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Search references for CYP2C19. Phrases containing CYP2C19
See searches and references containing CYP2C19!CYP2C19
Mammalian protein found in humans
Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme protein. It is a member of the CYP2C subfamily of the cytochrome P450 mixed-function oxidase system
CYP2C19
Medication to treat gastroesophageal reflux disease and other conditions
enzymes CYP2C19 and CYP3A4. Clopidogrel is an inactive prodrug that partially depends on CYP2C19 for conversion to its active form. Inhibition of CYP2C19 may
Omeprazole
Antiplatelet medication
syndrome may increase adverse cardiac outcomes, possibly due to inhibition of CYP2C19, which is required for the conversion of clopidogrel to its active form
Clopidogrel
Benzodiazepine medication
The demethylation is facilitated by CYP2C19, CYP3A4, and CYP2B6 and the 4'-Hydroxyclobazam by CYP2C18 and CYP2C19. N-desmethylclobazam is further metabolized
Clobazam
Tricyclic antidepressant
recommends considering an alternative drug not metabolized by CYP2C19 in patients who are CYP2C19 ultrarapid metabolizers. A reduction in the starting dose
Amitriptyline
SSRI antidepressant
in feces. CYP2C19 and CYP2B6 are thought to be the key cytochrome P450 enzymes involved in the metabolism of sertraline. Relative to CYP2C19 normal (extensive)
Sertraline
Sedating antidepressant
significantly reduced at 238 L/hour. CYP2C19 was involved in the metabolism of (Z)-doxepin, with clearance rates of 191 L/hour in CYP2C19 extensive metabolizers and
Doxepin
Muscle relaxant
irritability. The metabolism of metaxalone involves enzymes CYP1A2 and CYP2C19 in the cytochrome P450 system. [medical citation needed] Because many medications
Metaxalone
Anticonvulsant medication
[citation needed] Oxcarbazepine and licarbazepine are potent inhibitors of CYP2C19 and thus have the potential to increase plasma concentration of drugs,
Oxcarbazepine
Statin medication
Bioavailability 20% Protein binding 88% Metabolism Liver: CYP2C9 (major) and CYP2C19-mediated; ~10% metabolized Metabolites N-desmethyl rosuvastatin (major;
Rosuvastatin
Medication used to treat seizures
a minor metabolic pathway via CYP2C19-dependent hydroxylation. Individuals who have no CYP2C19 enzyme activity, "CYP2C19 poor metabolizers", will have
Brivaracetam
Beta blocker drug
cytochrome P450 enzymes including CYP2D6, CYP1A2, and CYP2C19. CYP1A2 and CYP2D6 have a major role, while CYP2C19 and CYP3A4 have a minor role.[additional citation(s)
Propranolol
Antidepressant pharmacology hypotheses
150–250 2 hr 80% Urine CYP2D6 CYP2C19 CYP3A3 CYP3A4 ? Imipramine High 12 (30) 18 175–300 1–2 hr 90% Urine CYP1A2 CYP2C19 CYP2D6 ? Lofepramine 7% 1.7–2
Pharmacology of antidepressants
Pharmacology_of_antidepressants
Psychedelic drug
indole-3-acetic acid (IAA) and to a much lesser extent in the liver by CYP2D6 and CYP2C19. When taken intravenously, DMT is primarily metabolized by MAO-A in the
Dimethyltryptamine
Stomach acid suppressing medication
encodes for the metabolic enzyme CYP2C19. For example, people that are poor CYP2C19 metabolizers (i.e. their version of CYP2C19 is less effective than average)
Rabeprazole
SSRI antidepressant
CYP1A2, CYP2C9, CYP2C19, or CYP2E1. Exposure to escitalopram is increased moderately, by about 50%, when it is taken with omeprazole, a CYP2C19 inhibitor.
