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Type of therapy
Because most agents for targeted therapy are biopharmaceuticals, the term biologic therapy is sometimes synonymous with targeted therapy when used in the context
Targeted_therapy
Type of radiation therapy to treat cancer
Targeted alpha-particle therapy (or TAT) is an in-development method of targeted radionuclide therapy of various cancers. It employs radioactive substances
Targeted alpha-particle therapy
Targeted_alpha-particle_therapy
Academic journal
Signal Transduction and Targeted Therapy (STTT) is a multidisciplinary, peer-reviewed, open access scientific journal covering biomedical research with
Signal Transduction and Targeted Therapy
Signal_Transduction_and_Targeted_Therapy
Overview of current and historical management methods of breast cancer
therapy (surgery and radiation therapy) and systemic treatment (chemotherapy, hormonal therapy, targeted therapy, and immunotherapy). Local therapy is
Breast_cancer_treatment
first use of nitrogen mustards and folic acid antagonist drugs. The targeted therapy revolution has arrived, but many of the principles and limitations
History of cancer chemotherapy
History_of_cancer_chemotherapy
Medical intervention
Treatments can include surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy including small-molecule drugs or monoclonal antibodies
Cancer_treatment
Skin cancer originating in melanocytes
survival over monochemotherapy. Targeted therapies result in relatively short progression-free survival (PFS) times. The therapy combination of dabrafenib and
Melanoma
Treatment of cancer using drugs that inhibit cell division or kill cells
The use of drugs (whether chemotherapy, hormonal therapy, or targeted therapy) is systemic therapy for cancer: they are introduced into the blood stream
Chemotherapy
Targeted molecular therapy for neuroblastoma involves treatment aimed at molecular targets that have a unique expression in this form of cancer. Neuroblastoma
Targeted molecular therapy for neuroblastoma
Targeted_molecular_therapy_for_neuroblastoma
Medical condition
identify actionable lesions for targeted treatment in specific subgroups of patients. Natural killer (NK) cell therapy is used in pediatrics for children
Lymphoid_leukemia
Cancerous tumor originating in the stomach lining
include some combination of surgery, chemotherapy, radiation therapy, and targeted therapy. For certain subtypes of gastric cancer, cancer immunotherapy
Stomach_cancer
Medical condition
primarily on the tumor, or small molecules that target proteins mutated in the tumor. Targeted therapies may block enzymes or other proteins necessary for
Central_nervous_system_tumor
Medical condition
include a combination of surgery, radiation therapy, chemotherapy, hormone therapy, and targeted therapy. Just over 80% of women survive more than 5 years
Uterine_cancer
Hematologic cancer that affects lymphocytes
one or more of the following: chemotherapy, radiation therapy, proton therapy, targeted therapy, and surgery. In some non-Hodgkin lymphomas, an increased
Lymphoma
Medical intervention
Targeted therapy of lung cancer refers to using agents specifically designed to selectively target molecular pathways responsible for, or that substantially
Targeted therapy of lung cancer
Targeted_therapy_of_lung_cancer
Type of spreading cancer
hormone therapies. Tumors that contain large amounts of the protein human epidermal growth factor receptor 2 (HER2) can be treated with HER2-targeted therapies
Metastatic_breast_cancer
Type of endocrine gland cancer
cancer stages, surgical strategies, and targeted therapies, such as inhibition of growth factors, immune therapies, and vaccines. Bile acids may have a role
Pancreatic_cancer
Type of blood cancer
et al. (July 2018). "Paramount therapy for young and fit patients with mantle cell lymphoma: strategies for front-line therapy". J. Exp. Clin. Cancer Res
Mantle_cell_lymphoma
Lung cancer of glandular origin or characteristics
the primary tumor. Surgical resection, chemotherapy, radiotherapy, targeted therapy and immunotherapy are used in attempt to eradicate the cancerous cells
Adenocarcinoma_of_the_lung
British peer-reviewed medical journal
