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Drugs acting on the estrogen receptor
of selective estrogen receptor modulators Selective androgen receptor modulator Selective estrogen receptor degrader Selective receptor modulator Timeline
Selective estrogen receptor modulator
Selective_estrogen_receptor_modulator
Class of pharmaceutical drugs
Selective androgen receptor modulators (SARMs) are a class of drugs that selectively activate the androgen receptor in specific tissues, promoting muscle
Selective androgen receptor modulator
Selective_androgen_receptor_modulator
Drug affecting hormone receptors
A selective progesterone receptor modulator (SPRM) is an agent that acts on the progesterone receptor (PR), the biological target of progestogens like
Selective progesterone receptor modulator
Selective_progesterone_receptor_modulator
Class of experimental drugs
receptor modulators (SEGRMs) are typically nonsteroidal. The combined abbreviation of selective glucocorticoid receptor agonist and modulator is SEGRAM
Selective glucocorticoid receptor modulator
Selective_glucocorticoid_receptor_modulator
Classes of selective receptor modulators include: Selective androgen receptor modulator (SARM) Selective estrogen receptor modulator (SERM) Selective glucocorticoid
Selective_receptor_modulator
Substance that binds to and regulates the activity of chemical receptors
A receptor modulator, or receptor ligand, is a general term for a substance, endogenous or exogenous, that binds to and regulates the activity of chemical
Receptor_modulator
Pharmaceutical compound
S42 is a fully synthetic steroidal selective androgen receptor modulator (SARM) developed for the treatment of muscle wasting in the elderly. MK-4541
S42 (selective androgen receptor modulator)
S42_(selective_androgen_receptor_modulator)
This is a list of selective estrogen receptor modulators (SERMs). SERMs that have been approved for medical use include anordrin (+mifepristone (Zi Yun))
List of selective estrogen receptor modulators
List_of_selective_estrogen_receptor_modulators
Drug class
that act as a sphingosine-1-receptor modulator. Even though it has the drawback of not being a selective receptor modulator it has passed all clinical
Sphingosine-1-phosphate receptor modulator
Sphingosine-1-phosphate_receptor_modulator
Ionotropic receptor and ligand-gated ion channel
receptor GABAB receptor GABAA-ρ receptor Gephyrin Glycine receptor GABAA receptor agonist GABAA receptor positive allosteric modulator GABAA receptor
GABAA_receptor
Chemical which binds to and activates a biochemical receptor
phenomenon are "functional selectivity", "protean agonism", or selective receptor modulators. As mentioned above, agonists have the potential to bind in
Agonist
A selective PPAR modulator (SPPARM) is a selective receptor modulator of the peroxisome proliferator-activated receptor (PPAR). Examples include SPPARMs
Selective_PPAR_modulator
Chemical compound
and by the black-market name Testolone or Testalone, is a selective androgen receptor modulator (SARM) which is under development for the treatment of hormone-sensitive
Vosilasarm
Genes on human chromosome 3
non-selective over vasopressin receptors LIT-002 – extremely potent; improved social deficits in mice; non-selective over vasopressin receptors TC OT
Oxytocin_receptor
Investigational generalized anxiety disorder drugs
Seroquel XL; Seroquel XR) – atypical antipsychotic (non-selective monoamine receptor modulator) [21] Agomelatine (AGO-178; AGO178; Alodil; Melitor; S-20098;
List of investigational generalized anxiety disorder drugs
List_of_investigational_generalized_anxiety_disorder_drugs
Drug class
A GABAA receptor negative allosteric modulator is a negative allosteric modulator (NAM), or inhibitor, of the GABAA receptor, a ligand-gated ion channel
GABAA receptor negative allosteric modulator
GABAA_receptor_negative_allosteric_modulator
Pharmaceutical compound
these indications. The drug is a GABAA receptor α2 and α3 subunit-selective partial positive allosteric modulator acting via the benzodiazepine site. It
AXS-17
Chemical compound
name VK5211 and by the black-market name Ligandrol, is a selective androgen receptor modulator (SARM) which is under development for the treatment of muscle
LGD-4033
Topics referred to by the same term