Escitalopram
Medication which reduces stomach acid
inactive prodrug that partially depends on CYP2C19 for conversion to its active form; inhibition of CYP2C19 blocks the activation of clopidogrel, thus
Esomeprazole
Muscle relaxant medication
P450 oxidase isozyme CYP2C19, excreted by the kidneys and has about an eight-hour half-life. In patients with low levels of CYP2C19 (poor metabolizers)
Carisoprodol
Nonsteroidal anti-inflammatory drug
protons, NADPH CYP3A4, CYP2C19, CYP2C8, CYP2C9 2-hydroxyibuprofen NADP, water ibuprofen oxygen, protons, NADPH CYP2C8, CYP2C9, CYP2C19 3-hydroxyibuprofen
Ibuprofen
Benzodiazepine sedative
the placement of an IV catheter. Dean L (2016). "Diazepam Therapy and CYP2C19 Genotype". In Pratt VM, McLeod HL, Rubinstein WS, et al. (eds.). Medical
Diazepam
Enzyme protein
epoxide products that act as signaling molecules. It along with CYP2C8, CYP2C19, CYP2J2, and possibly CYP2S1 are the principle enzymes which metabolizes
CYP2C9
Coronary medication
better for people with genetic loss-of-function variants of the enzyme CYP2C19 that influence the pharmacodynamic efficacy of clopidogrel. Ticagrelor
Ticagrelor
Serotonin modulator antidepressant
of vortioxetine, but others including CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP3A4/5 are also involved. It is also metabolized by alcohol dehydrogenase
Vortioxetine
SSRI antidepressant
compounds water-soluble. Citalopram is metabolized in the liver mostly by CYP2C19, but also by CYP3A4 and CYP2D6. Metabolites desmethylcitalopram and didesmethylcitalopram
Citalopram
Swedish-British pharmaceutical company
five-times higher than those with normal CYP2C19 production. In contrast, esomeprazole is metabolized by both CYP2C19 and CYP3A4, providing less-variable drug
AstraZeneca
Sleep medication
metabolized by CYP3A4 (61%) CYP2C9 (22%), CYP1A2 (14%), CYP2D6 (<3%), and CYP2C19 (<3%). Less than 1% is excreted in urine unchanged. It is principally metabolized
Zolpidem
Stomach acid suppressing medication
cytochrome P450 system. Metabolism mainly consists of demethylation by CYP2C19 followed by sulfation. Another metabolic pathway is oxidation by CYP3A4
Pantoprazole
Vertebrate natural glucocorticoid hormone
Zhang XY, Shen Y, Zhang HW, Wang YQ, et al. (October 2021). "Impact of CYP2C19 genotype on voriconazole exposure and effect of voriconazole on the activity
Cortisol
Medication used to treat ADHD
unspecified enzyme into 2-hydroxymethylatomoxetine, and N-demethylation by CYP2C19 into N-desmethylatomoxetine. In addition, N-desmethylatomoxetine undergoes
Atomoxetine
Immunomodulatory drug which can cause birth defects
and (S)-(−)-enantiomers, respectively Metabolism Liver (minimally via CYP2C19-mediated 5-hydroxylation; mostly via non-enzymatic hydrolysis at the four
Thalidomide
Triazolobenzodiazepine
catalysed by CYP2B6, CYP2C19, and CYP3A4. 4-hydroxy bromazolam, as well as α-hydroxy bromazolam, were formed by CYP2B6, CYP2C19, CYP3A4, and CYP3A5. Additionally
Bromazolam
Drug class of antiplatelet agents
clopidogrel resistance. The major factor in clopidogrel resistance is CYP2C19 polymorphism, which occurs in 30-55% patients. This led to loss of functions
Adenosine diphosphate receptor inhibitor
Adenosine_diphosphate_receptor_inhibitor
Chemical compound
Probenecid, also sold under the brand name Probalan, is a medication that increases uric acid excretion in the urine. It is primarily used in treating
Probenecid
Antibiotic
