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Clumping of abnormal cold-sensitive proteins in blood
Cryoglobulinemia is a rare medical condition characterized by the presence of cryoglobulins in the blood. Cryoglobulins are abnormal proteins composed
Cryoglobulinemia
Antibodies sensitive to cold temperature
of symptoms, cryoglobulinemia and cold agglutinin disease differ in the process by which blood vessels become blocked. In cryoglobulinemia, antibodies
Cold_sensitive_antibodies
Spectrum of blood disorders
cryoglobulinemia (i.e. essential cryoglobulinemia) occurs in patients without these or other identifiable conditions. Non-essential cryoglobulinemia is
Plasma_cell_dyscrasias
Inflammation of small blood vessels due to cold-sensitive antibodies in the blood
women. Cryoglobulinemia is classified according to the Brouet criteria based on immunoglobulin clonality and composition. Type II cryoglobulinemia is defined
Cryoglobulinemic_vasculitis
Medical condition
Others: Physical trauma to the extremities Lyme disease Hypothyroidism Cryoglobulinemia Cancer Myalgic encephalomyelitis/chronic fatigue syndrome Reflex sympathetic
Raynaud_syndrome
Spontaneous detachment of an appendage
often followed by gangrene. Autoamputation is a feature of ainhum, cryoglobulinemia and thromboangiitis obliterans. In 1881, Thornton made the case of
Autoamputation
Medical condition
skin biopsy. Differential diagnosis Urticarial vasculitis, lupus, cryoglobulinemia, Schnitzler syndrome, mast cell disorders, polymorphic eruption of
Chronic_spontaneous_urticaria
Autoimmune disease
erythematosus with congenital heart block requiring a pacemaker. Type I cryoglobulinemia is a known complication of Sjögren's disease. Sjögren's disease can
Sjögren's_disease
Italian scientist (born 1947)
devoted tof systemic sclerosis, cryoglobulinemic vasculitis (mixed cryoglobulinemia) and other autoimmune systemic disorders. For in-depth overview of
Clodoveo_Ferri
Persistent blue or cyanotic discoloration of the extremities
conditions include infections, toxicities, antiphospholipid syndrome, cryoglobulinemia, neoplasms. In these cases, the observed cutaneous changes are known
Acrocyanosis
Excess myeloma protein or monoclonal gamma globulin in the blood
to precipitate within blood vessel with cold, a phenomenon known as cryoglobulinemia. Others may make blood too viscous to flow smoothly (usually with IgM
Monoclonal_gammopathy
Medical disorders that destroy blood vessels by inflammation
CRP and eosinophilia IgA vasculitis (Henoch–Schönlein purpura) None Cryoglobulinemia Cryoglobulins, rheumatoid factor, complement components, hepatitis
Vasculitis
Medical condition
consists of: palpable purpura arthralgia (joint pain) weakness. In cryoglobulinemia, immunoglobulins and sometimes complement components precipitate from
Meltzer's_triad
Medical condition
cryofibrinogenemia. Cryoglobulinemia may occur without evidence of an underlying associated disorders, i.e. primary cryoglobulinemia (also termed essential
Cryofibrinogenemia
Molecule formed binding antigens to antibodies
feature of several autoimmune diseases, including rheumatoid arthritis, cryoglobulinemia, scleroderma, polyarteritis nodosa, and Sjögren's syndrome. An inability
Immune_complex
Soluble protein complex in blood plasma and involved in clot formation
bodily extremities. Cryoglobulinemia may occur without evidence of an underlying associated disorder, i.e. primary cryoglobulinemia (also termed essential
Fibrinogen
Human viral infection
common problem due to hepatitis C but not involving the liver is mixed cryoglobulinemia (usually the type II form) – an inflammation of small and medium-sized
Hepatitis_C
Medical condition
cryovalent vasculitis. Cryoglobulins type II and III, also known as mixed cryoglobulinemia, are composed of polyclonal immunoglobulin (Ig)G and either monoclonal
Systemic_vasculitis
Condition in which bones are abnormally hardened
Schnitzler syndrome Mastocytosis Skeletal fluorosis Monoclonal IgM Kappa cryoglobulinemia Hepatitis C. Malignant infantile osteopetrosis Neuropathic infantile
Osteosclerosis
Autoimmune vascular inflammatory disease
purpura from other diseases that cause it, such as vasculitis due to cryoglobulinemia; on microscopy, the appearances are of a hypersensitivity vasculitis
Henoch–Schönlein_purpura
Medical condition
intravascular protein deposition diseases causing retiform purpura are cryoglobulinemia (type I), cryofibrinogenemia, and paraproteinemia. Some embolic disorders
Retiform_purpura
