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CD40

  • CD40
  • Mammalian protein found in humans

    Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding

    CD40

    CD40

    CD40

  • CD154
  • Protein found in humans

    CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules

    CD154

    CD154

    CD154

  • Act 1 adaptor protein
  • Type of protein

    signaling pathway. Moreover, this protein is only used in cells expressing CD40 and CD40L, which are also from the tumor necrosis receptor superfamily and

    Act 1 adaptor protein

    Act_1_adaptor_protein

  • Hyper IgM syndrome
  • Primary immune deficiency disorders

    recombination (Ig-CSR) deficiencies. The most common causes are mutations in the CD40 Ligand (CD40LG) gene located at Xq26.3-27 leading to X-linked HIGM (XHIGM)

    Hyper IgM syndrome

    Hyper IgM syndrome

    Hyper_IgM_syndrome

  • Frexalimab
  • Monoclonal antibody

    Frexalimab (SAR441344) is a second-generation monoclonal antibody that inhibits CD40 ligand. It is in development by Sanofi for the treatment of relapsing multiple

    Frexalimab

    Frexalimab

  • Macrophage
  • Type of white blood cell

    immunohistochemical staining by their specific expression of proteins such as CD14, CD40, CD11b, CD64, F4/80 (mice)/EMR1 (human), lysozyme M, MAC-1/MAC-3 and CD68

    Macrophage

    Macrophage

    Macrophage

  • B cell
  • Type of white blood cell

    co-stimulatory factor for B cell activation by binding the B cell surface receptor CD40, which promotes B cell proliferation, immunoglobulin class switching, and

    B cell

    B cell

    B_cell

  • Germinal center
  • Lymphatic tissue structure

    interaction between B and T cells in the interfollicular area of the lymph node, CD40-CD40L ligation, NF-kB signaling and expression of IRF4 and BCL6. GC B cells

    Germinal center

    Germinal center

    Germinal_center

  • Tegoprubart
  • Experimental drug

    conference demonstrated that tegoprubart, a monoclonal antibody inhibiting the CD40 ligand, enabled 100% insulin independence in ten evaluable patients following

    Tegoprubart

    Tegoprubart

  • T helper cell
  • Type of immune cell

    aid those cells through a combination of cell to cell interactions (e.g. CD40 (protein) and CD40L) and through cytokines.[citation needed] Th cells are

    T helper cell

    T helper cell

    T_helper_cell

  • Dacetuzumab
  • Monoclonal antibody

    is a humanized monoclonal antibody being developed for the treatment of CD40-positive cancers like non-Hodgkin's lymphoma and hematological malignancies

    Dacetuzumab

    Dacetuzumab

  • Teneliximab
  • Monoclonal antibody

    a chimeric monoclonal antibody binding to the immune stimulatory protein CD40. As of 2009[update], it has not entered clinical trials. International Nonproprietary

    Teneliximab

    Teneliximab

  • Antigen-presenting cell
  • Cell that displays antigen bound by MHC proteins on its surface

    several co-stimulatory molecules required for T cell activation, including CD40 and B7. The latter can interact with CD28 on the surface of a CD4+ T cell

    Antigen-presenting cell

    Antigen-presenting cell

    Antigen-presenting_cell

  • Lucatumumab
  • Monoclonal antibody

    Lucatumumab (CHIR 12.12 or HCD122) is a human monoclonal antibody against CD40 development of which was discontinued by Novartis in 2013 after it was investigated

    Lucatumumab

    Lucatumumab

  • Hypergammaglobulinemia
  • Excess amounts of gamma globulin in the blood

    which codes for CD40 ligand. This gene is located on the long arm of the X chromosome at position 26, denoted Xq26. Normally, CD40 ligand is expressed

    Hypergammaglobulinemia

    Hypergammaglobulinemia

  • TTRAP
  • Protein-coding gene in the species Homo sapiens

    and CD40. This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor

    TTRAP

    TTRAP

  • Cytotoxic T cell
  • T cell that kills infected, damaged or cancerous cells

    cells proceeds by signaling between CD154/CD40L on the T helper cell and the CD40 receptor on the antigen-presenting cell during immunological synapse formation

    Cytotoxic T cell

    Cytotoxic T cell

    Cytotoxic_T_cell

  • Immunotherapy
  • Activation or suppression of the immune system to treat disease

    agonistic antibodies (e.g., anti-CD40) that are conjugated with antigen of interest. Multiple, next-generation anti-CD40 platforms are being actively developed

