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Oligonucleotide or peptide molecules that bind specific targets
Aptamers are oligomers of artificial ssDNA, RNA, XNA, or peptide that bind a specific target molecule, or family of target molecules. They exhibit a range
Aptamer
Aptamers, single-stranded RNA and DNA sequences, bind to an analyte and change their conformation. They function as nucleic acids selectively binding molecules
Electrochemical aptamer-based biosensors
Electrochemical_aptamer-based_biosensors
synthetically derived RNA aptamer born out of the need for a way of studying the role of RNAs at the cellular level. This aptamer was created using Systematic
Spinach_aptamer
RNA-like molecule
An L-ribonucleic acid aptamer (L-RNA aptamer, trade name Spiegelmer) is an RNA-like molecule built from L-ribose units. It is an artificial oligonucleotide
L-Ribonucleic_acid_aptamer
Oligonucleotides which recognize the exosites of human thrombin
Anti-thrombin aptamers are G-quadruplex-bearing oligonucleotides, which recognizes the exosites of human thrombin. The first anti-thrombin aptamer, TBA, was
Anti-thrombin_aptamers
Technique for producing oligonucleotides that specifically bind to a target
ligands. These single-stranded DNA or RNA are commonly referred to as aptamers. Although SELEX has emerged as the most commonly used name for the procedure
Systematic evolution of ligands by exponential enrichment
Systematic_evolution_of_ligands_by_exponential_enrichment
Medications based on ribonucleic acids
antisense RNA (asRNA), RNA interference (RNAi), RNA activation (RNAa) and RNA aptamers. Of the four types, mRNA-based therapy is the only type which is based
RNA_therapeutics
increased scalability and consistency in manufacture compared to standard aptamer molecules. Optimer ligands are composed of single-stranded DNA or RNA polymers
Optimer_ligand
Conserved RNA structure
nadA motif RNAs invariably occur as a tandem pair of two highly similar aptamer domains, referred to as Domain 1 and Domain 2. Each domain forms two base-paired
NAD-I_riboswitch
American biochemist and synthetic biologist
on in vitro selection techniques and is credited with coining the term "aptamer" to describe nucleic acid molecules that bind specific targets. His laboratory's
Andrew_D._Ellington
Sub-type of substance that forms a complex with a biomolecule
Known examples of smart ligands include DNA smart aptamers; however, RNA and peptide smart aptamers can also be developed. Smart ligands can find a set
Smart_ligand
DNA-based experimental drug
international nonproprietary name is Rovunaptabin, is an oligonucleotide aptamer, a synthetic DNA compound designed to bind other chemicals. BC-007 is in
BC-007
Structure in molecular biology
thrombin-binding aptamers evaluated in early clinical studies and the nucleolin-targeting aptamer AS1411, which reached phase II oncology trials. Aptamers are short
G-quadruplex
Japanese researcher
alongside Paul Weiss and Anne M. Andrews. Her doctoral research considered aptamer-functionalised field effect transistors for serotonin and dopamine sensing
Nako_Nakatsuka
American biochemist (1944–2019)
linker synthesized with an alpha-1,3-gal-gal bond on one end and a DNA aptamer devised to bind specifically to the strain of influenza you have on the
Kary_Mullis
been used to study protein DNA interactions Acrydite-modified aptamers (and also aptamers containing internal acrylamide modifications) have been used
Acrydite
DNA synthesis technique
immuno-RCA, the ssDNA RCA primer can be conjugated to the 3' end of a DNA aptamer as well. The primer tail can be amplified through rolling circle amplification
Rolling_circle_replication
RNA family
messenger RNA (mRNA) that selectively binds to purine ligands via a natural aptamer domain. This binding causes a conformational change in the mRNA that can
Purine_riboswitch
Molecule that carries genetic information
and streptavidin proteins. DNA and other nucleic acids are the basis of aptamers, synthetic oligonucleotide ligands for specific target molecules used in
DNA
Measured quantity of a medicine, nutrient, or pathogen which is delivered as a unit
cocaine levels in undiluted blood serum with electrochemical aptamer-based sensing. DNA aptamers, which are peptides that have with specific target molecules
Dose_(biochemistry)
Hypothetical life with reversed molecular chirality
L-ribonucleic acid aptamers: Artificial oligonucleotides that are constructed from the mirror-image versions of their natural forms. L-RNA aptamers are highly
Mirror-image_life
RNA element
