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Group of lipids
Thromboxane is a member of the family of lipids known as eicosanoids. The two major thromboxanes are thromboxane A2 and thromboxane B2. The distinguishing
Thromboxane
Chemical compound
Thromboxane A2 (TXA2) is a type of thromboxane that is produced by activated platelets during hemostasis and has prothrombotic properties: it stimulates
Thromboxane_A2
Mammalian protein found in Homo sapiens
The thromboxane receptor (TP) also known as the prostanoid TP receptor is a protein that in humans is encoded by the TBXA2R gene, The thromboxane receptor
Thromboxane_receptor
Mammalian protein found in Homo sapiens
Thromboxane A synthase 1 (EC 5.3.99.5, platelet, cytochrome P450, family 5, subfamily A), also known as TBXAS1, is a cytochrome P450 enzyme that, in humans
Thromboxane-A_synthase
Chemical compound
Thromboxane B2 (TXB2) is an inactive metabolite/product of thromboxane A2. It is almost completely cleared in the urine. It itself is not involved in platelet
Thromboxane_B2
Anti-inflammatory medication
showed that aspirin suppressed the production of prostaglandins and thromboxanes. For this discovery, he was awarded the 1982 Nobel Prize in Physiology
Aspirin
Group of physiologically active lipid compounds
well as regulating the contraction of smooth muscle tissue. Conversely, thromboxanes (produced by platelet cells) are vasoconstrictors and facilitate platelet
Prostaglandin
Pharmaceutical drug
SER150 (formerly EV 077) is an inhibitor of thromboxane synthase and an antagonist of the thromboxane prostanoid receptor. It was developed for diabetic
SER150
Class of enzymes
99.1) that is responsible for biosynthesis of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member
Cyclooxygenase
Class of therapeutic drug
mediators, namely prostaglandins, which are involved in inflammation, and thromboxanes, which are involved in blood clotting. There are two general types of
Nonsteroidal anti-inflammatory drug
Nonsteroidal_anti-inflammatory_drug
Increased blood pressure in lung arteries
vasoconstrictor thromboxane is also synthesized from arachidonic acid. In PAH, the balance shifts away from prostacyclin synthesis toward synthesis of thromboxane. The
Pulmonary_hypertension
Chemical compound
effective vasodilator. Prostacyclin's interactions contrast with those of thromboxane (TXA2), another eicosanoid. Both molecules are derived from arachidonic
Prostacyclin
thromboxanes is due to its irreversible inactivation of the cyclooxygenase (COX) enzyme. Cyclooxygenase is required for prostaglandin and thromboxane
Mechanism of action of aspirin
Mechanism_of_action_of_aspirin
Chemical compound
endoperoxide prostaglandin PGH2 first prepared in 1975, and acts as a thromboxane A2 (TP) receptor agonist. It potently stimulates TP receptor-mediated
U46619
Class of biomolecules regulating inflammatory response
prostaglandins (mediators of inflammatory and anaphylactic reactions), the thromboxanes (mediators of vasoconstriction), and the prostacyclins (active in the
Prostanoid
Chemical compound
platelet-aggregating action of thromboxanes. Terbogrel is an orally available thromboxane A2 receptor antagonist and a thromboxane A synthase inhibitor. The
Terbogrel
Chemical compound
upon by: prostacyclin synthase to create prostacyclin thromboxane-A synthase to create thromboxane A2 and 12-(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid
Prostaglandin_H2
Nonsteroidal anti-inflammatory drug (NSAID)
as heart attack and stroke. Although meloxicam inhibits formation of thromboxane A, it does not appear to do so at levels that would interfere with platelet
Meloxicam
Narrowing of blood vessels due to the constriction of smooth muscle cells
Walsh; et al. (2005-08-01) [Published on Journal website 2005-07-26]. "Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves
Vasoconstriction
Chemical compound
Ozagrel (INN) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor. The free-radical halogenation of ethyl 4-methylcinnamate (1) with
Ozagrel
Drug discovery
the conversion of polyunsaturated fatty acids to prostaglandins and thromboxane(s). Their main role is to catalyze the transformation of arachidonic
Discovery and development of cyclooxygenase 2 inhibitors
Discovery_and_development_of_cyclooxygenase_2_inhibitors
Chemical compound
