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Spectrum of blood disorders
In hematology, plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more
Plasma_cell_dyscrasias
White blood cell that secretes large volumes of antibodies
Plasma cells, also called plasma B cells or effector B cells, are white blood cells that originate in the lymphoid organs as B cells and secrete large
Plasma_cell
Medical condition
called plasma cells. It is the terminal stage and most aggressive form of these dyscrasias, constituting 2% to 4% of all cases of plasma cell malignancies
Plasma_cell_leukemia
Any of various disorders in medicine
dyscrasia. In modern medicine, the term is still occasionally used in medical context for an unspecified disorder of the blood, such as a plasma cell
Dyscrasia
Type of blood cancer
lymphomas. It is commonly classified as a form of plasma cell dyscrasia, similar to other plasma cell dyscrasias that, for example, lead to multiple myeloma
Waldenström_macroglobulinemia
Cancer of plasma cells
myeloma (MM), also known as plasma cell myeloma and simply myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibodies
Multiple_myeloma
Type of white blood cell
closely related to or a subtype of plasma cells. This cell type is found in pre-malignant and malignant plasma cell dyscrasias that are associated with the
B_cell
Paraneoplastic syndrome
small fibre sensory modalities. Plasma cell dyscrasias are a group of monoclonal gammopathies in which normal plasma cells in the bone marrow and soft tissues
POEMS_syndrome
Medical condition
to a wider family of progressive plasma cell disorders known as plasma cell dyscrasias. There is a risk of eventual progression to multiple myeloma, a
Smouldering_myeloma
Metabolic disease involving abnormal deposited amyloid proteins
deposition of amyloid proteins in the bone marrow without causing plasma cell dyscrasias is called amyloidoma. It is commonly found in cervical, lumbar,
Amyloidosis
Growth of a plasma cell tumour within soft tissue or the axial skeleton
Plasmacytoma is a plasma cell dyscrasia in which a plasma cell tumour grows within soft tissue or within the axial skeleton. The International Myeloma
Plasmacytoma
American pathologist (1928–2026)
with plasma cell dyscrasias. Throughout his career Kyle published more than 1,850 scientific papers and abstracts on myeloma and other plasma cell disorders
Robert_A._Kyle
Medical condition
undetermined significance (MGUS) is a plasma cell dyscrasia in which plasma cells or other types of antibody-producing cells secrete a myeloma protein, i.e.
Monoclonal gammopathy of undetermined significance
Monoclonal_gammopathy_of_undetermined_significance
Medical condition
immunoglobulins are produced by monoclonal plasma cells, which are found in a variety of plasma cell dyscrasias. The deposition of monoclonal immunoglobulins
Monoclonal immunoglobulin deposition disease
Monoclonal_immunoglobulin_deposition_disease
Presence of an excess of serum proteins in the urine
Pre-malignant plasma cell dyscrasias: Monoclonal gammopathy of undetermined significance Smoldering multiple myeloma Malignant plasma cell dyscrasias Multiple
Proteinuria
Academic journal
related disorders, including macroglobulinemia, amyloidosis, and plasma-cell dyscrasias. The journal is abstracted and indexed in Index Medicus/MEDLINE/PubMed
Clinical Lymphoma, Myeloma & Leukemia
Clinical_Lymphoma,_Myeloma_&_Leukemia
Diseases caused by abnormal protein structure
become misfolded. The structurally abnormal proteins disrupt the function of cells in tissues and organs. Often the proteins fail to fold into their normal
Proteinopathy
Excess myeloma protein or monoclonal gamma globulin in the blood
especially multiple myeloma. It is sometimes considered equivalent to plasma cell dyscrasia. The most common form of the disease is monoclonal gammopathy of
Monoclonal_gammopathy
Abnormal immunoglobulin fragment
intermediate in a spectrum of step-wise progressive diseases termed plasma cell dyscrasias. Elevated paraprotein level (above 30 g/L) in conjunction with end
Myeloma_protein
Medical condition
half of people with light chain deposition disease also have a plasma cell dyscrasia, a spectrum of diseases that includes multiple myeloma, Waldenström's
Light chain deposition disease
Light_chain_deposition_disease
In biology, cells derived from a single clonal origin