Nervous system disease affecting nerves beyond the brain and spinal cord
Infections: leprosy, lyme disease, parvovirus B19, HIV Sarcoidosis Cryoglobulinemia Reactions to exposure to chemical agents, including trichloroethylene
Peripheral_neuropathy
Indications of a specific illness, including psychiatric
(painful and weak muscles). Meltzer's triad indicates the condition cryoglobulinemia. Huntington's disease is a neurodegenerative disease that is characterized
Signs_and_symptoms
Medical condition
membranoproliferative glomerulonephritis Bacterial endocarditis Shunt nephritis Cryoglobulinemia Nephrotic syndrome Causes of generalized edema: Malnutrition Malabsorption
Acute proliferative glomerulonephritis
Acute_proliferative_glomerulonephritis
Human viral infection
Other immune-mediated hematological disorders, such as essential mixed cryoglobulinemia and aplastic anemia, have been described as part of the extrahepatic
Hepatitis_B
Autoimmune disease affecting the peripheral nervous system
gammopathies with subtypes: Waldenström's macroglobulinemia Mixed cryoglobulinemia, gait ataxia, late-onset polyneuropathy syndrome Myelin-associated
Chronic inflammatory demyelinating polyneuropathy
Chronic_inflammatory_demyelinating_polyneuropathy
Triads of medical diseases
conjunctivitis Measles Meltzer's triad Purpura, arthralgias, weakness/myalgias Cryoglobulinemia Triad of reactive arthritis Urethritis, conjunctivitis and anterior
List of medical triads, tetrads, and pentads
List_of_medical_triads,_tetrads,_and_pentads
Removal, treatment and return of blood plasma
syndrome HELLP syndrome HIV-related neuropathy Hyperviscosity syndromes: Cryoglobulinemia Paraproteinemia Waldenström macroglobulinemia Idiopathic pulmonary
Plasmapheresis
Type of blood cancer
effects of the IgM paraprotein, which may cause autoimmune phenomena or cryoglobulinemia. Other symptoms of Waldenström macroglobulinemia are due to hyperviscosity
Waldenström_macroglobulinemia
Category of diseases
arthritis - inflammatory musculoskeletal condition linked to psoriasis. Cryoglobulinemia - condition sometimes associated with systemic lupus erythematosus
Connective_tissue_disease
Paraneoplastic syndrome
diagnosis Chronic inflammatory demyelinating polyradiculoneuropathy, cryoglobulinemia, nodular localized cutaneous amyloidosis, multiple myeloma, monoclonal
POEMS_syndrome
Medical condition
glomerulonephritis is characterized by glomerular involvement in those with cryoglobulinemia. In light microscopy it presents as a membranoproliferative or endocapillary
Monoclonal gammopathy of renal significance
Monoclonal_gammopathy_of_renal_significance
Allergic reaction to low temperatures
condition characterized by wheals, due to serum abnormalities such as cryoglobulinemia or cryofibrinogenemia are extremely rare, and are then associated with
Cold_urticaria
Nicaraguan musical duo
Salvador Cardenal died on March 8, 2010, after a long battle with cryoglobulinemia. Studio albums Un Trago de Horizonte (1982) Si Buscabas (1985) Días
Duo_Guardabarranco
Human disease caused by Orthohepevirus A
meningoencephalitis. Glomerulonephritis with nephrotic syndrome and/or cryoglobulinemia Mixed cryoglobulinemia, where antibodies in the bloodstream react inappropriately
Hepatitis_E
Medical condition
gammopathy of undetermined significance (MGUS), other causes of hives, cryoglobulinemia, mastocytosis, chronic neonatal onset multisystem inflammatory disease
Schnitzler_syndrome
Type of firm, hemorrhagic skin lesion, usually asymptomatic
linked to sepsis, reactions to drugs, connective tissue diseases, cryoglobulinemia, hepatitis C or B infection, or underlying cancers. Children and young
Palpable_purpura
Medical techniques to separate one or more components of blood
Coagulation factor inhibitors Immunoadsorption III Plasmapheresis III Cryoglobulinemia Severe/symptomatic Plasmapheresis II Secondary to Hepatitis C Immunoadsorption
Apheresis
Skin sore sustained by a vasculatory disease
pyoderma gangrenosum or Sweet's syndrome; vasculitic processes such as cryoglobulinemia; calciphylaxis (often seen in people with end-stage kidney disease
Venous_ulcer
Blood vessels narrowing due to arterial spasm
contrast mediated selective renal vasospasm, hypercoagulability and cryoglobulinemia likely represent just a few of the known pieces of this puzzling phenomena
Vasospasm
Medical condition
polycythemia vera, thrombocytopenic purpura, macroglobulinemia, and cryoglobulinemia. Skin lesion James, William D.; Berger, Timothy G.; et al. (2006).
