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Immunomodulatory drug which can cause birth defects
Thalidomide, sold under the brand names Contergan, Distaval and Thalomid among others, is an oral administered medication used to treat a number of cancers
Thalidomide
Birth defects linked to thalidomide use
In the late 1950s and early 1960s, thalidomide was prescribed to women in 46 countries who were pregnant or who subsequently became pregnant, and consequently
Thalidomide_scandal
Medical condition
cause of phocomelia is the mother being prescribed the use of the drug thalidomide during pregnancy; however, the causes of most cases are to be determined
Phocomelia
Class of immunomodulatory drugs
immune responses) containing an imide group. The IMiD class includes thalidomide and its analogues (lenalidomide, pomalidomide, mezigdomide, iberdomide
Cereblon_E3_ligase_modulator
English actor
English rock musician, actor, writer and performance artist. He has thalidomide-induced phocomelia. Mat Fraser was born in 1961 or 1962 in Colchester
Mat_Fraser_(actor)
English thalidomide survivor and activist
Australian born English thalidomide survivor and activist. She has chaired the National Advisory Committee of the Thalidomide Trust, advised BBC producers
Michaelina_Argy
Canadian-American physician and pharmacologist (1914–2015)
and Drug Administration (FDA). As a reviewer, she refused to authorize thalidomide for market because she had concerns about the lack of evidence regarding
Frances_Oldham_Kelsey
Subdiscipline of chemistry
example of the importance of stereochemistry relates to the thalidomide disaster. Thalidomide is a pharmaceutical drug, first prepared in 1957 in Germany
Stereochemistry
German pharmaceutical company
the teratogenic drug thalidomide, marketed as the sleeping pill Contergan and promoted as a morning sickness preventive. Thalidomide caused severe birth
Grünenthal
Nonfiction book by Jennifer Vanderbes
Wonder Drug: The Secret History of Thalidomide in America and Its Hidden Victims is a nonfiction book authored by Jennifer Vanderbes and published by
Wonder_Drug_(book)
Study of developmental anomalies
proteins, and DNA, and alter signal transduction. Teratogens such as thalidomide, methamphetamine, and phenytoin are known to enhance ROS formation, potentially
Teratology
considered a side effect. For information regarding birth defects, see thalidomide. Somnolence (drowsiness; ~40%) Edema (~60%) Hypotension (low blood pressure)
List of thalidomide side effects
List_of_thalidomide_side_effects
Australian obstetrician (1927–2018)
Australian obstetrician. He published a letter on the teratogenicity of thalidomide in 1961, following the findings of a midwife named Pat Sparrow. which
William_McBride_(doctor)
Canadian Paralympic swimmer
paralympic gold medallist swimmer, and thalidomide survivor. In 2019, she served as president of the Thalidomide Victims Association of Canada. Lake was
Josée_Lake
2005 British musical by Mat Fraser
Thalidomide!! A Musical is a British musical written and composed by Mat Fraser, who was born with phocomelia as a result of the drug thalidomide being
Thalidomide!!_A_Musical
1962 United States federal health legislation
designed to strengthen drug regulation in the United States due to the thalidomide tragedy, which demonstrated the risks of unsafe and ineffective medications
Kefauver–Harris_Amendment
Pair of enantiomers
adjusted in people with kidney problems. Lenalidomide is closely related to thalidomide, which is known to cause severe birth defects, so its use during pregnancy
Lenalidomide
English gardening expert and TV presenter
born with an upper limb disability called phocomelia caused by the drug Thalidomide, she has 8 in (20 cm) arms and seven fingers. Kent made her television
Sue_Kent
Canadian disabilities activist
gain support for the survivors of thalidomide. Her efforts resulted in life-time compensation for Canadian "thalidomiders", as well as a special fund for
Mercédes_Benegbi
German pediatrician, medical geneticist and dysmorphologist (1919–1995)
geneticist and dysmorphologist who was among the first to recognize the thalidomide syndrome in 1961 and alert the world to the dangers of limb and other
Widukind_Lenz
Protein in humans
activity of thalidomide in the chick and zebrafish was cast into doubt due to a 2013 report that pomalidomide (a more potent thalidomide analogue) does
Cereblon