    Immunotherapy

    Immunotherapy

  • Dendritic cell
  • Accessory cell of the mammalian immune system

    co-receptors in T-cell activation such as CD80 (B7.1), CD86 (B7.2), and CD40 greatly enhancing their ability to activate T-cells. They also upregulate

    Dendritic cell

    Dendritic cell

    Dendritic_cell

  • Memory B cell
  • Cell of the adaptive immune system

    T-cell zone will bind to the MHCII ligand. The T cells will then express the CD40 ligand (CD40L) molecule and will begin to secrete cytokines which cause the

    Memory B cell

    Memory B cell

    Memory_B_cell

  • Reactive arthritis
  • Inflammatory arthritis triggered by infection elsewhere in the body

    Lanier, L.L. (February 1995). "T-cell costimulation via CD28-CD80/CD86 and CD40-CD40 ligand interactions". Research in Immunology. 146 (3): 171–176. doi:10

    Reactive arthritis

    Reactive arthritis

    Reactive_arthritis

  • Sertoli cell
  • Cells found in human testes which help produce sperm

    T-cells on the periphery. CD40, a molecule associated with dendritic cells (DCs). SCs are able to down regulate the expression of CD40 on the surface of DCs

    Sertoli cell

    Sertoli cell

    Sertoli_cell

  • Langhans giant cell
  • Cell type

    activated CD4+ T cells and monocytes are in close contact, interaction of CD40-CD40L between these two cells and subsequent IFNγ secretion by the T cells

    Langhans giant cell

    Langhans giant cell

    Langhans_giant_cell

  • Toralizumab
  • Monoclonal antibody

    Monoclonal antibody Type Whole antibody Source Humanized (from mouse) Target CD40 ligand Clinical data ATC code none Identifiers CAS Number 252662-47-8 N ChemSpider

    Toralizumab

    Toralizumab

  • Rheumatoid arthritis
  • Type of autoimmune arthritis

    include genes affecting co-stimulatory immune pathways—for example CD28 and CD40, cytokine signaling, lymphocyte receptor activation threshold (e.g., PTPN22)

    Rheumatoid arthritis

    Rheumatoid arthritis

    Rheumatoid_arthritis

  • TRAF3
  • Protein-coding gene in the species Homo sapiens

    (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response

    TRAF3

    TRAF3

    TRAF3

  • Christina Annunziata
  • American medical oncologist

    and residency training in internal medicine. Her dissertation was titled CD40 signaling Hodgkin's disease. She came to the National Cancer Institute (NCI)

    Christina Annunziata

    Christina Annunziata

    Christina_Annunziata

  • CD37
  • Mammalian protein found in humans

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    CD37

    CD37

    CD37

  • Cytokine
  • Category of small signaling proteins

    extracellular binding domain, and includes several other non-cytokine ligands like CD40, CD27 and CD30, besides the ligands on which the family is named. Seven transmembrane

    Cytokine

    Cytokine

    Cytokine

  • Follicular B helper T cells
  • Type of immune cell involved in germinal center formation and maintenance

    formation and maintenance of germinal centers through the expression of CD40 ligand (CD40L) and the secretion of IL-21 and IL-4. TFH cells also migrate

    Follicular B helper T cells

    Follicular B helper T cells

    Follicular_B_helper_T_cells

  • Seth Lederman
  • American pharmacologist (born 1957)

    Presbyterian Hospital). As assistant professor at Columbia, Lederman discovered the CD40-Ligand (CD154) and elucidated the molecular basis of T cell helper function

    Seth Lederman

    Seth Lederman

    Seth_Lederman

  • Trap
  • Topics referred to by the same term

    receptor-associated proteins TNF-related activation protein, also known as CD40 ligand Tripartite ATP-independent periplasmic transporter, in prokaryotes

    Trap

    Trap

  • AKNA
  • Protein-coding gene in the species Homo sapiens

    different isoforms. AKNA is known to upregulate expression of the receptor CD40 and its ligand CD40L/CD154. AKNA is an essential part in the construction

    AKNA

    AKNA

    AKNA

  • List of minor planets: 483001–484000
  • 2000 CX39 — January 11, 2000 Socorro LINEAR  · 1.4 km MPC · JPL 483421 2000 CD40 — February 3, 2000 Socorro LINEAR  · 2.1 km MPC · JPL 483422 2000 CE59 —