Biologics: Targets and Therapy is a peer-reviewed medical journal covering research on the clinical application of biologic agents in the management of
Biologics: Targets and Therapy
Biologics:_Targets_and_Therapy
Type of cancer
Treatment may involve some combination of chemotherapy, radiation therapy, targeted therapy, and bone marrow transplant, with supportive and palliative care
Leukemia
Cancer of the myeloid line of blood cells
with gene mutations: A category of subtypes that may qualify for targeted therapies. AML not otherwise specified (NOS) Most cases of AML do not have exposure
Acute_myeloid_leukemia
Bone marrow cancer in which lymphocytes are overproduced
symptomatic disease (summarized as "active disease"). Targeted therapy attacks cancer cells at a specific target, with the aim of not harming normal cells. In
Chronic_lymphocytic_leukemia
Medical procedure
with photon or proton therapy, physicians may choose proton therapy if it is important to deliver a higher radiation dose to targeted tissues while significantly
Proton_therapy
produced at CERN-MEDICIS, samarium and terbium, are of interest for targeted therapy alike lutetium already used in the clinics. Lutetium emits low energy
CERN-MEDICIS
Group of diseases involving cell growth
with some combination of radiation therapy, surgery, chemotherapy and targeted therapy. More personalized therapies that harness a patient's immune system
Cancer
Cancer arises in the head or neck region
Treatment may include a combination of surgery, radiation therapy, chemotherapy, and targeted therapy. In the early stage head and neck cancers are often curable
Head_and_neck_cancer
Topics referred to by the same term
Geographic targeting Inflation targeting, in economics Targeted therapy, the use of molecules to selectively interfere with cancer cells Targeting (gridiron
Targeting
Cell cycle regulation pathway
"PIM kinase inhibition: co-targeted therapeutic approaches in prostate cancer". Signal Transduction and Targeted Therapy. 5 7. doi:10.1038/s41392-020-0109-y
PI3K/AKT/mTOR_pathway
Medical condition
Crizotinib is a targeted therapy (FDA approved in 2011), manufactured by Pfizer and marketed under the brand name Xalkori and Crizalk that targets the EML4/ALK
ALK_positive_lung_cancer
Pharmaceutical compound
February 2026. Retrieved 12 July 2026. "FDA Approves First in Class Targeted Therapy for Metastatic Pancreatic Cancer" (Press release). U.S. Food and Drug
Daraxonrasib
biology) by specific biomolecular targets: targeted therapy molecular chaperone therapy by chelation: chelation therapy by specific chemical elements: by
List_of_therapies
Medical condition
options may include surgery, targeted therapy and radiation therapy. In certain cases, ablation therapy, embolization therapy or liver transplantation may
Liver_cancer
Academic journal
OncoTargets and Therapy is a peer-reviewed medical journal covering research on all aspects of oncology. The journal was established in 2008 and is published
OncoTargets_and_Therapy
Type of therapy to improve mental health
Cognitive behavioral therapy (CBT) is a form of psychotherapy that combines basic principles from cognitive psychology and behaviorism. It aims to reduce
Cognitive_behavioral_therapy
Type of radiotherapy
Peptide receptor radionuclide therapy (PRRT) is a type of radionuclide therapy, using a radiopharmaceutical that targets peptide receptors to deliver localised
Peptide receptor radionuclide therapy
Peptide_receptor_radionuclide_therapy
Type of radiation therapy
This is a type of targeted therapy which uses the physical, chemical and biological properties of the radiopharmaceutical to target areas of the body
Radionuclide_therapy
Form of phototherapy
Photodynamic therapy (PDT) is a form of phototherapy involving light and a photosensitizing chemical substance used in conjunction with molecular oxygen
Photodynamic_therapy
Malignancy originating in the thyroid gland
may include surgery, radiation therapy including radioactive iodine, chemotherapy, thyroid hormone, targeted therapy, and watchful waiting. Surgery may
Thyroid_cancer
Form of kidney cancer
nodes, lungs, liver, adrenal glands, brain or bones. Immunotherapy and targeted therapy have improved the outlook for metastatic RCC. RCC is also associated