German classical bass-baritone (born 1959)
and solo jazz improvisations. Born with severe birth defects caused by thalidomide, Quasthoff is 1.34 m (4 ft 4+3⁄4 in), and has phocomelia. Quasthoff was
Thomas_Quasthoff
Mixture with equal amounts of left- and right-handed chiral isomers
the other enantiomer is harmful, like salbutamol and thalidomide. The (R) enantiomer of thalidomide is effective against morning sickness, while the (S)
Racemic_mixture
Condition that serves as a reason not to take a certain medical treatment
that they are absolutely contraindicated in pregnancy; examples include thalidomide and isotretinoin. Relative contraindications are contraindications for
Contraindication
Nazi doctor
pharmaceutical company, where he further developed the infamous drug thalidomide which had been synthesized in 1952 by Chemical Industry Basel. Aggressively-marketed
Heinrich_Mückter
British businesswoman, artist and disability rights campaigner (born 1960)
prescribed thalidomide in pregnancy. She is known for her advocacy work on behalf of disabled people, her role in establishing the Thalidomide Memorial
Rosaleen_Moriarty-Simmonds
British journalist and writer (1928–2020)
seek compensation for mothers who had taken the morning sickness drug thalidomide, which led to their children having severely deformed limbs. In 1984
Harold_Evans
Chemical reaction(s) which favor one chiral isomer over another
following the thalidomide disaster the development and licensing of drugs changed dramatically. First synthesized in 1953, thalidomide was widely prescribed
Enantioselective_synthesis
Nausea due to pregnancy
anticoagulant properties. In the late 1950s and early 1960s, the use of thalidomide in 46 countries by women who were pregnant or who subsequently became
Morning_sickness
Class of drugs
wildly in their pharmacokinetic, pharmacodynamic profile. The tragedy of thalidomide illustrates the potential for extreme consequences resulting from the
Chiral_drugs
American law firm
subject to an ethics investigation and sanction over its handling of thalidomide litigation involving alleged birth defects. Hagens Berman was founded
Hagens_Berman
British chemist (1902–1972)
generally available. In the 1960s, Phillips was a key whistleblower in the thalidomide scandal. Phillips married Helena May Matilda Holland (1902–1980) in June
Montague_Phillips_(chemist)
American cardiologist (1898–1986)
rather than by sound. Taussig is also known for her work in banning thalidomide and was widely recognized as a highly skilled physician. She was the
Helen_B._Taussig
Genetic disorder affecting blood vessel development
that are weak and therefore prone to bleeding. Because thalidomide is a teratogen, thalidomide is considered by many to be a last resort therapy, and
Hereditary hemorrhagic telangiectasia
Hereditary_hemorrhagic_telangiectasia
Paraneoplastic syndrome
improvement) in patients treated with thalidomide plus dexamethasone compared to patients treated with a thalidomide placebo plus dexamethasone. Since VEGF
POEMS_syndrome
Chemical compound
compound of pomalidomide, thalidomide, was originally discovered to inhibit angiogenesis in 1994. Based upon this discovery, thalidomide was taken into clinical
Pomalidomide
Organic compound, core structure of many drugs
structural component in several pharmacologically active compounds, including thalidomide, lenalidomide, cycloheximide, and glutethimide, which exhibit immunomodulatory
Glutarimide
Former alcoholic beverages company
was also responsible for the manufacture of the drug Thalidomide in the United Kingdom. Thalidomide had been developed by Grunenthal with whom, in July
The_Distillers_Company
Malformation of the limbs
inherited), e.g. via amniotic band syndrome teratogenic drugs (e.g. thalidomide, which causes phocomelia) or environmental chemicals ionizing radiation
Congenital_limb_deformities
American actress and thalidomide victim (born 1932)
of controversy when she sought an abortion after discovering that the thalidomide she had been taking caused serious fetal deformities when used in the
Sherri_Chessen
Cancer of plasma cells
are the major side effects of thalidomide and lenalidomide. Lenalidomide causes more myelosuppression, and thalidomide causes more sedation. Chemotherapy-induced
Multiple_myeloma
Protein-coding gene in humans
complexes containing Cereblon are also targeted by the teratogenic drug thalidomide. Human CUL4B is 913 amino acids long and shares a high degree of sequence
