxilin
POSTSYNAPTIC DENSITY
POSTSYNAPTIC DENSITY
POSTSYNAPTIC DENSITY
POSTSYNAPTIC DENSITY
Boy/Male
English
From Simon's Estate
Boy/Male
Hindu
With smile
Girl/Female
Indian
Beloved, Sweetheart, Darling
Girl/Female
Hindu
Lord of poets, Lord Ganesh, Small poem
Boy/Male
Arabic, French, Hindu, Indian, Lebanese, Muslim, Sindhi
Lucky; Righteous; He who is on the Right; Blessed; Right Hand
Boy/Male
Tamil
Peak
Female
Thai/Siamese
Thai name WAAN means "sweet."
Boy/Male
Hindu
Limitless
Male
Gaelic
Old Gaelic occupational name transferred to forename use, derived from the word cealloir, CEALLAIR means "superior of a church cell."Â
Female
Hindi/Indian
Variant spelling of Hindi Nitya, NITHYA means "always; eternally."
POSTSYNAPTIC DENSITY
POSTSYNAPTIC DENSITY
POSTSYNAPTIC DENSITY
POSTSYNAPTIC DENSITY
POSTSYNAPTIC DENSITY
n.
A form of hydrometer, specially graduated, for finding the density of milk, and thus discovering whether it has been mixed with water or some of the cream has been removed.
n.
To break the natural course of, as rays of light orr heat, when passing from one transparent medium to another of different density; to cause to deviate from a direct course by an action distinct from reflection; as, a dense medium refrcts the rays of light as they pass into it from a rare medium.
n.
The state or quality of being solid; density; consistency, -- opposed to fluidity; compactness; fullness of matter, -- opposed to openness or hollowness; strength; soundness, -- opposed to weakness or instability; the primary quality or affection of matter by which its particles exclude or resist all others; hardness; massiveness.
n.
The quality of being dense; density.
n.
An instrument for determining the strength or purity of wine by measuring its density.
n.
Depth of shade.
a.
Having equal density, as different regions of a medium; passing through points at which the density is equal; as, an isopycnic line or surface.
n.
The curve formed by a rope or chain of uniform density and perfect flexibility, hanging freely between two points of suspension, not in the same vertical line.
n.
A measure of weight, being a thousand grams, equal to 2.2046 pounds avoirdupois (15,432.34 grains). It is equal to the weight of a cubic decimeter of distilled water at the temperature of maximum density, or 39¡ Fahrenheit.
n.
The unit of weight in the metric system. It was intended to be exactly, and is very nearly, equivalent to the weight in a vacuum of one cubic centimeter of pure water at its maximum density. It is equal to 15.432 grains. See Grain, n., 4.
n.
The quality or state of being rare; rareness; thinness; as, the rarity (contrasted with the density) of gases.
n.
A line or surface passing through those points in a medium, at which the density is the same.
n.
The ratio of mass, or quantity of matter, to bulk or volume, esp. as compared with the mass and volume of a portion of some substance used as a standard.
n.
The quality or state of being porous; -- opposed to density.
n.
The science of the determination of the density of vapors and gases.
n.
The quality of being dense, close, or thick; compactness; -- opposed to rarity.
n.
The change in the direction of ray of light, heat, or the like, when it enters obliquely a medium of a different density from that through which it has previously moved.
n.
An instrument for ascertaining the specific gravity or density of a substance.