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Drugs that modify immune system response
Biological response modifiers (BRMs) are substances that modify immune responses. They can be endogenous (produced naturally within the body) or exogenous
Biological_response_modifier
Activation or suppression of the immune system to treat disease
the mutualistic and symbiotic approach being much more likely. Biological response modifier Sepsivac Checkpoint inhibitor Interleukin-2 immunotherapy Immunostimulant
Immunotherapy
Drug class
include the following: disease-modifying antirheumatic drugs, biologic response modifiers, analgesics, non-steroidal anti-inflammatory drugs, and corticosteroids
Antiarthritics
Type of therapy
immunology. Thus, as immunomodulators, they are one type of biological response modifiers. The most successful targeted therapies are chemical entities
Targeted_therapy
Proteins present in many animal tissues
In relation to diseases, thymosins have been categorized as biological response modifiers. Thymosins are important for proper T-cell development and differentiation
Thymosin
Long-term inflammatory arthritis
HAQ ≤0.5. Biologics (also called biological response modifiers) are a class of therapeutics developed using recombinant DNA technology. Biologic medications
Psoriatic_arthritis
Italian allergist and pulmonologist
innovative treatment strategies for allergic diseases which includes biological response modifier in form of targeted immunotherapy with primary emphasis on sublingual
Giorgio_Walter_Canonica
countries for use as an anti-tumor drug. It appears to work as a biological response modifier (BRM), enhancing the body's own use of macrophages and T-lymphocytes
Polysaccharide_peptide
Collection of human autoimmune diseases
(2017-07-01). "Additional Improvements in Clinical Response From Adjuvant Biologic Response Modifiers in Adults With Moderate to Severe Systemic Lupus Erythematosus
Lupus_erythematosus
Medical treatment
interactions Staren ED, Essner R, Economou JS (1989). "Overview of biological response modifiers". Seminars in Surgical Oncology. 5 (6): 379–84. doi:10.1002/ssu
Biological therapy for inflammatory bowel disease
Biological_therapy_for_inflammatory_bowel_disease
Species of edible kelp
T.; et al. (1993). "Eisenin (L-pyroGlu-L-Gln-L-Ala), a new biological response modifier". Journal of Immunotherapy. 13 (1): 36–42. doi:10.1097/00002371-199301000-00005
Arame
Chemical compound
glucose polymers commonly called beta-glucans demonstrating biological response modifier properties. These immunomodulating properties render the host
Pleuran
System of procedure codes within ICD-9 Clinical Modification
tranquilizer (99.27) Iontophoresis (99.28) Injection or infusion of biological response modifier (BRM) as an antineoplastic agent (99.29) Injection or infusion
ICD-9-CM_Volume_3
Polyoxyethylene-polyoxypropylene block co-polymer
evolution of drug delivery concept from inert nanocarriers to biological response modifiers". Journal of Controlled Release. 130 (2): 98–106. doi:10.1016/j
Poloxamer
Topics referred to by the same term
Organization for Standardization (ISO) procedure Biological response modifiers, substances that alter immune response British Railway Modelling, a British hobby
BRM_(disambiguation)
American biochemist (born 1937)
neuropathy. Dr. Goldstein's research has helped define the role of biological response modifiers in health and disease, and has led to the discovery of important
Allan_L._Goldstein
Medical treatment in addition to a primary treatment to maximise effectiveness
Systemic therapy consists of chemotherapy, immunotherapy or biological response modifiers or hormone therapy. Oncologists use statistical evidence to
Adjuvant_therapy
Non-profit organization
cell biology, molecular biology, biochemistry, and the use of biological response modifiers clinically. As the premier organization in the field of cytokine
International Cytokine & Interferon Society
International_Cytokine_&_Interferon_Society
Physiological and psychological changes in preparation for sexual intercourse
