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Class of enzymes
Aconitase (aconitate hydratase; EC 4.2.1.3) is an enzyme that catalyses the stereo-specific isomerization of citrate to isocitrate via cis-aconitate in
Aconitase
Chemical compound
is a tricarboxylic acid. The compound is an inhibitor of the enzyme aconitase and therefore interferes with the Krebs cycle. Esters of propane-1,2,3-tricarboxylic
Propane-1,2,3-tricarboxylic acid
Propane-1,2,3-tricarboxylic_acid
Enzyme found in humans
mitochondrial, also called Aconitase 2, is a enzyme that in humans is encoded by the ACO2 gene. This form of aconitase is located in the mitochondria
Aconitate hydratase, mitochondrial
Aconitate_hydratase,_mitochondrial
Enzyme found in humans
aconitate hydratase, also called Aconitase 1, is an enzyme that in humans is encoded by the ACO1 gene. This form of aconitase is located in the cytoplasm and
Aconitate hydratase, cytoplasmic
Aconitate_hydratase,_cytoplasmic
Method of studying the mechanisms of chemical reactions
the mechanism of aconitase action. Isotope scrambling experiments using tritium, deuterium, and 18O were carried out on the aconitase hydratase reaction
Crossover experiment (chemistry)
Crossover_experiment_(chemistry)
Metabolic pathway
dehydratase/hydratase as PrpD; Methylcitrate dehydratase as AcnD; Methylaconitate cis-trans isomerase as PrpF; Aconitase as AcnB; and methylisocitrate lyase as PrpB.
Methylcitrate_cycle
Chemical compound
cycle. Isocitrate is formed from citrate with the help of the enzyme aconitase, and is acted upon by isocitrate dehydrogenase. Isocitric acid is commonly
Isocitric_acid
Chemical compound
fluoroacetic acid and is very toxic because it is not processable using aconitase in the citrate cycle (where fluorocitrate takes place of citrate as the
Fluorocitric_acid
Proteins containing iron-sulfur clusters
They have many other functions including catalysis as illustrated by aconitase, generation of radicals as illustrated by SAM-dependent enzymes, and as
Iron–sulfur_protein
Proteins performing more than one function
presence of high iron concentrations, aconitase functions as an enzyme while at low iron concentration, aconitase functions as an iron-responsive element-binding
Protein_moonlighting
to an inhibition of the enzyme aconitase (EC 4.2.1.3) by high concentrations of reactive oxygen species (ROS) Aconitase catalyzes the conversion of citrate
Glutaminolysis
Protein family
or degradation. It functions also as the cytoplasmic isoform of aconitase. Aconitases are iron-sulfur proteins that require a 4Fe-4S cluster for their
Iron-responsive element-binding protein
Iron-responsive_element-binding_protein
Weak organic acid
with acetyl CoA to form citrate. Citrate then acts as the substrate for aconitase and is converted into aconitic acid. The cycle ends with regeneration
Citric_acid
Chemical compound
to isocitrate in the citric acid cycle. It is acted upon by the enzyme aconitase. Aconitic acid can be synthesized by dehydration of citric acid using
Aconitic_acid
Essential elements required by organisms
oxidase Cu–Zn superoxide dismutase Cytochrome c oxidase Fe Fe3+, Fe2+ Aconitase Succinate dehydrogenase Cytochromes Nitrite reductase Mn Mn2+ Mn-superoxide
Micronutrient
Class of enzymes
3-Isopropylmalate dehydratase (EC 4.2.1.33) is an aconitase homologue, which catalyses the isomerisation of 2-isopropylmalate to 3-isopropylmalate, via
3-Isopropylmalate_dehydratase
Interconnected biochemical reactions releasing energy
irreversible, extends the 4C oxaloacetate to a 6C molecule 1 Dehydration Citrate Aconitase cis-Aconitate + H2O reversible isomerisation 2 Hydration cis-Aconitate
Citric_acid_cycle
with oxaloacetate to form fluorocitrate, which binds irreversibly to aconitase and thereby competes with normal citrate as a substrate, causing disruption
List_of_poisonous_plants
Chemical compound
fluorocitric acid, which is very toxic because it is not processable using aconitase in the Krebs cycle (where fluorocitrate takes place of citrate as the
