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Pathogenic type of misfolded protein
A prion (/ˈpriːɒn/ ) is a misfolded protein that induces folding problems in normal variants of the same protein, leading to cellular death. Prions are
Prion
Group of brain diseases induced by prions
Prion diseases are caused by abnormally shaped proteins called prions, an idea once considered radical, but now well supported by evidence. Prions consist
Transmissible spongiform encephalopathy
Transmissible_spongiform_encephalopathy
Protein involved in multiple prion diseases
The major prion protein (PrP) is encoded in the human body by the PRNP gene also known as CD230 (cluster of differentiation 230). Expression of the protein
Major_prion_protein
Neurodegenerative disease caused by prions
the transmissible spongiform encephalopathy (TSE) group, also known as prion diseases. Early symptoms include memory problems, behavioral changes, poor
Creutzfeldt–Jakob_disease
Topics referred to by the same term
Fungal prion, a prion that infects fungal hosts Prion protein, the human gene encoding for the major prion protein PrP (for prion protein) Prion diseases
Prion_(disambiguation)
Fatal neurodegenerative disease of cattle
thought to occur due to an infection by a misfolded protein, known as a prion. Cattle are believed to have been infected by being fed meat-and-bone meal
Bovine spongiform encephalopathy
Bovine_spongiform_encephalopathy
Prion disease of the human brain
Fatal insomnia is a rare, invariably fatal neurodegenerative disease and prion disease characterized by progressive and unrelenting insomnia, autonomic
Fatal_insomnia
Group of birds
The prions (/ˈpraɪɒn/) or whalebirds are small petrels in the genera Pachyptila and Halobaena. They form one of the four groups within the Procellariidae
Prion_(bird)
Prion disease affecting the deer family
family. TSEs are a family of diseases caused by misfolded proteins called prions and include similar diseases such as mad cow disease in cattle, Creutzfeldt–Jakob
Chronic_wasting_disease
Species of bird
The fairy prion (Pachyptila turtur) is a small seabird with the standard prion plumage of blue-grey upperparts with a prominent dark "M" marking and white
Fairy_prion
species, and subspecies belonging to the prions, which belong to the Procellariiformes. Pachyptila turtur, fairy prion breeds on subtropical and subantarctic
List_of_prions
Rare neurodegenerative disease caused by prions
was formerly common among the Fore people of Papua New Guinea. It was a prion disease that caused tremors and loss of coordination from neurodegeneration
Kuru_(disease)
Species of bird
The Antarctic prion (Pachyptila desolata) also known as the dove prion, or totorore in Māori, is the largest of the prions, a genus of small petrels of
Antarctic_prion
Prion that infects fungal hosts
A fungal prion is a prion that infects hosts which are fungi. Fungal prions are naturally occurring proteins that can switch between multiple, structurally
Fungal_prion
Three-month research moratorium on prions
The 2021 French moratorium on prion research was a three-month moratorium on research on prions in France. The moratorium was announced in July 2021 by
2021 French moratorium on prion research
2021_French_moratorium_on_prion_research
Species of bird
fulmar prion (Pachyptila crassirostris) is a species of seabird in the family Procellariidae, found in the southern oceans. Its common name "prion" (not
Fulmar_prion
Degenerative brain disease caused by prions
expectancy following the onset of symptoms is 13 months. It is caused by prions, which are misfolded proteins. Spread is believed to be primarily due to
Variant Creutzfeldt–Jakob disease
Variant_Creutzfeldt–Jakob_disease
Species of bird
MacGillivray's prion (Pachyptila macgillivrayi) is a species of small petrel (a prion) in the Southern Ocean. It is found on Roche Quille, off Saint Paul
MacGillivray's_prion
Human neurodegenerative disease
the causative role played by the PRNP gene, which encodes for the human prion protein. It was discovered by Josef Gerstmann, Ernst Sträussler, and Ilya
Gerstmann–Sträussler–Scheinker syndrome
Gerstmann–Sträussler–Scheinker_syndrome
Inherited neurodegenerative disease
