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Mammalian protein found in Homo sapiens
Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. CD61 is a cluster of differentiation found on thrombocytes. The
Integrin_beta_3
Mammalian protein found in Homo sapiens
In molecular biology, CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one
Integrin_beta_2
Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) to form the heterodimeric integrin
Integrin_beta_7
Mammalian protein found in Homo sapiens
Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. This integrin associates with integrin
Integrin_beta_1
Protein-coding gene in the species Homo sapiens
Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins are αβ heterodimeric glycoproteins
Integrin_beta_6
Protein-coding gene in the species Homo sapiens
Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. Integrins are heterodimers composed of alpha and beta
Integrin_beta_4
Protein-coding gene in the species Homo sapiens
Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene. This gene is a member of the integrin beta chain family and encodes a single-pass
Integrin_beta_8
Mammalian protein found in Homo sapiens
Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes
Integrin_alpha_3
Protein-coding gene in the species Homo sapiens
subunit of integrin that can interact with the integrin alpha v to form the integrin alpha v beta 5 integrin heterodimer. Integrin alpha V beta 5 is a receptor
Integrin_beta_5
αVβ3 is a type of integrin that is a receptor for vitronectin. It consists of two components, integrin alpha V and integrin beta 3 (CD61), and is expressed
Alpha-v_beta-3
Mammalian protein found in Homo sapiens
Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are
Integrin_alpha_2b
Mammalian protein found in Homo sapiens
protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain
Integrin_alpha_X
Integrin complex found on platelets
inhibitors Vickers JD (July 1999). "Binding of polymerizing fibrin to integrin alpha(IIb)beta(3) on chymotrypsin-treated rabbit platelets decreases phosphatidylinositol
Glycoprotein_IIb/IIIa
Integrin dimer
Integrin α4β1 (very late antigen-4) is an integrin dimer. It is composed of CD49d (alpha 4) and CD29 (beta 1). The alpha 4 subunit is 155 kDa, and the
VLA-4
Transmembrane receptors involved in cellular adhesion and signalling
Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal
Integrin
Protein
chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain
Integrin_alpha_5
Mammalian protein found in Homo sapiens
alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are
Integrin_alpha_V
biology, CD11 is the α (alpha) component of various integrins, especially ones in which the β (beta) component is CD18 (β2) and mediate leukocyte adhesion
CD11
Protein-coding gene in the species Homo sapiens
encoded by the ITGAE gene. CD103 binds integrin beta 7 (β7– ITGB7) to form the complete heterodimeric integrin molecule αEβ7, which has no distinct name
Integrin_alpha_E
Mammalian protein found in Homo sapiens
alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha
Integrin_alpha_4
Protein-coding gene in the species Homo sapiens
Integrin subunit beta like 1 is a protein that in humans is encoded by the ITGBL1 gene. This gene encodes a beta integrin-related protein that is a member
Integrin_subunit_beta_like_1
Mammalian protein found in Homo sapiens
common beta chain. They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved
Integrin_alpha_2
Protein found in humans
catalytic domain. Integrins lack enzymatic activity and depend on adapters to signal proteins. ILK is linked to beta-1 and beta-3 integrin cytoplasmic domains
Integrin-linked_kinase
Cytokine
"The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis". Cell. 96 (3): 319–28
Transforming growth factor beta
Transforming_growth_factor_beta
join with beta 1 to form an integrin that binds to the extracellular matrix protein laminin-1. The primary binding partners of alpha-7 integrin are laminin-1
Integrin_alpha_7
Mammalian protein found in Homo sapiens
Integrin alpha M (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1)
Integrin_alpha_M
Protein-coding gene in the species Homo sapiens
ITGAD integrin, alpha D". Van der Vieren M, Le Trong H, Wood CL, et al. (1996). "A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3". Immunity
Integrin_alpha_D
Protein-coding gene in the species Homo sapiens
encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell
Integrin_alpha_9
Mammalian protein found in Homo sapiens
beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1
Integrin_alpha_L
Mammalian protein found in Homo sapiens
alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion
Integrin_alpha_6
Mammalian protein found in humans
suggested to be integrins. Thy1 is one of the known ligands of beta 3 integrins. Interaction of thy1 expressed on maturing axons with beta 3 integrins expressed
