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Protein-coding gene in the species Homo sapiens
The thrombopoietin receptor also known as the myeloproliferative leukemia protein or CD110 (Cluster of Differentiation 110) is a protein that in humans
Thrombopoietin_receptor
Mammalian protein found in Homo sapiens
Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the THPO gene. Thrombopoietin
Thrombopoietin
Medical condition with rash and bleeding risk
development of a class of ITP-targeted medications referred to as thrombopoietin receptor agonists. The stimulus for auto-antibody production in ITP is probably
Immune thrombocytopenic purpura
Immune_thrombocytopenic_purpura
Class of drugs
Thrombopoietin mimetics are drugs that considerably increase platelet production by stimulating the receptor for the hormone thrombopoietin; Romiplostim
Thrombopoietin_mimetics
Chemical compound
Lusutrombopag, sold under the brand name Mulpleta among others, is a medication that has been developed for certain conditions that lead to thrombocytopenia
Lusutrombopag
Chemical compound
(abnormally low platelet counts) and severe aplastic anemia. It is a thrombopoietin receptor agonist. It is taken by mouth. Eltrombopag was discovered as a
Eltrombopag
Chemical compound
thrombocytopenia and anemia. It is a non-peptide small‐molecule thrombopoietin receptor agonist. In China, it is approved for second-line treatment for
Hetrombopag
Receptors on the surface of cells
Erythropoietin receptor GM-CSF receptor G-CSF receptor Thrombopoietin receptor Growth hormone receptor Prolactin receptor Leptin receptor Oncostatin M receptor Leukemia
Type_I_cytokine_receptor
Chemical compound
Union in June 2019, and Australia in January 2023. It acts as a thrombopoietin receptor agonist. The chemical synthesis of avatrombopag was recently reported:
Avatrombopag
Overproduction of platelets in the bone marrow
gene is responsible for making thrombopoietin receptor proteins which promote the growth and division of cells. This receptor protein is vital in producing
Essential_thrombocythemia
Pharmaceutical drug
under the brand name Nplate among others, is a fusion protein analog of thrombopoietin, a hormone that regulates platelet production. The most common side
Romiplostim
Drug given during chemotherapy to increase blood cell regeneration
See here instead. Thrombopoietin Agonists: Eltrombopag Pegacaristim Promegapoietin Romiplostim Avatrombopag Lusutrombopag Thrombopoietin (THPO, MGDF) Interferon
Promegapoietin
Rare type of blood cancer
which include erythropoietin and thrombopoietin. The MPL gene codes for a protein that acts as a receptor for thrombopoietin, a growth factor that enhances
Primary_myelofibrosis
Class of enzymes
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90
Receptor_tyrosine_kinase
that the orphan MPL receptor had as ligand a megakaryopoiesis stimulating factor that had all the characteristics of thrombopoietin, a presumptive humoral
William_Vainchenker
Medical intervention
Batroxobin Carbazochrome Concizumab Etamsylate Fostamatinib Marstacimab thrombopoietin receptor agonist Romiplostim Avatrombopag Eltrombopag Lusutrombopag Rafutrombopag
Hemostatic Powder Spray TC-325
Hemostatic_Powder_Spray_TC-325
Diverse collection of blood-related cancers
not requiring a transfusion). Romiplostim and eltrombopag are thrombopoietin receptor agonists that act on megakaryocytes (platelet precursor cells)
Myelodysplastic_syndrome
Japanese pharmaceutical company
a thrombopoietin receptor agonist. Osphena, an estrogen receptor agonist, marketing rights sold to Duchesnay in 2017. Symproic, a μ-opioid receptor antagonist
Shionogi
Overproduction of blood cells in the bone marrow
the JAK2 V617F mutation in up to 55% of cases and with an MPL (thrombopoietin receptor) mutation in up to 5% of cases. There should be no increase in
Myeloproliferative_neoplasm
Overview of and topical guide to immunology
(CD110, Thrombopoietin receptor) - Homodimer upon ligand binding GHR (Growth hormone receptor) - Homodimer upon ligand binding PRLR (Prolactin receptor) Type
Outline_of_immunology
Medical condition
of CAMT is believed to be mutations in the MPL gene coding for thrombopoietin receptor, which is expressed in pluripotent hematopoietic stem cells and
Congenital amegakaryocytic thrombocytopenia
Congenital_amegakaryocytic_thrombocytopenia
Chronic disease of the liver, characterized by fibrosis
low-risk procedures, the AGA does not recommend the routine use of thrombopoietin receptor agonists for bleeding prevention. In hospitalized patients who
Cirrhosis
Transmembrane protein
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Medical condition
medications can be pursued. These interventions include Rituximab and thrombopoietin receptor agonists. Splenectomy can be considered if all other treatments