Familial Alzheimer-like prion disease is an exceptionally rare inherited prion disease. Its name comes from its presentation, which is similar to Alzheimer's
Familial Alzheimer-like prion disease
Familial_Alzheimer-like_prion_disease
Degenerative disease that affects sheep and goats
spongiform encephalopathies (TSEs), and as such it is thought to be caused by a prion. Scrapie has been known since at least 1732 and does not appear to be transmissible
Scrapie
Biological entity that causes disease in its host
infectious microorganism or agent, such as a virus, bacterium, protozoan, prion, viroid, or fungus. Small animals, such as helminths and insects, can also
Pathogen
Species of bird
Salvin's prion (Pachyptila salvini), also known as the medium-billed prion, is a species of seabird in the petrel family Procellariidae. Salvin's prion is a
Salvin's_prion
Series of small-format hardback novels
Prion Humour Classics are a series of small-format hardback novels published by Prion Books in the UK published by Barry Winkleman. "Low Prices in Electronics
Prion_Humour_Classics
RNA family
The prion pseudoknot is predicted RNA pseudoknot structure found in prion protein mRNA. It has been suggested that this element has a possible effect
Prion_pseudoknot
Itching caused by Creutzfeldt-Jakob disease
Prion pruritus is the intense itching during the prodromal period of the Creutzfeldt–Jakob disease. Pruritus Freedberg IM, Eisen AZ, Wolff K, Austen KF
Prion_pruritus
Israeli musical artist
Eran Prion (Hebrew: ערן פריאון; born April 18, 1974), professionally known as Prayon, is an Israeli musician and music producer based in Tel Aviv and
Eran_Prion
Species of bird
The slender-billed prion (Pachyptila belcheri) or thin-billed prion, is a species of petrel, a seabird in the family Procellariidae. It is found in the
Slender-billed_prion
Practice of eating the flesh of a human being from the same community
by prions that are found in humans. Human prion diseases come in sporadic, genetic, and infectious forms. Kuru was the first infectious human prion disease
Endocannibalism
American prion researcher
Sonia Minikel Vallabh is an American scientist focused on prion diseases, particularly fatal familial insomnia. She is noted for being a "patient-scientist"
Sonia_M._Vallabh
Species of bird
broad-billed prion (Pachyptila vittata) is a small pelagic seabird in the shearwater and petrel family, Procellariidae. It is the largest prion, with grey
Broad-billed_prion
Genus of birds
called prions. They range throughout the southern hemisphere, often in the much cooler higher latitudes. Three species, the broad-billed prion (Pachyptila
Pachyptila
Type of behavior of a dynamical system
reproductive machinery of cells through a process of infection. Harmful prion proteins can replicate by converting normal proteins into rogue forms. Computer
Self-replication
Medical condition
spongiform encephalopathy first described in an abstract for a conference on prions in 2006. The study was published in a 2008 report on 11 cases. It was first
Variably protease-sensitive prionopathy
Variably_protease-sensitive_prionopathy
caerulea Fairy prion, Pachyptila turtur (A) Broad-billed prion, Pachyptila vittata (A) Salvin's prion, Pachyptila salvini (A) Antarctic prion, Pachyptila
List_of_birds_of_Antarctica
Diseases caused by abnormal protein structure
Creutzfeldt–Jakob disease (and a variant associated with mad cow disease) and other prion diseases, Alzheimer's disease, Parkinson's disease, amyloidosis, multiple
Proteinopathy
Australian neuroscientist
Australia) is an Australian-born research scientist notable for his work on prion diseases, which include bovine spongiform encephalopathy and vCJD. His most
David R. Brown (neuroscientist)
David_R._Brown_(neuroscientist)
Explanation of the flow of genetic information within a biological system
functional molecules of that sequence into the alternate prion form. In some types of prion in fungi, this change is continuous and direct; the information
Central dogma of molecular biology
Central_dogma_of_molecular_biology
Warm-blooded animals with wings and feathers
kingfishers and terns plunge dive after their prey. Flamingos, three species of prion, and some ducks are filter feeders. Geese and dabbling ducks are primarily
Bird
