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Search references for CYP2E1. Phrases containing CYP2E1
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Enzyme found in humans
Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism
CYP2E1
Alternate ethanol oxidizing system in human metabolism
requires the CYP2E1 enzyme, part of the cytochrome P450 family of enzymes, to convert ethanol to acetaldehyde. Ethanol’s affinity for CYP2E1 is lower than
Microsomal ethanol oxidizing system
Microsomal_ethanol_oxidizing_system
Medication for pain and fever
metabolic pathway (5–15%) of oxidation by cytochrome P450 enzymes, mainly by CYP2E1, forms a toxic metabolite known as NAPQI (N-acetyl-p-benzoquinone imine)
Paracetamol
Hydrocarbon compound (C6H6)
P450 2E1 (CYP2E1), quinine oxidoreductase (NQ01 or DT-diaphorase or NAD(P)H dehydrogenase (quinone 1)), GSH, and myeloperoxidase (MPO). CYP2E1 is involved
Benzene
Species of flowering plant in the cabbage family
the nation's watercress capital. By inhibiting the cytochrome P450 enzyme CYP2E1, the phenethyl isothiocyanate within watercress may cause adverse drug interactions
Watercress
Class of enzymes
the name when referring to the gene. For example, CYP2E1 is the gene that encodes the enzyme CYP2E1—one of the enzymes involved in paracetamol (acetaminophen)
Cytochrome_P450
Organic compound
metabolism of ethanol is additionally aided by the cytochrome P450 enzyme CYP2E1 in humans, while trace amounts are also metabolized by catalase. The resulting
Ethanol
Central nervous system stimulant
Bioavailability 99% Protein binding 10–36% Metabolism Primary: CYP1A2 Minor: CYP2E1, CYP3A4, CYP2C8, CYP2C9 Metabolites Paraxanthine 84% Theobromine 12% Theophylline
Caffeine
Central nervous system stimulant
CES1-only framework. Accumulating evidence strongly indicates that CYP2B6, CYP2E1, and CYP3A4 contribute substantially to the clearance and metabolic fate
Dexmethylphenidate
Chemical compound
paracetamol (acetaminophen), theophylline and caffeine. Disulfiram is a potent CYP2E1 inhibitor, explaining how it reduces the metabolism of several other medicines
Disulfiram
Muscle relaxant
reduced the paracetamol-induced toxicity via competitive inhibition of CYP2E1-mediated metabolism". Future Journal of Pharmaceutical Sciences. 9 (1) 34
Chlorzoxazone
Biochemical modification of drugs or foreign compounds by living organisms
Cytochrome P450 enzymes, like CYP2E1, which enhances the metabolism of ethanol. As a consequence, the induction of CYP2E1 will increase a person's tolerance
Drug_metabolism
Chemical compound and histologic stain
of CYP1A1, CYP1A2 and CYP1B1, as well as a weak inhibitor of CYP2A6 and CYP2E1. Madder has been cultivated as a dyestuff since antiquity in central Asia
Alizarin
Organic compound ((CH3)2CO); simplest ketone
atmospheric chemistry of acetone. Acetone can then be metabolized either by CYP2E1 via methylglyoxal to D-lactate and pyruvate, and ultimately glucose/energy
Acetone
Active ingredient in fermented drinks
Weakly or not at all Metabolism Liver (90%): • Alcohol dehydrogenase • MEOS (CYP2E1) Metabolites Acetaldehyde; acetic acid; acetyl-CoA; carbon dioxide; water;
Alcohol_(drug)
Medication
is formed from it by the cytochrome P450 system (specifically, CYP1A2, CYP2E1, and CYP3A4). Cimetidine is used in cancer metastasis research as a blocker
Cimetidine
Pharmacodynamics and pharmacokinetics of ethanol
specifically mediated by the cytochrome P450 enzyme CYP2E1, is another major route of ethanol metabolism. CYP2E1 is predominantly active at higher concentrations
