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Enzyme-coding gene in humans
N-methyltransferase SETDB1 is an enzyme that in humans is encoded by the SETDB1 gene. SETDB1 is also known as KMT1E or H3K9 methyltransferase ESET. The human SETDB1 protein
SETDB1
Mammalian protein found in Homo sapiens
"master controller" MyoD has become active, SETDB1 is required to maintain MyoD expression within the cell. Setdb1 appears to be necessary to maintain both
MyoD
Histone acetylation on tail of histone H3
domain of the H3K9 methyltransferase SETDB1 binds to methylated H3 with both K14 acetylation and K9 methylation. SETDB1 silences retroviruses and gene regulation
H3K14ac
Protein
histone H3 at the lysine 4 residue (K4). SETD1A is highly homologous with SETDB1 but has a distinct subnuclear distribution. Mutations of the SETD1A gene
SETD1A
Species of fish
genes known to be amplified and overexpressed in human melanoma. One gene, SETDB1, markedly accelerated tumor formation in the zebrafish system, demonstrating
Zebrafish
Protein-coding gene in the species Homo sapiens
formation via the Mi2α-SETDB1-HP1 macromolecular complex. KAP1 recruits and interacts directly with the histone methyltransferase SETDB1 and with histone deacetylases
TRIM28
Protein family
MeCP2, MBD1 and MBD2, preferentially to methylated CpG. In human MBD3 and SETDB1, the MBD has been shown to mediate protein-protein interactions. MBDs are
Methyl-CpG-binding_domain
Protein-coding gene in the species Homo sapiens
been found by yeast two hybrid screen to bind to SETDB1 a histone protein methyltransferase enzyme. SETDB1 has been implicated in Huntington's disease, a
C11orf1
Protein-coding gene in the species Homo sapiens
identification of a MECP2 duplication and novel alterations in MBD5, MBD6, and SETDB1". Autism Research. 5 (6): 385–397. doi:10.1002/aur.1251. PMC 3528798. PMID 23055267
Methyl-CpG binding domain protein 5
Methyl-CpG_binding_domain_protein_5
Protein-coding gene in the species Homo sapiens
modification through interaction with the histone H3K9 methyltransferase SETDB1. H3K9me3 is a repressive modification. DNA methylation is the major modification
MBD1
Project to catalogue genetic mutations responsible for cancer
novel genomic subtype accounting for about 3% of samples with: TP53 and SETDB1 mutations and loss of one copy of nearly all chromosomes (which researchers
The_Cancer_Genome_Atlas
Largest class of small non-coding RNA molecules in animals
Sister of Yb (SoYB) Vasa Maelstrom (Mael) Rhino (HP1D) Deadlock Cutoff SetDB1 (Eggless) SuVar3–9 Major advances in the study of piRNA have been achieved
Piwi-interacting_RNA
Class of enzymes
SETD1A, SETD1B, SETD2, SETD3, SETD4, SETD5, SETD6, SETD7, SETD8, SETD9, SETDB1, SETDB2 SETMAR, SMYD1, SMYD2, SMYD3, SMYD4, SMYD5, SUV39H1, SUV39H2, KMT5B
Histone_methyltransferase
specific TF according to literature or domain structure – No motif [807] SETDB1 ENSG00000143379 MBD Known motif – In vivo/Misc source [808] RACTHCMDYTCCCRKVRDGCHNYG
List of human transcription factors
List_of_human_transcription_factors
Field of study
demethylase 1 (LSD1), and an H3K9me2 methyltransferase SET domain bifurcated 1 (SETDB1) were also implicated in diabetes related adipogenesis. The inflammatory
Epigenetics of diabetes type 2
Epigenetics_of_diabetes_type_2
Protein family
PRDM2, PRDM5 SETD1A, SETD2, SETD3, SETD4, SETD5, SETD6, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD1, SMYD3, SMYD4, SMYD5, SUV39H1, SUV39H2, KMT5B, SUV420H2
SET_domain
American biologist
the testes. She is investigating the gene targets of dSETDB1 and the mechanisms by which dSETDB1 identifies the targets in the genome. In September 2019
Tulle_Hazelrigg
American geneticist
Taiping; Li, En; Lin, Haifan (January 2021). "The Essential Function of SETDB1 in Homologous Chromosome Pairing and Synapsis during Meiosis". Cell Reports
Haifan_Lin
Protein-coding gene in the species Homo sapiens
POGZ subunit additionally binds and recruits the H3K9 methyltransferase SETDB1 to these regions. Through this activity the complex contributes to transcriptional
CHAMP1
Protein-coding gene in the species Homo sapiens
Tong, Rongsheng; Zhong, Lei (2022). "Role of histone methyltransferase SETDB1 in regulation of tumourigenesis and immune response". Frontiers in Pharmacology
ATF7IP
Q8TBK2 14625 SETD7 HGNC:30412; Q8WTS6 14626 SETD9 HGNC:28508; Q8NE22 14627 SETDB1 HGNC:10761; Q15047 14628 SETDB2 HGNC:20263; Q96T68 14629 SETMAR HGNC:10762;
List of human protein-coding genes 7
List_of_human_protein-coding_genes_7
Field of study
trimethylation is linked to an increased expression of the methyltransferase ESET/SETDB1 (ERG-associated protein with SET domain (ESET)), which targets and trimethylates
Epigenetics of neurodegenerative diseases
Epigenetics_of_neurodegenerative_diseases
SETDB1
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Boy/Male
Arabic, Australian, Malaysian, Muslim
Thankfulness; Thanking
Boy/Male
Hindu
Lord Shiva
Boy/Male
Australian, Hebrew, Jewish
Given by God
Girl/Female
Biblical
Nativity, generation.
Female
Egyptian
, the mother of Bebe.
Surname or Lastname
English, Scottish, Dutch, and North German
English, Scottish, Dutch, and North German : status name for a champion, Middle English and Middle Low German kempe. In the Middle Ages a champion was a professional fighter on behalf of others; for example the King’s Champion, at the coronation, had the duty of issuing a general challenge to battle to anyone who denied the king’s right to the throne. The Middle English word corresponds to Old English cempa and Old Norse kempa ‘warrior’; both these go back to Germanic campo ‘warrior’, which is the source of the Dutch and North German name, corresponding to High German Kampf.Dutch : metonymic occupational name for someone who grew or processed hemp, from Middle Dutch canep ‘hemp’.
Girl/Female
Assamese, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Punjabi, Sikh, Telugu
Famed
Girl/Female
Arabic, Muslim, Sindhi
Lament; Scar; Mark
Male
Dutch
, who is like God?
Boy/Male
Muslim
Praise
SETDB1
SETDB1
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