CD90
Mammalian protein found in Homo sapiens
Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a
Integrin_alpha-1
Medication used for the treatment of gastro-intestinal diseases
to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin beta-7), blocking the α4β7 integrin results
Vedolizumab
Protein-coding gene in humans
"Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit". J Cell Biol. 131 (3): 807–16
ITGB3BP
Contrast agent for cancer imaging
(LAP) in its complex with transforming growth factor beta 1 (TGF-β1). Binding of αvβ6-integrin to LAP releases and thus, activates TGF-β1. In early-stage
Ga-68-Trivehexin
"The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis". Cell. 96 (3): 319–328
TGF_beta_Activation
Protein-coding gene in the species Homo sapiens
an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears
Integrin_alpha_11
Protein found in humans
containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue. TAR
Integrin_alpha_10
Integrin found on lymphocytes
Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key role in emigration, which
Lymphocyte function-associated antigen 1
Lymphocyte_function-associated_antigen_1
Surface glycoproteins involved in hemostasis
Calvete JJ (1995). "On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor". Proc. Soc. Exp. Biol. Med. 208 (4):
Platelet membrane glycoprotein
Platelet_membrane_glycoprotein
Protein-coding gene in the species Homo sapiens
Sheetz MP (Sep 2009). "Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction".
TLN2
Conversion of mechanical stimulus of a cell into electrochemical activity
extracellular matrix ligands, integrins are also receptive to autocrine and paracrine signals such as growth factors in the TGF-beta family. Chondrocytes have
Mechanotransduction
Protein-coding gene in the species Homo sapiens
Lam SC (Oct 1999). "Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding
TLN1
Protein-coding gene in the species Homo sapiens
glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. ILKAP has been shown to interact with Integrin-linked kinase. GRCh38:
ILKAP
Contact-based cell-cell signalling
cell communication. Cells use mainly the receptor integrin to interact with ECM proteins. Integrins are a family of receptor proteins that integrate the
Juxtacrine_signalling
Protein-coding gene in humans
JM (October 1999). "Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine
ADAM2
Cell cycle regulation pathway
cellular quiescence, proliferation, cancer, and longevity. Phosphoinositide 3-kinase (PI3K) phosphorylates and activates AKT, localizing it in the plasma
PI3K/AKT/mTOR_pathway
Protein family
The transforming growth factor beta (TGF-β) superfamily is a large group of structurally related cell regulatory proteins that was named after its first
Transforming growth factor beta superfamily
Transforming_growth_factor_beta_superfamily
Mammalian protein found in Homo sapiens
expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus
ICAM-1
American immunologist
H.; Calderwood, D. A. (2003). "Talin binding to integrin beta tails: a final common step in integrin activation". Science. 302 (5642): 103–106. Bibcode:2003Sci
Timothy_A._Springer
Protein-coding gene in the species Homo sapiens
laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins". Journal of Cell Science. 113 (5): 869–76. doi:10
Laminin,_beta_2
Protein found in humans
Ginsberg MH (1995). "Calpain cleavage of the cytoplasmic domain of the integrin beta 3 subunit". J. Biol. Chem. 270 (44): 26146–51. doi:10.1074/jbc.270.44
Calpain-1_catalytic_subunit
α5β1, also known as the fibronectin receptor, is an integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis. It
Alpha-5_beta-1
Type of proteins
alpha (Gα), beta (Gβ) and gamma (Gγ) subunits. In addition, the beta and gamma subunits can form a stable dimeric complex referred to as the beta-gamma complex
G_protein
Protein-coding gene in the species Homo sapiens
D (September 2005). "Integrin-mediated activation of latent transforming growth factor beta". Cancer Metastasis Reviews. 24 (3): 395–402. doi:10.1007/s10555-005-5131-6
TGF_beta_1
Protein-coding gene in the species Homo sapiens
POSTN gene. Periostin functions as a ligand for alpha-V/beta-3 and alpha-V/beta-5 integrins to support adhesion and migration of epithelial cells. Periostin
Periostin
Medical treatment
trials for Crohn's disease. Etrolizumab is an integrin receptor antagonist that targets beta 7 integrins. Etrolizumab has shown efficacy in phase 2 trials
Biological therapy for inflammatory bowel disease
Biological_therapy_for_inflammatory_bowel_disease
Pharmaceutical compound
(MEDI-523) is a humanized monoclonal antibody against the vascular integrin alpha-v beta-3. It is shown to be a promising angiogenesis inhibitor used in the