Thrombocytopenic_purpura
Family of proteins that bind to fibroblast growth factors
The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of
Fibroblast growth factor receptor
Fibroblast_growth_factor_receptor
American medical doctor and hematologist
Kaushansky K. YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation. Blood 2008 112:2222-2231
Kenneth_Kaushansky
Transmembrane proteins
Type II cytokine receptors, also commonly known as class II cytokine receptors, are transmembrane proteins that are expressed on the surface of certain
Type_II_cytokine_receptor
Chemical compound
included corticosteroids, immunoglobulins, splenectomy, and/or a thrombopoietin receptor agonist. Participants were allowed to continue previous ITP treatment
Fostamatinib
Topics referred to by the same term
(gene), which encodes the myeloproliferative leukemia protein (thrombopoietin receptor) Marfanoid–progeroid–lipodystrophy syndrome Medial patellar luxation
MPL
Protein-coding gene in the species Homo sapiens
The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52 kDa peptide with a single carbohydrate chain resulting
Erythropoietin_receptor
Cell surface receptors for interleukin-13
The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by IL13RA1 and IL4R, respectively
Interleukin-13_receptor
Protein found in humans
Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming
Tropomyosin_receptor_kinase_A
Protein found in humans
Death receptor 3 (DR3), also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25), is a cell surface receptor of the tumor necrosis
Death_receptor_3
Cell receptor protein found in humans
insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone
Insulin-like growth factor 1 receptor
Insulin-like_growth_factor_1_receptor
Protein family
VEGF receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending
VEGF_receptor
Protein family
Transforming growth factor beta (TGFβ) receptors are single pass serine/threonine kinase receptors that belong to TGFβ receptor family. They exist in several different
TGF_beta_receptor
Protein-coding gene in the species Homo sapiens
Ectodysplasin A receptor (EDAR) is a protein that in humans is encoded by the EDAR gene. EDAR is a cell surface receptor for ectodysplasin A which plays
Ectodysplasin_A_receptor
Human protein-coding gene
The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) before discovery that p75NTR
Low-affinity nerve growth factor receptor
Low-affinity_nerve_growth_factor_receptor
Cell surface receptors
Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF)
Platelet-derived growth factor receptor
Platelet-derived_growth_factor_receptor
Protein-coding gene in humans
also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six
Common_gamma_chain
Lymphocyte receptor specific for Interleukin-2
The interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds
IL-2_receptor
Protein found in humans
Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. Interleukin 6 (IL6) is a potent pleiotropic
Interleukin-6_receptor
Mammalian protein found in Homo sapiens
The interferon-gamma receptor (IFNGR) protein complex is the heterodimer of two chains: IFNGR1 and IFNGR2. It binds interferon-γ, the sole member of interferon
Interferon-gamma_receptor
Immune system protein
C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it
CCR5
Human protein-coding gene
Platelet-derived growth factor receptor A, also termed CD140a, is a receptor located on the surface of a wide range of cell types. The protein is encoded
Platelet-derived growth factor receptor A
Platelet-derived_growth_factor_receptor_A
Protein that binds to a cytokine
Cytokine receptors are receptors that bind to cytokines. The binding of cytokines to receptors allows the cell that houses the receptor to be able to receive
Cytokine_receptor
Protein superfamily of cytokine receptors
The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis
TNF_receptor_superfamily
Protein and coding gene in humans
Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type
Tropomyosin_receptor_kinase_B
Family of proteins involved in a TGF signaling pathway
factor beta (TGFβ) receptors are a family of serine/threonine kinase receptors involved in TGF beta signaling pathway. These receptors bind growth factor
TGF-beta_receptor_family
Mammalian protein found in humans
Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ERBB2 gene. ERBB is abbreviated
HER2
Mammalian protein and protein-coding gene
Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation
KIT_gene
Group of protein families
Neurotrophic factor receptors or neurotrophin receptors are a group of growth factor receptors which specifically bind to neurotrophins (neurotrophic factors)
Neurotrophic_factor_receptor
