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The 43S preinitiation complex (43S PIC) is a ribonucleoprotein complex that exists during an early step of eukaryotic translation initiation. The 43S PIC
43S_preinitiation_complex
Protein involved in gene expression
Met-tRNAiMet called the 43S preinitiation complex (43S PIC). Additional factors of the eIF4F complex (eIF4A, E, and G) recruit the 43S PIC to the five-prime
Eukaryotic_initiation_factor
Protein in translation of RNA
ternary complex (TC) with GTP and the initiator Met-tRNAiMet. After its formation, the TC binds the 40S ribosomal subunit to form the 43S preinitiation complex
EIF2
Protein-coding gene in the species Homo sapiens
the 43S preinitiation complex (PIC). eIF1 and eIF1A bind cooperatively to the 40S to stabilize an "open" conformation of the preinitiation complex (PIC)
EIF1
Cellular process of protein synthesis
role in circularization of the mRNA during translation. This 43S preinitiation complex (43S PIC) accompanied by the protein factors moves along the mRNA
Translation_(biology)
Protein-coding gene in the species Homo sapiens
interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7
EIF3L
Protein-coding gene in the species Homo sapiens
initiation factor 3 (eIF3) complex. The encoded protein is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome
EIF3CL
Multiprotein complex used in gene expression
the formation of a single-stranded RNA landing pad for the 43S preinitiation complex (43S PIC) via eIF4A's RNA helicase activity. The eIF4F proteins interact
Eukaryotic initiation factor 4F
Eukaryotic_initiation_factor_4F
Protein-coding gene in the species Homo sapiens
(November 2005). "mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation
EIF3B
Protein coding gene in Humans
mRNA, a critical step necessary for the recruitment of the 43S preinitiation complex, and thus the translation of protein in eukaryotes. It was first
EIF4A1
Protein-coding gene in the species Homo sapiens
complex cytosol eukaryotic translation initiation factor 3 complex, eIF3m eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex Biological
EIF3M
Large molecular machine for synthesizing proteins from messenger RNA
A.; Frank, J. (2013). "Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29". Cell. 153 (5): 1108–1119
Eukaryotic_ribosome
Protein-coding gene in the species Homo sapiens
Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". J. Biol. Chem. 272 (2): 1110–6. doi:10.1074/jbc
EIF3H
Multiprotein complex that functions during the initiation phase of eukaryotic translation
and mRNA. eIF3 is a component of the multifactor complex (MFC) and 43S and 48S preinitiation complexes (PICs). The interactions of eIF3 with other initiation
Eukaryotic initiation factor 3
Eukaryotic_initiation_factor_3
Protein-coding gene in humans
Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". J. Biol. Chem. 272 (2): 1110–6. doi:10.1074/jbc
EIF3I
Protein-coding gene in the species Homo sapiens
of the subunits of Eukaryotic initiation factor 3 (eIF3) a multiprotein complex playing major roles in translation initiation in eukaryotes. EIF3A has
EIF3A
Protein-coding gene in the species Homo sapiens
the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain
EIF3D
Protein-coding gene in the species Homo sapiens
Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". J. Biol. Chem. 272 (2): 1110–6. doi:10.1074/jbc
EIF3G
Protein-coding gene in the species Homo sapiens
TV, Frank J (May 2013). "Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29". Cell. 153 (5): 1108–19. doi:10
DHX29
Protein-coding gene in the species Homo sapiens
Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". J. Biol. Chem. 272 (2): 1110–6. doi:10.1074/jbc
EIF3F
Protein-coding gene in the species Homo sapiens
subunit binding Cellular component cellular component eukaryotic 43S preinitiation complex Biological process translational initiation protein biosynthesis
EIF1B
Protein-coding gene in the species Homo sapiens
Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". J. Biol. Chem. 272 (2): 1110–6. doi:10.1074/jbc
EIF3E
Protein-coding gene in the species Homo sapiens
Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". J. Biol. Chem. 272 (2): 1110–6. doi:10.1074/jbc
EIF3C
Protein-coding gene in the species Homo sapiens
directly to the 40S ribosomal subunit and promoting formation of the 43S preinitiation complex. eIF3k has been shown to interact with Cyclin D3 and eIF3a. Eukaryotic
EIF3K
Protein-coding gene in the species Homo sapiens
is reported to play an important role in the assembly of the 43S pre-initiation complex. It specifically binds to the 40S subunit in vitro and increases
EIF3J
Small ribosomal subunit of eukaryotic 80S ribosomes
component of several translation initiation complexes, including the 43S and 48S preinitiation complexes (PICs), being bound by several eukaryotic initiation
Eukaryotic small ribosomal subunit (40S)
Eukaryotic_small_ribosomal_subunit_(40S)
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