Vitaxin
Protein-coding gene in humans
protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3). CIB1 is a small protein
CIB1
Subset of cell adhesion proteins
transcription. Integrins are heterodimeric, as they consist of an alpha and beta subunit. There are currently 18 alpha subunits and 8 beta subunits, which
Cell_adhesion_molecule
Protein-coding gene in the species Homo sapiens
"Transforming growth factor-beta (TGF-beta)". Int. J. Biochem. Cell Biol. 30 (3): 293–8. doi:10.1016/S1357-2725(97)00128-3. PMID 9611771. Wick W, Platten
TGF_beta_2
Proteins from viper venom inhibiting platelets aggregation
clumping of platelets. They interact with the beta-1 and -3 families of integrins receptors. Integrins are cell receptors involved in cell–cell and cell–extracellular
Disintegrin
Enzyme found in humans
Medicine. Li J, Mayne R, Wu C (Feb 2000). "A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation". J
Nicotinamide riboside kinase 2
Nicotinamide_riboside_kinase_2
Protein-coding gene in the species Homo sapiens
Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene. The cytoplasmic domains of integrins are essential for
ITGB1BP1
not listed on hcdm Bennett JS. Structure and function of the platelet integrin alphaIIbbeta3. J Clin Invest 2005; 115:3363-9. "FITC Anti-human CD51 Antibody
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Mammalian protein found in Homo sapiens
"Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin". Journal
Alpha-actinin-3
Protein domain
codistributes with concentrations of integrins in the plasma membrane. Furthermore, in vitro binding studies suggest that integrins bind to talin, although with
Talin_(protein)
Cascade of intracellular and molecular events for transmission/amplification of signals
signaling is mainly orchestrated in focal adhesions, regions where the integrin-bound actin cytoskeleton detects changes and transmits them downstream
Signal_transduction
Medical condition
have an inherited molecular defect that causes a deficiency of the β-2 integrin subunit, also called CD18, which is encoded by the ITGB2 gene found on
Leukocyte_adhesion_deficiency
Macrophage found in the lungs
"The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis". Cell. 96 (3): 319–28
Alveolar_macrophage
Type of chemical bond
molecule 1, integrin alpha M beta 2 with ICAM-1, integrin alpha V beta 3 with fibronectin, and integrin alpha IIb beta 3 with fibronectin or fibrinogen
Catch_bond
Medication used to treat multiple sclerosis and Crohn's disease
a humanized monoclonal antibody against the cell adhesion molecule α4-integrin. It is given by intravenous infusion. The drug is believed to work by reducing
Natalizumab
Protein involved in cell adhesion, cell growth, cell migration and differentiation
extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as
Fibronectin
Protein-coding gene in humans
and suggested that interaction with the cytoplasmic region of the beta-3 integrin subunit is important. The amino-terminal domains of FAK share a significant
PTK2
Protein-coding gene in the species Homo sapiens
melanoma cell migration and invasion by laminin-5 and alpha3beta1 integrin (VLA-3)". Clin. Exp. Metastasis. 19 (2): 127–34. doi:10.1023/A:1014573204062
Laminin_subunit_gamma-3
Structures which transmit force and signals between a cell and the extracellular matrix
the DGEA and GFOGER motifs found in collagen. Integrins are heterodimers which are formed from one beta and one alpha subunit. These subunits are present
Focal_adhesion
Human protein-coding gene
attachment and spreading on human tenascin is mediated by alpha 2 beta 1 and alpha v beta 3 integrins". Journal of Cell Science. 105 (4): 1001–1012. doi:10.1242/jcs
Tenascin_C
Protein-coding gene in the species Homo sapiens
β(2) integrin function depend on both cell type (Natural killer cell or Leukocytes) and the integrin activation stimulus. The prevention of the beta-3 activation
FERMT3
Mammalian protein found in Homo sapiens
Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and
Interleukin_1_beta
Protein found in humans
presumed through a direct association with the cytoplasmic tail of beta-integrin. The N-terminal region of paxillin is rich in protein–protein interaction
Paxillin
Series of molecular signals
Springer International Publishing. pp. 79–98. doi:10.1007/978-3-319-89512-3_5. ISBN 978-3-319-89512-3. PMC 6879322. PMID 30030823. Hunter GL, Hadjivasiliou Z
Notch_signaling_pathway
Peptides released by neurons as intercellular messengers
Additionally, dense core vesicles contain a small amount of neuropeptide (3 - 10mM) compared to synaptic vesicles containing neurotransmitters (e.g. 100mM
Neuropeptide
Human protein-encoding gene
in association with integrins alpha(6), alpha(3) and beta(1)". Molecular Human Reproduction. 6 (3): 252–7. doi:10.1093/molehr/6.3.252. PMID 10694273.
