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Serotonin modulator antidepressant
Vortioxetine, sold under the brand names Trintellix (in the US) and Brintellix (in Europe) among others, is an antidepressant medication of the serotonin
Vortioxetine
Class of antidepressant medication
describe the mechanism of action of the serotonergic antidepressant vortioxetine, which acts as a serotonin reuptake inhibitor (SRI), agonist of the 5-HT1A
Serotonin modulator and stimulator
Serotonin_modulator_and_stimulator
Chemical compound
tedatioxetine but was focused on another, more advanced Lundbeck drug candidate, vortioxetine. Tedatioxetine reached Phase II clinical trials for major depressive
Tedatioxetine
Class of antidepressant medication
mirtazapine Topiramate trazodone nefazodone The agents vilazodone and vortioxetine are partly atypical. Typical antidepressants include the SSRIs, SNRIs
Atypical_antidepressant
(Serzone) Serotonin modulators and stimulators include: Vilazodone (Viibryd) Vortioxetine (Trintellix, Brintellix) Serotonin antagonist and reuptake inhibitors
List_of_antidepressants
Class of drug
Seproxetine ((S)-norfluoxetine) Trazodone (Desyrel) Vilazodone (Viibryd) Vortioxetine (Trintellix) Cianopramine (Ro 11-2465) Litoxetine (SL-810,385) Lubazodone
Serotonin_reuptake_inhibitor
Medication used to treat premature ejaculation
(2020). "Antistress and antidepressant properties of dapoxetine and vortioxetine". Acta Neurobiologiae Experimentalis. 80 (3): 217–224. doi:10.21307/ane-2020-020
Dapoxetine
Class of drug
generally labeled as serotonin modulator and stimulator.[citation needed] vortioxetine (Trintellix) – another closely related drug generally labeled as a serotonin
Serotonin antagonist and reuptake inhibitor
Serotonin_antagonist_and_reuptake_inhibitor
Class of antidepressant medication
less with atypical antidepressants like bupropion, agomelatine, and vortioxetine. In addition, whereas the SSRI escitalopram was associated with emotional
Selective serotonin reuptake inhibitor
Selective_serotonin_reuptake_inhibitor
Class of CNS depressant drugs
g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2
Benzodiazepine
Class of medication used to treat depression and other conditions
disorder, and fluoxetine was no better than a placebo in clinical trials. Vortioxetine may be of benefit. SSRIs are used as a first-line treatment for social
Antidepressant
SSRI antidepressant
Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine Others Agomelatine Amisulpride Dextromethorphan/bupropion Esketamine
Escitalopram
Class of chemical compounds
2-Methylphenylpiperazine (oMPP) 2-Methoxyphenylpiperazine (oMeOPP) Mefeclorazine Vortioxetine Enpiprazole is known to produce oCPP as a metabolite. It was initially
Substituted_piperazine
SNRI antidepressant
agomelatine, amitriptyline, escitalopram, mirtazapine, paroxetine, and vortioxetine were more effective than other antidepressants, although the quality
Venlafaxine
Medication to prevent nausea and vomiting
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Ondansetron
Muscle relaxant medication
Lubazodone LY-393558 Quipazine SB-649915 TGBA01AD Trazodone Vilazodone Vortioxetine Serotonin–norepinephrine reuptake inhibitors: Atomoxetine (tomoxetine)
Cyclobenzaprine
and long in clinical trials in Japan. Takeda and Lundbeck submitted vortioxetine (Trintellix) to the Ministry of Health, Labour and Welfare in Japan.