The term prion derives from "proteinaceous infectious particle". Unlike other infectious agents such as viruses, bacteria, and fungi, prions do not contain
Brain_as_food
King of the United Kingdom from 1901 to 1910
Richard (1988), The Savile Row Story: An Illustrated History, London: Prion, ISBN 978-1-85375-000-7 Watson, Alfred Edward Thomas (1911), King Edward
Edward_VII
American medical researcher (1923–2008)
Prusiner and others led to the identification of endogenous proteins called prions as the cause of these diseases. In his 1977 paper "Unconventional Viruses
Daniel_Carleton_Gajdusek
Austrian physician and neuropathologist
on infectious diseases of the nervous system, particularly HIV/AIDS and prion diseases, as well as neurodegenerative diseases and brain tumors. He has
Herbert_Budka
Prion disease of mink
is a transmissible spongiform encephalopathy, caused by proteins called prions. This illness has a minimum incubation period of 7 months with a maximum
Transmissible mink encephalopathy
Transmissible_mink_encephalopathy
Feline brain disease
is caused by contact from a misfolded form of the prion protein (PrPSc) which causes normal prion protein molecules (PrPC) to become misfolded. Better-known
Feline spongiform encephalopathy
Feline_spongiform_encephalopathy
Pathogenic entities
properties of viruses. Subviral agents consist of satellites, viroids, prions, defective interfering particles, viriforms, and, most recently, obelisks
List_of_subviral_agents
Pharmaceuticals designed to combat prions
are hypothetical drugs that work against prions. The discovery of antiprion drugs is a priority because prion diseases are untreatable and fatal. Therefore
Antiprion_drug
American neurologist and chemist (born 1942)
the University of California, San Francisco (UCSF). Prusiner discovered prions, a class of infectious self-reproducing pathogens primarily or solely composed
Stanley_B._Prusiner
Highly sensitive assay for prion detection
Real-time quaking-induced conversion (RT-QuIC) is a highly sensitive assay for prion detection. It is nearly 100% specific for the diagnosis of Creutzfeldt-Jakob
Real-time quaking-induced conversion
Real-time_quaking-induced_conversion
Species of beetle
modification of prions. This compound in the hemolymph of T. dichotomus demonstrates strain-dependent anti-prion activity, as it only reduces prion formation
Japanese_rhinoceros_beetle
Island in the Bay of Isles, South Georgia
Prion Island is an island 2.4 km (1.5 mi) north-northeast of Luck Point, lying in the Bay of Isles, South Georgia. It was charted in 1912–13 by Robert
Prion_Island
Biological process
acids RNA DNA Other Defective interfering particle RNA DNA Prion Mammalian prion Fungal prion Nucleic acid self-replication Mobile genetic elements Mobilome
Cell_division
Biological kingdom
Integrative and conjugative element Jeewanu Phagemid Plasmid Episome Prion Fungal prion Proteinoid microsphere Retroelements not elsewhere classified Retron
Animal
Rare neurodegenerative disease
component of the inclusion bodies is SOD1 or FUS protein, respectively. Prion-like propagation of misfolded proteins from cell to cell may explain why
ALS
Village in Denbighshire, Wales
Prion is a village in the Vale of Clwyd, and is located in the community of Llanrhaeadr-yng-Nghinmeirch in Denbighshire, Wales, about two miles south
Prion,_Denbighshire
demonstrated SOFIA's unprecedented ability to detect naturally occurring prions in the blood and urine of disease carriers. This is expected to lead to
Surround optical-fiber immunoassay
Surround_optical-fiber_immunoassay
2000 book by Stephen Robins
a humorous self-help book by author Stephen Robins. It was published by Prion Books in August 2000 and re-released as a paperback in 2001. Using an alphabetic
The Importance of Being Idle (book)
The_Importance_of_Being_Idle_(book)
Process that eliminates all biological agents on an object or in a volume
unicellular eukaryotic organisms) and other biological agents (such as prions or viruses) present in fluid or on a specific surface or object. Sterilization
Sterilization_(microbiology)
Swiss neuroscientist (b. 1961)
abnormally folded proteins in Alzheimer's disease occurs by a prion-like mechanism. The prion concept has since been expanded to include several other proteins
