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Pharmacological phenomenon
Reverse tolerance or drug sensitization is a pharmacological phenomenon describing subjects' increased reaction (positive or negative) to a drug following
Reverse_tolerance
Reduced reaction to a drug following repeated use
not incompatible and tolerance may sometimes lead to reverse tolerance. For example, heavy drinkers initially develop tolerance to alcohol (requiring
Drug_tolerance
Bodily responses to the functional effects of ethanol within alcoholic beverages
dependence. Heavy alcohol consumption over a period of years can lead to "reverse tolerance". A liver can be damaged by chronic alcohol use, leading to a buildup
Alcohol_tolerance
Non-associative learning process
procedures than those who were given anesthesia. Drug sensitization (or reverse tolerance) occurs in substance use disorder, and is defined as an increased
Sensitization
Medical condition caused by drug addiction
healthcare professional. Chemical dependency Drug detoxification Drug tolerance Hangover List of investigational substance-related disorder drugs Neonatal
Drug_withdrawal
Medical condition
defines a situation in which one has developed one or more of either tolerance, withdrawal symptoms, drug seeking behaviors, such as continued use despite
Benzodiazepine_dependence
Form of behavioral dependence involving emotional symptoms
feedback mechanism that involves neuronal-counter adaptation, leading to tolerance to the desirable effects of certain drugs or stimuli and a subsequent
Psychological_dependence
Atypical opioid drug
less analgesic tolerance. Moreover, substitution of conventional opioids like morphine with SR-17018 can reverse analgesic tolerance and suppress withdrawal
SR-17018
Harmful repetitive gambling
exposure to a stimulus (e.g., drug intake) drug sensitization or reverse tolerance – the escalating effect of a drug resulting from repeated administration
Problem_gambling
Benzodiazepine analog drug
benzodiazepine binding sites (tolerance/dependence), while etizolam caused an increase in alpha-2 benzodiazepine binding sites (reverse tolerance to anti-anxiety effects)
Etizolam
Process of extracting design information from anything artificial
the reverse engineering of a cylinder head, which includes freeform cast features, such as water jackets and high-tolerance machined areas. Reverse engineering
Reverse_engineering
Proposed compulsive sexual disorder
effects, reward deficiency syndrome, withdrawal syndrome with cessation, tolerance, or enhanced late positive potentials." Аs well as evidence of a key neurobiological
Sexual_addiction
Drug mixture used mainly to treat ADHD and narcolepsy
to prevent the development of tolerance. A 2026 systematic review on ADHD medication tolerance found evidence of tolerance developing to some affective
Adderall
State of unresponsiveness of the immune system
Immune tolerance, also known as immunological tolerance or immunotolerance, is the immune system's state of unresponsiveness to substances or tissues that
Immune_tolerance
Need for a drug, whose discontinuation results in withdrawal symptoms
single diagnosis of substance use disorders. This was done because "the tolerance and withdrawal that previously defined dependence are actually very normal
Substance_dependence
Discomfort following alcohol consumption
Association between Alcohol Hangover Frequency and Severity: Evidence for Reverse Tolerance?". Journal of Clinical Medicine. 8 (10): 1520. doi:10.3390/jcm8101520
Hangover
Central nervous system stimulant
recovery process. Tolerance is expected to develop with regular methamphetamine use and, when used recreationally, this tolerance develops rapidly. In
Methamphetamine
Drugs used to achieve relief from pain
origin. Dextromethorphan has been noted to slow the development of and reverse tolerance to opioids, as well as to exert additional analgesia by acting upon
Analgesic
CNS stimulant and isomer of amphetamine
to prevent the development of tolerance. A 2026 systematic review on ADHD medication tolerance found evidence of tolerance developing to some affective
Dextroamphetamine
Antidepressant medication
5-HT2A receptor, and antagonists at this receptor typically induce reverse tolerance. Thus, the antidepressant and anxiolytic effects of mirtazapine occur
Mirtazapine
Consequence affecting an organism's future behavior
down-regulation due to continual drug stimulation, producing 'liking' tolerance. Incentive-sensitization would produce addiction, by selectively magnifying
Reinforcement
Continued use of cannabis despite clinically significant impairment
emotion and addiction severity. Cannabis users can develop tolerance to the effects of THC. Tolerance to the behavioral and psychological effects of THC has
Cannabis_use_disorder
Continual use of drugs despite negative consequences
taking opiates as prescribed, they may experience physiologic effects of tolerance and withdrawal, but this would not cause an individual to meet criteria
Substance_use_disorder
Punishment policy with no discretion for leniency
A zero-tolerance policy is one which imposes a punishment for every infraction of a stated rule. Zero-tolerance policies forbid people in positions of
Zero_tolerance
Resilience of systems to component failures or errors
Fault tolerance is the ability of a system to contain the propagation of faults (e.g. failed transistor, shorted connector, intermittent data bus). Faults
Fault_tolerance
Medical condition
of the following criteria must be manifest during a 12-month period: Tolerance Withdrawal symptoms or clinically defined alcohol withdrawal syndrome
Alcohol_dependence
Disorder resulting in compulsive behaviors
will result. Those who show signs of food addiction may develop food tolerances, in which they eat more, despite the food becoming less satisfactory.