for targeted, mass spectrometry-based quantitative proteomics Selective receptor modulator, a type of drug Specified risk material, animal tissue that may
SRM
VERU-024) – selective androgen receptor modulator for breast cancer GSK-2881078 – selective androgen receptor modulator for cachexia OPK-88004 (LY-2452473;
List of investigational sex-hormonal agents
List_of_investigational_sex-hormonal_agents
Pharmaceutical compound
SKF-39315 is a monoamine receptor modulator of the 3-benzazepine family. It is a cyclized phenethylamine analogue of the neurotransmitter dopamine. The
SKF-39315
Chemical compound
LGD-2941 is a drug which acts as a selective androgen receptor modulator (SARM). It is no longer being developed. List of investigational sexual dysfunction
LGD-2941
Class of drugs
AMPA receptor positive allosteric modulators are positive allosteric modulators (PAMs) of the AMPA receptor (AMPR), a type of ionotropic glutamate receptor
AMPA receptor positive allosteric modulator
AMPA_receptor_positive_allosteric_modulator
Type of medication which modulates the GnRH receptor
GnRH modulator, or GnRH receptor modulator, also known as an LHRH modulator or LHRH receptor modulator, is a type of medication which modulates the GnRH
Gonadotropin-releasing hormone modulator
Gonadotropin-releasing_hormone_modulator
Investigational selective androgen receptor modulator
MK-2866, and S-22, is a selective androgen receptor modulator (SARM) which is under development for the treatment of androgen receptor-positive breast cancer
Enobosarm
Steroid drug
synthetic steroidal selective androgen receptor modulator (SARM). It is a gene-selective partial agonist of the androgen receptor (AR) and does not induce
YK-11
Class of antidepressant medication
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder
Selective serotonin reuptake inhibitor
Selective_serotonin_reuptake_inhibitor
Selective estrogen receptor modulator
(pending more study) for cancer. It is a third-generation selective estrogen receptor modulator (SERM). Since late 2013 it has had U.S. FDA approval for
Bazedoxifene
Drug class
of the serotonin 5-HT2A receptor are generally not selective for this receptor and also interact with other serotonin receptors, such as the serotonin
Serotonin 5-HT2A receptor agonist
Serotonin_5-HT2A_receptor_agonist
Chemical compound
Andarine (developmental code names GTx-007, S-4) is a selective androgen receptor modulator (SARM) which was developed by GTX, Inc for the treatment of
Andarine
Chaperone protein
The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling
Sigma-1_receptor
Acetylcholine receptors named for their selective binding of nicotine
selectively binds to nicotinic receptors but not to other acetylcholine receptors. (The other type of acetylcholine receptor, the muscarinic receptor
Nicotinic acetylcholine receptor
Nicotinic_acetylcholine_receptor
Class of cell surface receptors
Z (June 2006). "The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats"
Sigma_receptor
Type of cell receptor found in humans
(May 2007). "Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators". Proceedings of the National Academy of
Alpha-7_nicotinic_receptor
Class of neurotransmitter modulators
pharmacology, GABAA receptor positive allosteric modulators, also known as GABAkines or GABAA receptor potentiators, are positive allosteric modulator (PAM) molecules
GABAA receptor positive allosteric modulator
GABAA_receptor_positive_allosteric_modulator
Protein-coding gene in the species Homo sapiens, named for ketazocine
allosteric modulator of KOR, and a variety of natural alkaloids, terpenoids, and synthetic ligands bind to the receptor. Dysregulation of this receptor system
Κ-opioid_receptor
Class of antidepressant medication
A serotonin modulator and stimulator (SMS), sometimes referred to more simply as a serotonin modulator, is a type of drug with a multimodal action specific
Serotonin modulator and stimulator
Serotonin_modulator_and_stimulator
Pharmaceutical
experimental selective mineralocorticoid receptor modulator developed by AstraZeneca for heart failure. Compared to mineralocorticoid receptor antagonists
Balcinrenone
Type of drug
some receptor types and antagonist for others or agonist in some tissues while antagonist in others (also known as selective receptor modulators). A Full
