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In biochemistry, the preference of ligands to bind with one receptor over another
In chemistry, binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex. Binding selectivity describes how
Binding_selectivity
Topics referred to by the same term
Look up selectivity in Wiktionary, the free dictionary. Selectivity may refer to: Choice, making a selection among options Discrimination, the ability
Selectivity
Substance that forms a complex with a biomolecule
advantages compared to their monovalent counterparts (such as tissue selectivity, increased binding affinity, and increased potency or efficacy), bivalents may
Ligand_(biochemistry)
Biochemical analysis procedure
estimate a specified model for the binding. Competition binding is used to determine the presence of selectivity for a particular ligand for receptor
Ligand_binding_assay
Topics referred to by the same term
constant Binding domain Binding protein Binding selectivity Binding site BindingDB, an online database of measured binding affinities Binding potential
Binding
Pharmacologic characteristic
selectivity (or agonist trafficking, biased agonism, biased signaling, ligand bias, and differential engagement) is the ligand-dependent selectivity for
Functional_selectivity
Selective relaxant binding agents (SRBAs) are a new class of drugs that selectively encapsulates and binds neuromuscular blocking agents (NMBAs). The
Selective relaxant binding agents
Selective_relaxant_binding_agents
Drugs acting on the estrogen receptor
the binding cavity of ERβ is slightly narrower than that of ERα, however, this by itself leads to modest selectivity. To attain strong selectivity, the
Selective estrogen receptor modulator
Selective_estrogen_receptor_modulator
Former Chinese custom
Foot binding (simplified Chinese: 缠足; traditional Chinese: 纏足; pinyin: chánzú), or footbinding, was the Chinese custom of breaking and tightly binding the
Foot_binding
Computational tools
two goals: efficiency and selectivity. Efficiency involves taking into account such factors as GC-content, efficiency of binding, complementarity, secondary
In_silico_PCR
Class of drugs
conditions. Selectivity, or “binding selectivity”, describes how a ligand may bind more preferentially to one receptor than another. Selectivity can also
Adrenergic_neuron_blockers
Half maximal inhibitory concentration
vivo. IC50 can be determined with functional assays or with competition binding assays. Sometimes, IC50 values are converted to the pIC50 scale. pIC 50
IC50
Integral of drug concentration in blood plasma over time
action Mode of action Binding Receptor (biochemistry) Desensitization (medicine) Other effects of ligand Selectivity (Binding, Functional) Pleiotropy
Area under the curve (pharmacokinetics)
Area_under_the_curve_(pharmacokinetics)
Theoretical drug measure in pharmacology
solubility (non-polarity), low rates of ionization, or low plasma protein binding capabilities. Disease states which increase V D {\displaystyle V_{D}} include
Volume_of_distribution
Prokaryotic potassium ion channel
channels was centered on the use of small toxin binding to reveal the location of the pore and selectivity filter among channel residues. MacKinnon's group
KcsA_potassium_channel
Subdiscipline of chemistry concerned with chemical equilibrium
objective of these studies is often to find systems with a high binding selectivity of a host (receptor) for a particular target molecule or ion, the
Equilibrium_chemistry
Family of transport proteins
lacks the selectivity filter found in animal CNG channels as well as lacks a glycine-tyrosine-glycine-aspartate (GYGD) motif in the K+-selectivity filter
Cyclic nucleotide–gated ion channel
Cyclic_nucleotide–gated_ion_channel
Pharmaceutical compound
Cys-797 residue of the ATP-binding site of EGFR via a Michael addition to form a covalent bond. It has binding selectivity for T790M mutant over wild‑type
Firmonertinib
Chemical similar in structure to vitamin B12
behavior of Sinorhizobium meliloti largely correlates with the cofactor binding selectivity of its methylmalonyl-CoA mutase (MCM). Among adenyl-cobamides, paseudovitamin
Pseudovitamin_B12