Addiction
Cognitive process
user may want the drug more and more while liking it less and less as tolerance develops to the drug's pleasurable effects. Amphetamine improves task
Motivational_salience
Physical condition caused by chronic use of a tolerance-forming drug
Physical dependence is a physical condition caused by chronic use of a tolerance-forming drug, in which abrupt or gradual drug withdrawal causes unpleasant
Physical_dependence
Chemical substance that alters brain function
to dependence or long-term neural adaptations such as sensitization or tolerance. Addiction and dependence involve psychological and physical reliance
Psychoactive_drug
Medical condition
stimulates the up-regulation and reverses the uncoupling of benzodiazepine receptors to the GABAA receptor, thereby reversing tolerance and reducing withdrawal
Benzodiazepine withdrawal syndrome
Benzodiazepine_withdrawal_syndrome
Allowing or permitting a religion of which one disapproves
Religious tolerance or religious toleration may signify "no more than forbearance and the permission given by the adherents of a dominant religion for
Religious_tolerance
Predisease state of hyperglycemia
be diagnosed by measuring hemoglobin A1c, fasting glucose, or glucose tolerance test. Many people may be diagnosed through routine screening tests. The
Prediabetes
Restrictions on the psychoactive plant
kappa Opioid receptors and is noted for its reverse tolerance. As such, using Salvia divinorum decreases tolerance to salvinorin A and makes dysphoria more
Legal status of Salvia divinorum in the United States
Legal_status_of_Salvia_divinorum_in_the_United_States
Dormant, persistent state of a bacterial population
dormancy or quiescence. Persister cells in their dormancy do not divide. The tolerance shown in persister cells differs from antimicrobial resistance in that
Persister_cells
Addiction to playing video games
attempting to cut down or stop gaming, or when you are unable to play? Tolerance. Do you feel the need to play for increasing amounts of time, play more
Video_game_addiction
Topics referred to by the same term
within the microstructure of an alloy Drug sensitization, also called Reverse tolerance "Sensitized", a song by Kylie Minogue from X Sensitivity (disambiguation)
Sensitization (disambiguation)
Sensitization_(disambiguation)
Rewarding and reinforcing behaviours
exposure to a stimulus (e.g., drug intake) drug sensitization or reverse tolerance – the escalating effect of a drug resulting from repeated administration
Addictive_behavior
Range of genetic and environmental risk factors for developing an addiction
Cannabinoid Type 1 Receptors in Dopamine D2 Receptor Knockout Mice Is Reversed by Chronic Forced Ethanol Consumption". Alcoholism: Clinical and Experimental
Addiction_vulnerability
Compulsive engagement of excessive physical exercise despite negative consequences
harmful. A desire to experience euphoria; exercise may be increased as tolerance of the euphoric state increases. Not participating in physical activity
Exercise_addiction
Protein
cocaine continues to increase ΔFosB levels with no apparent ceiling of tolerance.[citation needed] Elevated levels of ΔFosB leads to increases in brain-derived
FOSB
Inability to perform physical exercise at normal levels
elevated blood levels of creatine kinase. Exercise tolerance is significantly compromised. Exercise tolerance reflects the combined capacity of components in
Exercise_intolerance
2024 Indian film by Shankar
for INDIAN-2 distribution in Kerala! 🇮🇳 Senapathy returns with zero-tolerance against corruption across the region. 🤞🏻🔥 #Indian2 🇮🇳 In Cinemas
Indian_2