Fluoroacetic_acid
Rare autosomal-recessive human disease
required for mitochondrial electron transport and assembly of functional aconitase and iron dysmetabolism of the entire cell. Balance difficulty, loss of
Friedreich's_ataxia
Species of bacterium
glucose, pyruvate, or lactate. These enzymes, namely citrate synthase, aconitase, and isocitrate dehydrogenase, are needed for the incorporation of acetate
Neisseria_gonorrhoeae
Sean; Graziano, Joseph H. (1998). "Manganese inhibits mitochondrial aconitase: A mechanism of manganese neurotoxicity". Brain Research. 799 (2): 334–342
Manganese_poisoning
Chemical compound
A, catalyzed by citrate synthase. Fluorocitrate binds very tightly to aconitase, thereby halting the citric acid cycle. This inhibition results in an
Sodium_fluoroacetate
poisoning cellular energy production. The most sensitive targets of NO are aconitase, an enzyme that catalyzes the isomerization of citrate to isocitrate in
Nitric_oxide_dioxygenase
Chemical compound
citrate, which is normally formed. Fluorocitrate inhibits the enzyme aconitase and causes the citric cycle to be blocked.[AI-retrieved source] Lethal
Fluoroacetone
Class of enzymes
inactivates the citric acid cycle enzyme aconitase, can poison energy metabolism, and releases potentially toxic iron. Aconitase is one of several iron-sulfur-containing
Superoxide_dismutase
British biochemist (born 1931)
cycle, in particular aconitase-catalyzed citrate, and its conformation as a ligand to iron atoms of the iron-sulfur cluster of aconitase, which led to a better
Jenny_Glusker
Aspect of DNA sequences
division) Major Vault Protein homologs TCA cycle genes citrate synthase aconitase cfbB and cfbC Coenzyme F420:L-glutamate ligase - cofE Electron bifurcating
Borg_(microbiology)
Space within the inner membrane of the mitochondrion
acid cycle is facilitated by pyruvate dehydrogenase, citrate synthase, aconitase, isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, succinyl-CoA
Mitochondrial_matrix
Species of plant
being a competitive substrate for aconitase (whose normal substrate is citrate). It binds irreversibly to the aconitase but cannot be released, disrupting
Dichapetalum_cymosum
Mitochondrial protein involved in iron–sulfur cluster biosynthesis
Swedish type; myopathy with deficiency of succinate dehydrogenase and aconitase; myoglobinuria due to abnormal glycolysis; myopathy with deficiency of
ISCU
Protein that contains a metal ion cofactor
Manganese Arginase Oxygen-evolving complex Iron Catalase Hydrogenase IRE-BP Aconitase Cobalt Nitrile hydratase Methionyl aminopeptidase Methylmalonyl-CoA mutase
Metalloprotein
Chemical compound
fluoroacetate. Fluoroacetate is a precursor to fluorocitrate, an inhibitor of aconitase, an enzyme that participates in the TCA cycle. Reported effects of 2-fluoroethanol
2-Fluoroethanol
Medical condition
Cerebellar-Retinal Degeneration Associated with a Mutation in Mitochondrial Aconitase, ACO2". American Journal of Human Genetics. 90 (3): 518–523. doi:10.1016/j
Infantile cerebellar retinal degeneration
Infantile_cerebellar_retinal_degeneration
Muscle disorders caused by mitochondrial dysfunction
Swedish type; myopathy with deficiency of succinate dehydrogenase and aconitase; myoglobinuria due to abnormal glycolysis; Larsson–Linderholm syndrome;
Mitochondrial_myopathy
Chemical compound
citrate ion to transition metal ions in solution and at the active site of aconitase". Journal of the American Chemical Society. 99 (2): 562–572. doi:10.1021/ja00444a041
Iron(II)_citrate
Mammalian protein found in Homo sapiens
hexokinase I putatively forms a protein complex with EAAT2, Na+/K+ ATPase, and aconitase, which functions to remove glutamate from the perisynaptic space and maintain
Hexokinase_I
Species of bacterium
malate dehydrogenase, ferredoxin oxidoreductase, succinate-CoA ligase, aconitase and citratesynthase. Moreover, this bacterium uses oxygen, hydrogen, and
"Aquifex_aeolicus"
False appearance of an athletic body due to disease or injury
