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Protein and coding gene in humans
receptor 1 or S1PR1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled
S1PR1
Sphingosine-1-phosphate (S1P). They are divided into five subtypes: S1PR1, S1PR2, S1PR3, S1PR4 and S1PR5. In 1990, S1PR1 was the first member of the S1P receptor family to
Sphingosine-1-phosphate receptor
Sphingosine-1-phosphate_receptor
Human lectin protein
complex with S1PR1 (not S1PR3 or S1PR5). This association is dependent on the interaction between the CD69 transmembrane domain and helix-4 of S1PR1. Following
CD69
Mammalian protein found in humans
inhibits binding to the receptor altogether. Source: MC4R MC3R MC5R MC1R GPR12 S1PR1 S1PR2 LPAR1 CNR1 S1PR3 GPR6 GPR3 S1PR5 LPAR3 S1PR4 CNR2 GPR119 LPAR2 melanocortin
ACTH_receptor
Mammalian protein found in humans
identification of dermopterans as the closest primate relatives. Source: CNR2 S1PR1 LPAR1 S1PR3 S1PR5 S1PR2 GPR6 GPR12 S1PR4 LPAR3 LPAR2 GPR3 MC3R MC5R MC2R
Cannabinoid_receptor_1
Protein-coding gene in the species Homo sapiens
obesity. Inverse agonists Cannabidiol Source: GPR6 GPR3 S1PR5 CNR1 CNR2 MC4R S1PR1 MC3R MC2R S1PR2 MC1R S1PR3 LPAR2 MC5R LPAR1 S1PR4 LPAR3 GPR119 GRCh38: Ensembl
GPR12
Protein and coding gene in humans
growth of developing and injured neuronal and vascular system. Source: S1PR1 S1PR3 S1PR5 S1PR4 LPAR2 LPAR1 LPAR3 CNR1 GPR6 MC3R GPR12 GPR3 MC4R MC1R
S1PR2
Protein-coding gene in humans
has been shown to interact with: GPR143, RGS12, RGS14, RGS19, RIC8A, and S1PR1. GRCh38: Ensembl release 89: ENSG00000127955 – Ensembl, May 2017 GRCm38:
GNAI1
Protein controlling mammalian coloration
convergent evolution. Source: MC4R MC3R MC5R MC2R GPR6 GPR12 S1PR2 GPR3 S1PR1 LPAR1 CNR1 LPAR2 GPR119 S1PR3 S1PR5 LPAR3 CNR2 S1PR4 Chromatophore Melanocyte
Melanocortin_1_receptor
Signaling sphingolipid
discovered to be an extracellular ligand for G protein-coupled receptor S1PR1 in 1998. It is now known that sphingosine-1-phosphate receptors (S1P receptors)
Sphingosine-1-phosphate
Type of G protein-coupled receptor
receptor 5 " GPR92 LPAR6 LPA6 lysophosphatidic acid receptor 6 " P2RY5 S1PR1 275 sphingosine-1-phosphate receptor 1 S1P EDG1 S1PR2 276 sphingosine-1-phosphate
Lysophospholipid_receptor
Protein-coding gene in the species Homo sapiens
Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012) Source: S1PR1 S1PR3 S1PR2 S1PR4 LPAR1 LPAR2 GPR3 LPAR3 GPR12 CNR1 GPR6 CNR2 MC4R MC3R
S1PR5
Mammalian protein found in humans
inhibitor MCL-0129 ML-00253764 MPB-10 Semax Source: MC5R MC3R MC1R MC2R S1PR1 LPAR1 GPR12 S1PR3 LPAR2 S1PR2 GPR6 GPR3 LPAR3 GPR119 CNR1 S1PR5 S1PR4 CNR2
Melanocortin_4_receptor
Protein-coding gene in the species Homo sapiens
Cannabidiol Solangepras (solengepras; CVN-424) Source: GPR3 GPR12 S1PR5 S1PR1 CNR1 S1PR2 LPAR2 CNR2 MC1R S1PR3 S1PR4 GPR119 MC3R MC4R MC5R LPAR1 LPAR3
GPR6
Chemical compound
lie in its activity at one of the five sphingosine-1-phosphate receptors, S1PR1. Phospho-fingolimod causes the internalization of S1P receptors, which sequesters
Fingolimod
Protein
uterine cervical preneoplastic lesions progression. Source: LPAR2 LPAR3 S1PR1 S1PR3 S1PR5 S1PR4 S1PR2 CNR1 MC3R MC5R MC4R GPR12 MC2R GPR6 CNR2 GPR3 MC1R
LPAR1
Mammalian protein found in humans
purpurea AM-630 BML-190 JTE-907 SR-144,528 APD371 Source: CNR1 GPR12 GPR6 S1PR1 S1PR4 S1PR3 S1PR5 S1PR2 LPAR1 GPR3 LPAR3 LPAR2 MC4R MC5R GPR119 MC1R MC3R