Generalised alphabetical order
trailing "0" digit. When negative numbers are also considered, one has to reverse the order for comparing negative numbers. This is not usually a problem
Lexicographic_order
Integral of drug concentration in blood plasma over time
Mathematical Model for the Determination of Total Area Under Glucose Tolerance and Other Metabolic Curves" purports to have independently discovered
Area under the curve (pharmacokinetics)
Area_under_the_curve_(pharmacokinetics)
Laboratory technique to multiply an RNA sample for study
Reverse transcription polymerase chain reaction (RT-PCR) is a laboratory technique combining reverse transcription of RNA into DNA (in this context called
Reverse transcription polymerase chain reaction
Reverse_transcription_polymerase_chain_reaction
School policy
A zero-tolerance policy in schools is a policy of strict enforcement of school rules against behaviors or the possession of items deemed undesirable.
Zero-tolerance policies in schools
Zero-tolerance_policies_in_schools
Half maximal inhibitory concentration
and examining the effect of different concentrations of antagonist on reversing agonist activity. IC50 values can be calculated for a given antagonist
IC50
Ability to digest milk after infancy
Lactase persistence or lactose tolerance is the continued activity of the lactase enzyme in adulthood, allowing the digestion of lactose in milk. In most
Lactase_persistence
Allowing or permitting something that one disapproves
of social or political practices and 'tolerance' as a set of attitudes." Random House Dictionary defines tolerance as "a fair, objective, and permissive
Toleration
Curved South East Asian knife
A modern karambit, held in reverse grip (left) called hammer grip, and held traditionally (right).
Karambit
Removing the protective cover of an integrated circuit
epoxy packages. Delidding may also be done to test the chip for radiation-tolerance with a heavy-ion beam or in an effort to reduce the operating temperatures
Decapping
Investigative procedure in microbiology
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
Gram_stain
Discrimination against members of a dominant or majority group
Reverse discrimination based on race or ethnicity is also called reverse racism. Philosopher Richard Arneson argues that while a program of reverse discrimination
Reverse_discrimination
Test to differentiate between skin fungi
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
KOH_test
Deuterium-substituted isotopologue of caffeine
as caffeine. d9-Caffeine was non-genotoxic in both the Ames’s bacterial reverse mutation assay and mammalian cell micronucleus assay. In a human clinical
D9-Caffeine
Drug discovery by identifying protein targets
In the field of drug discovery, reverse pharmacology also known as target-based drug discovery (TDD), a hypothesis is first made that modulation of the
Reverse_pharmacology
Backward recording technique
records, reversed". In the movie Gold Diggers of 1935, the end of the dancing-pianos musical number, "The Words Are in My Heart," is filmed in reverse motion
Backmasking
Smallest value Indian banknote
Standard weight and remedy allowed.—The standard paper weight and remedy (tolerance) allowed in printing of One Rupee Currency Notes shall be as specified
Indian_1-rupee_note
2017–2018 U.S. border policy
parents or guardians. The policy was presented to the public as a "zero tolerance" approach, intended to encourage tougher legislation and discourage unauthorized
Trump administration family separation policy
Trump_administration_family_separation_policy
Typographic character indicating a question (?)