interbreeding populations. The effect of sexual response is thought to be a plastic positive reinforcement behavior modifier associated with the Baldwin effect. The
Sexual_arousal
Proteins that control apoptosis
which prevents the activation of BAX and BAK. crmA, or cytokine response modifier A, is a cowpox serpin that inhibits caspases 1, 6 and 8, forming complexes
Inhibitor_of_apoptosis
Medical condition
In the remaining 20% of TRALI cases, non–antibody factors or biological response modifiers are suggested to contribute the second hit, and these may possibly
Transfusion-related acute lung injury
Transfusion-related_acute_lung_injury
Monoclonal antibody
Substances (INN), World Health Organization. Khardori NM (2011). Biologic Response Modifiers in Infectious Diseases, An Issue of Infectious Disease Clinics
Foravirumab
Tripeptide with immunological activity
T. (January 1993). "Eisenin (L-pyroGlu-L-Gln-L-Ala), a new biological response modifier". Journal of Immunotherapy with Emphasis on Tumor Immunology
Eisenin
Special form of in vitro fertilisation
In 2002, the US Food and Drug Administration (FDA) asked a Biological Response Modifiers Advisory Committee Meeting to advise on the technique of cytoplasmic
Mitochondrial replacement therapy
Mitochondrial_replacement_therapy
American physician (born 1960)
antioxidant selenium and the anti-inflammatory drug class called biological response modifiers on male fertility. He has also tried to better delineate the
Paul_J._Turek
Family of proteins which attach to other proteins to modify them
In molecular biology, SUMO (Small Ubiquitin-like MOdifier) proteins are a family of small proteins that are covalently attached to and detached from other
SUMO_protein
Protein-coding gene in the species Homo sapiens
Journal of Biological Response Modifiers. 8 (5): 501–10. PMID 2552026. Cohen S, Velan B, Grosfeld H, et al. (1985). "Cloning, expression and biological activity
IFNA7
bioavailable – biochanin A – biochemical reactions – biological response modifier – biological therapy – biomarker – Biomed 101 – biopsy – biopsy specimen
Index_of_oncology_articles
Enzyme in glutathione biosynthesis
ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response". The Journal of Biological Chemistry
Glutamate–cysteine_ligase
Type of modifier gene
A human disease modifier gene is a modifier gene that alters expression of a human gene at another locus that in turn causes a genetic disease. Whereas
Human_disease_modifier_gene
Type of cancer
immune response. They can be administered alone or be linked (conjugated) to anticancer drugs, radioisotopes, or other biologic response modifiers. There
Germinal center B-cell like diffuse large B-cell lymphoma
Germinal_center_B-cell_like_diffuse_large_B-cell_lymphoma
Protein-coding gene in the species Homo sapiens
Ubiquitin-like modifier activating enzyme 1 (UBA1) is an enzyme which in humans is encoded by the UBA1 gene. UBA1 participates in ubiquitination and the
UBA1
Protein found in humans
Journal of Biological Chemistry. 261 (19): 8811–6. doi:10.1016/S0021-9258(19)84453-8. PMID 3087979. "Entrez Gene: ISG15 ISG15 ubiquitin-like modifier". Subedi
ISG15
Mammalian protein found in Homo sapiens
2004.05.032. PMID 15261142. Reang P, Gupta M, Kohli K (2006). "Biological response modifiers in cancer". MedGenMed. 8 (4): 33. PMC 1868326. PMID 17415315
Hepatocyte growth factor receptor
Hepatocyte_growth_factor_receptor
evolution of drug delivery concept from inert nanocarriers to biological response modifiers". Journal of Controlled Release. 130 (2): 98–106. doi:10.1016/j
Alexander_Kabanov_(chemist)
American oncologist and researcher
lymphoblastoid interferon in patients with multiple myeloma". Journal of Biological Response Modifiers. 7 (3): 318–325. ISSN 0732-6580 PMID 3392554 Laszlo, John (1995)
John_Laszlo
Physical effects resulting from activation of the immune system
Latin: inflammatio) is part of the biological defence response of body tissues. Inflammatory immunovascular responses can be triggered by a broad range
Inflammation
Protein-coding gene in the species Homo sapiens