potent inhibitor of the cytochrome P450 isoforms CYP2C19 and CYP3A4 in the liver. Inhibition of CYP2C19 causes decreased metabolism and therefore increased
Chloramphenicol
Cannabinoid metabolite
Δ9-THC and Δ8-THC, HHC is processed by cytochrome P450 (CYP3A4, CYP2C9 and CYP2C19) to a series of oxygenated derivatives, some of which maintain activity
8-Hydroxyhexahydrocannabinol
SSRI antidepressant
CYP3A4 (weak) inhibitor. CYP1A2 (weak) inhibitor. CYP2C9 (weak) inhibitor. CYP2C19 (weak) inhibitor. Paroxetine has been shown to be an inhibitor of G protein-coupled
Paroxetine
Synthetic opioid painkiller
active metabolite nortilidine occurs with the participation of CYP3A4 and CYP2C19. The inhibition of these enzymes can thus alter the efficacy and tolerability
Tilidine
SSRI antidepressant
metabolizes nonsteroidal anti-inflammatory drugs, phenytoin, sulfonylureas, etc. CYP2C19 (strongly) which metabolizes clonazepam, diazepam, phenytoin, etc. CYP2B6
Fluvoxamine
Medication used to treat epilepsy and migraine
the plasma levels of phenytoin. Topiramate itself is a weak inhibitor of CYP2C19 and induces CYP3A4; a decrease in plasma levels of estrogens and digoxin
Topiramate
Synthetic opioid pain medication
Guideline for Serotonin Reuptake Inhibitor Antidepressants and CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A – CPIC". Retrieved 23 November 2023. Miotto
Tramadol
SSRI antidepressant
(which is also the chief enzyme responsible for their metabolism) and CYP2C19, and mild to moderate inhibitors of CYP2B6 and CYP2C9. In vivo, fluoxetine
Fluoxetine
Chemical compound
℞ (Prescription only) Pharmacokinetic data Protein binding 75% Metabolism By liver (CYP2C19) Metabolites cycloguanil and 4-chlorophenylbiguanide Elimination half-life
Proguanil
Opioid analgesic of benzenoid class
pancreatitis. People who are rapid or ultra rapid metabolizers for the CYP2C9, CYP2C19, and CYP2D6 enzymes may not respond adequately to tapentadol therapy. Due
Tapentadol
Drugs used to achieve relief from pain
80–100%; protein binding = 90–99%; hepatic metabolism, mostly via CYP2C9 and CYP2C19-mediated oxidation; excretion = Urine (50–60%), faeces. Pain; fever; inflammatory
Analgesic
Antidepressant medication
drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4". Clin Pharmacol Ther. 95 (6): 653–62. doi:10.1038/clpt.2014
Trazodone
Psychoactive component of cannabis
metabolism of THC occurs mainly in the liver by cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP3A4. CYP2C9 and CYP3A4 are the primary enzymes involving in metabolizing
Tetrahydrocannabinol
Chemical compound
administration Oral ATC code none Pharmacokinetic data Metabolism Hepatic (CYP2C19-mediated) Elimination half-life 4.8 to 7.7 hours Identifiers IUPAC name
Tenatoprazole
Stimulant drug
corresponding lactam as well as ring opening to the corresponding carboxylic acid. CYP2C19 and CYP2D6 have been identified as the isoenzymes mainly responsible for
3',4'-Methylenedioxy-α-pyrrolidinobutiophenone
3',4'-Methylenedioxy-α-pyrrolidinobutiophenone
Chemical compound
vitro. But the pharmacokinetics of gliclazide MR are affected mainly by CYP2C19 genetic polymorphism instead of CYP2C9 genetic polymorphism. "Gliclazide
Gliclazide
Medication mainly used for depression and smoking cessation
CYP2B6 leading to R,R- and S,S-hydroxybupropion and, to a lesser degree, CYP2C19 leading to 4'-hydroxybupropion. The reductive pathways are by 11β-hydroxysteroid
Bupropion
Hormone released by the pineal gland