Pharmacology_of_ethanol
Bitter alkaloid of the cacao plant
subsequently into methyluric acid. Important enzymes include CYP1A2 and CYP2E1. The elimination half life of theobromine is between 6 and 8 hours. Unlike
Theobromine
Chemical compound
metabolize caffeine into 1,3,7-trimethyluric acid in humans include CYP1A2, CYP2E1, CYP2C8, CYP2C9, and CYP3A4. "1,3,7-trimethyluric acid". PubChem Compound
1,3,7-Trimethyluric_acid
Hypnotic medication
weakly bound to plasma protein. Cytochrome P450 (CYP) isozymes CYP3A4 and CYP2E1 are involved in the biotransformation of eszopiclone; thus, drugs that induce
Eszopiclone
Toxicity due to paracetamol overdose
paracetamol toxicity. Chronic excessive alcohol consumption can induce CYP2E1, thus increasing the potential toxicity of paracetamol. In one study of
Paracetamol_poisoning
Hypnotic medication
playing the most significant role in zopiclone metabolism are CYP3A4 and CYP2E1. In addition, about 50% of the administered dose is decarboxylated and excreted
Zopiclone
Sedative/Hypnotic medication for alcohol withdrawal
acts on chloride ion channels.[citation needed] Clomethiazole is a potent CYP2E1 enzyme inhibitor which slows down the metabolism of ethanol, hence its use
Clomethiazole
Microscopic anatomical divisions of the liver
histologically; the detoxifying zone III cells have the highest concentration of CYP2E1 and thus are most sensitive to NAPQI production in acetaminophen toxicity
Lobules_of_liver
SSRI antidepressant
82%. Escitalopram does not inhibit CYP3A4, CYP1A2, CYP2C9, CYP2C19, or CYP2E1. Exposure to escitalopram is increased moderately, by about 50%, when it
Escitalopram
Medication used to treat Alzheimer's disease
CYP3A4/5, CYP1A2, CYP2D6, and CYP2C9. It also does not inhibit CYP2A6 or CYP2E1. However, it might have a small effect on CYP2B6. The oral bioavailability
Memantine
Antibiotic medication
Bioavailability 70 to 80% Protein binding 70 to 90% Metabolism Liver (mostly CYP2E1-mediated) Elimination half-life 20 to 30 hours Excretion Kidney Identifiers
Dapsone
Group of chemical compounds
medications. In human volunteers, in vivo inhibition includes CYP1A2 and CYP2E1 through use of probe drugs to measure inhibition. Its anxiolytic and hepatotoxic
Kavalactone
Muscle relaxant
CYP1A2 and CYP2C19, an inhibitor of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A, and an inducer of CYP1A2 and CYP3A4. Nirogi et al. reported
Metaxalone
Drug used to treat respiratory diseases
Protein binding 40% (primarily to albumin) Metabolism Hepatic: CYP1A2, CYP2E1, CYP3A4 Metabolites • 1,3-Dimethyluric acid • 1-Methylxanthine • 3-Methylxanthine
Theophylline
Chemical compound
of CYP1A1, CYP1A2 and CYP1B1, as well as a weak inhibitor of CYP2A6 and CYP2E1. Madder root has been used for dying cloth at least since 1500 BC. Purpurin
1,2,4-Trihydroxyanthraquinone
Medical condition
CYP1A2, CYP2B6, CYP2E1, CYP2C8, and CYP1A1. The first four seem to be involved in the hydroxylation of toluene to benzyl alcohol. CYP2E1 seems to be the
Toluene_toxicity
Field of study
on regulatory regions of mouse Cyp2e1 has been associated with the metabolism mediated by its encoded protein. Cyp2e1 mediated hydroxylation of its probe
Pharmacoepigenetics
Class of vitamins
Vitamin B3, colloquially referred to as niacin, is a vitamin family that includes three forms, or vitamers: nicotinic acid (niacin), nicotinamide (niacinamide)
Vitamin_B3
Class of medications