Antidepressants_in_Japan
Chemical element with atomic number 54 (Xe)
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Xenon
Colourless non-flammable greenhouse gas
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Nitrous_oxide
Psychedelic drug
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
2C-B
Type of medication
previous drug, with longer intervals for drugs such as fluoxetine and vortioxetine. Switching from one classic MAOI to another is usually handled more cautiously
Monoamine_oxidase_inhibitor
South American psychoactive decoction
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Ayahuasca
Cough suppressant and dissociative drug
Lubazodone LY-393558 Quipazine SB-649915 TGBA01AD Trazodone Vilazodone Vortioxetine Serotonin–norepinephrine reuptake inhibitors: Atomoxetine (tomoxetine)
Dextromethorphan
(oxcarbazepine) – an anticonvulsant used as a mood stabilizer Trintellix (vortioxetine) – an antidepressant of the serotonin modulator and stimulator class
List of psychotropic medications
List_of_psychotropic_medications
SSRI antidepressant
Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine Others Agomelatine Amisulpride Dextromethorphan/bupropion Esketamine
Fluvoxamine
Mushrooms containing psychoactive indole alkaloids
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Psilocybin_mushroom
Beta blocker drug
g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2
Propranolol
SSRI antidepressant
Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine Others Agomelatine Amisulpride Dextromethorphan/bupropion Esketamine
Fluoxetine
Psychedelic drug
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Dimethyltryptamine
Psychoactive substance found in plants in the family Apocynaceae
Lubazodone LY-393558 Quipazine SB-649915 TGBA01AD Trazodone Vilazodone Vortioxetine Serotonin–norepinephrine reuptake inhibitors: Atomoxetine (tomoxetine)
Ibogaine
Benzodiazepine medication
g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2
Alprazolam
Medication used to treat anxiety disorders
g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2
Buspirone
Brazil's federal drug control statute
Valdecoxib Sodium valproate Venlafaxine Veralipride Vigabatrin Vilazodone Vortioxetine Ziprasidone Zotepine Zuclopenthixol Acitretin Adapalene Bexarotene Isotretinoin
Brazilian Controlled Drugs and Substances Act
Brazilian_Controlled_Drugs_and_Substances_Act
Medication mainly used for depression and smoking cessation
Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine Others Agomelatine Amisulpride Dextromethorphan/bupropion Esketamine
Bupropion
Benzodiazepine sedative
g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2
Diazepam
Muscle relaxant medication
g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2
Baclofen
Atypical antipsychotic medication
Lubazodone LY-393558 Quipazine SB-649915 TGBA01AD Trazodone Vilazodone Vortioxetine Serotonin–norepinephrine reuptake inhibitors: Atomoxetine (tomoxetine)
Quetiapine
Group of chemical compounds
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Β-Carboline
Trimipramine Valbenazine, Valproate, Venlafaxine, Vilazodone, Viloxazine, Vortioxetine, Varenicline Xanomeline/trospium chloride Zaleplon, Zimelidine, Ziprasidone
List of psychiatric medications
List_of_psychiatric_medications
Antidepressant medication
Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine Others Agomelatine Amisulpride Dextromethorphan/bupropion Esketamine
Mirtazapine
Gamma-aminobutyric acid analog
g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2
Gabapentin
Antihistamine drug
g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2
Hydroxyzine
Chemical compound found in some species of mushrooms
Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine Others Agomelatine Amisulpride Dextromethorphan/bupropion Esketamine
Psilocybin
Atypical antipsychotic and antiemetic medication
Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine Others Agomelatine Amisulpride Dextromethorphan/bupropion Esketamine
Amisulpride
Psychoactive drug, often called ecstasy
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
MDMA
Benzodiazepine medication
g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2
Clonazepam
Dissociative anesthetic and anti-depressant
Lubazodone LY-393558 Quipazine SB-649915 TGBA01AD Trazodone Vilazodone Vortioxetine Serotonin–norepinephrine reuptake inhibitors: Atomoxetine (tomoxetine)
Ketamine
Medication used to treat ADHD and depression
Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine Others Agomelatine Amisulpride Dextromethorphan/bupropion Esketamine
Viloxazine
Species of psychoactive cactus
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Peyote
Pharmaceutical compound
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Landipirdine
Psychedelic drug
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
LSD
Medication used for the treatment of migraine headaches
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Rizatriptan
Central nervous system stimulant
Lubazodone LY-393558 Quipazine SB-649915 TGBA01AD Trazodone Vilazodone Vortioxetine Serotonin–norepinephrine reuptake inhibitors: Atomoxetine (tomoxetine)
Methylphenidate
CNS depressant medication
g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2
Phenibut
Antidepressant medication
Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine Others Agomelatine Amisulpride Dextromethorphan/bupropion Esketamine
Vilazodone
Fluoroquinolone antibiotic
Sonepiprazole TFMPP Tolpiprazole Trazodone Urapidil Vesnarinone Vilazodone Vortioxetine WAY-100,135 WAY-100,635 Benzylpiperazines 2C-B-BZP 3-Methylbenzylpiperazine