Ifetroban is a potent and selective thromboxane receptor antagonist. It has been studied in animal models for the treatment of cancer metastasis, myocardial
Ifetroban
Non-steroidal anti-inflammatory drug
PMID 8542839. Lees P, Ewins CP, Taylor JB, Sedgwick AD (1987). "Serum thromboxane in the horse and its inhibition by aspirin, phenylbutazone and flunixin"
Carprofen
Class of pharmaceuticals
a.k.a. PAR-1) Vorapaxar (Zontivity) Thromboxane inhibitors Thromboxane receptor antagonists Terutroban Thromboxane synthase inhibitors Prevention and treatment
Antiplatelet_drug
Chemical used in the treatment of asthma
Seratrodast (development name, AA-2414; marketed originally as Bronica) is a thromboxane A2 (TXA2) receptor (TP receptor) antagonist used primarily in the treatment
Seratrodast
20-Carbon polyunsaturated fatty acid
is a precursor in the formation of leukotrienes, prostaglandins, and thromboxanes. Together with omega−3 fatty acids and other omega−6 fatty acids, arachidonic
Arachidonic_acid
Chemical compound
Dazoxiben is an orally active thromboxane synthase inhibitor. It has shown a significant clinical improvement in patients with Raynaud's syndrome. One
Dazoxiben
Class of compounds
subfamilies of eicosanoids, including most prominently the prostaglandins, thromboxanes, leukotrienes, lipoxins, resolvins, and eoxins. For each subfamily, there
Eicosanoid
Component of blood aiding in coagulation
responsible for thromboxane A2 synthesis. This dense tubular system is connected to the surface platelet membrane to aid thromboxane A2 release. Circulating
Platelet
18-Carbon polyunsaturated fatty acid
PGH1, which in turn forms PGE1 and the thromboxane TXA1. Both PGE11 and TXA1 are anti-inflammatory; thromboxane TXA1, unlike its series-2 variant, induces
Γ-Linolenic_acid
Chemical compound
a thromboxane synthase inhibitor and a thromboxane receptor inhibitor, the latter by modifying cellular responses to activation of the thromboxane receptor
Picotamide
Class of enzymes
used as substrate. Examples include CYP5A1, thromboxane A2 synthase, abbreviated to TBXAS1 (thromboxane A2 synthase 1), and CYP51A1, lanosterol 14-α-demethylase
Cytochrome_P450
20-Carbon polyunsaturated fatty acid
animal products. The eicosanoid metabolites of DGLA are: Series-1 thromboxanes (thromboxanes with 1 double-bond), via the COX-1 and COX-2 pathways. Series-1
Dihomo-γ-linolenic_acid
Topics referred to by the same term
Proanthocyanidin B2, a B type proanthocyanidin Thromboxane B2, an inactive metabolite/product of thromboxane A2 Vitamin B2 B2, a postcode area in central
B2
Nonsteroidal anti-inflammatory drug (NSAID) used to treat pain
that high-dose naproxen induced near-complete suppression of platelet thromboxane throughout the dosing interval and appeared not to increase cardiovascular
Naproxen
Nonsteroidal anti-inflammatory drug
various prostaglandins (which mediate pain, inflammation, and fever) and thromboxane A2 (which stimulates platelet aggregation and promotes blood clot formation)
Ibuprofen
Medical condition
refractory anemia. It is associated with a deficiency of Thromboxane-A synthase, which produces Thromboxane A2. Although this disease is like Camurati–Engelmann
Ghosal hematodiaphyseal dysplasia
Ghosal_hematodiaphyseal_dysplasia
Chemical compound
Ramatroban (INN; also known as BAY u3405) is a thromboxane receptor antagonist. It is also a DP2 receptor antagonist. Ramatroban is indicated for the
Ramatroban
Nonsteroidal anti-inflammatory medication
concentrations) inhibits the production of prostaglandins and the production of thromboxane A2, a platelet activator. COX-1 is traditionally defined as a constitutively
Celecoxib
COX-2 selective NSAID medication
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Etoricoxib
Nonsteroidal anti-inflammatory drug
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Diclofenac
Chemical compound
5-(3-pyridinylmethyl)benzofurancarboxylic acid, is a chemical compound with thromboxane enzyme inhibiting properties that was originally developed by Pharmacia
Furegrelate
Chemical element with atomic number 34 (Se)
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Selenium
18-Carbon polyunsaturated fatty acid
the precursor to some prostaglandins, leukotrienes (LTA, LTB, LTC), thromboxane (TXA) and the N-acylethanolamine (NAE) arachidonoylethanolamine (AEA:
Linoleic_acid
Chemical compound