Mathias_Jucker
Zoonotic epidemic in the United Kingdom
scandal, when vCJD was linked to the consumption of beef contaminated with prions — the infectious agent associated with BSE and other transmissible spongiform
United_Kingdom_BSE_outbreak
Inherited neurodegenerative disease
of inherited prion disease. Unlike most prion diseases, PrP systemic amyloidosis is not isolated to the central nervous system; the prion amyloid has extensive
PrP_systemic_amyloidosis
DNA that does not code for proteins
acids RNA DNA Other Defective interfering particle RNA DNA Prion Mammalian prion Fungal prion Nucleic acid self-replication Mobile genetic elements Mobilome
Non-coding_DNA
Protein-coding gene in the species Homo sapiens
Prion protein 2 (dublet), also known as PRND, or Doppel protein, is a protein which in humans is encoded by the PRND gene. This gene is found on chromosome
PRND
Biological process
acids RNA DNA Other Defective interfering particle RNA DNA Prion Mammalian prion Fungal prion Nucleic acid self-replication Mobile genetic elements Mobilome
DNA_replication
Matter with biological processes
Integrative and conjugative element Jeewanu Phagemid Plasmid Episome Prion Fungal prion Proteinoid microsphere Retroelements not elsewhere classified Retron
Life
Group of six protein isoforms produced from the MAPT gene
infectious it is not considered to be a true prion but instead a "prion-like" protein. Much like true prions, pathological tau aggregates have been shown
Tau_protein
Test for prion disease
chain reaction (PCR) but not involving nucleotides) to multiply misfolded prions originally developed by Soto and colleagues. It is a test for spongiform
Protein misfolding cyclic amplification
Protein_misfolding_cyclic_amplification
Clinic in the United Kingdom
The National Prion Clinic (UK) is part of the University College London Hospitals NHS Foundation Trust. Its aim is to diagnose and treat patients with
National_Prion_Clinic_(UK)
American neuroscientist
the accumulation of Aβ can be initiated in transgenic mouse models by a prion-like mechanism in which 'seeds' of abnormal Aβ precipitate the formation
Lary_Walker
Chemical compound
subsequently shown in prion-infected mouse neuroblastoma cells that pentosan polysulfate could rapidly reduce the levels of abnormal (scrapie) prion without affecting
Pentosan_polysulfate
Oldest cultured human cell line (1951)
Integrative and conjugative element Jeewanu Phagemid Plasmid Episome Prion Fungal prion Proteinoid microsphere Retroelements not elsewhere classified Retron
HeLa
Broad-billed prion, Pachyptila vittata LC Salvin's prion, Pachyptila salvini LC Antarctic prion, Pachyptila desolata LC Slender-billed prion, Pachyptila
List_of_procellariiformes
Life that has no cellular structure
Virus-like particle Hypothetical types of biochemistry Nanobe Plasmid Pre-cell Prion Protocell List of subviral agents "What is Non-Cellular Life?". Wise Geek
Non-cellular_life
Method for detecting large protein polymers
unlike most large protein complexes. This method is very useful for studying prions and amyloids, which are characterized by the formation of proteinaceous
SDD-AGE
Metabolic disease involving abnormal deposited amyloid proteins
AαSyn α-Synuclein CNS L A ATau Tau CNS L A APrP Prion protein, wild type Prion protein variants Prion protein variant CJD, fatal insomnia CJD, GSS syndrome
Amyloidosis
Insoluble protein aggregate with a fibrillar morphology
are only familial. Some result from medical treatment[citation needed]. Prions are an infectious form of amyloids that can act as a template to convert
Amyloid
Island in South Georgia
283°W / -54.033; -37.283) is an island 1.2 km (0.75 miles) southwest of Prion Island, lying in the Bay of Isles, South Georgia. First charted in 1912–13
Petrel_Island_(South_Georgia)
Central nervous system disease
disease, Huntington's disease, multiple system atrophy, tauopathies, and prion diseases. Neurodegeneration can be found in the brain at many different
Neurodegenerative_disease
Health crisis in 1990s
is a fatal disease, similar to scrapie in sheep and goats, caused by a prion. A major epizootic affected the UK, and to a lesser extent a number of other
Mad_cow_crisis
Cognitive decline