Category of small signaling proteins
several non-immunological cytokines including erythropoietin (EPO) and thrombopoietin (TPO). They can be grouped into long-chain and short-chain cytokines
Cytokine
RNA family
Vainchenker W, Giraudier S, Constantinescu SN (July 2010). "miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative
Mir-708 microRNA precursor family
Mir-708_microRNA_precursor_family
Bone marrow cell which produces platelets
mutation induces an unregulated proliferative signal from the thrombopoietin (TPO) receptor in the absence of TPO causing clonal expansion of bone marrow
Megakaryocyte
Protein-coding gene in humans
Chemokine receptor CXCR3 is a Gαi protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9)
CXCR3
Cytokine receptor
Chemokine receptors are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called a chemokine. There have been
Chemokine_receptor
Protein-coding gene in humans
Chemokine (C-C motif) receptor 8, also known as CCR8, is a protein which in humans is encoded by the CCR8 gene. CCR8 has also recently been designated
C-C motif chemokine receptor 8
C-C_motif_chemokine_receptor_8
Protein family
CXC chemokine receptors are integral membrane proteins that specifically bind and respond to cytokines of the CXC chemokine family. They represent one
CXC_chemokine_receptors
Protein-coding gene in humans
Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene. This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine
EPHA8
Protein encoding gene in humans
chemokine receptor that in humans is encoded by the CXCR2 gene. The protein encoded by this gene is a member of the G-protein-coupled receptor family. This
CXCR2
Tumor necrosis factor receptor-associated factors (TRAFs) are a family of proteins that function as signaling molecules and are primarily involved in the
TNF receptor associated factor
TNF_receptor_associated_factor
Protein-coding gene in the species Homo sapiens
activation of several receptors, including stem cell factor receptor (c-kit), thrombopoietin receptor (MPL), erythropoietin receptor (EPOR), platelet-derived
SH2B3
Platelet reduction following transfusion
patients with platelet refractoriness who require procedures include thrombopoietin receptor agonists, complement inhibitors such as eculizumab, and slow infusion
Platelet transfusion refractoriness
Platelet_transfusion_refractoriness
Cytokine receptor which binds interleukin 1
Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1. Two forms of the receptor exist. The type I receptor is primarily responsible
Interleukin-1_receptor
Protein-coding gene in humans
associated protein (hNUDC) binds to the extracellular domain of thrombopoietin receptor (Mpl)". Journal of Cellular Biochemistry. 96 (4): 741–50. doi:10
NUDC
Group of blood-based disorders
Examples of such receptors include the erythropoietin receptor, Thrombopoietin receptor, granulocyte colony-stimulating factor receptor, Granulocyte macrophage
Clonal_hypereosinophilia
Mammalian protein found in Homo sapiens
coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes. The receptor belongs to the type I cytokine receptor family and
Interleukin-3_receptor
Chemical compound
array of nuclear and cell surface receptors, and acting as a neurosteroid and modulator of neurotrophic factor receptors. In the United States, DHEA is sold
Dehydroepiandrosterone
Mammalian protein found in humans
Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a protein that in humans is encoded by the CALCRL gene
CALCRL
Protein that stimulates red blood cell production
period; renal production predominates in adulthood. It is homologous with thrombopoietin. Exogenous erythropoietin, recombinant human erythropoietin (rhEPO)
Erythropoietin
Interleukin-10 receptor subunit alpha precursor - Homo sapiens (Human)". www.uniprot.org. Retrieved 2015-10-13. "IL10RB - Interleukin-10 receptor subunit beta
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Mammalian protein found in humans
Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene. CCR6 has also recently been designated
C-C_chemokine_receptor_type_6
Protein found in humans
Insulin-like growth factor 2 receptor (IGF2R), also called the cation-independent mannose-6-phosphate receptor (CI-MPR) is a protein that in humans is
Insulin-like growth factor 2 receptor
Insulin-like_growth_factor_2_receptor
InterPro Family
Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system. Trk receptors affect neuronal
Trk_receptor
Protein found in humans
EPH receptor A2 (ephrin type-A receptor 2) is a protein that in humans is encoded by the EPHA2 gene. This gene belongs to the ephrin receptor subfamily
EPH_receptor_A2
Mammalian protein found in humans