Opioid analgesic of benzenoid class
such as desvenlafaxine and duloxetine. Tapentadol exhibits high binding selectivity and affinity for MOR, which is the principal target of the endogenous
Tapentadol
Chaperone protein
and subtype selectivity Agents exist that have high σ1 affinity but either lack subtype selectivity or have high affinity at other binding sites, thus
Sigma-1_receptor
Electrostatic phenomenon
strong affinity to the binding site. This conductivity-selectivity paradox has been explained as being a consequence of selective barrier-less conduction
Ionic_Coulomb_blockade
Monoclonal antibody
IgG2 monoclonal antibody that inhibits interleukin-31 signaling by binding selectively to interleukin-31 receptor alpha. It is an interleukin-31 receptor
Nemolizumab
Human glycoprotein that binds to androgens and estrogens
Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to androgens and estrogens. When produced by the
Sex_hormone–binding_globulin
Set of laboratory techniques for separation of mixtures
hospitals. Affinity chromatography Aqueous normal-phase chromatography Binding selectivity Chiral analysis Chromatofocusing Chromatography in blood processing
Chromatography
Chemical compound
and 3.61 nM, respectively, demonstrating 9-fold binding selectivity and 11-fold functional selectivity for the ERβ over the ERα. An enantiomer of SERBA-2
SERBA-2
Pharmaceutical compound
receptors. Study of the binding mode of Z2504 and how it achieves functional selectivity for 5-HT2A despite similar binding at all three subtypes has
Z3881312504
Beta-1 selective adrenenergic blocker medication used to treat cardiovascular diseases
degree of β1-selectivity compared to atenolol, metoprolol and betaxolol. With a selectivity ranging from being 11 to 15 times more selective for β1 over
Bisoprolol
Pharmaceutical compound
most tryptamines are highly non-selective in terms of binding to serotonin receptors, 1-propyl-5-MeO-AMT shows selectivity for the serotonin 5-HT2A receptor
1-Propyl-5-MeO-AMT
Human protein
late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific
Urokinase
Class of drug
Manning et al. presented two high-affinity MAT-ligands with good binding selectivity for SERT and DAT, namely the 4-indolyl and 1-naphthyl arylalkylamines
Serotonin–dopamine reuptake inhibitor
Serotonin–dopamine_reuptake_inhibitor
Pharmaceutical compound
only a 3-fold binding selectivity for ERβ over the estrogen receptor alpha (ERα), it shows more than a 100-fold functional selectivity for ERβ over ERα
OSU-ERβ-12
Type of receptor ligand or drug that blocks a biological response
receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist. Antagonist
Receptor_antagonist
Protein-coding gene in the species Homo sapiens
(TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity".
Parathyroid_hormone_2
Chemical which binds to and activates a biochemical receptor
Terms that describe this phenomenon are "functional selectivity", "protean agonism", or selective receptor modulators. As mentioned above, agonists have
Agonist
Ion channel that selectively passes K+
remove the hydration shell from the ion when it enters the selectivity filter. The selectivity filter is formed by a five residue sequence, TVGYG, termed
Potassium_channel
First generation antihistamine
000-fold selectivity for the histamine H1 receptor over the muscarinic acetylcholine receptors (for comparison, diphenhydramine had 20-fold selectivity for
Mepyramine
Chemical compound
for the nonyloxy derivative, having a 5-HT1B binding affinity of 1.0 nM, and around 300-fold selectivity over the related 5-HT1A receptor. 5-Allyloxy-AMT
5-(Nonyloxy)tryptamine
Rule established in an earlier legal case
In common law, precedent can either be something courts must follow (binding) or something they can consider but do not have to follow (persuasive)
Precedent
Fungal metabolite
interactions with PKA in particular are used to illuminate the roles of selectivity and protein flexibility in the inhibition of kinases. For instance, the
Balanol
Regulation of enzyme activity
by the binding of a ligand at an allosteric site topographically distinct from the orthosteric site. Due to the often high receptor selectivity and lower
Allosteric_regulation