    List of minor planets: 483001–484000

    List_of_minor_planets:_483001–484000

  • Centroblast
  • Enlarged B cell in the germinal center of lymphoid follicles

    centroblast development. Interaction between CD40 ligand on an activated helper T cell and the B cell CD40 receptor induces centroblasts to express activation-induced

    Centroblast

    Centroblast

    Centroblast

  • IL2RA
  • Mammalian protein found in Homo sapiens

    TNF receptor 1-10 TNFR1 (TNFRSF1A) TNFR2 (TNFRSF1B) LTBR (TNFRSF3) TNFRSF4 CD40 (TNFRSF5) Fas receptor (TNFRSF6) DcR3 (TNFRSF6B) CD27 (TNFRSF7) CD30 (TNFRSF8)

    IL2RA

    IL2RA

    IL2RA

  • Mannose receptor
  • Protein family

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    Mannose receptor

    Mannose_receptor

  • CD79
  • Protein family

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    CD79

    CD79

  • CAR T cell
  • Genetically engineered T cell

    including the use of nonconventional costimulatory molecules like MyD88/CD40, highlight the innovative approaches being taken to optimize CAR T-cell therapies

    CAR T cell

    CAR_T_cell

  • California's 40th congressional district
  • U.S. House district for California

    Election Returns: District Definitions California Voter Foundation map – CD40 33°53′41″N 117°55′23″W / 33.894642°N 117.922955°W / 33.894642; -117.922955

    California's 40th congressional district

    California's_40th_congressional_district

  • Immunoglobulin class switching
  • Biological mechanism

    these activated B cells encounter specific signaling molecules via their CD40 and cytokine receptors (both modulated by T helper cells), they undergo antibody

    Immunoglobulin class switching

    Immunoglobulin class switching

    Immunoglobulin_class_switching

  • IL2RB
  • Protein-coding gene in the species Homo sapiens

    TNF receptor 1-10 TNFR1 (TNFRSF1A) TNFR2 (TNFRSF1B) LTBR (TNFRSF3) TNFRSF4 CD40 (TNFRSF5) Fas receptor (TNFRSF6) DcR3 (TNFRSF6B) CD27 (TNFRSF7) CD30 (TNFRSF8)

    IL2RB

    IL2RB

    IL2RB

  • CD163
  • Protein found in humans

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    CD163

    CD163

    CD163

  • IFITM1
  • Protein-coding gene in the species Homo sapiens

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    IFITM1

    IFITM1

    IFITM1

  • Baculoviral IAP repeat-containing protein 2
  • Protein-coding gene in the species Homo sapiens

    Zoog SJ, Dang TT, Kehry MR, Crute JJ (2001). "Molecular characterization of CD40 signaling intermediates". The Journal of Biological Chemistry. 276 (46):

    Baculoviral IAP repeat-containing protein 2

    Baculoviral IAP repeat-containing protein 2

    Baculoviral_IAP_repeat-containing_protein_2

  • Adenoviridae
  • Family of viruses

    (November 2009). "A genetically engineered adenovirus vector targeted to CD40 mediates transduction of canine dendritic cells and promotes antigen-specific

    Adenoviridae

    Adenoviridae

    Adenoviridae

  • T-cell surface glycoprotein CD3 zeta chain
  • Protein-coding gene in the species Homo sapiens

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    T-cell surface glycoprotein CD3 zeta chain

    T-cell surface glycoprotein CD3 zeta chain

    T-cell_surface_glycoprotein_CD3_zeta_chain

  • Integrin alpha 2b
  • Mammalian protein found in Homo sapiens

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    Integrin alpha 2b

    Integrin alpha 2b

    Integrin_alpha_2b

  • Immune checkpoint
  • Regulators of the immune system

    are members of the tumor necrosis factor (TNF) receptor superfamily—CD27, CD40, OX40, GITR and CD137. Another two stimulatory checkpoint molecules belong