TrkA receptor facilitates receptor dimerization and tyrosine residue phosphorylation of the cytoplasmic tail by adjacent Trk receptors. Trk receptor phosphorylation
Nerve_growth_factor
Protein-coding gene in the species Homo sapiens
Oncostatin-M specific receptor subunit beta also known as the Oncostatin M receptor (OSMR), is one of the receptor proteins for oncostatin M, that in humans
Oncostatin_M_receptor
Mammalian protein found in Homo sapiens
characteristics. Treatment is primarily supportive. In a phase 2 trial, the thrombopoietin receptor agonist eltrombopag significantly increased platelet counts in
MYH9
Protein in humans
interleukin-31 receptor (IL-31R) is a receptor bound and activated by interleukin-31 (IL-31). It is a heterodimer consisting of IL-31 receptor A (IL31RA)
Interleukin-31_receptor
Protein-coding gene in the species Homo sapiens
The interleukin 4 receptor is a type I cytokine receptor. It is a heterodimer, that is, composed of two subunits. IL4R is the human gene coding for IL-4Rα
Interleukin-4_receptor
Heterodimeric receptor
The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. Endogenous human
Interferon-alpha/beta receptor
Interferon-alpha/beta_receptor
The interleukin-1 receptor (IL-1R) associated kinase (IRAK) family plays a crucial role in the protective response to pathogens introduced into the human
Interleukin-1 receptor associated kinase
Interleukin-1_receptor_associated_kinase
Protein-coding gene in the species Homo sapiens
domain receptor (KDR, a type IV receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor. KDR
Kinase_insert_domain_receptor
Protein-coding gene in humans
granulocyte-macrophage colony-stimulating factor receptor, also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte-macrophage colony-stimulating
Granulocyte-macrophage colony-stimulating factor receptor
Granulocyte-macrophage_colony-stimulating_factor_receptor
Protein-coding gene in the species Homo sapiens
Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a type I cytokine receptor. IL9R also denotes its human gene. The
Interleukin-9_receptor
Protein
C-X-C chemokine receptor type 4 (CXCR-4) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4
CXCR4
Protein found in humans
interleukin-23 receptor is a type I cytokine receptor. It is encoded in human by the IL23R gene. In complex with the interleukin-12 receptor β1 subunit (IL-12Rβ1)
Interleukin-23_receptor
Mammalian protein found in Homo sapiens
Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity
Hepatocyte growth factor receptor
Hepatocyte_growth_factor_receptor
Protein found on the surface of cells
consists of two subunits, interleukin-7 receptor-α (CD127) and common-γ chain receptor (CD132). The common-γ chain receptors is shared with various cytokines
Interleukin-7_receptor
Protein encoding gene found in humans
CXCR1 is a chemokine receptor that in humans is encoded by the CXCR1 gene. This gene has also been designated as CD181 (cluster of differentiation 181)
CXCR1
Protein found in humans
Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase
Tropomyosin_receptor_kinase_C
Form of localized cell signaling
receptors bind are for erythropoietin (important for erythropoiesis), thrombopoietin (important for platelet formation), and interferon (important for mediating
Paracrine_signaling
Protein found in humans
Fibroblast growth factor receptor 1 (FGFR-1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome
Fibroblast growth factor receptor 1
Fibroblast_growth_factor_receptor_1
Protein found in humans
is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell-
Atypical_chemokine_receptor_4
Protein found in humans
Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation
Colony stimulating factor 1 receptor
Colony_stimulating_factor_1_receptor
Mammalian protein found in Homo sapiens
The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2
IL2RA
Receptor protein that binds to a growth factor protein
A growth factor receptor is a receptor that binds to a growth factor. Growth factor receptors are the first stop in cells where the signaling cascade
Growth_factor_receptor
Protein-coding gene in the species Homo sapiens
type I cytokine receptor and is a subunit of the functional interleukin-7 receptor and thymic stromal lymphopoietin (TSLP) receptors. GRCh38: Ensembl
Interleukin-7_receptor-α
Protein-coding gene in the species Homo sapiens
C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene. Two ligands have been identified for this receptor: the chemokine
C-C_chemokine_receptor_type_7
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THROMBOPOIETIN RECEPTOR
THROMBOPOIETIN RECEPTOR
THROMBOPOIETIN RECEPTOR
THROMBOPOIETIN RECEPTOR
THROMBOPOIETIN RECEPTOR
THROMBOPOIETIN RECEPTOR
THROMBOPOIETIN RECEPTOR
THROMBOPOIETIN RECEPTOR
THROMBOPOIETIN RECEPTOR
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