CUL4B
Failure of limb(s) to develop during embryonic growth
as thalidomide. A prosthesis can be given to compensate for the missing limb(s). Amniotic band constriction Dysmelia Hemimelia Phocomelia Thalidomide Bowen
Amelia_(birth_defect)
British actor and victim of thalidomide
Terrence 'Terry' Wiles (born 12 January 1962) was one of the most visible thalidomide babies born in the United Kingdom. He has since become known internationally
Terry_Wiles
US pharmaceutical company
Richardson-Merrell's best-known incidents revolved around its efforts to introduce thalidomide into the US market in the 1950s and 1960s under the brand name "Kevadon"
Marion_Merrell_Dow
Industry involved with discovery, development, production and marketing of drugs
Company of Cincinnati, submitted a new drug application for Kevadon (thalidomide), a sedative that had been marketed in Europe since 1956. The FDA medical
Pharmaceutical_industry
American singer
composer, singer, and songwriter who was born without arms. His mother took thalidomide while pregnant, which caused his disability. Meléndez has learned to
Tony_Meléndez
Australian radiologist (1935–2023)
Injury as being the pathogenesis of congenital malformations of the thalidomide type. She was also one of the instigators of BreastScreen NSW. McCredie
Janet_McCredie
Human disease
ruptures can be caused by:[citation needed] teratogenic drugs (e.g. thalidomide, which causes phocomelia), or environmental chemicals ionizing radiation
Congenital_amputation
Scottish general practitioner
known for his letter on his observations of neurological side effects of thalidomide, published on 31 December 1960 in the British Medical Journal, and noticed
Leslie_Florence
2008 documentary directed by Niko von Glasow
powerful campaign for the victims of thalidomide. NoBody's Perfect explores the specific problems which the twelve thalidomide victims faced during their lives
NoBody's_Perfect
Topics referred to by the same term
human embryology nomenclature Thalidomide embryopathy, a congenital deformation related to the use of the drug thalidomide Thioescaline, a psychoactive
TE
1981 Canadian science fiction horror film
ephemerol also mirrors the real-life thalidomide scandal, in which the popular West German medication thalidomide caused severe birth defects in children
Scanners
Act of the Parliament of the United Kingdom
The act was introduced following problems with the off-label use of thalidomide. The act established the forerunner to the current Commission on Human
Medicines_Act_1968
lives by January 1958. 66 "Children of Thalidomide" Thalidomide scandal 1958 The immunomodulatory drug thalidomide is first introduced in the European market
List of references in We Didn't Start the Fire
List_of_references_in_We_Didn't_Start_the_Fire
Lady Mayoress of London
Mayoress of London and advocate for thalidomide-affected babies and children. She founded a charity for thalidomide-affected children, the Lady Hoare Trust
Mary_Hoare,_Lady_Hoare
Type of drug
interactions which may trigger hypertensive crisis and/or serotonin syndrome. Thalidomide — originally prescribed for morning sickness, withdrawn in 1961 owing
Drug_of_last_resort
Inflammation of fat tissue under the skin
Corticosteroids and colchicine can be used in severe refractory cases. Thalidomide has been used successfully in the treatment of Erythema nodosum leprosum
Erythema_nodosum
English influencer (born 2000)
"Mikey" Argy, was born with shortened arms due to a birth defect from thalidomide, a sleeping pill developed in Germany. Michaelina was awarded an MBE
Madeline_Argy
German personal care product manufacturer
Grünenthal, which famously developed and marketed the embryopathic drug Thalidomide; and Dalli-Group. Mäurer & Wirtz now produces detergents, soap products
Mäurer_&_Wirtz
Organic compound
Dimethylamine can also be used. Some examples of phthalimide drugs include thalidomide, amphotalide, taltrimide, talmetoprim, and apremilast. With a trichloromethylthio
Phthalimide
American painter
Chicago politics, Daley Machine, 1968) and social issues (Homage to Spain, Thalidomide Children and Others, 1965) that in their focus on generalized dehumanization
Seymour_Rosofsky
Small molecule (PROTAC)
TL 12-186, a thalidomide-based PROTAC targeting the protein GSPT1, a translation termination factor
Proteolysis_targeting_chimera