Agonist-antagonist
Type of drug
AZD5423 (glucocorticoid), mapracorat (SGRMTooltip Selective glucocorticoid receptor modulator) Nonsteroidal antiandrogen Nonsteroidal estrogen Edward
Nonsteroidal
Investigational anxiety disorder drugs
allosteric modulator [3] BAER-101 (AZ-7325; AZD-7325) – selective GABAA α2 and α3 subunit-containing receptor positive allosteric modulator and
List of investigational anxiety disorder drugs
List_of_investigational_anxiety_disorder_drugs
Pharmaceutical compound
or by its developmental code name ASR-3004, is a serotonin receptor modulator of the tryptamine family. It is an asymmetrical analogue of dipropyltryptamine
Propylallyltryptamine
Pharmaceutical compound
orally. The drug is a selective and partial positive allosteric modulator of α2, α3, and α5 subunit-containing GABAA receptors, whereas it shows no activity
ENX-102
Chemical compound
designations. It is a nonsteroidal combined selective estrogen receptor modulator (SERM) and selective estrogen receptor degrader (SERD) (described as a "SERM/SERD
Elacestrant
G-protein-coupled receptor
shows a 5- to 10-fold selectivity for orexin receptor type 2, whilst orexin-A is equipotent at both receptors. Several orexin receptor antagonists are in
Orexin_receptor
Chemical compound
drug developed by Acadia Pharmaceuticals which acts as a selective androgen receptor modulator (SARM). Chemically it possesses endo-exo isomerism, with
AC-262,536
Neurotransmission-modulating substance
Trazodone Nefazodone Another subclass consists of drugs selectively acting at the 5-HT3 receptors, and thus are known as 5-HT3 antagonists. They are effective
Serotonin_receptor_antagonist
Protein-coding gene in humans
(LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor". Journal of Medicinal Chemistry
Dopamine_receptor_D1
D1 receptor positive allosteric modulator under development for Parkinson's disease
Glovadalen (developmental code name UCB-0022) is a dopamine D1 receptor positive allosteric modulator which is under development for the treatment of Parkinson's
Glovadalen
Protein-coding gene in the species Homo sapiens
"Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3
Muscarinic acetylcholine receptor M5
Muscarinic_acetylcholine_receptor_M5
Opioid receptor
modulator, non-selective) TRV250 (biased agonist) Xorphanol Buprenorphine Naltriben Naltrindole Mitragynine 7-Hydroxymitragynine δ-opioid receptors have
Δ-opioid_receptor
Chemical compound
acts as a selective androgen receptor modulator (SARM), with good oral bioavailability. It is a selective agonist for the androgen receptor, producing
LGD-3303
Chemical compound
BMS‐986122 is a selective positive allosteric modulator (PAM) of the μ-opioid receptor (MOR). MOR PAMs like BMS-986122 could be useful as novel analgesics
BMS‐986122
Type of receptor ligand or drug that blocks a biological response
maximum are obtained. Enzyme inhibitor Growth factor receptor inhibitor Selective receptor modulator "Pharmacology Guide: In vitro pharmacology: concentration-response
Receptor_antagonist
Chemical compound
ADX-71441 is a GABAB receptor positive allosteric modulator currently being investigated as a potential treatment for anxiety, epilepsy, pain and other
ADX-71441
Chemical compound
Compound 2f (SARM) is a drug which acts as a selective androgen receptor modulator (SARM), originally developed by Takeda Pharmaceutical for the treatment
Compound_2f_(SARM)
Class of G protein-coupled receptors
The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline)
Adrenergic_receptor
Investigational selective androgen receptor modulator
investigational selective androgen receptor modulator (SARM) developed by GTX, Inc as a potential male hormonal contraceptive. It binds to the androgen receptor more
S-23_(drug)
Subtype of serotonin receptor
oleamide analogue JPC0323. Another selective serotonin 5-HT2A receptor positive allosteric modulator is AB0124. 5-HT2A-receptor ligands may differentially activate
5-HT2A_receptor
Proteins activated by the hormone estrogen
to the beta receptor Subtype selective estrogen receptor modulators preferentially bind to either the α- or the β-subtype of the receptor. In addition
Estrogen_receptor
Diterpine alkaloid and opioid receptor modulator