Ciprofloxacin
Atypical antipsychotic medication
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Olanzapine
Tropane alkaloid and stimulant drug
Lubazodone LY-393558 Quipazine SB-649915 TGBA01AD Trazodone Vilazodone Vortioxetine Serotonin–norepinephrine reuptake inhibitors: Atomoxetine (tomoxetine)
Cocaine
Medication mainly used to treat gout
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Colchicine
SNRI antidepressant
Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine Others Agomelatine Amisulpride Dextromethorphan/bupropion Esketamine
Desvenlafaxine
Wakefulness-promoting medication
Lubazodone LY-393558 Quipazine SB-649915 TGBA01AD Trazodone Vilazodone Vortioxetine Serotonin–norepinephrine reuptake inhibitors: Atomoxetine (tomoxetine)
Modafinil
Weight loss medication
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Phentermine
Class of G protein-coupled receptors
blockers) Metoprolol Atenolol Bisoprolol Propranolol Timolol Nebivolol Vortioxetine β2 Isoprenaline > epinephrine > norepinephrine Smooth muscle relaxation
Adrenergic_receptor
Species of cactus
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Echinopsis_lageniformis
Pharmaceutical compound
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Isoergine
SSRI antidepressant
Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine Others Agomelatine Amisulpride Dextromethorphan/bupropion Esketamine
Citalopram
SNRI medication
Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine Others Agomelatine Amisulpride Dextromethorphan/bupropion Esketamine
Duloxetine
Typical antipsychotic medication
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Chlorpromazine
Pharmaceutical compound
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
TMU4142
Benzodiazepine used for anesthesia and procedural sedation
g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2
Midazolam
Pharmaceutical compound
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Bromojimscaline
Pharmaceutical compound
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
MW073
Pharmaceutical compound
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
SB-224289
Anxiolytic drug
g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2
Binospirone
Pharmaceutical compound
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
11-Chloroasimilobine
Class of depressant drugs derived from barbituric acid
g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2
Barbiturate
Cardiovascular medication
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Centhaquine
Medication used to treat ADHD
Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine Others Agomelatine Amisulpride Dextromethorphan/bupropion Esketamine
Atomoxetine
Pharmaceutical compound
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Z5247692566
Drug for angina pectoris sold under many brand names
Sonepiprazole TFMPP Tolpiprazole Trazodone Urapidil Vesnarinone Vilazodone Vortioxetine WAY-100,135 WAY-100,635 Benzylpiperazines 2C-B-BZP 3-Methylbenzylpiperazine
Trimetazidine
Class of medications
Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine Others Agomelatine Amisulpride Dextromethorphan/bupropion Esketamine
Tricyclic_antidepressant
Monoamine neurotransmitter
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Serotonin
Gamma-aminobutyric acid analogs
g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2
Gabapentinoid
Mescaline-containing cactus
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Echinopsis_pachanoi
Chemical compound
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
2C2-NBOMe
Pharmaceutical compound
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
4-AcO-EPT
Medication used to treat Alzheimer's disease
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Memantine
Species of flowering plant
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Valerian_(herb)
Sedating antihistamine
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Promethazine
Naturally occurring psychedelic compound
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Mescaline
CHCl3, historical anaesthetic and common solvent
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Chloroform
Anti-nausea group of medications
Indole 5-HT3 receptor antagonist 5.6 hours CYP 3A3/4/5, CYP2D6 200 μg/kg Vortioxetine Phenylpiperazine 5-HT3 receptor antagonist Antidepressant 66 hours CYP
5-HT3_antagonist
Pharmaceutical compound
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
AOP-208
SSRI antidepressant
Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine Others Agomelatine Amisulpride Dextromethorphan/bupropion Esketamine
Paroxetine
Pharmaceutical compound
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
BK-5-MAPBT
Adrenergic antidepressant
Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine Others Agomelatine Amisulpride Dextromethorphan/bupropion Esketamine
AW-15'1129
Pharmaceutical compound
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
13-Fluorolysergol
Pharmaceutical compound
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
O-Methylanhalonidine
Neurotransmission-modulating substance
anxiolytics, but also as antidepressants. The antidepressants vilazodone and vortioxetine are 5-HT1A receptor partial agonists. Flibanserin, a drug used for female
Serotonin_receptor_agonist
Withdrawn anti-obesity drug combination
hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole
Fenfluramine/phentermine
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