Renal_cell_carcinoma
Cancer of plasma cells
about with steroids, chemotherapy, targeted therapy, and stem cell transplant. Bisphosphonates and radiation therapy are sometimes used to reduce pain
Multiple_myeloma
Cancer that originates in mammary glands
treatments may be used, including surgery, radiation therapy, chemotherapy, hormonal therapy, and targeted therapy. Types of surgery vary from breast-conserving
Breast_cancer
Medical condition
it is most often paired with immunotherapy treatments. A type of targeted therapy that recognizes specific proteins in leukemia cells preventing collateral
B-cell prolymphocytic leukemia
B-cell_prolymphocytic_leukemia
Cancer of the colon or rectum
cancer may include some combination of surgery, radiation therapy, chemotherapy, and targeted therapy. Cancers that are confined within the wall of the colon
Colorectal_cancer
Interdisciplinary medical research field
different methods of treatment of cancer, especially chemotherapy and targeted therapy. Since 2018 the European Society of Cardiology has had a council of
Cardiooncology
Type of breast cancer lacking certain gene expressions
area, treatment is limited to chemotherapy and in some cases further targeted therapy. Triple-negative breast cancers have a relapse pattern that is very
Triple-negative_breast_cancer
Form of treatment for genetic disorders and other illnesses
Antisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA
Antisense_therapy
British organic chemist
known for first synthesizing Tamoxifen (ICI-46,474), a groundbreaking targeted therapy for hormone-sensitive breast cancer, in England in 1962. Her research
Dora_Richardson
Uterine cancer that is located in tissues lining the uterus
salpingo-oophorectomy. In more advanced cases, radiation therapy, chemotherapy or hormone therapy may also be recommended. If the disease is diagnosed at
Endometrial_cancer
British oncologist (1951–2019)
particular interest in personalised medicine and bringing new therapies, such as targeted therapy and cancer immunotherapy, into the clinic. He received a
Martin_Gore_(oncologist)
Medical condition
recommended for PRCC treatment, often accompanied with several targeted molecular therapies to inhibit metastatic spread. PRCC patients are predominantly
Papillary renal cell carcinoma
Papillary_renal_cell_carcinoma
Type of cancer of lymph nodes
areas. Treatments may include chemotherapy, radiation, immunotherapy, targeted therapy, stem-cell transplantation, surgery, or watchful waiting. If the blood
Non-Hodgkin_lymphoma
American doctor and researcher
and his research has sought to assess the effectivity of hormone-targeted therapy in treating prostate cancer, the importance of social systems like
Paul_L._Nguyen
Biologics: Targets and Therapy Biosimilars† Blood and Lymphatic Cancer: Targets and Therapy Botanics: Targets and Therapy† Breast Cancer: Targets and Therapy Cancer
List of Dove Medical Press academic journals
List_of_Dove_Medical_Press_academic_journals
Peer-reviewed scientific journal
molecular oncology, cancer genetics, epigenetics, signal transduction, and targeted therapy. The journal is indexed in PubMed, and Scopus. The journal has a 2021
Molecular_Cancer
Potential cancer treatment
what kills the targeted cells. Unlike photodynamic therapy, photothermal therapy does not require oxygen to interact with the target cells or tissues
Photothermal_therapy
Cancer that starts in the kidneys
biopsy. Treatment may include surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy. Kidney cancer newly affected about 403,300 people
Kidney_cancer
Therapy using ionizing radiation, usually to treat cancer
radiopharmaceutical therapy, molecular radiotherapy, or targeted radionuclide therapy), is a form of targeted therapy. Targeting can be due to the chemical properties of
Radiation_therapy
Protein-coding gene in humans
S2CID 73414179. "FDA Approves First Targeted Therapy for Lung Cancer Mutation Previously Considered Resistant to Drug Therapy". U.S. Food and Drug Administration
KRAS
Academic journal
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy is a peer-reviewed medical journal covering research on diabetes, metabolic syndromes, and