metabolized by the liver enzyme CYP1A2 and to a lesser extent by CYP1A1, CYP2C19, and CYP1B1. For both research and clinical purposes, melatonin levels
Melatonin
Class of depressant drugs derived from barbituric acid
Barbiturates induce a number of hepatic CYP enzymes (most notably CYP2C9, CYP2C19, and CYP3A4), leading to exaggerated effects from many prodrugs and decreased
Barbiturate
Antiandrogen medication used in treatment of prostate cancer
inducer of multiple cytochrome P450 enzymes including CYP3A4, CYP2C9, and CYP2C19 and hence has a high potential for clinically relevant drug interactions
Enzalutamide
Chemical compound
pethidine to norpethidine is carried out mainly by the CYP enzymes, CYP2B6, CYP2C19 and CYP3A4, in the liver, and since the activity of these enzymes can vary
Norpethidine
Allergy medication
CYP2D6, and CYP3A4/CYP3A5, and not to inhibit CYP1A2, CYP2C8, CYP2C9, or CYP2C19. Desloratadine was found to be a potent and relatively selective inhibitor
Desloratadine
Study of the role of the genome in drug response
metabolism of 70–80% of all medications used clinically. CYP3A4, CYP2C9, CYP2C19, and CYP2D6 are major CYP enzymes involved in drug metabolism and are all
Pharmacogenomics
Primary male sex hormone
the liver by cytochrome P450 enzymes, including CYP3A4, CYP3A5, CYP2C9, CYP2C19, and CYP2D6. 6β-Hydroxylation and to a lesser extent 16β-hydroxylation
Testosterone
Antibiotic for treatment of tuberculosis
Isoniazid, also known as isonicotinic acid hydrazide (INH), is an antibiotic used for the treatment of tuberculosis. For active tuberculosis, it is often
Isoniazid
List of Cytochrome P450 enzymes
The fluctuation in the amount of CYP450 enzymes (CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5) in phase 1 (detoxification) can have varying
Cytochrome P450 (individual enzymes)
Cytochrome_P450_(individual_enzymes)
Medication
inhibitor of certain cytochrome P450 (CYP) enzymes, including CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4. The drug appears to primarily inhibit CYP1A2
Cimetidine
Antihistamine medication
metabolized by the cytochrome P450 enzymes CYP2D6, CYP1A2, CYP2C9, and CYP2C19. The elimination half-life of diphenhydramine has not been fully elucidated
Diphenhydramine
Nigerian pharmacist and academic
use of proguanil suggested that some Nigerians are carriers of mutant CYP2C19 genes and poor drug metabolizers. Babalola is a recipient of several fellowships
Chinedum_Babalola
Wakefulness-promoting medication
Modafinil is a weak to moderate inducer of CYP3A4 and a weak inhibitor of CYP2C19, enzymes of the cytochrome P450 system. Modafinil also induces or inhibits
Modafinil
Sex hormone
• Albumin: 80% • CBG: 18% • SHBG: <1% • Free: 1–2% Metabolism Hepatic (CYP2C19, CYP3A4, CYP2C9, 5α-reductase, 3α-HSDTooltip 3α-hydroxysteroid dehydrogenase
Progesterone
Chemical compound
effects of apalutamide on other drugs, the exposure of substrates of CYP3A4, CYP2C19, CYP2C9, UDP-glucuronosyltransferase, P-glycoprotein, ABCG2, or OATP1B1
Apalutamide
Anticonvulsant medication
UDP-glucuronosyltransferase, and increase plasma levels of drugs metabolized by CYP2C19. Interaction studies have been conducted with a number of common anticonvulsants
Eslicarbazepine_acetate
Chemical compound
cannabidiol, generated in the body from cannabidiol by the action of the enzyme CYP2C19. While methods have been developed for its synthetic production, and measurement
7-Hydroxycannabidiol
Class of antidepressant medication