cimetidine is an inhibitor of the P450 enzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4. By reducing the metabolism of drugs through these enzymes, cimetidine
H2_receptor_antagonist
Toxic byproduct of acetaminophen
metabolized via the cytochrome P-450 pathway (to be specific, CYP3A4 and CYP2E1) into NAPQI, which is extremely toxic to liver tissue, as well as being
NAPQI
oxidase Category:Cytochrome P450 Aromatase EC 1.14.14.1 CYP2D6 EC 1.14.14.1 CYP2E1 EC 1.14.14.1 CYP3A4 EC 1.14.14.1 Cytochrome P450 oxidase Category:EC 1.14
List_of_enzymes
Peripheral D2 receptor antagonist
involved in the N-dealkylation of domperidone, while CYP3A4, CYP1A2, and CYP2E1 are involved in its aromatic hydroxylation. All of the metabolites of domperidone
Domperidone
Combination pain relief drug
Hydrocodone: extensively liver, primarily CYP3A4; /Paracetamol: liver, CYP2E1 Elimination half-life for hydrocodone: 228–294 mins (3.8–4.9 hrs); for paracetamol:
Hydrocodone/paracetamol
Change in the action or side effects of a drug caused
3, and the most important enzymes are CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4. The majority of the enzymes are also involved in the metabolism
Drug_interaction
List of Cytochrome P450 enzymes
other P450s. Watercress is also a known inhibitor of the cytochrome P450 CYP2E1, which may result in altered drug metabolism for individuals on certain
Cytochrome P450 (individual enzymes)
Cytochrome_P450_(individual_enzymes)
Medication used to treat absence seizures
only) Pharmacokinetic data Bioavailability 93% Metabolism liver (CYP3A4, CYP2E1) Elimination half-life 53 hours Excretion kidney (20%) Identifiers IUPAC
Ethosuximide
General anaesthetic
controlled substances) US: ℞-only Pharmacokinetic data Metabolism Hepatic (CYP2E1) Excretion Kidney, respiratory Identifiers IUPAC name 2-Bromo-2-chloro-1
Halothane
Chemical compound formerly used as a refrigerant
species-specific metabolic differences (specifically the activity of the CYP2E1 enzyme in mouse kidneys but not in humans). Bromomethane Dichloromethane
Chloromethane
Medication
Fomepizole, also known as 4-methylpyrazole, is a medication used to treat methanol and ethylene glycol poisoning. It may be used alone or together with
Fomepizole
Aryl amine
Lidocaine-Induced Methemoglobinemia Is Caused by Human Carboxylesterase-, CYP2E1-, and CYP3A4-Mediated Metabolic Activation". Drug Metab. Dispos. 41 (6):
O-Toluidine
Vitamer of Vitamin B3
progression of atherosclerosis. Nicotinic acid inhibits cytochrome P450 enzymes CYP2E1, CYP2D6 and CYP3A4. Niacin produces a rise in serum unconjugated bilirubin
Nicotinic_acid
Discomfort following alcohol consumption
cortisol, and glucose in blood and urine samples. Alcohol also induces the CYP2E1 enzyme, which metabolizes ethanol and other substances into more reactive
Hangover
Chemical compound
(70–80% CYP1A2-mediated; minor contributions from CYP2C9, CYP2C19, CYP2D6 and CYP2E1) Elimination half-life 2.4 hours Excretion Urine (80%) Identifiers IUPAC
Pirfenidone
COX-2 inhibitor compound
rutaecarpine may be at least a weak inhibitor of CYP1A2, CYP2C9, CYP2C19, CYP2E1, and CYP3A4 enzymes. At the same time, it is believed to be a strong inducer
Rutecarpine
Biological process of increasing toxicity
metabolite NAPQI via the cytochrome P450 oxidase system, mainly by the subfamily CYP2E1. Hepatic reduced glutathione (GSH) will detoxify this formed NAPQI quickly
Toxication
Inhalational anaesthetic