frontotemporal dementia, Lewy body disease for dementia with Lewy bodies, and prion diseases. Subtypes of neurodegenerative dementias may also be based on the
Dementia
American immunologist and anti-vaccinationist
Facebook post claiming that the mRNA vaccines against COVID-19 could cause prion diseases was based on a paper by Classen. The paper was published in Microbiology
J._Bart_Classen
Branch of virology
acids RNA DNA Other Defective interfering particle RNA DNA Prion Mammalian prion Fungal prion Nucleic acid self-replication Mobile genetic elements Mobilome
Synthetic_virology
Chemical compound
chloride has been shown to "cure" prion positive yeast cells (i.e. cells exhibiting a prion positive phenotype revert to a prion negative phenotype). This is
Guanidinium_chloride
Sheep and goats are both small ruminants with cosmopolitan distributions due to their being kept historically and in modern times as grazers both individually
List of infectious sheep and goat diseases
List_of_infectious_sheep_and_goat_diseases
Adventures (Prion, 2007): Biggles in the Baltic, Biggles Sees it Through, Biggles Flies North, Biggles in the Jungle Biggles’ Dangerous Missions (Prion, 2008):
List_of_Biggles_books
Process of copying a segment of DNA into RNA
acids RNA DNA Other Defective interfering particle RNA DNA Prion Mammalian prion Fungal prion Nucleic acid self-replication Mobile genetic elements Mobilome
Transcription_(biology)
Phylogenetic group described in January 2024
Integrative and conjugative element Jeewanu Phagemid Plasmid Episome Prion Fungal prion Proteinoid microsphere Retroelements not elsewhere classified Retron
Obelisk_(biology)
Type of meat cut
Bickel, p. 489 Bugialli, p. 444 Wright, p. 139 Wright, p. 141 Prion, p. 163 Viazzi, p. 130 Prion, p. 164 Bugialli, p. 443 Hess, p. 164 Villafañe, p. 44 Villafañe
Pork_chop
Group of peptides
a prion infection. The oligomers are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like
Amyloid_beta
Chemical compound
including prion and Alzheimer's diseases. Treatment with GSK2606414 was found to be neuroprotective in mice against damage caused by prions, and prevented
GSK2606414
Phenomenon in materials science
Metastability Ostwald's rule of stages Protein folding#Misfolded proteins Prion Protein folding#Energy landscape of protein folding Proteinopathy#Seeded
Disappearing_polymorph
Prion disease
ungulate encephalopathy is a transmissible spongiform encephalopathy (TSE), or prion disease, identified in infected organs of zoo animals. This subgroup of
Exotic ungulate encephalopathy
Exotic_ungulate_encephalopathy
Hungarian-Swiss biologist (1931–2025)
contributions to the unraveling of the molecular genetics of neurogenerative prion diseases such as scrapie, Creutzfeldt–Jakob disease, and "mad cow disease"
Charles_Weissmann
Disease of blood vessels of the brain
associated with gelsolin amyloid (AGel). Some prion diseases exhibit CAA caused by deposition of the prion protein. CAA is associated with brain hemorrhages
Cerebral_amyloid_angiopathy
Retrieved 23 June 2013. Cawthorne, Nigel (1996). Sex Lives of the Popes. Prion. p. 160. ASIN 185375546X. Stefano Infessura, Diario della città di Roma
List_of_sexually_active_popes
Extracellular deposits of the amyloid beta protein
the formation and spread of prions in diseases known as spongiform encephalopathies or prion diseases. According to the prion paradigm, certain proteins
Amyloid_plaques
American biochemist
This contrasts with the assertion that the host encoded amyloid forming prion protein, without nucleic acid, is the infectious agent. Early in her career
Laura_Manuelidis
Medication
infections. Mepacrine has been shown to bind to the prion protein and prevent the formation of prion aggregates in vitro, and full clinical trials of its
Mepacrine
Evolutionary biology hypothesis
correctly at the ends of proteins. Sup35p comes in a normal form ([psi-]) and a prion form ([PSI+]). When [PSI+] is present, this depletes the amount of normal
Evolutionary_capacitance
Israeli author and filmmaker (1924–2005)
Kishon at Internet Archive. 1989 New York, Shapolsky Publishers; London, Prion More of the Funniest Man in the World: the wild and crazy humor of Ephraim
Ephraim_Kishon
travel, tourism, insurance
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