types and tissues. This product is further metabolized by thromboxane synthase to thromboxane A2, 12-hydroxyheptadecatrienoic acid, and malonyldialdehyde
Malondialdehyde
Chemical compound used in medicines and industry
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Salicylic_acid
Process of preventing and stopping bleeding
serotonin and thromboxane A2. Adenosine diphosphate (ADP) attracts more platelets to the affected area, serotonin is a vasoconstrictor and thromboxane A2 assists
Hemostasis
Nonsteroidal anti-inflammatory drug (NSAID; analgesic)
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Ketorolac
Anti-inflammatory drug
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Indometacin
Human enzyme involved in inflammation
converted to prostaglandins (PGD2, PGE2, PGF2α), prostacyclin (PGI2), or thromboxane A2 by tissue-specific isomerases (Figure 2). While metabolizing arachidonic
Cyclooxygenase-2
Micronized purified flavonoid fraction
explained by its antagonist activity against prostaglandin E2 (PgE2) and thromboxane (TxA2) biosynthesis leading to inhibition of inflammatory process. Moreover
Daflon
Topics referred to by the same term
Testosterone propionate, an androgen and anabolic steroid medication Thromboxane prostanoid receptor, a protein found in humans and other mammals Thymidine
TP
Chemical compound C6H5NHC(O)CH3
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Acetanilide
Nonsteroidal anti-inflammatory drug
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Rofecoxib
Principal curcuminoid of turmeric
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Curcumin
Ester of salicylic acid
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Methyl_salicylate
Medication used for constipation
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Lubiprostone
Anti-inflammatory medication
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Mesalazine
Dietary supplement
acid which in turn results in elevated leukotriene, prostaglandin and thromboxane production. The ingredients in Azerizin are known to inhibit each of
Azerizin
Type of nonsteroidal anti-inflammatory drug
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Cyclooxygenase-2_inhibitor
Enzyme involved in prostaglandin synthesis
inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin. Thromboxane A2, the major product of COX-1 in platelets, induces platelet aggregation
Cyclooxygenase-1
Degree of activation of airway muscle
leukotrienes act via a common cys-LT1 receptor. Thromboxane is a direct bronchoconstrictor that acts via the thromboxane receptor on airway smooth muscle cells
Airway_tone
Chemical compound
cyclooxygenase and lipoxygenase, increases the correlation prostacyclin/ thromboxane A2 and blocks the leukotriene formation. Increases the content of polar
Emoxypine
Enzyme involved in prostanoid synthesis
mechanism to novel biological mediators: prostaglandin endoperoxides, thromboxanes, and leukotrienes. Nobel Lecture, 8 December 1982". Biosci. Rep. 3 (9):
Cyclooxygenase-3
Chemical compound
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Latanoprost
Process of formation of blood clots
activation: Platelet activators, such as platelet activating factor and thromboxane A2, activate platelets in the bloodstream, leading to attachment of platelets'
Coagulation
Chemical compound
antiplatelet agent developed by Servier Laboratories. It is a selective thromboxane prostanoid (TP) antagonist and is an orally active drug in clinical development
Terutroban
NSAID analgesic and anti-inflammatory drug
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Nabumetone
Chemical compound
inhibiting degranulation of platelets which reduces the release of ADP and thromboxane. Like other uricosurics, sulfinpyrazone works by competitively inhibiting
Sulfinpyrazone
Medication for pain and fever
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Paracetamol
NSAID analgesic medication
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Ketoprofen
Primary male sex hormone
enhance muscle growth. Testosterone also regulates the population of thromboxane A2 receptors on megakaryocytes and platelets and hence platelet aggregation
Testosterone
20-Carbon polyunsaturated fatty acid
precursor for prostaglandin-3 (which inhibits platelet aggregation), thromboxane-3, and leukotriene-5 eicosanoids. EPA is both a precursor and the hydrolytic