    Immune checkpoint

    Immune checkpoint

    Immune_checkpoint

  • Glycoprotein IX
  • Protein-coding gene in the species Homo sapiens

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    Glycoprotein IX

    Glycoprotein IX

    Glycoprotein_IX

  • VPREB1
  • Protein-coding gene in the species Homo sapiens

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    VPREB1

    VPREB1

    VPREB1

  • Integrin beta 3
  • Mammalian protein found in Homo sapiens

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    Integrin beta 3

    Integrin beta 3

    Integrin_beta_3

  • ALCAM
  • Protein-coding gene in the species Homo sapiens

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    ALCAM

    ALCAM

    ALCAM

  • CD52
  • Protein-coding gene found in humans

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    CD52

    CD52

    CD52

  • Signal-regulatory protein alpha
  • Protein-coding gene in the species Homo sapiens

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    Signal-regulatory protein alpha

    Signal-regulatory protein alpha

    Signal-regulatory_protein_alpha

  • Glycoprotein 130
  • Mammalian protein found in Homo sapiens

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    Glycoprotein 130

    Glycoprotein 130

    Glycoprotein_130

  • List of minor planets: 761001–762000
  • 2010 Mount Lemmon Mount Lemmon Survey EOS 1.5 km MPC · JPL 761582 2010 CD40 — February 13, 2010 Mount Lemmon Mount Lemmon Survey  · 2.2 km MPC · JPL

    List of minor planets: 761001–762000

    List_of_minor_planets:_761001–762000

  • IL3RA
  • Human gene

    TNF receptor 1-10 TNFR1 (TNFRSF1A) TNFR2 (TNFRSF1B) LTBR (TNFRSF3) TNFRSF4 CD40 (TNFRSF5) Fas receptor (TNFRSF6) DcR3 (TNFRSF6B) CD27 (TNFRSF7) CD30 (TNFRSF8)

    IL3RA

    IL3RA

    IL3RA

  • CD82 (gene)
  • Mammalian protein found in humans

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    CD82 (gene)

    CD82 (gene)

    CD82_(gene)

  • Decoy receptor 2
  • Protein-coding gene in the species Homo sapiens

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    Decoy receptor 2

    Decoy receptor 2

    Decoy_receptor_2

  • Waldenström macroglobulinemia
  • Type of blood cancer

    overexpressed. The following signalling pathways have been implicated: CD154/CD40 Akt ubiquitination, p53 activation, and cytochrome c release NF-κB Wnt/beta-catenin

    Waldenström macroglobulinemia

    Waldenström_macroglobulinemia

  • List of minor planets: 580001–581000
  • — October 20, 2003 Kitt Peak Spacewatch  · 3.1 km MPC · JPL 580594 2015 CD40 — November 3, 2004 Kitt Peak Spacewatch GEF 1.5 km MPC · JPL 580595 2015

    List of minor planets: 580001–581000

    List_of_minor_planets:_580001–581000

  • List of therapeutic monoclonal antibodies
  • Bivatuzumab mab humanized CD44 v6 squamous cell carcinoma Bleselumab mab human CD40 organ transplant rejection Blinatumomab Blincyto BiTE mouse CD19 Y pre-B

    List of therapeutic monoclonal antibodies

    List of therapeutic monoclonal antibodies

    List_of_therapeutic_monoclonal_antibodies

  • CD80
  • Mammalian protein found in humans

    interleukin 2 (IL-2) as well as ɑ-chain of CD25 (which is a receptor of IL-2), CD40 ligand, tumor necrosis factor-α (TNFα), TNF-β, and interferon-γ (IFN-γ).

    CD80

    CD80

    CD80

  • Dipeptidyl peptidase-4
  • Mammalian protein found in humans

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    Dipeptidyl peptidase-4

    Dipeptidyl peptidase-4

    Dipeptidyl_peptidase-4

  • LILRB2
  • Protein-coding gene in the species Homo sapiens

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    LILRB2

    LILRB2

    LILRB2

  • PDCD1LG2
  • Protein-coding gene in the species Homo sapiens

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    PDCD1LG2

    PDCD1LG2

    PDCD1LG2

  • Bhaskar Saha
  • Indian cell biologist (born 1964)

    he is involved in five projects viz. Leishmania-macrophage interaction, CD40 signaling, DC subset mediated priming against prostate cancer, Development

    Bhaskar Saha

    Bhaskar_Saha

  • CD48
  • Protein-coding gene in humans

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    CD48

    CD48

    CD48

  • Hypogammaglobulinemia
  • Human disease

    treatment for many combined primary immunodeficiencies including SCID, CD40 deficiency, CD40 ligand deficiency, and Wiskott-Aldrich syndrome, but has been extended