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Diabetes,_Metabolic_Syndrome_and_Obesity:_Targets_and_Therapy
Hormone therapy for cancer
(pharmacotherapy for cancer), others being cytotoxic chemotherapy and targeted therapy (biotherapeutics). It involves the manipulation of the endocrine system
Hormonal_therapy_(oncology)
Blood cancer characterized by overproduction of lymphoblasts
steroids, radiation therapy, intensive combined treatments (including bone marrow or stem cell transplants), targeted therapy, and/or growth factors
Acute_lymphoblastic_leukemia
Drugs that are useful against cancer
includes several noncytotoxic classes of therapy, such as hormonal therapy and targeted therapy (biologic therapy). Those agents are described in the relevant
List of chemotherapeutic agents
List_of_chemotherapeutic_agents
Branch of medicine dealing with, or specializing in, cancer
with both systemic therapies and radiation. Medical oncology: focuses on the treatment of cancer with chemotherapy, targeted therapy, immunotherapy, and
Oncology
Combination of cancer diagnosis and treatment
used for diagnostic imaging and targeted therapy. These substances may include ligands of receptors present on the target tissue or compounds, like iodine
Theranostics
Biotechnology company based in Rockville, Maryland, US
analogs for human infertility and animal superovulation, as well as targeted therapy and imaging of thyroid, ovarian, breast, prostate and testicular cancers
Trophogen
Sonodynamic therapy (SDT) is a noninvasive treatment, often used for tumor irradiation, that utilizes a sonosensitizer and the deep penetration of ultrasound
Sonodynamic_therapy
Cancer Center in Houston, Texas. He is known for his research on targeted therapies, mechanisms of therapeutic resistance, angiogenesis, and biomarker
John_V._Heymach
Medical condition
chemotherapy, stem cell transplant, radiation therapy and targeted therapy. Immunotherapy is another type of therapy that is currently in clinical trials. Chemotherapy
Childhood_leukemia
Chemical compound
fatigue, and musculoskeletal pain. Sotorasib is the first approved targeted therapy for people with tumors with any KRAS mutation, which accounts for approximately
Sotorasib
Medical intervention
AK (July 2009). "EGFR targeted therapy in non-small cell lung cancer: potential role of cetuximab". Biologics: Targets and Therapy. 3: 215–224. doi:10.2147/btt
Treatment_of_lung_cancer
American oncologist and cancer researcher
Toxicities for Metastatic RCC Hedefi 12'den vuruyor Yeni umut Kanserajan Targeted therapy for the treatment of advanced renal cell carcinoma Immunotherapy Combinations
Thomas_Hutson
American physician-scientist (born 1949)
preclinical discoveries that led to the development of Gleevec, the first targeted therapy for chronic myelogenous leukemia. Witte also co-discovered the gene
Owen_Witte
Most common type of skin cancer
the rare cases in which distant spread has occurred, chemotherapy or targeted therapy may be used. Basal-cell cancer accounts for at least 32% of all cancers
Basal-cell_carcinoma
Radiopharmaceutical
allow 99mTc-DMTHF to target FR-α reliably. Although no studies to date have explored using a DMTHF-drug conjugate for targeted therapy of cancer, it could
DMTHF-Tc
Action to achieve a result in the delivery of healthcare
Cytoluminescent therapy Insulin potentiation therapy Low-dose chemotherapy Monoclonal antibody therapy Photodynamic therapy Radiation therapy Targeted therapy Tracheal
Medical_procedure
Alternative or complementary type of therapy
hormone levels. The specific animal-assisted therapy can be classified by the type of animal, the targeted population, and how the animal is incorporated
Animal-assisted_therapy
Tumors of the endocrine and nervous systems
of 70% compared to 10% in strongly positive SRSS carcinoid tumors. Targeted therapy with everolimus (Afinitor) and sunitinib (Sutent) is approved by the
Neuroendocrine_tumor
Radiopharmaceutical precursor
as PSMA-617) is a radiopharmaceutical precursor molecule used in targeted therapies for prostate cancer and other tumors expressing prostate-specific
Vipivotide_tetraxetan
American actress (born 1972)
mastectomy, chemotherapy, and radiation. As of May 2025, she was receiving targeted therapy. Aradillas, Elaine (March 8, 2010). "'I'm in the Best Shape of My Life'"
