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S1PR1

  • S1PR1
  • Protein and coding gene in humans

    receptor 1 or S1PR1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled

    S1PR1

    S1PR1

    S1PR1

  • Sphingosine-1-phosphate receptor
  • Sphingosine-1-phosphate (S1P). They are divided into five subtypes: S1PR1, S1PR2, S1PR3, S1PR4 and S1PR5. In 1990, S1PR1 was the first member of the S1P receptor family to

    Sphingosine-1-phosphate receptor

    Sphingosine-1-phosphate receptor

    Sphingosine-1-phosphate_receptor

  • CD69
  • Human lectin protein

    complex with S1PR1 (not S1PR3 or S1PR5). This association is dependent on the interaction between the CD69 transmembrane domain and helix-4 of S1PR1. Following

    CD69

    CD69

    CD69

  • ACTH receptor
  • Mammalian protein found in humans

    inhibits binding to the receptor altogether. Source: MC4R MC3R MC5R MC1R GPR12 S1PR1 S1PR2 LPAR1 CNR1 S1PR3 GPR6 GPR3 S1PR5 LPAR3 S1PR4 CNR2 GPR119 LPAR2 melanocortin

    ACTH receptor

    ACTH receptor

    ACTH_receptor

  • Cannabinoid receptor 1
  • Mammalian protein found in humans

    identification of dermopterans as the closest primate relatives. Source: CNR2 S1PR1 LPAR1 S1PR3 S1PR5 S1PR2 GPR6 GPR12 S1PR4 LPAR3 LPAR2 GPR3 MC3R MC5R MC2R

    Cannabinoid receptor 1

    Cannabinoid receptor 1

    Cannabinoid_receptor_1

  • GPR12
  • Protein-coding gene in the species Homo sapiens

    obesity. Inverse agonists Cannabidiol Source: GPR6 GPR3 S1PR5 CNR1 CNR2 MC4R S1PR1 MC3R MC2R S1PR2 MC1R S1PR3 LPAR2 MC5R LPAR1 S1PR4 LPAR3 GPR119 GRCh38: Ensembl

    GPR12

    GPR12

    GPR12

  • S1PR2
  • Protein and coding gene in humans

    growth of developing and injured neuronal and vascular system. Source: S1PR1 S1PR3 S1PR5 S1PR4 LPAR2 LPAR1 LPAR3 CNR1 GPR6 MC3R GPR12 GPR3 MC4R MC1R

    S1PR2

    S1PR2

    S1PR2

  • GNAI1
  • Protein-coding gene in humans

    has been shown to interact with: GPR143, RGS12, RGS14, RGS19, RIC8A, and S1PR1. GRCh38: Ensembl release 89: ENSG00000127955 – Ensembl, May 2017 GRCm38:

    GNAI1

    GNAI1

    GNAI1

  • Melanocortin 1 receptor
  • Protein controlling mammalian coloration

    convergent evolution. Source: MC4R MC3R MC5R MC2R GPR6 GPR12 S1PR2 GPR3 S1PR1 LPAR1 CNR1 LPAR2 GPR119 S1PR3 S1PR5 LPAR3 CNR2 S1PR4 Chromatophore Melanocyte

    Melanocortin 1 receptor

    Melanocortin 1 receptor

    Melanocortin_1_receptor

  • Sphingosine-1-phosphate
  • Signaling sphingolipid

    discovered to be an extracellular ligand for G protein-coupled receptor S1PR1 in 1998. It is now known that sphingosine-1-phosphate receptors (S1P receptors)

    Sphingosine-1-phosphate

    Sphingosine-1-phosphate

  • Lysophospholipid receptor
  • Type of G protein-coupled receptor

    receptor 5 " GPR92 LPAR6 LPA6 lysophosphatidic acid receptor 6 " P2RY5 S1PR1 275 sphingosine-1-phosphate receptor 1 S1P EDG1 S1PR2 276 sphingosine-1-phosphate

    Lysophospholipid receptor

    Lysophospholipid_receptor

  • S1PR5
  • Protein-coding gene in the species Homo sapiens

    Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012) Source: S1PR1 S1PR3 S1PR2 S1PR4 LPAR1 LPAR2 GPR3 LPAR3 GPR12 CNR1 GPR6 CNR2 MC4R MC3R