    Hypogammaglobulinemia

    Hypogammaglobulinemia

  • CD1A
  • Protein-coding gene in humans

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    CD1A

    CD1A

    CD1A

  • Integrin beta 4
  • Protein-coding gene in the species Homo sapiens

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    Integrin beta 4

    Integrin beta 4

    Integrin_beta_4

  • Enadenotucirev
  • Species of oncocytic human adenovirus

    contains two transgenes expressing the heavy and light chains for a secreted CD40 agonist monoclonal antibody. NG-641: This vector contains four transgenes

    Enadenotucirev

    Enadenotucirev

  • Interleukin-31 receptor
  • Protein in humans

    TNF receptor 1-10 TNFR1 (TNFRSF1A) TNFR2 (TNFRSF1B) LTBR (TNFRSF3) TNFRSF4 CD40 (TNFRSF5) Fas receptor (TNFRSF6) DcR3 (TNFRSF6B) CD27 (TNFRSF7) CD30 (TNFRSF8)

    Interleukin-31 receptor

    Interleukin-31_receptor

  • Melanocyte
  • Melanin-producing cells of the skin

    Importantly, melanocytes stimulated by cytokines express surface proteins such as CD40 and ICAM1 in addition to MHC class II, allowing for co-stimulation of T cells

    Melanocyte

    Melanocyte

    Melanocyte

  • LILRB3
  • Protein-coding gene in the species Homo sapiens

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    LILRB3

    LILRB3

    LILRB3

  • Immune system
  • Biological system protecting an organism against disease

    an upregulation of molecules expressed on the T cell's surface, such as CD40 ligand (also called CD154), which provide extra stimulatory signals typically

    Immune system

    Immune system

    Immune_system

  • Kinase insert domain receptor
  • Protein-coding gene in the species Homo sapiens

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    Kinase insert domain receptor

    Kinase insert domain receptor

    Kinase_insert_domain_receptor

  • MAPK/ERK pathway
  • Cell signaling pathway

    aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival". Blood. 102 (3):

    MAPK/ERK pathway

    MAPK/ERK_pathway

  • B7 (protein)
  • Integral membrane protein

    to continue the immune response can come from B7-CD28 and CD40–CD40L interactions. When CD40 on the APC binds CD40L(CD154) on the T cell, signals are sent

    B7 (protein)

    B7_(protein)

  • HLA-DMA
  • Protein-coding gene in the species Homo sapiens

    cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)". J. Immunol. 155 (2): 917–24. doi:10.4049/jimmunol

    HLA-DMA

    HLA-DMA

    HLA-DMA

  • NF-κB
  • Family of transcription factor protein complexes

    Wilson CA, Lee SJ, Zhao X, Benveniste EN (November 2005). "LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages

    NF-κB

    NF-κB

    NF-κB

  • APC Activator
  • Type of immunotherapy

    antigen-specific immune responses. Professional APCs express MHC class II and CD40 molecules as surface receptors, and can be activated through direct interactions

    APC Activator

    APC_Activator

  • Co-stimulation
  • Signal to activate immune cells

    TNF receptor super-family (TNFRSF) (such as 41-BB, OX40, CD27, GITR, HVEM, CD40, BAFFR, BAFF and others). Additionally, some co-stimulatory molecules belong

    Co-stimulation

    Co-stimulation

  • Fucosyltransferase 3
  • Protein and coding gene in humans

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    Fucosyltransferase 3

    Fucosyltransferase 3

    Fucosyltransferase_3

  • Sjögren's disease
  • Autoimmune disease

    Ohlsson M, Szodoray P, Loro LL, Johannessen AC, Jonsson R (December 2002). "CD40, CD154, Bax and Bcl-2 expression in Sjögren's syndrome salivary glands: a

    Sjögren's disease

    Sjögren's disease

    Sjögren's_disease

  • RANKL
  • Mammalian protein found in Homo sapiens

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    RANKL

    RANKL

    RANKL

  • Kell antigen system
  • Human blood group classification

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    Kell antigen system

    Kell_antigen_system

  • Hyper-IgM syndrome type 2
  • Primary immune deficiency disorder

    group of primary immune deficiency disorders characterized by defective CD40 signaling; via B cells affecting class switch recombination (CSR) and somatic