Unanswered question in the study of consciousness
(cognitive) binding problem is the problem of how objects, background, and abstract or emotional features are combined into a single experience. The binding problem
Binding_problem
Chemical process for converting alkenes to aldehydes
work demonstrated that the ligand tributylphosphine (PBu3) improved the selectivity of the cobalt-catalysed process. The mechanism of Co-catalyzed hydroformylation
Hydroformylation
Protein-coding gene in humans
6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol: antagonist, moderate binding selectivity over D1 SCH 23390 D5 receptor has been shown to form heteromers with
Dopamine_receptor_D5
ligand with high affinity and selectivity for the (+)-MK801-insensitive [3H]1-]1-(2-thienyl)cyclohexyl]piperidine binding site (PCP site 2) of guinea pig
PCP_site_2
Drug class
However, highly selective serotonin 5-HT2A receptor agonists, such as TGF-8027, have also been developed. In addition to degree of selectivity for the serotonin
Serotonin 5-HT2A receptor agonist
Serotonin_5-HT2A_receptor_agonist
Chemical compound
14-fold binding selectivity for the ERβ over the ERα (Ki = 0.19 nM versus 2.68 nM, respectively). However, it shows 32-fold functional selectivity for activation
Erteberel
Ionotropic receptor and ligand-gated ion channel
producing α2-selective agonists as anticonvulsants which lack the side effects of older drugs such as sedation and amnesia. The binding site for benzodiazepines
GABAA_receptor
Chemical compound
5 μM, respectively. As such, its binding selectivity for the ERβ over the ERα was 7-fold and its functional selectivity for the ERβ over the ERα was between
DCW234
Mammalian protein found in humans
are crucial for ligand binding and specificity. The CALCRL/RAMP complex presents a unique ligand-binding pocket, enabling selective recognition of peptide
CALCRL
Subtype of serotonin receptor
animal studies. TCB-2 25C-NBOMe 25CN-NBOH – 100× selectivity for 5-HT2A over 5-HT2C, 46× selectivity over 5-HT2B. 3-Carboxy indole PB-22 (1-pentyl-indole-3-carboxylic
5-HT2A_receptor
Class of proteins
Penicillin-binding proteins (PBP) are a group of proteins that are characterized by their affinity for and binding of penicillin. They are a normal constituent
Penicillin-binding_proteins
Pharmaceutical compound
is potent, selective, and shows full efficacy as an SRA in serotonin transporter (SERT)-transfected HEK293T cells. This includes selectivity for the SERT
UCD0168
Pharmaceutical compound
reported to be subtype-selective for 5-HT2AR, which are summarized in Table 3. [...] DOHx and DOBz also have high binding selectivity for 5-HT2AR against
2,5-Dimethoxy-4-hexylamphetamine
2,5-Dimethoxy-4-hexylamphetamine
Enclosing or separating membrane in organisms acting as selective semi-permeable barrier
A biological membrane or biomembrane is a selectively permeable membrane that separates the interior of a cell from the external environment or creates
Biological_membrane
Protein
This selectivity increases the separation between the desired antiinflammatory effects and undesired metabolic side effects of these selective glucocorticoids
Nuclear_receptor
Protein molecule receiving signals for a cell
currents of different ions. This is accomplished with selectivity filters, such as the selectivity filter of the K+ ion channel Guyton, Arthur C.; Hall
Receptor_(biochemistry)
Class of antidepressant medication
for inhibition of serotonin reuptake over norepinephrine reuptake. The selectivity ratios are approximately 1:30 for venlafaxine, 1:10 for duloxetine, and
Selective serotonin reuptake inhibitor
Selective_serotonin_reuptake_inhibitor
Opioid analgesic
of (+)-cis-3-methylfentanyl with a 27,000-fold binding selectivity for mu versus delta opioid binding sites". Life Sciences. 48 (23): PL111–PL116. doi:10
Ohmefentanyl
Hydrogenated derivative of THC
chiral orientation are believed to be important for cannabinoid receptor binding. HHC has been typically described as weaker than delta-9-THC in psychoactive
Hexahydrocannabinol
Drug class
determine the selectivity. Compounds with substituents in position 2' have selectivity for NET. Compounds with substituents in position 4' are selective serotonin