reported to act as a μ-opioid receptor (MOR) positive allosteric modulator (PAM). The drug potentiated responses to the selective MOR agonist DAMGO at low
Ignavine
cannabinoid receptor modulator Cannabidivarin (CBDV; GWP-42006) – cannabinoid receptor modulator CMX-020 – TRPV1 modulator as well as CB1 and CB2 receptor modulator
List of investigational analgesics
List_of_investigational_analgesics
Chemical compound
TCS 1205 is a GABAA receptor positive allosteric modulator of the tryptamine family. It is a benzodiazepine site agonist selective for certain subunits
TCS-1205
Substance related to dopamine functions
selective D1-like receptor agonists like fenoldopam are used to treat hypertensive crisis. Positive allosteric modulators of the dopamine D1 receptor
Dopaminergic
Compound binding to cannabinoid receptors
A cannabinoid receptor modulator is a compound that bind to the cannabinoid receptors, which are receptors in the human body that regulate multiple physiological
Cannabinoid receptor modulator
Cannabinoid_receptor_modulator
Investigational insomnia drugs
MT2 receptor agonist Brexpiprazole (Rexulti; Lu-AF41156; OPC-34712; OPDC-34712) – atypical antipsychotic (non-selective monoamine receptor modulator) Cannabidiol
List of investigational insomnia drugs
List_of_investigational_insomnia_drugs
Class of opioid receptors found in humans
design of a new class of opioids with functional selectivity. Three variants of the μ-opioid receptor are well characterized, though reverse transcription
Mu-opioid_receptor
Chemical compound
TT-701) is a non-steroidal indole derivative which acts as a selective androgen receptor modulator (SARM). It has been investigated by OPKO Health for the
OPK-88004
Class of ionotropic glutamate receptors
neurotransmitter glutamate. They were first identified as a distinct receptor type through their selective activation by the agonist kainate, a drug first isolated
Kainate_receptor
Hallucinogenic drug
No fully selective GABAA receptor agonists, for instance lacking any additional activity at the closely related GABAA-ρ and/or GABAB receptors, are currently
GABAA_receptor_agonist
Pharmaceutical compound
a serotonin 5-HT2A receptor positive allosteric modulator. It is highly selective for potentiation of the serotonin 5-HT2A receptor, with no potentiation
AB0124
Chemical compound
Morrison K, et al. (December 2017). "Cenerimod, a novel selective S1P1 receptor modulator with unique signaling properties". Pharmacology Research &
Cenerimod
Abandoned drug
MK-4541 is a dual selective androgen receptor modulator (SARM) and 5α-reductase inhibitor (5α-RI) which has been of interest for the potential treatment
MK-4541
tissue-selective estrogen complex (TSEC) is a combination of an estrogen, such as estradiol or conjugated estrogens, and a selective estrogen receptor modulator
Tissue-selective estrogen complex
Tissue-selective_estrogen_complex
Pharmaceutical compound
or by its developmental code name ASR-3002, is a serotonin receptor modulator of the tryptamine family. It is the 2-methyl derivative of iPALT.
2-Methyl-iPALT
Chemical compound
Darigabat acts as a GABAA receptor positive allosteric modulator It is specifically a positive allosteric modulator that selectively targets α2, α3, and α5
Darigabat
Pharmaceutical compound
bicalutamide may function as a selective AR modulator. However, in contrast to the selective estrogen receptor modulators tamoxifen and raloxifene, bicalutamide
Pharmacology_of_bicalutamide
G protein-coupled receptor
Additionally, vasopressin selectively contracts efferent arterioles probably through the V1R, but not the afferent arteriole. V2 receptor (V2R) differs from
Vasopressin_receptor
Chemical compound
Name), a nonsteroidal selective estrogen receptor modulator of the triphenylethylene group, acts by antagonizing the estrogen receptor (ER) in the pituitary
Enclomifene
Pharmaceutical compound
from the piperidine family, which acts as a selective positive allosteric modulator of the 5-HT2C receptor, with higher potency than older drugs such as
CTW0415
Abandoned drug
also known as PF-05314882, is a steroidal, orally active selective androgen receptor modulator (SARM) that was under development by Merck and GTx for the
MK-0773
Pharmaceutical compound
5-HT2A receptor positive allosteric modulator. 5-HT2C receptor § Positive allosteric modulators 5-HT2A receptor § Positive allosteric modulators AB0124