    Hyper-IgM syndrome type 2

    Hyper-IgM syndrome type 2

    Hyper-IgM_syndrome_type_2

  • Anaplastic lymphoma kinase
  • Protein found in humans

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    Anaplastic lymphoma kinase

    Anaplastic lymphoma kinase

    Anaplastic_lymphoma_kinase

  • List of minor planets: 755001–756000
  • February 2, 2017 Haleakala Pan-STARRS 1  · 1.5 km MPC · JPL 755359 2017 CD40 — February 1, 2017 Mount Lemmon Mount Lemmon Survey  · 1.6 km MPC · JPL 755360

    List of minor planets: 755001–756000

    List_of_minor_planets:_755001–756000

  • Kevin Slawin
  • American physician (born 1961)

    "BPSA". Slawin is a co-inventor with David Spencer, PhD, of inducible CD40 (iCD40), a re-engineered dendritic cell receptor protein which allows for the

    Kevin Slawin

    Kevin_Slawin

  • ADAMDEC1
  • Protein

    "Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells". The Journal of Experimental Medicine

    ADAMDEC1

    ADAMDEC1

  • Lymphatic system
  • Organ system in vertebrates complementary to the circulatory system

    Olsson Bontell, T; Smits, A; Essand, M; Dimberg, A (5 July 2021). "Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint

    Lymphatic system

    Lymphatic system

    Lymphatic_system

  • Esther Lutgens
  • Dutch physician, molecular biologist and professor

    particular, the signalling axis between the protein CD40 and its ligand, CD40L. Lutgens identified that the CD40 ligand was expressed in atherosclerotic plaque

    Esther Lutgens

    Esther_Lutgens

  • Melanoma
  • Skin cancer originating in melanocytes

    antibodies (ipilimumab and tremelimumab), toll-like receptor (TLR) agonists, CD40 agonists, anti-PD-1 (pembrolizumab, pidilizumab, and nivolumab) and PD-L1

    Melanoma

    Melanoma

    Melanoma

  • CD20
  • Mammalian protein found in humans

    physically coupled to major histocompatibility complex class II (MHCII), CD40 and B-cell receptor (BCR). The biological function of CD20 as well as its

    CD20

    CD20

    CD20

  • Major prion protein
  • Protein involved in multiple prion diseases

    CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100

    Major prion protein

    Major prion protein

    Major_prion_protein

  • Immune disorder
  • Medical condition

    syndrome: X-linked disorder that causes a deficiency in the production of CD40 ligand on activated T cells. This increases the production and release of

    Immune disorder

    Immune_disorder

  • Kawasaki disease
  • Disease found in young children

    with Asian and non-Asian backgrounds. SNPs in FCGR2A, CASP3, BLK, ITPKC, CD40 and ORAI1 have all been linked to susceptibility, prognosis, and risk of

    Kawasaki disease

    Kawasaki disease

    Kawasaki_disease

AI & ChatGPT searchs for online references containing CD40

CD40

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CD40

AI search queries for Facebook and twitter posts, hashtags with CD40

CD40

Follow users with usernames @CD40 or posting hashtags containing #CD40

CD40

Online names & meanings

  • Shinoj
  • Boy/Male

    Hindu

    Shinoj

  • Qeehael
  • Boy/Male

    Arabic

    Qeehael

    The Biblical Cain is the English Language Equivalent

  • Lochni
  • Girl/Female

    Indian

    Lochni

    Eye

  • Sulochna
  • Boy/Male

    Hindu, Indian

    Sulochna

    Beautiful Eyes

  • Baalah
  • Girl/Female

    Biblical

    Baalah

    Her idol; she that is governed or subdued; a spouse.

  • Pradanya
  • Girl/Female

    Hindu

    Pradanya

  • Gail
  • Boy/Male

    English American

    Gail

    Lively.

  • Joses
  • Biblical

    Joses

    same as Jose,exalted

  • Capper
  • Surname or Lastname

    English

    Capper

    English : from an agent derivative of Middle English cappe ‘cap’, ‘headgear’, hence an occupational name for a maker of caps and hats.Dutch : variant of Capers.

  • Yatri
  • Girl/Female

    Hindu

    Yatri

    Traveler

AI search & ChatGPT queries for Facebook and twitter users, user names, hashtags with CD40

CD40

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CD40

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Other words and meanings similar to

CD40

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CD40