CD9
Enzyme
Dib K (March 2003). "Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils"
Tyrosine-protein_kinase_SYK
Signaling pathway involving transforming growth factor beta proteins
The transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo
TGF_beta_signaling_pathway
Substance that forms a complex with a biomolecule
1982). "Narcotic antagonistic potency of bivalent ligands which contain beta-naltrexamine. Evidence for bridging between proximal recognition sites".
Ligand_(biochemistry)
Protein-coding gene in humans
associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility". J. Cell
PTK2B
Chemical compound
disease. It is a humanized monoclonal antibody against the β7 subunit of integrins α4β7 and αEβ7. Etrolizumab was developed by Genentech by engineering the
Etrolizumab
Protein-coding gene in humans
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene
CD47
Overview of and topical guide to immunology
- Heterodimer: CD49d / CD29 Alpha-5 beta-1 Integrin alpha6beta1 Vitronectin receptor: Alpha-v beta-3 Alpha-v beta-5 Immunoglobulin superfamily CAMs SynCAMs
Outline_of_immunology
Component of striated muscle cells
dystrophin-glycoprotein complex (DGC) and the integrin-vinculin-talin complex. The sarcoglycans of the DGC and the integrins of the integrin-vinculin-talin complex attach
Costamere
Protein found in humans
domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion
ANGPTL3
Pore-forming toxin produced by the bacteria Staphylococcus
protein-containing receptors, typically G-protein coupled receptors, or an integrin on the host cell's surface. The S subunit then recruits a second, "F" subunit
Leukocidin
Mammalian protein found in Homo sapiens
immune system. ICAM3 mediates adhesion between cells by binding to specific integrin receptors. It plays an important role in the immune cell response through
ICAM3
Protein found in humans
six-cysteine EGF-like domains, 7 eight-cysteine domains homologous with latent TGF-beta binding protein, and a proline-rich region. The FBN-1 gene is involved in
Fibrillin-1
Mammalian protein found in humans
CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)". Journal of Immunology. 157 (5): 2039–47. doi:10
CD63
Protein found in humans
Ugarova TP, Ye RD, Lau LF, Lam SC (June 2002). "Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61
CCN_family_member_2
Exocrine gland in humans and other mammals
cell growth or differentiation sub-locally. Important players include beta-1 integrin, epidermal growth factor receptor (EGFR), laminin-1/5, collagen-IV
Mammary_gland
Protein-coding gene in the species Homo sapiens
"Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". The Journal of Biological Chemistry. 273 (4): 2379–83. doi:10
Receptor for activated C kinase 1
Receptor_for_activated_C_kinase_1
Protein-coding gene in the species Homo sapiens
fibrinogen, fibronectin, laminin, collagens types V and VII and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation
Thrombospondin_1
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INTEGRIN BETA-3
INTEGRIN BETA-3
INTEGRIN BETA-3
INTEGRIN BETA-3
INTEGRIN BETA-3
INTEGRIN BETA-3
INTEGRIN BETA-3
INTEGRIN BETA-3
INTEGRIN BETA-3
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