Selective norepinephrine reuptake inhibitor
Selective_norepinephrine_reuptake_inhibitor
Enzyme
been developed that showed high selectivity for MMP-11. Derivatives based on phenyl rings showed the best selectivity. MMP-11 could be a useful target
Metalloprotease_inhibitor
Kappa opioid receptor radioligand
substantial selectivity over μ-opioid receptors (Ki = 16 ± 5 nmol/L) and δ-opioid receptors (Ki = 536 ± 234 nmol/L). It is approximately 800-fold selective for
GR-103545
exhibits selectivity and high affinity for NET, and are therefore generally SNRIs, compounds having substituent in the 4'-position exhibits selectivity and
Development and discovery of SSRI drugs
Development_and_discovery_of_SSRI_drugs
Ability of a substance to resist changes in structure under high temperatures
evolution of a G protein-coupled receptor for expression, stability, and binding selectivity". Proceedings of the National Academy of Sciences of the United States
Thermostability
German-Swiss biochemist and protein engineer
evolution of a G protein-coupled receptor for expression, stability, and binding selectivity". Proc. Natl. Acad. Sci. U.S.A. 105 (39): 14808–14813. doi:10.1073/pnas
Andreas_Plückthun
Parasympathetic nervous system inhibitors
These agents inhibit the parasympathetic nervous system by selectively blocking the binding of ACh to its receptor in nerve cells. The nerve fibers of
Anticholinergic
Chemical compound
"Beta 1-adrenoceptor selectivity of nebivolol and bisoprolol. A comparison of [3H]CGP 12.177 and [125I]iodocyanopindolol binding studies". European Journal
Nebivolol
Small molecule (PROTAC)
proteasome. Because PROTACs need only to bind their targets with high selectivity (rather than inhibit the target protein's enzymatic activity), efforts
Proteolysis_targeting_chimera
Drug class
agonist with approximately 4-fold greater selectivity for 5-HT2C over these related receptors, in terms of binding affinity. Vabicacserin is a full agonist
5-HT2C_receptor_agonist
Class of pharmacological agents
that affect the selectivity of the agonist. Visual inspection of selective β3-AR agonists revealed that they bind deep in the binding pocket of the receptors
Beta3-adrenergic_agonist
Drug discovery by identifying protein targets
action Mode of action Binding Receptor (biochemistry) Desensitization (medicine) Other effects of ligand Selectivity (Binding, Functional) Pleiotropy
Reverse_pharmacology
American cell physiologist and biologist
2025 A role for pH dynamics regulating transcription factor DNA-binding selectivity. Nucleic Acids Res. 53(10):gkaf474. PMID: 40464693 From 1995 to 2000
Diane_Barber
Stain used for diagnosis of malaria
microbiology Isolation and culture Isolation techniques Asepsis Streak plate Selective media Cultures by body site Blood culture Genital culture Sputum culture
Giemsa_stain
Canadian geneticist
2014.05.004. PMC 4048464. PMID 24856970. Klose, Rob (2005). "DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG"
Rob_Klose
Protein that regulates the rate of DNA transcription
sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to DNA sequences
Transcription_factor
G-protein-coupled receptor
each case, agonist binding results in an increase in intracellular calcium levels. However, orexin-B shows a 5- to 10-fold selectivity for orexin receptor
Orexin_receptor
Chemical compound
Both compounds showed moderate binding selectivity against the 5-HT2BR and 5-HT2CR, and overall better selectivity profiles than those of classic psychedelic
(R)-70
Medication class with multiple uses
metabolism) are less common with β1-selective (often termed "cardioselective") agents, but receptor selectivity diminishes at higher doses. Beta blockade
Beta_blocker
Chemical compound
RTI-31 is a relatively balanced reuptake inhibitor wrt the D/N/S ratio. The binding ligand affinities for the different transporters is skewed somewhat in
RTI-31
Opioid agonist peptide compound
family of naturally occurring peptides with high affinity and selectivity for delta opioid binding sites". Proc. Natl. Acad. Sci. U.S.A. 86 (13): 5188–92. Bibcode:1989PNAS
Dermorphin
Protein-coding gene in the species Homo sapiens
