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Protein-coding gene in humans
humans is encoded by the BCL10 gene. Like BCL2, BCL3, BCL5, BCL6, BCL7A, and BCL9, it has clinical significance in lymphoma. BCL10 was identified by its
BCL10
Protein-coding gene in humans
proteins in the CARD-CC family have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of NF-κB activation
CARD11
subsequently phosphorylates CARD9 that triggers recruitment of BCL10 and MALT1, leading to a CARD-CC/BCL10/MALT1 (CBM) signaling complex. This signaling complex
Mincle_receptor
Protein found in humans
complete genome data are available. Like BCL3, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma. The two isoforms of Bcl-2, Isoform
Bcl-2
Group of lymphomas
cases of EMZL. This translocation causes the overexpression of the BCL10 gene. Bcl10 protein contributes to the activation of NF-κB. 4) A t(3;14)(p13;q32)
Marginal_zone_lymphoma
Protein-coding gene in the species Homo sapiens
Bcl10-interacting CARD protein, also known as BinCARD, is a protein that in humans is encoded by the C9orf89 gene on chromosome 9. BinCARD is a member
BinCARD
Family of genes
known as "BCL1") BCL2 BCL3 BCL5 BCL6 BCL6B BCL7A BCL7B BCL7C BCL8 BCL9 BCL10 BCL11A BCL11B Bcl-2 family "Chronic lymphocytic leukaemia (CLL) and small
B-cell_CLL/lymphoma
Transcription factor for converting Naive T cells to TFH
cancers. Other BCL genes, including BCL2, BCL3, BCL5, BCL7A, BCL9, and BCL10, also have clinical significance in lymphoma. The protein encoded by the
BCL6
Transmembrane protein on the surface of a B cell
signaling complex protein CARMA1 (the complex itself comprising CARMA1, BCL10, and MALT1). These result in recruitment and summoning of the IKK (IkB kinase)
B-cell_receptor
Protein-coding gene in humans
lymphoma 10 (Bcl10) protein and a caspase-like domain. The death domain and immunoglobulin-like domains participate in binding to BCL10. Activation of
MALT1
Protein-coding gene in humans
607212), CARD10, CARD11 (MIM 607210), and CARD14 (MIM 607211) interact with BCL10 (MIM 603517) and are involved in NF-κB signaling complexes. Except for CARD9
CARD10
Protein-coding gene in humans
domain of BCL10, a positive regulator and NF-κB activation. It is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex
CARD9
Medical condition
alterations are known:[citation needed] t(1;14)(p22;q32), which deregulates BCL10, at the locus 1p22. t(14;18)(q32;q21), which deregulates MALT1, at the locus
MALT_lymphoma
Protein-coding gene in humans
nuclear residence of p50 NF-kappa B. Like BCL2, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma. BCL3 has been shown to interact
BCL3
Protein-coding gene in humans
subsequently phosphorylates CARD9 that triggers recruitment of BCL10 and MALT1, leading to a CARD-CC/BCL10/MALT1 (CBM) signaling complex. This signaling complex
CLEC7A
Family of enzymes
CARD11/BCL10/MALT1 complex → NF-κB adaptive immune system myelocyte immune system C-type lectin receptors (CLR) (Dectin 1, Mincle) CARD9/BCL10/MALT1 complex
Protein_kinase_C
White blood cells of the immune system
unfold and function as a scaffold. The cytosolic domains bind an adapter BCL10 via CARD (Caspase activation and recruitment domains) domains; that then
T_cell
Human chromosome
arginine decarboxylase (ADC) BCAS2: Breast carcinoma amplified sequence 2 BCL10 (1p22) LRIF1: encoding protein Ligand-dependent nuclear receptor-interacting
Chromosome_1
Human protein
(DDAH1), and synapse defective Rho GTPase homolog 2 (SYDE2). The BCL10 gene encodes the BCL10 scaffolding protein that controls immune and pro-inflammatory
C1orf52
Protein-coding gene in humans
Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Letters. 496 (2–3):
CARD14
Medical condition
Rozmus, J; Ruland, J; Snow, AL; Stepensky, P; Warnatz, K (2014). "The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary
BENTA_disease
Protein complex on the surface of T cells that recognizes antigens
conformational change which allows it to oligomerize and bind the adapter proteins BCL10, CARD domain and MALT1. This multi-subunit complex binds the ubiquitin ligase
T-cell_receptor
Protein-coding gene in humans
in recruitment of Syk and downstream activation of so-called CBM (CARD9-BCL10-MALT1) signalling complex, leading to NFκB activation and resulting in production
CLEC6A
Protein-coding gene in humans
org. Retrieved 2016-05-10. "www.genecards.org/cgi-bin/carddisp.pl?gene=BCL10". www.genecards.org. Retrieved 2016-05-10. Reference GH. "NRAS". Genetics
CCDC180
Protein-coding gene in the species Homo sapiens
I, O'Rourke K, Ultsch M, Seshagiri S, Eby M, Xiao W, Dixit VM (2004). "Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO". Nature
UBE2N