S, Poulsen HE, Brøsen K (1996). "Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine". European
Selective serotonin reuptake inhibitor
Selective_serotonin_reuptake_inhibitor
Chemical compound
liver enzymes CYP3A4 and CYP2C19, use of moderate to strong CYP3A4 inhibitors (such as grapefruit juice) and of the CYP2C19 inhibitor fluconazole is discouraged
Selumetinib
Antiretroviral medication
"Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of CYP3A as
Ritonavir
Wakefulness-promoting medication
cytochrome P450 enzymes. It moderately induces CYP3A4 and moderately inhibits CYP2C19. In contrast to modafinil, however, armodafinil does not induce CYP1A2
Armodafinil
Chemical compound
heart rate, and palpitations. Cilostazol is metabolized by CYP3A4 and CYP2C19, two isoenzymes of the cytochrome P450 system. Drugs that inhibit CYP3A4
Cilostazol
Chemical compound
(predominantly the CYP3A4 isozyme, with some contribution from CYP2C9 and CYP2C19) to a multitude of oxygenated derivatives, including 8-OH-HHC and 11-OH-HHC
11-Hydroxyhexahydrocannabinol
Anti-inflammatory drug
Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain
Indometacin
Chemical compound
metabolites neither inhibit nor induce the liver enzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. They also do not induce UGT enzymes. This means that
Racecadotril
Chemical compound
1:34,000, of which 40% of cases are fatal. Felbamate is an inhibitor of CYP2C19 – an enzyme involved in the metabolism of several commonly used medications
Felbamate
Breast cancer drug
needed] Letrozole inhibits the liver enzyme CYP2A6, and to a lesser extent CYP2C19, in vitro, but no relevant interactions with drugs like cimetidine and
Letrozole
Medication used to prevent formation of blood clots
as the estimated 2–14% of the US population who have low levels of the CYP2C19 liver enzyme needed to activate clopidogrel may not get the full effect
Prasugrel
Antifungal medication
inhibitor of the human cytochrome P450 system, particularly the isozyme CYP2C19 (CYP3A4 and CYP2C9 to lesser extent) In theory, therefore, fluconazole
Fluconazole
Stomach acid suppressing medication
Bioavailability 80% or more Protein binding 97% Metabolism Liver (CYP3A4- and CYP2C19-mediated) Elimination half-life 1.0–1.5 hours Excretion Kidney and fecal
Lansoprazole
Pharmacological measurement
(increased rate of metabolism), e.g., Phenytoin induces CYP1A2, CYP2C9, CYP2C19, and CYP3A4 Enzyme inhibition (decreased rate of metabolism), e.g., grapefruit
Bioavailability
Nonsteroidal anti-inflammatory drug
data Bioavailability 80–100% Protein binding 80–90% Metabolism Liver (CYP2C19 and possibly CYP3A), some is also hydrolysed to salicylate in the gut wall
Aspirin
Class of pharmaceutical drugs
unlikely to affect sorafenib. Sorafenib is a competitive inhibitor of CYP2C19, CYP2D6 and CYP3A4. It inhibits P-glycoprotein, therefore it can increase
VEGFR-2_inhibitor
Chemical compound
antacids decreases the absorption of ticlopidine. Ticlopidine inhibits liver CYP2C19 and CYP2B6 and thus can affect blood levels of medications metabolized
Ticlopidine
Chemical compound
quercetin is a strong inhibitor of the cytochrome P450 enzymes CYP3A4 and CYP2C19 and a moderate inhibitor of CYP2D6. Drugs that are metabolized by these
Quercetin
Antidepressant
completely metabolized in the liver; it is a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6 and CYP1A2. Less than 1 percent of the drug is excreted
Moclobemide
Set of cytochrome P450 enzymes