Histochemical studies show deficiency of succinate dehydrogenase and aconitase, defective oxidative phosphorylation. Some showed evidence of necrosis
Pseudoathletic_appearance
British biochemist (1911–96)
but a chiral object like a person can. Thus a chiral enzyme such as aconitase can act differently on two apparently equivalent groups on a prochiral
Alexander_George_Ogston
RNA family
enzyme in the TCA cycle. The tricarboxylic acid (TCA) cycle by repressing aconitase an enzyme in the cycle and the transcriptional regulator that forms a
Iron_stress_repressed_RNA
Series of interconnected biochemical reactions
enzymes associated with the tricarboxylic acid cycle: citrate synthase, aconitase, succinate dehydrogenase, fumarase, and malate dehydrogenase. The two
Glyoxylate_cycle
citrate ion to transition metal ions in solution and at the active site of aconitase". Journal of the American Chemical Society. 99 (2): 562–572. Bibcode:1977JAChS
Nickel_organic_acid_salts
Rare metabolic disorder
ceramides. Reduced activity of the iron–sulfur cluster-dependent enzyme aconitase was proposed to promote citrate accumulation and thereby lead to increased
MEPAN_syndrome
product. An example of feedback inhibition in human cells is the protein aconitase (an enzyme that catalyses the isomeration of citrate to isocitrate). When
Regulatory_enzyme
Protein in the mitochondrion mostly expressed in highly metabolic cells
Lonlay P, Chretien D, Foury F, Koenig M, Sidi D, et al. (October 1997). "Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia"
Frataxin
Class of enzymes
pyruvate in Escherichia coli. Involvement of methylcitrate dehydratase and aconitase". Eur. J. Biochem. 269 (24): 6184–94. doi:10.1046/j.1432-1033.2002.03336
2-methylcitrate_dehydratase
Class of enzymes
2-methylisocitrate dehydratase, isolated from Yarrowia lipolytica, in comparison to aconitase". Biosci. Biotechnol. Biochem. 59 (11): 2013–2017. doi:10.1271/bbb.59
2-methylisocitrate dehydratase
2-methylisocitrate_dehydratase
enolase enzyme present in the E. coli degradosome, the metabolic enzymes aconitase and phosphofructokinase have been identified in the C. crescentus and
Degradosome
Scientific discipline
Sean; Graziano, Joseph H. (1998). "Manganese inhibits mitochondrial aconitase: A mechanism of manganese neurotoxicity". Brain Research. 799 (2): 334–342
Nutritional_neuroscience
Human protein and coding gene
(September 2002). "Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism" (PDF). Nature Cell Biology. 4 (9): 674–80
LONP1
Functions of nitric oxide in organisms
from S to Fe. The iron-containing proteins ribonucleotide reductase and aconitase are deactivated by NO. NO has been demonstrated to activate NF-κB in peripheral
Biological functions of nitric oxide
Biological_functions_of_nitric_oxide
Class of neurotransmitters
oxidation of iron-containing proteins such as ribonucleotide reductase and aconitase, activation of the soluble guanylate cyclase, ADP ribosylation of proteins
Gasotransmitter
enzyme is also called citrate hydro-lyase. Neilson NE (May 1955). "The aconitase of Aspergillus niger". Biochimica et Biophysica Acta. 17 (1): 139–40.
Citrate_dehydratase
dismutase(SOD)), zwf (glucose-6-phosphate dehydrogenase(G6PDH)), acnA (aconitase A), nfsA (nitrate reductase A), fumC (fumarase C) and nfo (endonuclease
Oxidation_response
Chemical compound
fluorocitrate (FC) is formed which is the main toxic compound. It binds the aconitase enzyme with a very high affinity and therefore intervenes in the TCA cycle
Methyl_fluoroacetate
RNA family
humans, IRP1 binds with an iron-sulphur complex [4Fe-4S] and adopts an aconitase conformation unsuitable for IRE binding. In contrast, IRP2 is degraded
Iron_response_element
First commercially viable UV-visible light absorbance instrument
Society, was highly prized and in constant use. Kornberg used it to purify aconitase, an enzyme in the citric acid cycle. "The enzyme could be assayed in a
DU_spectrophotometer
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