Small ubiquitin-related modifier 1 is a protein that in humans is encoded by the SUMO1 gene. This gene encodes a protein that is a member of the SUMO (small
SUMO1
American physician, immunologist, oncologist, and professor (1940–2013)
Institute in 1984. In 1988, he was appointed chairman of the Biological Response Modifiers Committee of the National Institute of Allergy and Infectious
Ronald_B._Herberman
British surgeon
Cytofluorometry to predict effects of biological response modifiers in Poulik D. et al. eds. 'Protides of the biological fluids' 1989; 36: 3–17 Hobbs, J. R
John_Raymond_Hobbs
enhancement therapy Autophagy Beta-2 microglobulin Binding antibody Biological response modifiers Blocking antibody Blotto (biology) BNAber Body odor Bone marrow-derived
Index_of_immunology_articles
American biomedical scientist (1945-2018)
cells and T cell subsets as the head of a laboratory in the Biological Response Modifiers Program at the NCI-Frederick. Mathieson served as a program
Bonnie_Mathieson
Low-calorie sweetener and flavor modifier
Thaumatin (also known as talin) is a low-calorie sweetener and taste modifier. The protein is often used primarily for its flavor-modifying properties
Thaumatin
beta-2 microglobulin (β2M) – bilirubin – bioavailability – biological response modifiers (BRMs) – biopsy – biotechnology – blinded study – blips – blood–brain
Index of HIV/AIDS-related articles
Index_of_HIV/AIDS-related_articles
Protein-coding gene in the species Homo sapiens
Feinberg AP (1998). "Identification and mapping of human histone acetylation modifier gene homologues". Genomics. 51 (2): 262–269. doi:10.1006/geno.1998.5370
KAT2A
Protein-coding gene in the species Homo sapiens
Small ubiquitin-related modifier 2 is a protein that in humans is encoded by the SUMO2 gene. This gene encodes a protein that is a member of the SUMO (small
SUMO2
Exopolysaccharide
; BeMiller, James N. (January 1995). "(1→3)-β-d-Glucans as biological response modifiers: a review of structure-functional activity relationships". Carbohydrate
Botryosphaeran
696.477.136.377 – hemagglutinins MeSH D27.505.696.477.274 – biological response modifiers MeSH D27.505.696.477.274.050 – adjuvants, immunologic MeSH D27
List_of_MeSH_codes_(D27)
American patent attorney and government official
Administration inventions in the areas of cancer, gene therapy and biological response modifiers. While working at the NIH, Bahar first served as the regional
Mojdeh_Bahar
Protein-coding gene in the species Homo sapiens
Ubiquitin-like modifier-activating enzyme 5 is a protein that in humans is encoded by the UBA5 gene. This gene encodes a member of the E1-like activating
UBA5
Process of regulating a functional proteome
proteome. The proteostasis network includes competing and integrated biological pathways within cells that control the biogenesis, folding, trafficking
Proteostasis
Field of sexual orientation research
biological level. Researchers have suggested that this possibility could be further explored by studying young subjects to see if similar responses in
Biology and sexual orientation
Biology_and_sexual_orientation
Overreaction of the immune system to an antigen
immune complexes. Similarly, the glycosylation of IgG antibodies is a key modifier of effector functions, with afucosylation of the Fc glycan resulting in
Hypersensitivity
Protein-coding gene in the species Homo sapiens
1995.1083. PMID 7826375. "Entrez Gene: GCLM glutamate-cysteine ligase, modifier subunit". Dickinson DA, Levonen AL, Moellering DR, et al. (2005). "Human
GCLM
Immunotherapeutic company founded by Jonas Salk and Kevin Kimberlin
Lagakos, S (1 November 2000). "Evaluation of HIV-1 Immunogen, an Immunologic Modifier, Administered to Patients Infected With HIV Having 300 to 549 × 106/L CD4
The Immune Response Corporation
The_Immune_Response_Corporation
Species of ant (Anoplolepis gracilipes)
world's tropics. The yellow crazy ant has colloquially been given the modifier "crazy" on account of the ant's erratic movements when disturbed. Its long
Yellow_crazy_ant
Family of proteins