Cannabinoid_receptor_2
orchestrating immune cell positioning. His lab demonstrated that S1P receptor 1 (S1PR1) is essential for lymphocyte egress from the thymus and lymphoid organs—a
Jason_Cyster
Family of proteins
1-phosphate receptor InterPro: IPR004061 Sphingosine 1-phosphate receptor 1 (S1PR1) Sphingosine 1-phosphate receptor 2 (S1PR2) Sphingosine 1-phosphate receptor
Rhodopsin-like_receptors
CD361 Also known as EVI2B. CD362 Also known as SDC2, Syndecan-2. CD363 S1PR1 (Sphingosine-1-phosphate receptor 1) or EDG1. It is a G-protein-coupled
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Protein-coding gene in humans
microbiota-endocannabinoidome axis. Source: GPR6 MC5R MC3R MC4R CNR1 GPR12 S1PR1 MC1R S1PR3 S1PR5 GPR3 S1PR2 CNR2 LPAR3 LPAR1 LPAR2 MC2R S1PR4 GRCh38: Ensembl
GPR119
Mammalian protein found in humans
mixed MC3/MC4 antagonist. Source: MC5R MC4R MC1R MC2R LPAR1 S1PR2 GPR12 S1PR1 GPR6 LPAR2 S1PR3 GPR3 GPR119 CNR1 LPAR3 S1PR5 S1PR4 CNR2 Melanocortin receptor
Melanocortin_3_receptor
Protein-coding gene in the species Homo sapiens
lymphoid tissue. Agonists Sphingosine-1-phosphate CYM50308 Source: S1PR5 S1PR3 S1PR1 S1PR2 LPAR2 LPAR1 LPAR3 CNR1 GPR6 CNR2 GPR3 GPR12 MC4R MC5R MC3R MC2R MC1R
S1PR4
Small polypeptide subunit of myosin
and then leave the lymph nodes to migrate into inflammatory sites in an S1PR1-dependent manner." The proposed mechanisms of action of CD69/Myl9/12 system
Myosin_light_chain
Protein-coding gene in the species Homo sapiens
proteins. LPAR2 has been shown to interact with TRIP6. Source: LPAR1 LPAR3 S1PR1 S1PR5 S1PR4 S1PR2 S1PR3 GPR6 GPR3 GPR12 MC4R MC5R CNR1 MC3R CNR2 MC1R GPR119
LPAR2
Protein and coding gene in humans
regulation of angiogenesis and vascular endothelial cell function. Source: S1PR1 S1PR5 S1PR2 S1PR4 LPAR1 LPAR3 LPAR2 CNR1 MC5R GPR6 GPR12 MC4R CNR2 GPR3
S1PR3
Overview of and topical guide to immunology
CEACAM20 CEACAM21 CD24 CD44 CD146 CD164 CD69 Sphingosine-1-phosphate receptors S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 Co-stimulatory molecules CD80 - Expressed by APCs
Outline_of_immunology
Protein found in humans
protein (MRAP) traps MC5R protein inside cells. Source: MC4R MC3R MC1R MC2R S1PR1 LPAR1 S1PR3 GPR12 LPAR2 GPR3 S1PR2 GPR6 GPR119 LPAR3 CNR1 S1PR5 S1PR4 CNR2
Melanocortin_5_receptor
Protein
The following proteins are Paralogues of GPR3: GPR6 GPR12 S1PR5 LPAR2 S1PR1 S1PR2 LPAR3 LPAR1 CNR1 S1PR3 MC3R MC4R S1PR4 MC5R MC1R CNR2 MC2R GPR119
GPR3
Protein-coding gene in humans
interact with: RGS10 RGS12, RGS14, RGS16, RGS18, RGS19, RGS5, RIC8A, and S1PR1. Gi alpha subunit GRCh38: Ensembl release 89: ENSG00000065135 – Ensembl
GNAI3
pathologies. On the other hand, they have lower expression of S1P receptor S1PR1, homing receptor to lymph node CD62L, activation marker KLRG1, KLF2 and
Tissue-resident_memory_T_cell
Protein-coding gene in humans
receptor couples predominantly to G(q/11) alpha proteins. Source: LPAR1 LPAR2 S1PR1 S1PR3 S1PR4 S1PR2 S1PR5 CNR1 GPR3 MC5R GPR6 GPR12 MC4R CNR2 MC3R MC1R MC2R
LPAR3
P21817 14217 RYR2 HGNC:10484; Q92736 14218 RYR3 HGNC:10485; Q15413 14219 S1PR1 HGNC:3165; P21453 14220 S1PR2 HGNC:3169; O95136 14221 S1PR3 HGNC:3167; Q99500
List of human protein-coding genes 7
List_of_human_protein-coding_genes_7
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S1PR1
S1PR1
S1PR1
S1PR1
S1PR1
S1PR1
S1PR1
S1PR1
S1PR1
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