aberrant cell which has undergone carcinogenesis reproduces itself into a cancerous mass. Monoclonal plasma cell (also called plasma cell dyscrasia): A single
Monoclonality
Medical condition
chain disease is a form of paraproteinemia and plasma cell dyscrasia that involves the proliferation of cells producing immunoglobulin heavy chains. This
Heavy_chain_disease
Soluble protein complex in blood plasma and involved in clot formation
and/or blood clotting. Other, less well understood, causes are plasma cell dyscrasias and autoimmune disorders in which a circulating abnormal immunoglobulin
Fibrinogen
Medical condition
macroglobulins in the circulating blood. It is a plasma cell dyscrasia, resembling leukemia, with cells of lymphocytic, plasmacytic, or intermediate morphology
Macroglobulinemia
Mammalian protein found in humans
F, Semenzato G (March 2020). "NK cells and CD38: Implication for (Immuno)Therapy in Plasma Cell Dyscrasias". Cells. 9 (3): 768. doi:10.3390/cells9030768
CD31
Clumping of abnormal cold-sensitive proteins in blood
Dysfibrinogenemia Hematopoietic ulcer Hyperviscosity syndrome Paraproteinemia Plasma cell dyscrasias Killeen, Robert B.; Awais, Mashal; Mikes, Beverly A. (2025), "Cryoglobulinemia"
Cryoglobulinemia
Medical condition
dysfunctional due to the presence of liver disease, autoimmune disease, a plasma cell dyscrasias, or certain cancers. It is associated primarily with pathological
Dysfibrinogenemia
Protein found in humans
Barilà G, Sabrina Manni S (2020). "NK cells and CD38: Implication for (Immuno)Therapy in Plasma Cell Dyscrasias". Cells. 9 (3): 768. doi:10.3390/cells9030768
CD38
Medical condition
bone marrow biopsy may show evidence of a plasma cell dyscrasia with increased numbers of atypical plasma cells. Splenic infiltrates are typically found
Chronic_neutrophilic_leukemia
Medical condition
against the plasma cell surface protein CD38 daratumumab may also be used with very high efficacy against AL amyloidosis. B-cell dyscrasias associated
Monoclonal gammopathy of renal significance
Monoclonal_gammopathy_of_renal_significance
Medical condition
conditions. Hematological disorders such as myelodysplastic syndrome and plasma cell dyscrasias are common. The histopathology of NDDH lesions shows a dense neutrophil
Neutrophilic dermatosis of the dorsal hands
Neutrophilic_dermatosis_of_the_dorsal_hands
Medical condition
Lymphoproliferative disorders such as B-cell lymphomas, T-cell lymphomas, chronic lymphocytic leukemia, and various plasma cell dyscrasias (e.g. multiple myeloma, Waldenström's
Cryofibrinogenemia
Aspect of medicine
PMID 1737851. Merlini G, Pozzi C (2007). Mechanisms of renal damage in plasma cell dyscrasias: an overview. Contributions to Nephrology. Vol. 153. pp. 66–86.
Serum free light-chain measurement
Serum_free_light-chain_measurement
Treatment of cancer using drugs that inhibit cell division or kill cells
than cancer, such as in autoimmune disorders, and noncancerous plasma cell dyscrasia. In some cases they are often used at lower doses, which means that
Chemotherapy
Chemical compound
fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias. Allergic reactions to Sulfonamides have been shown to include the entire
Sulfamethoxazole
Scottish military surgeon
Retrieved 20 June 2013. Herrera, Guillermo A. (2007). The Kidney in Plasma Cell Dyscrasias: 13 Tables. Karger Publishers. pp. 16–7. ISBN 978-3-8055-8178-3
John_Rollo
Chemical compound
adverse effects include Stevens–Johnson syndrome, anaphylaxis and blood dyscrasias. Contraindications include: Hyperchloremic acidosis Hypokalemia (low blood
Acetazolamide
Small antibody polypeptide subunit (immunoglobin)
other than a blood cell dyscrasia, such as kidney disease. There is also a surrogate light chain IGLL1 (λ5) with a role in B cell development, a mammalian
Immunoglobulin_light_chain
Sore on the mucous membrane of the oral cavity
hypereosinophilic syndrome, leukemia, myelodysplastic syndromes, other white cell dyscrasias, and gammopathies. Gastrointestinal causes include celiac disease,
Mouth_ulcer
Antibiotic
Less common side effects can be nausea, vomiting, itching, and blood dyscrasias. The gastrointestinal effects, such as hairy tongue, nausea, vomiting
Ampicillin
Antifungal medication
seizures, alopecia, Stevens–Johnson syndrome, thrombocytopenia, other blood dyscrasias, serious hepatotoxicity including liver failure, anaphylactic/anaphylactoid
Fluconazole
Medical condition
