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THIOLACTONE

  • Thiolactone
  • Thiolactones are a class of heterocyclic compounds in organic chemistry. They are analogs of the more common lactones in which an oxygen atom is replaced

    Thiolactone

    Thiolactone

    Thiolactone

  • Homocysteine thiolactone
  • Chemical compound

    Homocysteine thiolactone (HTL) is an organosulfur compound with the formula H2NCHC(O)SCH2CH2. It is the thiolactone (intramolecular thioester) of homocysteine

    Homocysteine thiolactone

    Homocysteine thiolactone

    Homocysteine_thiolactone

  • Clopidogrel
  • Antiplatelet medication

    thiophene ring is converted to a thiolactone. This thiolactone is then oxidized by a cytochrome P450 into a thiolactone S-oxide, that is unstable and opens

    Clopidogrel

    Clopidogrel

    Clopidogrel

  • Homocysteine
  • Chemical compound

    for methionine synthase. Homocysteine can cyclize to give homocysteine thiolactone, a five-membered heterocycle. Because of this "self-looping" reaction

    Homocysteine

    Homocysteine

    Homocysteine

  • Prasugrel
  • Medication used to prevent formation of blood clots

    intestine and carboxylesterase 1 in the liver to a likewise inactive thiolactone, which is then converted by CYP3A4 and CYP2B6, and to a minor extent

    Prasugrel

    Prasugrel

    Prasugrel

  • Fukuyama coupling
  • Chemical reaction

    to the thiolactone intermediate 1. Shimizu and Seki realized the efficient synthesis of (+)-biotin via the Fukuyama coupling of the thiolactone 1 and an

    Fukuyama coupling

    Fukuyama_coupling

  • Bleomycin hydrolase
  • Protein-coding gene in the species Homo sapiens

    biological function is hydrolysis of the reactive electrophile homocysteine thiolactone. Another of its activities is metabolic inactivation of the glycopeptide

    Bleomycin hydrolase

    Bleomycin hydrolase

    Bleomycin_hydrolase

  • Lactone
  • Cyclic carboxylic ester

    Lactam, a cyclic amide Lactim, a cyclic imide Lactide, a cyclic diester Thiolactone Halolactonization Phthalein Ester "lactones", Compendium of Chemical

    Lactone

    Lactone

  • Adenosine diphosphate receptor inhibitor
  • Drug class of antiplatelet agents

    starts in the intestines where it is metabolized by esterase into a thiolactone, this inactive intermediate then undergoes CYP-mediated ring opening

    Adenosine diphosphate receptor inhibitor

    Adenosine_diphosphate_receptor_inhibitor

  • Acetolactone
  • Chemical compound

    trifluoromethyl groups. That compound has a half-life of 8 hours at 25 °C. Α-Thiolactones can be produced via oxygen transfer from a nitrone to a thioketene. α-Propiolactone

    Acetolactone

    Acetolactone

  • Vitamin B12 total synthesis
  • Industrial synthesis of chemical substance

    ring closure was also achieved by converting the thiolactone-thiolactame intermediate HE-40u to thiolactone-thioiminoester HE-45u by S-methylation of the

    Vitamin B12 total synthesis

    Vitamin_B12_total_synthesis

  • Accessory gene regulator
  • Type of regulator gene

    transcriptional quorum-sensing (QS) system activated by an autoinducing, thiolactone-containing cyclic peptide (AIP). Agr occurs in 4 allelic subtypes that

    Accessory gene regulator

    Accessory_gene_regulator

  • Kadethrin
  • Chemical compound

    especially when exposed to light (due to both the furan ring and the thiolactone group in the molecule). Kadethrin at Sigma-Aldrich John E. Casida (1980)

    Kadethrin

    Kadethrin

    Kadethrin

  • Thioester
  • Organosulfur compounds of the form R–SC(=O)–R′

    protein for degradation. Oxidation of the sulfur atom in thioesters (thiolactones) is postulated in the bioactivation of the antithrombotic prodrugs ticlopidine

    Thioester

    Thioester

    Thioester

  • Citiolone
  • Chemical compound

    Citiolone is a drug used in liver therapy. It is a derivative of the amino acid homocysteine. Citilone has also been studied with regard to hypothermia

    Citiolone

    Citiolone

    Citiolone

  • Organozinc chemistry
  • Study of compounds with carbon to zinc bonds

    (+)-biotin. In this case, the Fukuyama coupling takes place with the thiolactone: The Barbier reaction involves nucleophilic addition of a carbanion equivalent

    Organozinc chemistry

    Organozinc chemistry

    Organozinc_chemistry

  • Erdosteine
  • Chemical to treat chronic bronchitis

    acid: a novel mucolytic agent of the class of homocysteine thiolactone derivatives". Il Farmaco; Edizione Scientifica. 41 (1): 69–79. PMID 3956722

    Erdosteine

    Erdosteine

    Erdosteine

  • PON1
  • Protein-coding gene in the species Homo sapiens

    hydrolysing a wide variety of substrates, such as lactones, including thiolactones and pharmaceutical agents such as statins. PON1 substrates also include

    PON1

    PON1

    PON1

  • Outline of organic chemistry
  • Overview of and topical guide to organic chemistry

    Enals Enamines Enols Enolates Esters Lactones Sulfonates Thioesters Thiolactones Ethers Epoxides Silyl Ethers Thioethers Glycosides Glycosylamines Heterocyclic

    Outline of organic chemistry

    Outline_of_organic_chemistry

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