Hematopoietic_ulcer
American physician
significant contributions to our understanding of essential mixed cryoglobulinemia, a medical condition in which the blood contains large amounts of pathological
Edward_C._Franklin
2005 American TV series or program
conditions examined in the series are unusual or rare conditions (such as cryoglobulinemia) or genetic disorders, well-known conditions such as epilepsy, Myasthenia
Mystery_Diagnosis
Medical condition
Autoimmune Hemolytic anemia Autoimmune Hepatitis Behçet's disease Cryoglobulinemia Dermatomyositis Felty syndrome Gout Mixed connective tissue disease
Fever_of_unknown_origin
Musical artist
from a rare disease called Cryoglobulinemia. According to a 2009 news article, when he was diagnosed with Cryoglobulinemia, he was only given up to 10
Salvador_Cardenal
Growth of a plasma cell tumour within soft tissue or the axial skeleton
associated with plasmacytoma. Rarely, acquired Von Willebrand syndrome, Cryoglobulinemia (especially if Hepatitis C is present), Amyloidosis and Renal impairment
Plasmacytoma
Medical condition
and lead to vasculopathic disorders, such as in: Cryofibrinogenemia Cryoglobulinemia Besides blood clots, other foreign bodies called emboli can cause blockages
Occlusive_vasculopathy
syndrome Non-systemic vasculitic neuropathy (NSVN) Hepatitis C-related cryoglobulinemia neuropathy (CRYOVASC) Hepatitis B-associated PAN Diabetic lumbosacral
Microvasculitis
American biologist
evolutionary computation to be given there. When his father became ill with cryoglobulinemia, he moved with him to Hawaii for the warm temperatures. In 2002 Altenberg
Lee_Altenberg
Symptoms resulting from kidney inflammation
the glomerulus, causing glomerulonephritis and nephritic syndrome. Cryoglobulinemia - Antibodies that are sensitive to the cold can become activated in
Nephritic_syndrome
Medical condition
(osteomyelitis), infection of the lining of the heart (endocarditis), and cryoglobulinemia. Systemic lupus erythematosus is associated with low C3 and C4. Membranoproliferative
Complement_deficiency
Group of lymphomas
uncommonly, the stomach or other tissues. It is associated with type II cryoglobulinemia, i.e. the circulation of an immune complex consisting of polyclonal
Marginal_zone_lymphoma
Accumulation of clumps of misfolded or disordered proteins
oxidative stress can also lead to protein aggregation. One such disease is cryoglobulinemia. Extreme temperatures can weaken and destabilize the non-covalent interactions
Protein_aggregation
Overview of and topical guide to immunology
(Macroglobulinemia/Waldenström macroglobulinemia) heavy chain (Heavy chain disease) light chain (Primary amyloidosis) Other hypergammaglobulinemia Cryoglobulinemia
Outline_of_immunology
Medical condition
Microvascular occlusions can be caused by heparin-induced thrombocytopenia, cryoglobulinemia, angioinvasive organisms, embolization, disseminated intravascular
Microvascular_occlusion
Crouzon syndrome Crouzonodermoskeletal syndrome Crow–Fukase syndrome Cryoglobulinemia Cryophobia Cryptococcosis Cryptogenic organized pneumopathy Cryptomicrotia
List_of_diseases_(C)
Class of compounds
associated with mixed cryoglobulinemia (MC) have elevated levels of anti-sulfatide antibodies in their blood plasma. Mixed cryoglobulinemia (MC) is an immune
Sulfatide
deficiency Essential hypertension Essential iris atrophy Essential mixed cryoglobulinemia Essential thrombocytopenia Essential thrombocythemia - synonym of Essential
List_of_diseases_(E)
Italian scientist and entrepreneur
"Nonrheumatoid IgM in Human Hepatitis C Virus-Associated Type II Cryoglobulinemia Recognize Mimotopes of the CD4-Like LAG-3 Protein". The Journal of
Riccardo_Cortese
MeSH C15.378.147.780 – paraproteinemias MeSH C15.378.147.780.243 – cryoglobulinemia MeSH C15.378.147.780.490 – heavy chain disease MeSH C15.378.147.780
List_of_MeSH_codes_(C15)
MeSH C14.907.933.125 – arteriovenous fistula MeSH C14.907.934.140 – cryoglobulinemia MeSH C14.907.934.240 – Ehlers–Danlos syndrome MeSH C14.907.934.385
List_of_MeSH_codes_(C14)
MeSH C20.683.515.950 – tumor lysis syndrome MeSH C20.683.780.250 – cryoglobulinemia MeSH C20.683.780.490 – heavy chain disease MeSH C20.683.780.490.512
List_of_MeSH_codes_(C20)
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