    S1PR5

    S1PR5

    S1PR5

  • Melanocortin 4 receptor
  • Mammalian protein found in humans

    inhibitor MCL-0129 ML-00253764 MPB-10 Semax Source: MC5R MC3R MC1R MC2R S1PR1 LPAR1 GPR12 S1PR3 LPAR2 S1PR2 GPR6 GPR3 LPAR3 GPR119 CNR1 S1PR5 S1PR4 CNR2

    Melanocortin 4 receptor

    Melanocortin 4 receptor

    Melanocortin_4_receptor

  • GPR6
  • Protein-coding gene in the species Homo sapiens

    Cannabidiol Solangepras (solengepras; CVN-424) Source: GPR3 GPR12 S1PR5 S1PR1 CNR1 S1PR2 LPAR2 CNR2 MC1R S1PR3 S1PR4 GPR119 MC3R MC4R MC5R LPAR1 LPAR3

    GPR6

    GPR6

    GPR6

  • Fingolimod
  • Chemical compound

    lie in its activity at one of the five sphingosine-1-phosphate receptors, S1PR1. Phospho-fingolimod causes the internalization of S1P receptors, which sequesters

    Fingolimod

    Fingolimod

    Fingolimod

  • LPAR1
  • Protein

    uterine cervical preneoplastic lesions progression. Source: LPAR2 LPAR3 S1PR1 S1PR3 S1PR5 S1PR4 S1PR2 CNR1 MC3R MC5R MC4R GPR12 MC2R GPR6 CNR2 GPR3 MC1R

    LPAR1

    LPAR1

    LPAR1

  • Cannabinoid receptor 2
  • Mammalian protein found in humans

    purpurea AM-630 BML-190 JTE-907 SR-144,528 APD371 Source: CNR1 GPR12 GPR6 S1PR1 S1PR4 S1PR3 S1PR5 S1PR2 LPAR1 GPR3 LPAR3 LPAR2 MC4R MC5R GPR119 MC1R MC3R

    Cannabinoid receptor 2

    Cannabinoid receptor 2

    Cannabinoid_receptor_2

  • Jason Cyster
  • orchestrating immune cell positioning. His lab demonstrated that S1P receptor 1 (S1PR1) is essential for lymphocyte egress from the thymus and lymphoid organs—a

    Jason Cyster

    Jason_Cyster

  • Rhodopsin-like receptors
  • Family of proteins

    1-phosphate receptor InterPro: IPR004061 Sphingosine 1-phosphate receptor 1 (S1PR1) Sphingosine 1-phosphate receptor 2 (S1PR2) Sphingosine 1-phosphate receptor

    Rhodopsin-like receptors

    Rhodopsin-like receptors

    Rhodopsin-like_receptors

  • List of human clusters of differentiation
  • CD361 Also known as EVI2B. CD362 Also known as SDC2, Syndecan-2. CD363 S1PR1 (Sphingosine-1-phosphate receptor 1) or EDG1. It is a G-protein-coupled

    List of human clusters of differentiation

    List_of_human_clusters_of_differentiation

  • GPR119
  • Protein-coding gene in humans

    microbiota-endocannabinoidome axis. Source: GPR6 MC5R MC3R MC4R CNR1 GPR12 S1PR1 MC1R S1PR3 S1PR5 GPR3 S1PR2 CNR2 LPAR3 LPAR1 LPAR2 MC2R S1PR4 GRCh38: Ensembl

    GPR119

    GPR119

    GPR119

  • Melanocortin 3 receptor
  • Mammalian protein found in humans

    mixed MC3/MC4 antagonist. Source: MC5R MC4R MC1R MC2R LPAR1 S1PR2 GPR12 S1PR1 GPR6 LPAR2 S1PR3 GPR3 GPR119 CNR1 LPAR3 S1PR5 S1PR4 CNR2 Melanocortin receptor