Syndrome causing muscle loss
cachexia. The use of anti-inflammatory medications have been investigated. Thalidomide, an anti-inflammatory agent, has shown promise in preventing weight loss
Cachexia
Israeli physician (1914–1999)
Israeli physician best known for his 1964 serendipitous discovery that thalidomide can be used as a treatment for leprosy at Hadassah University in Jerusalem
Jacob_Sheskin
Toxicity as observed in the development of an organism
deficiency), drugs (e.g. anticancer drugs, tetracyclines, many hormones, thalidomide), and toxic environmental chemicals (e.g. mercury, lead, dioxins, PBDEs
Developmental_toxicity
Substance that inhibits the growth of new blood vessels
can also be harmful when used inappropriately. Thalidomide is one such antiangiogenic agent. Thalidomide was given to pregnant women to treat nausea. However
Angiogenesis_inhibitor
a young skinhead, Martin Atchitson, who grew up in 1970s London with thalidomide-related birth defects. Milligan has said the story partially addresses
Skin_(graphic_novel)
Stereoisomers that are nonsuperposable mirror images of each other
case for lactic acid. An example of such an enantiomer is the sedative thalidomide, which was sold in a number of countries around the world from 1957 until
Enantiomer
Protein-coding gene in humans
Cereblon, was discovered to be a major target of the teratogenic agent thalidomide. CUL4A protein is 759 amino acids long and forms an extended, rigid structure
CUL4A
Contergan Skandal, also known as the thalidomide disaster/tragedy, which makes reference to the drug thalidomide first marketed in 1957 in West Germany
Theresia_Degener
Pharmaceutical compound
2-7239 Ro 5-2537 RU-22930 RU-56187 RU-57073 RU-58642 RU-58841 Seviteronel Thalidomide Topilutamide (fluridil) Valproic acid Vinclozolin YM-580 YM-92088 YM-175735
Arcarine
Ratio of activity of drug enantiomers
antidepressant citalopram was isolated and marketed as the drug escitalopram. Thalidomide is a drug whose two enantiomers cause distinctly different effects from
Eudysmic_ratio
Chemical compound
Avadomide (CC-122) is an experimental cereblon E3 ligase modulator, or thalidomide analog (molecular glue) that was discovered and studied by Celgene to
Avadomide
Topics referred to by the same term
political party in Trinidad and Tobago Thalidomide, lenalidomide and pomalidomide, in the development of analogs of thalidomide drugs Thermolysin-like proteinase
TLP
Conversion of an optically active chemical compound into an inactive form
antagonist. Racemization of pharmaceutical drugs can occur in vivo. Thalidomide as the (R) enantiomer is effective against morning sickness, while the
Racemization
Antispasmodic agent
lawsuits due to allegations that it had caused birth defects similar to thalidomide, which Merrell had also marketed in the US and Canada. In the 1980s,
Dicycloverine
British multinational financial services company
previously headed its Australian operation. Peet helped the campaign for Thalidomide children, Legal & General then owning a large bloc of shares (3.5 million)
Legal_&_General
Program that monitors medications with a high potential for serious adverse effects
serious birth defects; clozapine, which can cause agranulocytosis; and thalidomide, which is used to treat leprosy and certain cancers but causes serious
Risk Evaluation and Mitigation Strategies
Risk_Evaluation_and_Mitigation_Strategies
Chemical compound
2-7239 Ro 5-2537 RU-22930 RU-56187 RU-57073 RU-58642 RU-58841 Seviteronel Thalidomide Topilutamide (fluridil) Valproic acid Vinclozolin YM-580 YM-92088 YM-175735
Arabilin
American biopharmaceutical company
THALOMID (thalidomide). Dr. Reddy's Laboratories sought the material for bioequivalency studies required to bring its own, generic, version of thalidomide to
Celgene
1989 single by Billy Joel
people, mostly in Lincoln, Nebraska. Children of Thalidomide: Many pregnant women taking the drug Thalidomide had children born with congenital birth defects
We_Didn't_Start_the_Fire
American lawyer
verdicts for plaintiffs in civil litigation, including the first in a thalidomide case. Butler was also known as a civil rights leader and an art collector
James_G._Butler
American businessman (1854–1919)
S. Representative from North Carolina. Thalidomide – Richardson-Merrell Inc. attempted to market thalidomide in the U.S. and was denied by the U.S. Food
Lunsford_Richardson