the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants". Journal of Neuroendocrinology. 11 (12): 941–9. doi:10
Pituitary adenylate cyclase-activating peptide
Pituitary_adenylate_cyclase-activating_peptide
Experimental technique in cell biology
very useful in biological studies of cell membrane diffusion and protein binding. In addition, surface deposition of a fluorescing phospholipid bilayer
Fluorescence recovery after photobleaching
Fluorescence_recovery_after_photobleaching
Chemical compound
selectivity over 5-HT2B and 49-fold selectivity over 5-HT2C. It has a 5-HT2A Ki of 680 nM and an EC50 of 41 nM. (R)-69 is a biased agonist selective for
(R)-69
Pregnancy termination based on predicted sex
overwhelmingly targets female fetuses, sex-selective abortion often specifically refers to female-selective abortion. Sex-selective abortion is closely linked to female
Sex-selective_abortion
Purification technique for biomolecules
acid binding interactions are frequently exploited for isolation of various biomolecules. Affinity chromatography is useful for its high selectivity and
Affinity_chromatography
Radioligand used for diagnostic purposes
technique is desired to investigate a function accurately, the selectivity of bindings to the specific targets is very important. List of PET radiotracers
PET_radiotracer
Extremely small sensors
to their sensitivity, as well as their tunability and resulting binding selectivity, nanosensors are very effective and can be designed for a wide variety
Nanosensor
Organic compound used as a chelator
like its carboxylic acid analog DOTA, but shows greater selectivity for large covalently binding metal ions. It was designed and first synthesized by Robert
DOTAM
Protein found in humans
Transcortin, also known as corticosteroid-binding globulin (CBG) or serpin A6, is a protein produced in the liver in animals. In humans it is encoded
Transcortin
Chemical compound
its binding potency for the dopamine transporter & a 52-fold enhanced affinity for the norepinephrine transporter. It also has a reduced selectivity for
Salicylmethylecgonine
Drug discovery
caused a loss of selectivity but not loss of the β-blockade itself. This illustrated the significance of para-substitution for β1 selectivity of β-blockers
Discovery and development of beta-blockers
Discovery_and_development_of_beta-blockers
Mammalian protein found in humans
antibiotic pressure has caused this class to evolve different patterns of binding diaminoheterocyclic molecules, leading to many "types" named under this
Dihydrofolate_reductase
Protein helix–loop–helix motif
This high selectivity is due to the relatively rigid coordination geometry, the presence of multiple charged amino acid side chains in the binding site, as
EF_hand
Chemical compound
addictive. This has been misinterpreted as a dopamine vs. norepinephrine selectivity ratio. Another study found that in the threo-isomers of methylphenidate
4-Fluoromethylphenidate
Receptor models to explain drug behavior
time, Ehrlich was trying to understand the basis of selectivity of agents. He theorized that selectivity was the basis of a preferential distribution of lead
Receptor_theory
Biological kingdom
used to make textiles, while animal sinews have been used as lashings and bindings, and leather is widely used to make shoes and other items. Animals have
Animal
Medication used to treat insomnia
found to affect the pharmacokinetics of zaleplon. Zaleplon is a high-selectivity, high-affinity ligand of positive modulatory benzodiazepine sites on
Zaleplon
Type of university early admission process
because it is non-binding. EA drives a large volume of applications (helping to lower the school's admission rate and increasing its selectivity) but hurts the
Early_action
resonant transitions to bound surface states.[citation needed] The selective adsorption binding energies can supply information on the gas-surface interaction
Selective_adsorption
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BINDING SELECTIVITY
BINDING SELECTIVITY
BINDING SELECTIVITY
BINDING SELECTIVITY
BINDING SELECTIVITY
BINDING SELECTIVITY
BINDING SELECTIVITY
BINDING SELECTIVITY
BINDING SELECTIVITY
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