    Melanocortin 3 receptor

    Melanocortin 3 receptor

    Melanocortin_3_receptor

  • S1PR4
  • Protein-coding gene in the species Homo sapiens

    lymphoid tissue. Agonists Sphingosine-1-phosphate CYM50308 Source: S1PR5 S1PR3 S1PR1 S1PR2 LPAR2 LPAR1 LPAR3 CNR1 GPR6 CNR2 GPR3 GPR12 MC4R MC5R MC3R MC2R MC1R

    S1PR4

    S1PR4

    S1PR4

  • Myosin light chain
  • Small polypeptide subunit of myosin

    and then leave the lymph nodes to migrate into inflammatory sites in an S1PR1-dependent manner." The proposed mechanisms of action of CD69/Myl9/12 system

    Myosin light chain

    Myosin light chain

    Myosin_light_chain

  • LPAR2
  • Protein-coding gene in the species Homo sapiens

    proteins. LPAR2 has been shown to interact with TRIP6. Source: LPAR1 LPAR3 S1PR1 S1PR5 S1PR4 S1PR2 S1PR3 GPR6 GPR3 GPR12 MC4R MC5R CNR1 MC3R CNR2 MC1R GPR119

    LPAR2

    LPAR2

    LPAR2

  • S1PR3
  • Protein and coding gene in humans

    regulation of angiogenesis and vascular endothelial cell function. Source: S1PR1 S1PR5 S1PR2 S1PR4 LPAR1 LPAR3 LPAR2 CNR1 MC5R GPR6 GPR12 MC4R CNR2 GPR3

    S1PR3

    S1PR3

    S1PR3

  • Outline of immunology
  • Overview of and topical guide to immunology

    CEACAM20 CEACAM21 CD24 CD44 CD146 CD164 CD69 Sphingosine-1-phosphate receptors S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 Co-stimulatory molecules CD80 - Expressed by APCs

    Outline of immunology

    Outline_of_immunology

  • Melanocortin 5 receptor
  • Protein found in humans

    protein (MRAP) traps MC5R protein inside cells. Source: MC4R MC3R MC1R MC2R S1PR1 LPAR1 S1PR3 GPR12 LPAR2 GPR3 S1PR2 GPR6 GPR119 LPAR3 CNR1 S1PR5 S1PR4 CNR2

    Melanocortin 5 receptor

    Melanocortin 5 receptor

    Melanocortin_5_receptor

  • GPR3
  • Protein

    The following proteins are Paralogues of GPR3: GPR6 GPR12 S1PR5 LPAR2 S1PR1 S1PR2 LPAR3 LPAR1 CNR1 S1PR3 MC3R MC4R S1PR4 MC5R MC1R CNR2 MC2R GPR119

    GPR3

    GPR3

    GPR3

  • GNAI3
  • Protein-coding gene in humans

    interact with: RGS10 RGS12, RGS14, RGS16, RGS18, RGS19, RGS5, RIC8A, and S1PR1. Gi alpha subunit GRCh38: Ensembl release 89: ENSG00000065135 – Ensembl

    GNAI3

    GNAI3

    GNAI3

  • Tissue-resident memory T cell
  • pathologies. On the other hand, they have lower expression of S1P receptor S1PR1, homing receptor to lymph node CD62L, activation marker KLRG1, KLF2 and

    Tissue-resident memory T cell

    Tissue-resident_memory_T_cell

  • LPAR3
  • Protein-coding gene in humans

    receptor couples predominantly to G(q/11) alpha proteins. Source: LPAR1 LPAR2 S1PR1 S1PR3 S1PR4 S1PR2 S1PR5 CNR1 GPR3 MC5R GPR6 GPR12 MC4R CNR2 MC3R MC1R MC2R

    LPAR3

    LPAR3

    LPAR3

  • List of human protein-coding genes 7
  • P21817 14217 RYR2 HGNC:10484; Q92736 14218 RYR3 HGNC:10485; Q15413 14219 S1PR1 HGNC:3165; P21453 14220 S1PR2 HGNC:3169; O95136 14221 S1PR3 HGNC:3167; Q99500

    List of human protein-coding genes 7

    List_of_human_protein-coding_genes_7

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