JPC0323
Investigational substance-related disorder drugs
combination of buprenorphine (non-selective opioid receptor modulator) and naloxone (orally/sublingually inactive opioid receptor antagonist) – opioid-related
List of investigational substance-related disorder drugs
List_of_investigational_substance-related_disorder_drugs
G protein-coupled receptor
endogenous agonist melanocyte-stimulating hormones. Several selective ligands for the melanocortin receptors are known, and some synthetic compounds have been investigated
Melanocortin_receptor
Investigational antimigraine drugs
OX1 and OX2 receptor antagonist – migraine [49] Flunarizine (XEN-007) – calcium channel blocker, non-selective monoamine receptor modulator, other actions
List of investigational headache and migraine drugs
List_of_investigational_headache_and_migraine_drugs
Pharmaceutical compound
name RGH-896) is an NR2B (GluN2B; GRIN2B) subunit-selective NMDA receptor negative allosteric modulator which is under development for the treatment of
Radiprodil
Chemical compound
developmental code name J-867) is a synthetic, steroidal selective progesterone receptor modulator that was under development by Schering and TAP Pharmaceutical
Asoprisnil
Class of transmembrane proteins
hence "5-HT") receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release
5-HT_receptor
List of pharmaceutical drugs under clinical development for treatment of depression
ionotropic glutamate NMDA receptor glycine site partial agonist and atypical antipsychotic (non-selective monoamine receptor modulator) combination Deupsilocin
List of investigational antidepressants
List_of_investigational_antidepressants
Topics referred to by the same term
SERM may refer to: Selective estrogen receptor modulator Structured entity relationship model Search engine reputation management This disambiguation
SERM
Chemical compound
LY305 is a transdermally bioavailable selective androgen receptor modulator (SARM) developed by Eli Lilly for the treatment of osteoporosis in men. Its
LY305
Pharmaceutical compound
be a biased allosteric modulator selective for certain signalling pathways. 5-HT2A receptor § Positive allosteric modulators CTW0415 AB0124 Wold EA,
CTW0404
Atypical opioid drug
receptor modulator with unusual actions and effects. It acts as a biased partial agonist of the μ-opioid receptor (MOR), showing strong selectivity for
SR-17018
ATL5; RLS103) – cannabinoid receptor modulator and other actions Cannabidiol (CBD; Empower CBD) – cannabinoid receptor modulator and other actions ENX-102
List of investigational social anxiety disorder drugs
List_of_investigational_social_anxiety_disorder_drugs
5-HT2C receptor antagonist and MT1 and MT2 receptor agonist Brexanolone (allopregnanolone; Zulresso) – GABAA receptor positive allosteric modulator – approved
List_of_antidepressants
Protein
as selective receptor modulators (SRMs). Examples include Selective Androgen Receptor Modulators (SARMs), Selective Estrogen Receptor Modulators (SERMs)
Nuclear_receptor
– a non-selective serotonin receptor agonist 5-Methoxytryptamine – a non-selective serotonin receptor agonist Aeruginascin – a non-selective serotonin
Peripherally_selective_drug
Pharmaceutical compound
from the indole family, which is acts as a selective positive allosteric modulator of the 5-HT2C receptor. It has anorectic effects in animal studies
VA012
Type of nicotinic acetylcholine receptor
The alpha-4 beta-2 nicotinic receptor, also known as the α4β2 receptor, is a type of nicotinic acetylcholine receptor implicated in learning, consisting
Alpha-4 beta-2 nicotinic receptor
Alpha-4_beta-2_nicotinic_receptor
Protein-coding gene in the species Homo sapiens
Phytoestrogens (e.g., coumestrol, daidzein, genistein, miroestrol) Selective estrogen receptor modulators (e.g., tamoxifen, clomifene, raloxifene) Antiestrogens (e
Estrogen_receptor_alpha
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SELECTIVE RECEPTOR-MODULATOR
SELECTIVE RECEPTOR-MODULATOR
SELECTIVE RECEPTOR-MODULATOR
SELECTIVE RECEPTOR-MODULATOR
SELECTIVE RECEPTOR-MODULATOR
SELECTIVE RECEPTOR-MODULATOR
SELECTIVE RECEPTOR-MODULATOR
SELECTIVE RECEPTOR-MODULATOR
SELECTIVE RECEPTOR-MODULATOR
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