Nicole_Eggert
Drug delivery method
protein expression in the targeted cells Personalized medicine Solid lipid nanoparticle Targeted drug delivery Targeted therapy Cheng, Qiang; Wei, Tuo;
Selective_organ_targeting
Cancer originating in smooth muscle
combination/gemcitabine and docetaxel/trabectedin; pazopanib is the targeted therapy used in metastatic leiomyosarcoma as second line and is well tolerated
Leiomyosarcoma
with other therapies including hormonal therapy, targeted therapy and vaccines. Although there have been many cases that metronomic therapy did not create
Metronomic_therapy
Interdisciplinary medical specialty
molecular scale. Also the development and application of molecularly targeted therapies. Molecular oncology has identified genes that are involved in the
Molecular_oncology
Type of cancer
Treatment often includes chemotherapy, radiation therapy, surgery, and stem cell transplant. Targeted therapy and immunotherapy are being studied. Five-year
Ewing_sarcoma
Chemical compound
Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of chronic myelogenous leukemia
Dasatinib
American medical oncologist
immunogenomic mechanisms contributing to response and resistance to targeted therapy and immunotherapy, as well as HIF-2α biology, rare kidney tumor subtypes
Toni_Choueiri
VeriStrat Status on Outcome of a Randomized Phase II Trial of First-Line Therapy with Gemcitabine, Erlotinib, or the Combination in Elderly Patients (Age
Veristrat
Immunotherapy using T cells
therapy. Although immunotherapy with immune checkpoint blockade and targeted therapy was used to treat and improve the survival of patients with several
Cellular adoptive immunotherapy
Cellular_adoptive_immunotherapy
Medical classification of asthma
predicting which patients will benefit from inhaled corticosteroids or targeted therapy using specific biologics, while phenotyping can help predict disease
Asthma phenotyping and endotyping
Asthma_phenotyping_and_endotyping
Drug class
"PIM kinase inhibition: co-targeted therapeutic approaches in prostate cancer". Signal Transduction and Targeted Therapy. 5 7. doi:10.1038/s41392-020-0109-y
MEK_inhibitor
Cancer of the lining of the lips, mouth, or upper throat
remove the tumor and regional lymph nodes), radiation therapy, chemotherapy, or targeted therapy. The types of treatments will depend on the size, locations
Oral_cancer
Pharmaceutical compound
advanced solid tumors with KRAS G12C mutation". Signal Transduction and Targeted Therapy. 10 (1) 189. doi:10.1038/s41392-025-02274-z. PMC 12170901. PMID 40523897
Garsorasib
Medical condition
cyclophosphamide), are still utilized as first-line therapy for those with advanced lesions. Targeted therapy: Given the poor response to chemotherapy, it is
Salivary_gland_tumour
Disease causing insufficient blood cells of all types
cyclophosphamide may also be effective but is more toxic than ATG. Antibody therapy such as ATG targets T cells, which are believed to attack the bone marrow. Corticosteroids
Aplastic_anemia
Use of epigenome-influencing techniques to treat medical conditions
ongoing research. Epigenetic therapies are reversible, unlike gene therapy. This means that they are druggable for targeted therapies. Epigenetic alterations
Epigenetic_therapy
Oncologist
PMC 2978644. PMID 20019577. Samlowski WE, Becker J. The Potential for Targeted Therapy of Merkel Cell Carcinoma. In Merkel Cell Carcinoma: A Multidisciplinary
Wolfram_Samlowski
Investigational radiopharmaceutical compound
(177Lu) with the targeting compound NNS309. Lutetium-177 has been widely discussed as a radioisotope of choice for targeted radionuclide therapy, featuring
177_Lu-NNS309
Method of gene modification
2021). "Viral vector platforms within the gene therapy landscape". Signal Transduction and Targeted Therapy. 6 (1): 53. doi:10.1038/s41392-021-00487-6. ISSN 2059-3635
Lentiviral vector in gene therapy
Lentiviral_vector_in_gene_therapy
Medical condition
Mateo-Lozano, Silvia; García del Muro, Xavier; Tirado, Oscar M. (2012). "Targeted Therapies in Sarcomas: Challenging the Challenge". Sarcoma. 2012: 1–13. doi:10
Epithelioid_sarcoma
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