CYP2C19 metabolizes clopidogrel to it active form. Consequently, patients with severe deficiencies in this CYP, i.e. bearers of CYP2C19*3 or CYP2C19*2
Epoxygenase
Cannabis sativa L. (marijuana; hemp) used medicinally
by urine. After delta-9-THC is hydroxylated into 11-OH-THC via CYP2C9, CYP2C19, and CYP3A4, it undergoes phase II metabolism into more than 30 metabolites
Medical_cannabis
Antifungal chemical compound
Ketoconazole, sold under the brand name Nizoral, among others, is an antiandrogen, antifungal, and antiglucocorticoid medication used to treat a number
Ketoconazole
Medication used to treat insomnia
rosuvastatin (a BCRP substrate), and the SSRI citalopram (primarily a CYP2C19 substrate). Daridorexant acts as a selective dual antagonist of the orexin
Daridorexant
Class of chemical compounds
via hepatic cytochrome P450 enzymes, including CYP1A2, CYP2B6, CYP2C9, CYP2C19, and CYP3A4, leading to hydroxylated, dealkylated, and oxidized metabolites
1,2-Diarylethylamine
Antibiotic medication
cytochrome P450 enzyme system, including isoenzymes CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP3A4, CYP3A5, and CYP3A7. It increases metabolism of many drugs and
Rifampicin
Anticonvulsant drug
midazolam and bupropion, respectively). Conversely, it inhibits the enzyme CYP2C19, potentially increasing concentrations of drugs metabolized by this enzyme
Cenobamate
Chemical compound
metabolized by the hepatic enzyme CYP2C19. Some individuals, such as people of Japanese ancestry, are more likely to be poor CYP2C19 metabolizers; that is, their
Azeloprazole
Substituted amphetamine derivative
The compound is metabolized by the cytochrome P450 enzymes CYP2B6 and CYP2C19 into erythro-4'-hydroxy-hydrobupropion and by various glucuronosyltransferase
Erythrohydrobupropion
Class of CNS depressant drugs
N-dealkylation, hydroxylation and glucuronide conjugation.CYP3A4, CYP3A5 and CYP2C19 are primary enzymes in benzodiazepine metabolism. Glucuronidation is mediated
Benzodiazepine
Triazole antifungical drug
Retrieved 30 July 2017. Dean L (December 2019). "Voriconazole Therapy and CYP2C19 Genotype". In Pratt VM, McLeod HL, Rubinstein WS, et al. (eds.). Medical
Voriconazole
Chemical compound
and CYP2C9 via 2-hydroxylation into 2-hydroxyestradiol, and by CYP2C9, CYP2C19, and CYP2C8 via 17β-hydroxy dehydrogenation into estrone, with various
Estradiol
Active metabolite of antidepressant drug doxepin
anticholinergic activities. Nordoxepin is formed from doxepin mainly by CYP2C19 (>50% contribution), while CYP1A2 and CYP2C9 are involved to a lesser extent
Nordoxepin
Atypical antidepressant classified primarily as a melatonin receptor agonist
relatively safe in overdose. Agomelatine is a substrate of CYP1A2, CYP2C9 and CYP2C19. Inhibitors of these enzymes, e.g. the SSRI antidepressant fluvoxamine
Agomelatine
CYP2C19
CYP2C19
CYP2C19
CYP2C19
Male
Polish
Polish form of Greek Hyakinthos, JACENTY means "hyacinth flower."
Girl/Female
Hebrew, Hindu, Indian, Sanskrit
Friend; Infinite; That which cannot be Erased; Limitless; Boundless
Boy/Male
Tamil
God of Yoga
Male
French
Short form of French Théodore, THÉO means "gift of God."
Girl/Female
Arabic, Muslim
Name of a Sahabiyah RA
Girl/Female
Australian, Christian, German, Greek, Lebanese, Swedish
Pearl
Boy/Male
Muslim
Friend of Allah
Boy/Male
Indian, Punjabi, Sikh
Unwavering in Naam
Female
Polish
Polish equivalent of English Alice, ALICJA means "noble sort."
Boy/Male
British, English, Jamaican
Son of Roger
CYP2C19
CYP2C19
CYP2C19
CYP2C19
CYP2C19