expression. Recently it was discovered that HSF1 is a powerful multifaceted modifier of carcinogenesis. HSF1 knockout mice show significantly decreased incidence
Heat_shock_protein
Concept in genetic epidemiology
contrasting cystic fibrosis endophenotypes recognizes KRT8 but not KRT18 as a modifier of cystic fibrosis disease severity and CFTR mediated residual chloride
Endophenotype
Protein-coding gene in the species Homo sapiens
Ubiquitin-fold modifier conjugating enzyme 1 is a protein that in humans is encoded by the UFC1 gene. UFC1 is an E2-like conjugating enzyme for ubiquitin-fold
Ubiquitin-fold modifier conjugating enzyme 1
Ubiquitin-fold_modifier_conjugating_enzyme_1
Attraction between people of the opposite sex or gender
support, scientists favor biologically based theories. There is considerably more evidence supporting nonsocial, biological causes of sexual orientation
Heterosexuality
Human protein and coding gene
Freshwater S, Harrer JM, He L, et al. (May 2002). "Glutamate-cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause
NFE2L2
Therapeutic cancer vaccine in development
using GM-CSF to grow more cells. The NIH calls this topic "Biological response modifiers (BRMs) occur naturally in the body and can be produced in the
Neuvenge
Enzyme
enzyme (AtSCE1) is an enzyme that is a member of the small ubiquitin-like modifier (SUMO) post-translational modification pathway. This process, and the SCE1
AtSCE1
Type of enzymes
binding to SIN3A. SUMOylation refers to the addition of Small Ubiquitin-like Modifier (SUMO) proteins onto histones. SUMOylation involves covalent attachments
Histone-modifying_enzymes
Protein-coding gene in the species Homo sapiens
Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene. The modification of proteins with ubiquitin is an
UBE1L
Chemical compound
first compound found in the hypobranchial gland mucus to produce a biological response. BrMT is a brominated tryptamine. It has a thiol group, allowing
BrMT
Surfactant and antiseptic agent
while more concentrated solutions require incorporation of rheology modifiers (alcohols, polyethylene glycols, etc.) to prevent increases in viscosity
Benzalkonium_chloride
Regulatory protein found in most eukaryotic tissues
ubiquitin-like modifier (SUMO), ubiquitin cross-reactive protein (UCRP, also known as interferon-stimulated gene-15 ISG15), ubiquitin-related modifier-1 (URM1)
Ubiquitin
habitat former or modifier; a secondary habitat former or modifier; and a focal organism that utilizes the secondary habitat former or modifier. For example
Habitat_cascade
Underground animal home dug in soft dirt
animals can be divided into three categories: primary excavators, secondary modifiers and simple occupants. Primary excavators are the animals that originally
Burrow
Protein-coding gene in the species Homo sapiens
been shown to interact with SMURF2, HDAC1, CDC5L, Small ubiquitin-related modifier 1, P53, and TOPBP1. In Drosophila Hadlaczky et al 1988 found DNA topoisomerase
TOP2A
Biological mechanism that controls circadian rhythm
hours. In response to light stimulus, the body corresponds with a system and network of pathways that work together to determine the biological day and
Circadian_clock
Statistics concept
is referred to as the moderator variable (or effect modifier) or simply the moderator (or modifier). The effect of a moderating variable is characterized
Moderation_(statistics)
Mammalian protein found in Homo sapiens
L, Pegoraro E, et al. (January 2017). "Evidence for ACTN3 as a genetic modifier of Duchenne muscular dystrophy". Nature Communications. 8 (1) 14143. Bibcode:2017NatCo
Alpha-actinin-3
Class of enzymes capable of forming isopeptide bonds in certain regions of proteins
L, Hitomi K, Kojima S (2015). Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery. Springer Japan. ISBN 978-4-431-55823-1
Transglutaminase
Peptide neurotoxin
"Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes". Journal of Biological Chemistry
Protoxin-I
Protein-coding gene in the species Homo sapiens
Ueno T, Kominami E (June 2006). "Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3".