(Prescription only) US: ℞-only EU: Rx-only Pharmacokinetic data Metabolism Liver by CYP2E1 Metabolites Hexafluoroisopropanol Elimination half-life 15–23 hours Excretion
Sevoflurane
Major metabolite of the antidepressant bupropion
the cytochrome P450 enzyme CYP2B6. However, CYP2C19, CYP3A4, CYP1A2, and CYP2E1 appear to play a minor role. CYP2B6 is highly polymorphic and is subject
(2R,3R)-Hydroxybupropion
Liver damage caused by a drug or chemical
cells. Activation of some enzymes in the cytochrome P-450 system such as CYP2E1 also lead to oxidative stress. Injury to hepatocyte and bile duct cells
Hepatotoxicity
Anticonvulsant drug
glucuronidation via the enzyme UGT2B7 and to a lesser extent UGT2B4. The enzymes CYP2E1, CYP2A6, CYP2B6, CYP2C19 and CYP3A4 play smaller roles in the drug's metabolism
Cenobamate
Tripelennamine Zuclopenthixol Dexamethasone Glutethimide Haloperidol Rifampicin CYP2E1 Cimetidine Niacin (nicotinic acid) and its form – niacinamide (nicotinamide)
List of cytochrome P450 modulators
List_of_cytochrome_P450_modulators
American medical toxicologist and pediatrician
Ramachandran A, Rumack BH, Wallace DP, Jaeschke H. Lack of mitochondrial Cyp2E1 drives acetaminophen-induced ER stress-mediated apoptosis in mouse and human
Barry_Rumack
Chemical compound
because it lacks the ability to interfere with the cytochrome enzymes CYP1A2, CYP2E1 and CYP3A4, thus preventing significant interaction with other drugs metabolized
Doxofylline
Enzyme in the human body
Metabolism/Transport Effects: Substrate of CYP1A2 (minor), CYP2B6 (minor), CYP2C9 (minor), CYP2E1 (minor), CYP3A4 (major), P-glycoprotein/ABCB1; Note: Assignment of Major/Minor
CYP1A2
Inhalational anesthesia medication
by albumin in the human body and is minimally metabolized by cytochrome CYP2E1 in the liver, which produces a metabolite trifluoroacetic acid and is eliminated
Desflurane
Substances which increase efficacy of drugs
S2CID 23346527. Bedada SK, Boga PK (December 2017). "Effect of piperine on CYP2E1 enzyme activity of chlorzoxazone in healthy volunteers". Xenobiotica; the
Bioenhancer
Cellular molecules that help resolve inflammation
first metabolized to 22-hydroxy-DHA by CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP2E1, or CYP3A4 and then metabolized through the cited epoxide-forming pathways
Specialized pro-resolving mediators
Specialized_pro-resolving_mediators
Class of compounds
P450 (CYP) epoxygenases, CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP2J2, and CYP2S1 metabolize arachidonic acid to the non-classic epoxyeicosatrienoic
Eicosanoid
Medical sign
dehydrogenase) Ethanol + NADPH + H+ + O2 → Acetaldehyde + NADP+ + 2H2O (catalyzed by CYP2E1) Acetaldehyde + NAD+ → Acetate + NADH + H+ (catalyzed by aldehyde dehydrogenase)
Pseudohypoxia
Set of biological processes
further metabolized to isopropanol which is excreted in breath/urine, or by CYP2E1 into hydroxyacetone (acetol). Acetol can be converted to propylene glycol
Fatty_acid_metabolism
Taking measures to decrease cancer incidence
Papadakis M, Jamal R, et al. (November 23, 2022). "Association between CYP2E1 polymorphisms and colorectal cancer risk: a systematic review and meta-analysis"
Cancer_prevention
Chemical compound
proteins. Secondly, methacrylonitrile can be metabolised in the liver by CYP2E1 (a Cytochrome-P450 enzyme). This is the most important enzyme for the oxidative
Methacrylonitrile
Chemical synthesis of ketone bodies
acetoacetate decarboxylase. It can then be further metabolized either by CYP2E1 into hydroxyacetone (acetol) and then via propylene glycol to pyruvate,