usually consist of two metabolite-binding aptamer domains with similar structures in tandem. The aptamers were originally thought to cooperatively bind
Glycine_riboswitch
Protein(s) forming a major part of an organism's immune system
specifically bind antigens. They consist of artificial peptides or proteins, or aptamer-based nucleic acid molecules with a molar mass of about 3 to 20 kDa. Antibody
Antibody
Organic dye
green. For example, Zhao et al., demonstrated the use of malachite green aptamer in microcantilever based sensors to detect low concentration of malachite
Malachite_green
Part of a messenger RNA molecule
are often conceptually divided into two parts: an aptamer and an expression platform. The aptamer directly binds the small molecule, and the expression
Riboswitch
Chemical compound
polymerases have enabled the in vitro selection of biologically stable TNA aptamers to both small molecule and protein targets. Such experiments demonstrate
Threose_nucleic_acid
Substance that forms a complex with a biomolecule
2010). "Optical thermophoresis for quantifying the buffer dependence of aptamer binding". Angewandte Chemie. 49 (12): 2238–2241. doi:10.1002/anie.200903998
Ligand_(biochemistry)
Chinese chemist (born 1960)
Edward S. Yeung. The main focus of Tan's group is in the field of DNA aptamers, molecular recognition and nano biosensors. The Tan group has pioneered
Tan_Weihong
Dance contest for scientists, sponsored by AAAS
Melting: A Love Story 2010 Chemistry Maureen McKeague Selection of a DNA Aptamer for Homocysteine using SELEX 2009 Graduate Student Sue Lynn Lau The Role
Dance_Your_Ph.D.
Protein that stimulates red blood cell production
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Erythropoietin
RNA family
its aptamer, which forms as many as five base-paired substructures. PreQ1-III riboswitch has a distinct structure and is also larger in aptamer size
PreQ1_riboswitch
important for aptamer generation. Citartan, Marimuthu; et al. (December 2011). "Asymmetric PCR for good quality ssDNA generation towards DNA aptamer production"
Asymmetric_PCR
Swiss multinational pharmaceutical corporation
Novartis purchased the rights to market Ophthotech's Fovista (an anti-PDGF aptamer, also being investigated for use in combination with anti-VEGF treatments)
Novartis
Family of proteins
12-dimethylbenzanthracene), a mutagen. Moreover, HSF1 inhibition by a potent RNA aptamer attenuates mitogenic (MAPK) signaling and induces cancer cell apoptosis
Heat_shock_protein
Iranian-American physician and entrepreneur
Philip W.; Langer, Robert; Farokhzad, Omid C. (2007-09-14). "Quantum Dot−Aptamer Conjugates for Synchronous Cancer Imaging, Therapy, and Sensing of Drug
Omid_Cameron_Farokhzad
Science of synthetic life forms
pair to DNA aptamer generation by in vitro selection (SELEX) and demonstrated the genetic alphabet expansion significantly augment DNA aptamer affinities
Xenobiology
Luminescent phenomenon in certain fluorescent dyes
detection based on supraparticle copper nanoclusters formed on bivalent aptamer". Biosensors and Bioelectronics. 132: 186–195. doi:10.1016/j.bios.2019
Aggregation-induced_emission
Protein found in humans
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Brain-derived neurotrophic factor
Brain-derived_neurotrophic_factor
Two nucleobases bound by hydrogen bonds
pair to DNA aptamer generation by in vitro selection (SELEX) and demonstrated the genetic alphabet expansion significantly augment DNA aptamer affinities
Base_pair
Non-protein chemical compound or metallic ion
Frank J, Burke DH (2003). "The tyranny of adenosine recognition among RNA aptamers to coenzyme A". BMC Evol. Biol. 3 26. doi:10.1186/1471-2148-3-26. PMC 317284
Cofactor_(biochemistry)
Method of separating chemical or biological samples
IL-1α and the aptamer. Huang et al. uses ACE to investigate protein-protein interactions using aptamers. A α-thrombin binding aptamer was labeled with
Capillary_electrophoresis
Medication
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Repotrectinib
Alternative to the polymerase chain reaction
DNA or RNA, pathogenic bacterial genomic DNA, as well as short length aptamer DNA. The three core RPA enzymes can be supplemented by further enzymes
Recombinase polymerase amplification
Recombinase_polymerase_amplification
Synthetic DNA analog experiment
The hachimoji DNA system produced one type of catalytic RNA (ribozyme or aptamer) in vitro. NASA funded this research to "expand[s] the scope of the structures
Artificially Expanded Genetic Information System
Artificially_Expanded_Genetic_Information_System
RNA family