ATG7
Protein-coding gene in the species Homo sapiens
CY (August 2004). "A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes". Nat. Genet. 36 (8): 837–41. doi:10
IκBα
Protein-coding gene in the species Homo sapiens
granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes". J. Biol. Chem. 271 (44): 27802–9
SERPINB9
Mammalian protein found in Homo sapiens
template switch pathway. Furthermore, sumoylation (by small ubiquitin-like modifier, SUMO) of PCNA lysine-164 (and to a lesser extent, lysine-127) inhibits
Proliferating cell nuclear antigen
Proliferating_cell_nuclear_antigen
Biological signaling pathway h
Regulation of Protein Solubility by Small Ubiquitin-like Modifier (SUMO)". Journal of Biological Chemistry. 286 (21): 18731–18746. doi:10.1074/jbc.M111
JAK-STAT_signaling_pathway
Analysis of material by examining response to heat
computer-aided cooling curve thermal analysis to optimise eutectic refiner and modifier in Al–Si alloys". Journal of Thermal Analysis and Calorimetry. 109 (1):
Thermal_analysis
Protein-coding gene in the species Homo sapiens
Ludolph AC, Patsch W, Weydt P (2013). "PGC-1α is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis". Human Molecular
PGC-1α
Corticosteroid precursor and metabolite of cortisol
prohormone of cortisol (hydrocortisone), which is responsible for its biological activity. It is metabolized into cortisol via the actions of 11β-hydroxysteroid
Cortisone
Statistical tool used in meta-analyses
disqualify it from being a regression model, one could argue that the modifier random-effect only adds to, not takes away from, what any regression model
Meta-regression
Earth, a natural material
as a means of water storage, water supply, and water purification as a modifier of Earth's atmosphere as a habitat for soil organisms All of these functions
Soil
Medication used to treat allergic reactions
mucus secretion and enhanced immune response, resulting in allergic inflammation. Leukotriene pathway modifiers can be classified into two types: the
Anti-allergic_agent
Class of chemical substance
inducing drug release, such as pH-response, magnetic-response, ion-response, temperature-response, and pressure response. In 2010, Smaldone et al., an international
Metal–organic_framework
Mitochondrion Mitosis Mitotic apparatus Mitotic crossover Model organisms Modifier gene Molecular biology Molecular chaperone Molecular farming Molecular
Index_of_genetics_articles
Glucocorticoid and mineralocorticoid hormone Cortisol supplied as a medication
(March 2009). "Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis". Biological Psychology. 80 (3): 265–278. doi:10
Hydrocortisone
attached to the enzyme protein. The most important groups that work as modifiers are phosphate, methyl, uridine, adenine and adenosine diphosphate ribosyl
Regulatory_enzyme
Species of protozoan parasite
development in T. gondii. Farhat and colleagues showed that chromatin modifiers MORC and HDAC3 play critical roles in silencing sexual development-specific
Toxoplasma_gondii
Protein and coding gene in humans
non-covalently in the same region as electrophiles and act as a gating modifier toxin for the receptor, stabilizing the channel in an open conformation
TRPA1
Sex hormone
changes in their progesterone levels. Therefore, females have an increased biological vulnerability to nicotine's reinforcing effects compared to males, and
Progesterone
Protein found in humans
Ubiquitin-like modifier-activating enzyme 6 is a protein that in humans is encoded by the UBA6 gene. GRCh38: Ensembl release 89: ENSG00000033178 – Ensembl
UBE1L2
Central nervous system stimulant
methylphenidate may act as a "DAT inverse agonist" or "negative allosteric modifier of the DAT" by reversing the direction of the dopamine flux through the
Methylphenidate
Class of steroid hormones
in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein
Corticosteroid
Protein-coding gene in the species Homo sapiens
(July 1998). "Identification and mapping of human histone acetylation modifier gene homologues". Genomics. 51 (2): 262–269. doi:10.1006/geno.1998.5370
Histone_deacetylase_2
Single nucleotide polymorphism in human BDNF gene
den Buuse, M. (2015-08-01). "The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy". Molecular
Rs6265
Protein-coding gene in humans
Feinberg AP (1998). "Identification and mapping of human histone acetylation modifier gene homologues". Genomics. 51 (2): 262–9. doi:10.1006/geno.1998.5370.