Ketogenesis
Medical condition
cells. Alcohol is metabolized to acetaldehyde in the liver via the enzymes CYP2E1 and aldehyde dehydrogenase. Acetaldehyde forms reactive oxygen species in
Alcoholic_hepatitis
Chemical compound
metabolized in the liver by the Cytochrome P-450 enzyme system (mainly CYP2E1) to cyanide. The absorption and distribution of allyl cyanide in rats is
Allyl_cyanide
Chemical compound
Cycloleucine treatment in conjunction with higher levels of cytochrome P450 2E1 (CYP2E1) and lower SAM levels in pyrazole hepatocytes[clarification needed] had
Cycloleucine
Study of interactions between the toxicant and a biological target
metabolized to trichloromethyl and trichloromethyl peroxy radicals by the CYP2E1 enzyme. The more reactive radical, trichloromethyl peroxy, can attack polyunsaturated
Toxicodynamics
Type of drugs
range Avoid drugs inducing / inhibiting CYP1A2 and CYP2E1 Caution Metabolised by CYP1A2 and CYP2E1 Smoking can induce methylxanthine metabolism Contraindications
Commonly_prescribed_drugs
Chemical compound
Sodium diethyldithiocarbamate is the organosulfur compound with the formula (CH3CH2)2NCS−2Na+. It is a pale yellow, water soluble salt. It is a precursor
Sodium_diethyldithiocarbamate
Chemical compound
experiments with rat and human liver microsomes suggest that the CYP450 enzyme CYP2E1 hydroxylates indole into indoxyl. Subsequently, indoxyl is converted into
Indoxyl_sulfate
Protein-coding gene in the species Homo sapiens
Yang M, Coles BF, Delongchamp R, et al. (2003). "Effects of the ADH3, CYP2E1, and GSTP1 genetic polymorphisms on their expressions in Caucasian lung
Aldehyde dehydrogenase 3 family, member A1
Aldehyde_dehydrogenase_3_family,_member_A1
Pharmacology of the antiparkinsonian and antidepressant selegiline
cytochrome P450 enzymes, including CYP1A2, CYP2A6, CYP2C8, CYP2D6, CYP2C19, and CYP2E1, may also be involved. One review concluded that CYP2B6 and CYP2C19 are
Pharmacology_of_selegiline
Chemical compound
amines, in animals. Pargyline is N-demethylated and N-depropargylated by CYP2E1 to form arylalkylamine and other metabolites including benzylamine, N-methylbenzylamine
Pargyline
Chemical compound
conjugation, sulfate conjugation or oxidation. The CYP450 dependent (CYP1A2, CYP2E1, and CYP3A4) oxidation pathway produces a reactive metabolite that conjugates
Benzhydrocodone
Chemical compound
Pharmacokinetic data Bioavailability n/a Protein binding 78% Metabolism Hepatic (CYP2E1) Elimination half-life 75 hours Excretion Renal Identifiers IUPAC name 1
Mitoxantrone
Chemical compound
Oxidation of acrylamide, catalyzed by the enzyme cytochrome P450 2E1 (CYP2E1) gives glycidamide. Saturated fatty acids protect the acrylamide from forming
Glycidamide
Chemical compound
subfamily, CYP3A4. In humans, CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP2J2, CYP3A4, and CYP2S1 metabolize EPA to EEQs, in most cases forming
Epoxyeicosatetraenoic_acid
Chemical compound
trifluoroacetaldehyde. The compound can also be produced if halothane is oxidized using CYP2E1. This is also done with CYP2A6 instead of CPY2E1, but less readily. Trifluoroacetyl
Trifluoroacetyl_chloride
Set of cytochrome P450 enzymes
or more PUFAs include CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP2J2, CYP2S1, CYP3A4, CYP4F2, CYP4F3A, CYP4F3B, CYP4A11, CYP4F8, and
Epoxygenase
Chemical compound
Indazole, also called isoindazole, is a heterocyclic aromatic organic compound. This bicyclic compound consists of the fusion of benzene and pyrazole.