NAD⁺ metabolism, neither binding domain of the NAD⁺-I riboswitch's dual-aptamer architecture has been shown to specifically recognize the nicotinamide
NAD-II_riboswitch
Long-term complication of COVID-19
and loratadine, various immune-modulating drugs, and the experimental aptamer compound BC-007 (Rovunaptabin). In 2021, the US National Institutes of
Long_COVID
Polymer with synthetic molecular receptor
a modified aptamer as a recognition macromonomer, encapsulated within a polymer nanoparticle scaffold. Producing the first truly aptamer-MIP hybrid (aptaMIP)
Molecularly_imprinted_polymer
Family of biomolecules
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Neurotrophic_factors
Pharmaceutical drug
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Brolucizumab
Biomolecule
circulating half-life. However, a large Phase III trial of PEGylated RNA aptamer against factor IX had to be discontinued by Regado Biosciences because
Small_interfering_RNA
American chemistry professor
molecules. She has demonstrated that nucleic acid aptamers can be used in biosensing. In particular, split aptamers can self-assemble when particular small molecules
Jennifer_M._Heemstra
Medical imaging technique
2014). "Intracellular gene transcription factor protein-guided MRI by DNA aptamers in vivo". FASEB Journal. 28 (1): 464–73. doi:10.1096/fj.13-234229. PMC 3868842
Magnetic_resonance_imaging
Medication
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Bevacizumab
Protein-coding gene in the species Homo sapiens
inspired autotaxin inhibitors could also be an option in the future. A DNA aptamer inhibitor of Autotaxin has also been described. Lysophosphatidic acid Lysophospholipid
Autotaxin
RNA secondary structure
secondary structure diagram. The x-ray crystal structure of the TPP riboswitch aptamer has been solved. Experimental 3D structure of the TPP riboswitch (PDB:
TPP_riboswitch
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
GDNF_family_of_ligands
Converter that measures a physical quantity and converts it into a signal
materials used in sensor development are molecularly imprinted polymers and aptamers. A chemical sensor array is a sensor architecture with multiple sensor
Sensor
Gene editing technique
pseudoknots were tested. One was a modified prequeosine1-1 riboswitch aptamer (evopreQ1), while the other was from the Moloney murine leukemia virus
Prime_editing
Targeted cancer drug
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Vemurafenib
In chemistry, average force on a particle
to show that potential of mean force decreases between thrombin and its aptamer (a protein-ligand complex) under the effect of electrical fields. Statistical
Potential_of_mean_force
Topics referred to by the same term
(Eulithis mellinata), a moth of the family Geometridae Spinach aptamer, a synthetic RNA aptamer designed as a mimic of green fluorescent protein Spinach (software)
Spinach_(disambiguation)
Carothers, James M. "Multi-state design of kinetically-controlled RNA aptamer ribosensors". bioRxiv 10.1101/213538. Yurke, Bernard; Millis, Allen P (2003)
Toehold mediated strand displacement
Toehold_mediated_strand_displacement
Branch of pharmacology
2010). "Optical thermophoresis for quantifying the buffer dependence of aptamer binding". Angewandte Chemie. 49 (12): 2238–41. Bibcode:2010ACIE...49.2238B
Pharmacokinetics
American biologist
cycles of selection, amplification and mutation. He isolated the first aptamer (term he used for the first time). He isolated RNA enzymes with RNA ligase
Jack_W._Szostak
Modified genetic code
pair to DNA aptamer generation by in vitro selection (SELEX) and demonstrated the genetic alphabet expansion significantly augment DNA aptamer affinities
Expanded_genetic_code
Synthetic protein
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
IGF-1_LR3
Kinase inhibitor for treatment of non-small-cell lung cancer
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Lorlatinib
Family of large biological molecules
biology List of RNA biologists RNA Society Macromolecule RNA-based evolution Aptamer RNA origami Transcriptome RNA world hypothesis Copley SD, Smith E, Markowitz
RNA
Mammalian protein found in humans
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HER2
Byproduct in PCR formed by primer annealing to itself
Non-covalent binding of inhibitor: in this method a peptide, antibody or aptamer are non-covalently bound to the enzyme at low temperature and inhibit its
Primer_dimer
Chemical compound
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Dihexa
Probe which tests for biological molecules