Emergency or complex health system that affects the public
Sinclair's book The Jungle. 1918-1920: Spanish flu 1963: Birth defects by thalidomide 1981: Toxic oil syndrome or simply toxic syndrome HIV/AIDS 1996: Bovine
Health_crisis
Detailed medical report on a patient
For example, the recognition of the link between administration of thalidomide to mothers and malformations in their babies was triggered by a case
Case_report
London art dealer (born 1939)
1939) is a London art dealer and Thalidomide parent activist. He is the father of a daughter, Louise, disabled by thalidomide. Mason was educated at Highgate
David_Mason_(art_dealer)
Hypothesis that prenatal conditions shape long-term health and related outcomes
The thalidomide disaster (late 1950s–early 1960s) caused an epidemic of severe congenital malformations in children whose mothers used thalidomide during
Fetal_origins_hypothesis
Medical condition
Zeldis JB (15 October 2008). "Seven-year median time to progression with thalidomide for smoldering myeloma: partial response identifies subset requiring
Smouldering_myeloma
Chemical compound
2-7239 Ro 5-2537 RU-22930 RU-56187 RU-57073 RU-58642 RU-58841 Seviteronel Thalidomide Topilutamide (fluridil) Valproic acid Vinclozolin YM-580 YM-92088 YM-175735
ACP-105
hypocalcaemia, hypokalaemia, peripheral neuropathy and thromboembolism. Thalidomide PO As above. Multiple myeloma, erythema nodosum leprosum and the following
List_of_antineoplastic_agents
Pharmaceutical compound
2-7239 Ro 5-2537 RU-22930 RU-56187 RU-57073 RU-58642 RU-58841 Seviteronel Thalidomide Topilutamide (fluridil) Valproic acid Vinclozolin YM-580 YM-92088 YM-175735
Rosolutamide
American surgeon and research biologist (1933–2008)
convinced the patient's doctor to try thalidomide, and that doctor ended up conducting a clinical trial of thalidomide for people with multiple myeloma in
Judah_Folkman
2022 novel by Cormac McCarthy
schizophrenia due to hallucinations of a deformed figure the narrator named "Thalidomide Kid" who perpetually teases and belittles her and summons his ghostly
The Passenger (McCarthy novel)
The_Passenger_(McCarthy_novel)
British national daily newspaper
magazine opined that: As Watergate is to [The] Washington Post, and thalidomide to [The] Sunday Times, so phone-hacking will surely be to The Guardian:
The_Guardian
Study of mental functions and behaviors
studies included the MIT-Harvard Fernald School radioisotope studies, the Thalidomide tragedy, the Willowbrook hepatitis study, Stanley Milgram's studies of
Psychology
Chemical compound
2-7239 Ro 5-2537 RU-22930 RU-56187 RU-57073 RU-58642 RU-58841 Seviteronel Thalidomide Topilutamide (fluridil) Valproic acid Vinclozolin YM-580 YM-92088 YM-175735
Nandrolone_nonanoate
Chemical compound
2-7239 Ro 5-2537 RU-22930 RU-56187 RU-57073 RU-58642 RU-58841 Seviteronel Thalidomide Topilutamide (fluridil) Valproic acid Vinclozolin YM-580 YM-92088 YM-175735
1-Testosterone
Motivational speaker and radio broadcaster
broadcaster. Law was born without arms as a consequence of his mother's use of thalidomide while pregnant. His birth parents put him up for adoption, and he was
Alvin_Law
Organic chemical compound
2-7239 Ro 5-2537 RU-22930 RU-56187 RU-57073 RU-58642 RU-58841 Seviteronel Thalidomide Topilutamide (fluridil) Valproic acid Vinclozolin YM-580 YM-92088 YM-175735
Azelaic_acid
THALIDOMIDE
THALIDOMIDE
THALIDOMIDE
THALIDOMIDE
Male
Italian
Italian form of Latin Josephus, GIUSEPPE means "(God) shall add (another son)."Â
Boy/Male
Muslim
Joyful
Boy/Male
Assamese, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Oriya, Tamil, Telugu
Command; Message; Order
Surname or Lastname
English
English : habitational name from any of the places called Bradshaw, for example in Lancashire and West Yorkshire, from Old English brÄd ‘broad’ + sceaga ‘thicket’.
Girl/Female
American, Anglo, Australian, British, Chinese, Christian, English, German, Greek, Latin, Spanish, Swedish
Beloved; Man; Pure; Abbreviation of Caridad; Dear; Darling; A Star in the Orion Constellation
Boy/Male
Muslim
Servant of the supreme inheritor
Boy/Male
Tamil
Victorious, Peepal tree, Holy tree, Buddha got wisdom under it
Girl/Female
Australian, French, Latin
Feminine Similar to Fabian; From the Roman Family Name Fabius
Girl/Female
Celtic Latin
An oath.
Male
Native American
Native American Dakota name WICASA means "sage."
THALIDOMIDE
THALIDOMIDE
THALIDOMIDE
THALIDOMIDE
THALIDOMIDE