dental restorative materials, mercury, nickel and acrylic, acrylic. Plasma cell gingivitis is a rare condition thought to be a hypersensitivity reaction
List_of_periodontal_diseases
Pharmaceutical drug
injection site and hair loss) in nature, although conjunctivitis, blood dyscrasias, kidney damage, joint pain, muscle aches/pains and liver dysfunction are
Sodium_aurothiomalate
Loop diuretic medication
also recommended to be alert for the occurrence of any potential blood dyscrasias. Furosemide works by decreasing the reabsorption of sodium by the kidneys
Furosemide
Nonsteroidal anti-inflammatory drug (NSAID)
marrow depression, rashes, malaise, blood dyscrasias, and diminished renal blood flow. Phenylbutazone has a plasma elimination half-life of 4–8 hours, however
Phenylbutazone
Combination of two antibiotic drugs
effective in clearing co-trimoxazole from the plasma. Calcium folinate treatment in cases of blood dyscrasias Forcing oral fluids Alkalinisation of the urine
Trimethoprim/sulfamethoxazole
Atypical antipsychotic medication
review and meta-analysis. Clozapine was first linked to serious blood dyscrasias in the 1970s, when eight deaths from agranulocytosis were reported in
Clozapine
Class of medications used primarily to treat high blood pressure
Hematologic effects, such as neutropenia, agranulocytosis and other blood dyscrasias, have occurred during therapy with ACE inhibitors, especially in people
ACE_inhibitor
Endocrine disorder in cats
treatments should be prioritised in case of cardiac, electrolyte, and renal dyscrasias. Rates of hypocalcaemia following bilateral thyroidectomy range from 6–82%
Feline_hyperthyroidism
Combination drug
structurally related to aminophenazone it has been associated with severe blood dyscrasias. However, it cannot be transformed into potentially carcinogenic nitrosamines
Propyphenazone/paracetamol/caffeine
Propyphenazone/paracetamol/caffeine
First generation antipsychotic medication
(a potentially fatal complication of antipsychotic treatment). Blood dyscrasias such as agranulocytosis, leukopenia and neutropenia are possible with
Thioridazine
Typical antipsychotic drug of the thioxanthene class
effects include Blood dyscrasias (abnormalities in the cell composition of blood), such as: Agranulocytosis – a drop in white blood cell counts that leaves
Flupentixol
Atypical antipsychotic and antiemetic medication
located on the lactotrophic cells found in the anterior pituitary gland. Amisulpride has a high propensity for elevating plasma prolactin levels as a result
Amisulpride
Atypical antipsychotic
incidence increases with concomitant use of lithium (medication) salts Blood dyscrasias — rare, sometimes life-threatening complications of the use of a number
Sulpiride
Antibiotic
cannot be used. Monitoring both blood levels of the medication and blood cell levels every two days is recommended during treatment. Common side effects
Chloramphenicol
Irreversible non-selective MAO inhibitor and antidepressant drug
incidence) adverse effects include: Increased/decreased appetite Blood dyscrasias Chest pain Diarrhea Edema Hallucinations Hyperreflexia Insomnia Jaundice
Tranylcypromine
Drug that block acetylcholine in synapses of cholinergic nervous system
For anticholinergics, such as Trimethoprim: Blood dyscrasias Suxamethonium: Hyperkalemia Low plasma-cholinesterase activity e.g. severe liver disease
Cholinergic_blocking_drug
Medication
paracetamol. Metamizole has a potential of blood-related toxicity (blood dyscrasias), but causes less kidney, cardiovascular, and gastrointestinal toxicity
Metamizole
Medical condition
hyalinization, mucin deposition, histiocytes and tiny granulomas, and plasma cell and eosinophil infiltrates. Although serologic analyses are frequently
Lupus erythematosus panniculitis
Lupus_erythematosus_panniculitis
Antidepressant
Seizures Syndrome of inappropriate secretion of antidiuretic hormone Blood dyscrasias including: Agranulocytosis Thrombocytopenia Eosinophilia Leukopenia Myocardial
Trimipramine
Class of medications
antipsychotic drugs) adverse effects of antipsychotics include: Blood dyscrasias (e.g., agranulocytosis, leukopenia, and neutropaenia), which is more common
Antipsychotic
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PLASMA CELL-DYSCRASIAS
PLASMA CELL-DYSCRASIAS
PLASMA CELL-DYSCRASIAS
PLASMA CELL-DYSCRASIAS
PLASMA CELL-DYSCRASIAS
PLASMA CELL-DYSCRASIAS
PLASMA CELL-DYSCRASIAS
PLASMA CELL-DYSCRASIAS
PLASMA CELL-DYSCRASIAS
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