typically consists of a bio-receptor (enzyme/antibody/cell/nucleic acid/aptamer), transducer component (semi-conducting material/nanomaterial), and electronic
Biosensor
Corticosteroid medication
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Dexamethasone
Chemical compound
translated into protein, and cell death ensues. Tobramycin also binds to RNA-aptamers, artificially created molecules to bind to certain targets. However, there
Tobramycin
Chemical compound
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Nintedanib
Biological molecule
ability to fold into three-dimensional structures, similar to proteins, aptamers and ribozymes. In 2015, Jain et al. described a trans-acting DNA-based
Peptide_nucleic_acid
Paper treated to react to contaminants
contaminant-detecting biosensors that are based on combinations of antibodies, enzymes, aptamers or bacteriophages, onto the structure of the paper. These combinations
Bioactive_paper
Tricyclic antidepressant
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Amitriptyline
InterPro Family
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Trk_receptor
Mammalian protein found in Homo sapiens
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Hepatocyte_growth_factor
Protein-coding gene in mammals
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Fibroblast_growth_factor_21
Protein involved in blood vessel growth
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Vascular endothelial growth factor
Vascular_endothelial_growth_factor
Pathogenic genus of Gram-negative bacteria
can be achieved with a dose of less than 7 mJ/cm2. A Legionella-specific aptamer has been discovered and in 2022 was developed into an assay for detecting
Legionella
Anticoagulant medication taken by mouth
anticoagulant. Some of the allosteric inhibitors discovered include DNA aptamers, benzofuran dimers, benzofuran trimers, as well as polymeric lignins. A
Direct_thrombin_inhibitor
American professional racing cyclist and NASA astronaut
engineering Thesis Identification of Malaria Parasite-Infected Red Blood Cell Aptamers by Inertial Microfluidics SELEX (2015) Doctoral advisor Jacquin Niles
Christina_Birch
Chemical compound
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Pazopanib
Group of simple sugar and carbohydrate compounds
makes these species more suitable for use in techniques such as PCR, RNA aptamer post-modification, antisense technology, and for phasing X-ray crystallographic
Ribose
Molecular diffusion under the effect of a thermal gradient
potential in facilitating drug discovery by allowing the detection of aptamer binding by comparison of the bound versus unbound motion of the target
Thermophoresis
Protein-coding gene in the species Homo sapiens
its cancerous proliferation properties. Drugs by the name of anti-cancer aptamers have been created to inhibit to proteins involved in MK's cancer cell "activation"
Midkine
DNA polymerases that originate from thermophiles
released in the process. Furthermore, polymerases can be inhibited with aptamers that denature upon heating. A fifth variant is a polymerase adsorbed on
Thermostable_DNA_polymerase
Chemical compound
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Cabozantinib
Chemical compound
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Dehydroepiandrosterone
Medication used for cancer
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Gefitinib
peptides, and nucleic acid aptamers. The aptamers bind to specific targets, and they are single-stranded DNA or RNA molecules. Aptamers can bind to thrombin
Exosite
Synthetic nucleic acid analogues
Spiegelmers bio-synthesis: Spiegelmers are created by selecting RNA or DNA aptamers against enantiomeric target molecules, followed by the chemical synthesis
Xeno_nucleic_acid
RNA family
into classes by the ligand that they bind because the ligand-binding or aptamer domain is highly conserved across species. Riboswitches, including the
Cobalamin_riboswitch
Family of proteins involved in anatomical development
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Fibroblast_growth_factor
Affinity reagents generated entirely in vitro
process. Synthetic antibodies include recombinant antibodies, nucleic acid aptamers and non-immunoglobulin protein scaffolds. As a consequence of their in
Synthetic_antibody
Transcription factor
PMID 19112021. Salamanca HH, Fuda N, Shi H, Lis JT (August 2011). "An RNA aptamer perturbs heat shock transcription factor activity in Drosophila melanogaster"
Heat_shock_factor
Protein and coding gene in humans
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:
Tropomyosin_receptor_kinase_B
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