ISBN 0-521-38104-5. Truss, Lynne (2003). Eats, Shoots & Leaves: The Zero Tolerance Approach to Punctuation. London: Profile Books. ISBN 1861976127. Lupton
Question_mark
Biochemical analysis procedure
Chemotherapy Lists of drugs WHO list of essential medicines Tolerance and resistance Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple
Ligand_binding_assay
Measure of organism response to stimulus
Chemotherapy Lists of drugs WHO list of essential medicines Tolerance and resistance Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple
Dose–response_relationship
Microbiological method for identification
radiating from the test organism near the S. aureus indicates positivity The reverse CAMP test is a method to identify Clostridium perfringens using β-hemolytic
CAMP_test
Benzodiazepine used for anesthesia and procedural sedation
a decrease in efforts to breathe, low blood pressure, and sleepiness. Tolerance to its effects and withdrawal syndrome may occur following long-term use
Midazolam
An inverse vaccine, reverse vaccine, or tolerogenic vaccine, is a hypothetical approach to the use of vaccines that trains the immune system to not respond
Inverse_vaccine
Criminological theory
"zero-tolerance" policing style, including in some academic studies. Bratton and Kelling have said that broken windows policing and zero tolerance are different
Broken_windows_theory
Contract bridge bidding convention
the bid major and 4 in an as yet undisclosed minor suit. If he has a tolerance for the major suit, the advancer passes. Otherwise, he bids 2NT, inviting
Cappelletti_convention
Theoretical drug measure in pharmacology
Chemotherapy Lists of drugs WHO list of essential medicines Tolerance and resistance Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple
Volume_of_distribution
Phrase describing policies of the Trump administration
were realizing that "the US administration does not have a very high tolerance for market and economic pressure, and will be quick to back off when tariffs
Trump_Always_Chickens_Out
Breakdown of red blood cells
and Listeria monocytogenes. A modified version of this test called the reverse CAMP test, utilizing S. agalactiae instead of S. aureus, can also be used
Hemolysis_(microbiology)
Machine to increase pressure of gas by reducing its volume
cavities or screws and compressor housing. They depend on fine machining tolerances to avoid high leakage losses and are prone to damage if operated incorrectly
Compressor
Sleep medication
and hallucinations. While flumazenil, a GABAA receptor antagonist, can reverse zolpidem's effects, usually supportive care is all that is recommended
Zolpidem
Class of CNS depressant drugs
and effective drugs in the short term for a wide range of conditions. Tolerance can develop to their effects and there is also a risk of dependence, and
Benzodiazepine
Training done by aviators and astronauts
research and literature, and training has contributed to extending pilots' g tolerance in both magnitude and duration. Training includes centrifuge, Anti-g Straining
High-g_training
Bacteriological technique
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
Ziehl–Neelsen_stain
World's first 8-speed automatic from 2006
previous unit. With new micro-laser technology gear tooth production tolerances have been reduced by 50%. Aluminum has also replaced steel on gear tooth
Aisin–Toyota 8-speed automatic transmission
Aisin–Toyota_8-speed_automatic_transmission
Test for syphilis
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
Rapid_plasma_reagin
Branch of medical science
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
Medical_microbiology
Benzodiazepine medication
depressed, there may be an increased risk of suicide. With long-term use, tolerance may develop, with larger doses required for the same effect. Physical
Lorazepam
Absence of disease-causing microorganisms
strict isolation vs. reverse isolation. Strict isolation quarantines patients to prevent them from infecting others, while reverse isolation prevents vulnerable
Asepsis
Centre-right political party in Germany
keen to clarify that CDU references to the "dominant culture" imply "tolerance and living together". According to party analyst Stephan Eisel, her avoiding
Christian Democratic Union of Germany
Christian_Democratic_Union_of_Germany
Country in South Asia
hotspots. India's wildlife, which has traditionally been viewed with tolerance in its culture, is supported in protected habitats. According to the Oxford
India
Font style with cursive typeface and slanted design
10 February 2017. Truss, Lynne (2004), Eats, Shoots & Leaves: The Zero Tolerance Approach to Punctuation, New York: Gotham Books, p. 146, ISBN 978-1-59240-087-4