Eicosapentaenoic_acid
Chemical compound
Hwa J, Martin K (2017). "Chapter 18: The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, & Related Compounds". In Katzung BG (ed.). Basic & Clinical
Prostaglandin_E2
Chemical compound
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Prostaglandin_E1
Chemical compound
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Prostaglandin_D2
Protein-coding gene in humans
defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2". The Journal of Clinical Investigation. 102 (11): 1994–2001. doi:10
HPGD
Chemical compound
and induce arachidonic acid pathway to synthesize endoperoxides (TxA2, thromboxane A2) Calcium binds to calmodulin which then binds and activates myosin
Carbazochrome
Organ dysfunction in an acutely ill person requiring medical intervention
are: tumor necrosis factor-alpha (TNF-α), interleukin-1, interleukin-6, thromboxane A2, prostacyclin, platelet activating factor, and nitric oxide. As a
Multiple organ dysfunction syndrome
Multiple_organ_dysfunction_syndrome
Group of tetraterpenes
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Retinoid
Chemical compound
E, Hamberg M, Hammarström S, Malmsten C (1978). "Prostaglandins and thromboxanes". Annual Review of Biochemistry. 47: 997–1029. doi:10.1146/annurev.bi
Prostaglandin_F2alpha
Chemical compound
intermediate, prostaglandin H2 (PGH2). Thromboxane synthase further metabolizes PGH2 to the 20 carbon product, thromboxane A2, the 17 carbon product, 12-HHT
12-Hydroxyheptadecatrienoic acid
12-Hydroxyheptadecatrienoic_acid
Chemical compound
12-HHT), a product made when prostaglandin H2 is metabolized to thromboxane A2 by thromboxane synthase or spontaneously rearranges non-enzymatically is the
12-Hydroxyeicosatetraenoic acid
12-Hydroxyeicosatetraenoic_acid
Combination drug used during eye surgery
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Phenylephrine/ketorolac
Medical condition
Sansone S, Secchi S, Covi G, Lechi A (November 1997). "The effects of thromboxane A2 inhibition (picotamide) and angiotensin II receptor blockade (losartan)
Raynaud_syndrome
Genetic neurological disease
G. C.; Wanders, R. J. (1994). "Studies on the urinary excretion of thromboxane B2 in Zellweger patients and control subjects: evidence for a major role
Adrenoleukodystrophy
Blood escaping from the circulatory system
prototype for these drugs is aspirin, which inhibits the production of thromboxane. NSAIDs (for example Ibuprofen) inhibit the activation of platelets,
Bleeding
Chemical compound
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Salicin
Acetylcholine receptors named for their selective binding of muscarine
2 LTB4 1 2 FPRL1 OXE Prostaglandin DP 1 2 EP 1 2 3 4 FP Prostacyclin Thromboxane Other Bile acid Cannabinoid CB1 CB2 GPR 18 55 119 EBI2 Estrogen Free
Muscarinic acetylcholine receptor
Muscarinic_acetylcholine_receptor
Chemical compound
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Bimatoprost
Drug class
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Prostaglandin_analogue
Medication to induce abortion and treat ulcers
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Misoprostol
Mixture of selenium sulfides
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Selenium_disulfide
Chemical compound
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Piroxicam
vasodilation, platelet activation inhibitor 10 Thromboxane TXA2 Eicosanoid Blood platelets thromboxane receptor vasoconstriction, platelet aggregation
List_of_human_hormones
Chemical compound
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Selexipag
Protein controlling mammalian coloration
2 LTB4 1 2 FPRL1 OXE Prostaglandin DP 1 2 EP 1 2 3 4 FP Prostacyclin Thromboxane Other Bile acid Cannabinoid CB1 CB2 GPR 18 55 119 EBI2 Estrogen Free
Melanocortin_1_receptor
Swedish biochemist (1934–2024)
arachidonic acid. This has led to the identification of endoperoxides, thromboxanes and the leukotrienes, and his group has chiefly been involved in studying
Bengt_I._Samuelsson
Chemical compound used as an antihemorrhagic
This appears to relate to increased platelet aggregation mediated by a thromboxane A2 or prostaglandin F2a dependent mechanism. It has also been associated
Etamsylate
Medication
Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE
Glimepiride
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