Indazole
cytochrome p-450 cyp2d6 inducers MeSH D27.505.389.249.600 – cytochrome p-450 cyp2e1 inducers MeSH D27.505.389.249.700 – cytochrome p-450 cyp3a inducers MeSH D27
List_of_MeSH_codes_(D27)
biotransformed to produce reactive intermediates. Acetaminophen is metabolized by CYP2E1 to produce NAPQI, which then causes significant oxidative stress due to
Pharmacotoxicology
Medication for the treatment of atrial fibrillation
Vernakalant does not inhibit the enzymes CYP3A4, CYP1A2, CYP2C9, CYP2C19, CYP2E1, nor the transporter protein P-gp. The molecule has three asymmetric carbon
Vernakalant
Class of enzymes
"Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1". The Journal of Pharmacology and Experimental Therapeutics. 294 (2): 473–479
Flavin-containing monooxygenase
Flavin-containing_monooxygenase
P33261 3873 CYP2D6 HGNC:2625; P10635 3874 CYP2D7 HGNC:2624; A0A087X1C5 3875 CYP2E1 HGNC:2631; P05181 3876 CYP2F1 HGNC:2632; P24903 3877 CYP2J2 HGNC:2634; P51589
List of human protein-coding genes 2
List_of_human_protein-coding_genes_2
Group of chemical compounds
epoxygenases. CYP1A1, CYP1A2, CYP2C18, CYP2E1, CYP4A11, CYP4F8, and CYP4F12 also metabolize DHA to EDPs. CYP2C8, CYP2C18, CYP2E1, CYP2J2, VYP4A11, CYP4F8, and
Epoxydocosapentaenoic_acid
944 – cytochrome p-450 cyp2d6 MeSH D08.244.453.040.972 – cytochrome p-450 cyp2e1 MeSH D08.244.453.040.986 – cytochrome p-450 cyp3a MeSH D08.244.453.085 –
List_of_MeSH_codes_(D08)
Chemical compound
responses. Various cytochrome P450 enzymes (e.g. CYP1A1, CYP1A2, CYP1B1, CYP2E1, CYP2S1, and CYP3A4) metabolize PGG2 and PGH2 to 12-HHT and MDA. While the
12-Hydroxyheptadecatrienoic acid
12-Hydroxyheptadecatrienoic_acid
Protein-coding gene in the species Homo sapiens
Wang J, Liu JM (2002). "The FANCG Fanconi anemia protein interacts with CYP2E1: possible role in protection against oxidative DNA damage". Carcinogenesis
Fanconi anemia group G protein
Fanconi_anemia_group_G_protein
cytochrome p-450 cyp2d6 MeSH D12.776.422.220.453.040.944 – cytochrome p-450 cyp2e1 MeSH D12.776.422.220.453.040.972 – cytochrome p-450 cyp3a MeSH D12.776.422
List_of_MeSH_codes_(D12.776)
Chemical compound
Worrall S, Etheridge N, Dodd PR, Wilce PA, et al. (2015). "Expression of CYP2E1 and CYP2U1 proteins in amygdala and prefrontal cortex: Influence of alcoholism
20-Hydroxyeicosatetraenoic acid
20-Hydroxyeicosatetraenoic_acid
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CYP2E1
CYP2E1
CYP2E1
CYP2E1
CYP2E1
CYP2E1
CYP2E1
CYP2E1
CYP2E1
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