Italic_type
in which he reiterated it as an example to emphasise Singapore's zero tolerance towards corruption. Despite the allegations, Lee acknowledged Teh's contributions
List of major crimes in Singapore (before 1990)
List_of_major_crimes_in_Singapore_(before_1990)
2024 video game
are based on the Social Stats from the Persona series: Courage, Wisdom, Tolerance, Eloquence, and Imagination. These are obtainable through doing in-game
Metaphor:_ReFantazio
Semiconductor light source
strings of LEDs will not share current evenly due to the manufacturing tolerances in their forward voltage. Running two or more strings from a single current
Light-emitting_diode
of the Department of Justice's Planning and Implementation of Its Zero Tolerance Policy and Its Coordination with the Department of Homeland Security and
Inspector General report on the Zero Tolerance Policy
Inspector_General_report_on_the_Zero_Tolerance_Policy
Species of archaeon
complexes. Reverse gyrases are composed of two domains: the first one is the helicase and second one is the topoisomerase I. A possible role of reverse gyrase
Sulfolobus_solfataricus
Chemical indicator that turns red in acidic solutions
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
Methyl_red
Form of the drug cocaine
heart attack. Other studies have also noted these risks. An appreciable tolerance to cocaine's high may develop, with many addicts reporting that they seek
Crack_cocaine
Chemical compound found in some species of mushrooms
variables. Tolerance to psilocybin builds and dissipates quickly; ingesting it more than about once a week can lead to diminished effects. Tolerance dissipates
Psilocybin
Species of plant
redistribution moving water from deeper levels to the upper and also reversing the process in times of severe drought. Scattered stands of the trees
Strombocarpa_tamarugo
Free online crowdsourced encyclopedia
harboring a battleground culture of sexism and harassment. The perceived tolerance of abusive language was a reason put forth in 2013 for the gender gap
Wikipedia
Autotomated microbiology analyzer
Oxidative/fermentation glucose test Phenylalanine deaminase test Reverse CAMP test Salt tolerance test Sulfide indole motility test Triple sugar iron test Urease
VITEK
condition where Mike learned that the oil contains more water than acceptable tolerances; further testing by Marc pointed that the water level is caused by condensation
List of Wheeler Dealers episodes
List_of_Wheeler_Dealers_episodes
President of the United States (2017–2021; since 2025)
Richard (June 19, 2018). "What We Know: Family Separation And 'Zero Tolerance' At The Border". NPR News. Retrieved May 30, 2020. Epstein, Jennifer (June
Donald_Trump
Certification process for the 737 MAX
the second revision to the list removed several exemptions and fault tolerances to ensure greater availability of the aircraft's redundant systems. On
Boeing_737_MAX_certification
Argochampsa krebsi and evolutionary implications for adaptation to salinity tolerance in marine crocodyliforms". Journal of Anatomy. 246 (6): 974–986. doi:10
2025 in archosaur paleontology
2025_in_archosaur_paleontology
Diplomatic row caused by a dispute regarding Taiwan
"openly turned back the wheel of history" and that "any appeasement or tolerance of these provocative moves by Japanese right-wing politicians will only
2025–2026 China–Japan diplomatic crisis
2025–2026_China–Japan_diplomatic_crisis
REVERSE TOLERANCE
REVERSE TOLERANCE
Boy/Male
English
Strict. Restrained. Surname.
Surname or Lastname
English
English : patronymic from Lever 3.
Girl/Female
British, English
Beaver-stream
Surname or Lastname
English
English : variant spelling of Revell.
Surname or Lastname
French
French : variant of Rivière, Rivoire, or Rivier, topographic name for someone living on the banks of a river, French rivier ‘bank’, or habitational name from any of the many places in France named with this word.English : nickname from Middle English revere ‘reiver’, ‘robber’.English : topographic name for someone who lived on the brow of a hill, from a misdivision of the Middle English phrase atter evere ‘at the brow or edge’ (from Old English yfer, efer ‘edge’) or a habitational name from a place named with this phrase, as for example River in West Sussex or Rivar in Wiltshire.Jewish (from Italy) : habitational name from a place in Mantua named Revere.The MA patriot Paul Revere (1734–1818), who in April 1775 undertook a famous ride from Boston to Lexington to warn of the approach of British troops, was a silversmith and instrument maker. He was descended from French Huguenots called Rivoire.