Class of enzymes
Hulpiau P, Lievens L, et al. (2018). "Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions"
Paracaspase
deficiency RhoH deficiency Activated PI3K delta syndrome MALT1 deficiency BCL10 deficiency BCL11B deficiency CARD11 deficiency MST1 deficiency TCRα deficiency
List of primary immunodeficiencies
List_of_primary_immunodeficiencies
Interaction motifs found in a wide array of proteins
cardiak, RIP2 or RICK kinase) [17] BCL10: B-cell lymphoma/leukemia 10 protein [18][permanent dead link] BINCA: Bcl10-interacting CARD protein or BinCARD
CARD_(domain)
Cancer originating in lymph nodes
KMT2D, STAT6, CARD11 (encoding a guanylate kinase which interacts with BCL10 and activates NF-κB to regulate cell survival); 2) changes in the expression
Follicular_lymphoma
Enzyme
Hulpiau P, Lievens L, et al. (2018). "Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions"
Tyrosine-protein_kinase_SYK
Protein-coding gene in humans
or via intraperitoneal injection. IKBKG has been shown to interact with: BCL10, CDC37, CHUK and IKK2, IRAK1, NCOA3, PPM1B, TANK, TNFAIP3, TRAF3IP2, and
IKBKG
Protein family
they are activated by different protein kinase C isoforms, and recruit BCL10 and the paracaspase MALT1 upon activation, forming a so-called CBM complex
CARD-CC_family
Medical condition
enter the complex of the inhibitor of NF-κB kinase (IKK) with the upstream Bcl10-MALT1 (mucosa-associated lymphatic tissue) adapter complex which were crucial
Caspase-8_deficiency
Protein-coding gene in the species Homo sapiens
(2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–11120
Baculoviral IAP repeat-containing protein 2
Baculoviral_IAP_repeat-containing_protein_2
Protein-coding gene in the species Homo sapiens
Lievens L, et al. (2018-05-24). "Ancient Origin of the CARD–Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions"
ZAP70
Protein-coding gene in the species Homo sapiens
(2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–20
Baculoviral IAP repeat-containing protein 3
Baculoviral_IAP_repeat-containing_protein_3
HGNC:1006; Q8WUZ0 1488 BCL9 HGNC:1008; O00512 1489 BCL9L HGNC:23688; Q86UU0 1490 BCL10 HGNC:989; O95999 1491 BCL11A HGNC:13221; Q9H165 1492 BCL11B HGNC:13222;
List of human protein-coding genes 1
List_of_human_protein-coding_genes_1
Kenyan molecular biologist
enabled antigen receptors to activate the canonical NF-κB pathway: CARD11, BCL10 and MALT1/paracaspase. Furthermore, he postulated a protease activity for
Vishva_Dixit
Simultaneous measurement of spectra and pictures
Langel FD, et al., Multiple protein domains mediate interaction between Bcl10 and Malt1, J. Biol. Chem., (2008) 283(47):32419-31. Clayton AH., The polarized
Chemical_imaging
Protein-coding gene in the species Homo sapiens
O'Rourke K, Ultsch M, Seshagiri S, Eby M, Xiao W, Dixit VM (January 2004). "Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO". Nature
UBE2V2
Protein-coding gene in the species Homo sapiens
2596504. PMC 528928. PMID 15489334. Liu Y, Dong W, Chen L, et al. (2004). "BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction
PELI2
Protein-coding gene in humans
transcript has been determined. TRAF2 has been shown to interact with: ASK1, BCL10, BIRC2, Baculoviral IAP repeat-containing protein 3, CASP8AP2, CD134, CD137
TRAF2
Protein-coding gene in the species Homo sapiens
Hulpiau P, Lievens L, et al. (2018). "Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions"
TNFAIP3
Protein-coding gene in humans
poor outcome in colorectal cancer. Like BCL2, BCL3, BCL5, BCL6, BCL7A, and BCL10, it has clinical significance in lymphoma. Common variations in the BCL9
BCL9
Protein found in humans
enter the complex of the inhibitor of NF-κB kinase (IKK) with the upstream Bcl10-MALT1 (mucosa-associated lymphatic tissue) adapter complex which were crucial
Caspase_8
BCL10
BCL10
BCL10
BCL10
Boy/Male
Tamil
Girl/Female
Hindu
Beautiful
Boy/Male
Tamil
Abbhinav | அபà¯à®ªà¯€à®¨à®¾à®µ
New, Novel, Innovative
Girl/Female
Australian, Gaelic
Slender; From the Forest; Similar to Caley or Cailley
Boy/Male
Biblical
Diffusion; inclination; theft.
Girl/Female
Hebrew
Ceremonial grain.
Girl/Female
Indian
Perfect, Complete, Healthy
Girl/Female
Hindu
Starry night
Girl/Female
American, British, English
Battle Chieftain; Modern Female Version of Cedric
Surname or Lastname
English
English : habitational name, perhaps from Winkleigh in Devon, named with an unattested Old English personal name Wineca + lēah ‘woodland clearing’. However, the modern surname occurs chiefly in South Yorkshire and Lancashire, which suggests that another, unidentified source may be involved.Americanized form of German Winkele.
BCL10
BCL10
BCL10
BCL10
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