PCAF
BIOLOGICAL RESPONSE-MODIFIER
BIOLOGICAL RESPONSE-MODIFIER
Boy/Male
Indian
The responsive
Boy/Male
Arabic, Hindu, Indian, Muslim, Sindhi
Rest; Response; Comfort
Girl/Female
Muslim
Rest, Repose
Boy/Male
Finnish, German
Responded; Prayed for
Boy/Male
Hindu, Indian
Biological
Boy/Male
Indian
The responsive, The answerer
Boy/Male
Muslim
The responsive
Boy/Male
Muslim
Responsive
Boy/Male
Muslim/Islamic
Rest Response
Boy/Male
Muslim/Islamic
Responsive
Boy/Male
Muslim
Rest. Repose.
Boy/Male
Arabic
Rest; Repose
Boy/Male
Biblical American Hebrew
Repose; consolation.
Boy/Male
Indian
Responsive
Boy/Male
Arabic, Muslim
Responsive
Boy/Male
Muslim
The responsive, The answerer
Boy/Male
Muslim
Responsive
Girl/Female
Indian
Rest, Repose
Boy/Male
Muslim/Islamic
Responder
Boy/Male
Indian, Sanskrit
In Attentive Response
BIOLOGICAL RESPONSE-MODIFIER
BIOLOGICAL RESPONSE-MODIFIER
Girl/Female
Indian, Sikh
Love and Fragrance
Girl/Female
Tamil
Devkanya | தேவகநà¯à®¯à®¾
Celestial maiden, Divine damsel
Boy/Male
British, English
Son in Law
Girl/Female
Arabic, Australian, Indian
Beautiful; Bright Face
Boy/Male
American, Australian, Christian, French
From the Large Town
Biblical
goat of God; the Lord my happiness
Girl/Female
Hindu
Earth
Boy/Male
Hindu
To rise, Blue lotus
Boy/Male
Latin
Fidde.
Girl/Female
Hindu, Indian
One who Loves World
BIOLOGICAL RESPONSE-MODIFIER
BIOLOGICAL RESPONSE-MODIFIER
BIOLOGICAL RESPONSE-MODIFIER
BIOLOGICAL RESPONSE-MODIFIER
BIOLOGICAL RESPONSE-MODIFIER
n.
Response.
v.
To lay at rest; to cause to be calm or quiet; to compose; to rest, -- often reflexive; as, to repose one's self on a couch.
v. i.
To show some effect in return to a force; to act in response; to accord; to correspond; to suit.
a.
Not responsive; not able, ready, or inclined to respond.
a.
Alt. of Biological
v. i.
To say somethin in return; to answer; to reply; as, to respond to a question or an argument.
a.
Relating to bryology; as, bryological studies.
a.
Ignorant or negligent of the rules of logic or correct reasoning; as, an illogical disputant; contrary of the rules of logic or sound reasoning; as, an illogical inference.
v. i.
To render satisfaction; to be answerable; as, the defendant is held to respond in damages.
a.
Neologic; neological.
a.
Circular; illogical.
n.
An answer; a response.
a.
Without echo or response.
n.
An antiphonary; a response book.
a.
Pertaining to the study of inanimate things.
imp. & p. p.
of Respond
n.
Fig.: Sympathetic recognition; response; answer.
a.
Giving no response.
a.
Of or relating to biology.
a.
That responds; ready or inclined to respond.