Boy/Male
Dutch
Weaver.
Surname or Lastname
English (of Norman origin)
English (of Norman origin) : habitational name from any of various places in northern France called Rivières, from the plural form of Old French rivière ‘river’ (originally meaning ‘riverbank’, from Latin riparia). The absence of English forms without the final -s makes it unlikely that it is ever from the borrowed Middle English vocabulary word river, but the French and other Romance cognates do normally have this sense.Common Americanized form of French Larivière. ire.
Boy/Male
Indian
Rising
Boy/Male
African, American, British, English, French
Riverbank; Derived from Place-name Deverel
Boy/Male
American, British, English
Wanderer
Boy/Male
Australian, British, English
Name Derived from a Surname
Boy/Male
English French
Derived from place-name Deverel.
Male
English
Anglicized form of Welsh Rhys, REESE means "ardor, heat of passion."
Surname or Lastname
English
English : metronymic from Sever.Dutch : variant of Sievers.
Boy/Male
English
Name derived from a surname, and only used as a first name since the 19th century.
Surname or Lastname
English
English : topographic name for someone who lived on the edge of an escarpment, from Middle English evere ‘edge’, a word that is probably of Old English origin, though unattested.English : patronymic from the Middle English personal name Ever, from Old English Eofor ‘boar’.North German and Dutch : patronymic from Evert.
Boy/Male
Shakespearean
King Henry the Sixth, Part III' Lord Rivers, brother to Lady Grey. 'King Richard III' Earl...
Male
African
reversed.
Boy/Male
American, British, English
Severe; Strict
Surname or Lastname
English
English : variant of Revell.
REVERSE TOLERANCE
REVERSE TOLERANCE
Boy/Male
Welsh
Lionlike. Leader.
Girl/Female
Arabic, Celebrity, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Muslim, Parsi, Sindhi, Tamil, Telugu
From Kashmir; The Holy City
Girl/Female
American, Arabic, Hebrew
Night; Lovelorn; Seductive
Girl/Female
Indian
Lalitha Devi
Girl/Female
Danish, German, Swedish
Thor's Battle
Girl/Female
Arabic, Muslim
Intelligent; Adorned with Intellect
Girl/Female
American, Australian, British, English, Greek, Spanish
Defender of Mankind; Short Form of Alexandrina
Boy/Male
British, English
Traveler
Boy/Male
Hindu, Indian, Kannada, Marathi, Tamil, Telugu
Abode of Lord Murugan; A Free Man
Boy/Male
Muslim
Painter, Artist
REVERSE TOLERANCE
REVERSE TOLERANCE
REVERSE TOLERANCE
REVERSE TOLERANCE
REVERSE TOLERANCE
a.
Annulled and the contrary substituted; as, a reversed judgment or decree.
v. i.
To become or be reversed.
n.
Alt. of Revery
v. t.
To reverse.
a.
The back side; as, the reverse of a drum or trench; the reverse of a medal or coin, that is, the side opposite to the obverse. See Obverse.
v. t.
To release.
n.
One who reveres.
a.
Alt. of Renverse
n.
Same as Reverie.
v. i.
To change back, as from a soluble to an insoluble state or the reverse; thus, phosphoric acid in certain fertilizers reverts.
a.
Reversed; as, a reverse shell.
a.
Turned backward; having a contrary or opposite direction; hence; opposite or contrary in kind; as, the reverse order or method.
a.
Intended to reverse; implying reversal.
a.
To overthrow by a contrary decision; to make void; to under or annual for error; as, to reverse a judgment, sentence, or decree.
v. i.
To return; to revert.
imp. & p. p.
of Revere
n.
One who reverses.
a.
The act of reversing; complete change; reversal; hence, total change in circumstances or character; especially, a change from better to worse; misfortune; a check or defeat; as, the enemy met with a reverse.
a.
Perverse; adverse; untoward.
imp. & p. p.
of Reverse