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Medical condition
Diabetic foot ulcer is a breakdown of the skin and sometimes deeper tissues of the foot that leads to sore formation. It is thought to occur due to abnormal
Diabetic_foot_ulcer
Medical condition
infection, diabetic foot ulcer and neuropathic osteoarthropathy is called diabetic foot syndrome. The resulting bone deformity is known as Charcot foot. Due
Diabetic_foot
Inflamed break in bodily tissue that impedes function of the affected organ
fissure, an ulcer or tear near the anus or within the rectum Diabetic foot ulcer, a major complication of the diabetic foot Callous ulcer, a chronic nonhealing
Ulcer
Medical condition
They most often form following a diabetic foot ulcer, though not all foot ulcers become infected. Diabetic foot ulcers can be caused by vascular disease
Diabetic_foot_infection
Cast designed to take weight of the foot
off of the foot (off-loading) in patients with diabetic foot ulcers (DFUs). Reducing pressure on the wound by taking weight off the foot has proven to
Total_contact_casting
Shoes intended to reduce the risk of skin breakdown in diabetics
skin breakdown in diabetics with existing foot disease and relieve pressure to prevent diabetic foot ulcers. People with diabetic neuropathy in their
Diabetic_shoe
Type of cutaneous condition
diseases. Diabetic foot ulcer: a major complication of diabetes mellitus, and probably the major component of the diabetic foot. Venous ulcer: thought
Ulcer_(dermatology)
Blood product used in transfusion medicine
that the growth factors present in PRP are vital in the healing of diabetic foot ulcers; specifically in their closure. The treatments were reported to significantly
Platelet-rich_plasma
Method of measuring skin conductance
PMID 34684109. Wang, Xuan; Yuan, Chong-Xi; Xu, Bin; Yu, Zhi (2022-12-15). "Diabetic foot ulcers: Classification, risk factors and management". World Journal of Diabetes
Electrochemical skin conductance
Electrochemical_skin_conductance
Skin sore on the hands and feet due to insufficient blood flow
of sensation due to diabetic neuropathy. Prevention is the first step in avoiding the development of an arterial insufficiency ulcer. Preventative steps
Arterial_insufficiency_ulcer
Chemical compound
been marketed by Heber Biotech as an intralesional injection for diabetic foot ulcer under the trade name Heberprot-P since 2006. As of 2016, Heberprot-P
Nepidermin
Pharmaceutical compound
is used for treating: Painful diabetic neuropathy, Diabetic foot ulcers, Endothelial dysfunction associated with diabetic peripheral neuropathy, Hyperhomocysteinemia
Metanx
Chinese biopharmaceutical company
under development include thermal burns, diabetic foot ulcers (DFUs), fresh wounds, pressure ulcers, radiation ulcers, dry eye syndrome, corneal injury, photodermatitis
B&K_Corporation
Medical condition
chronic wounds. Chronic wounds such as venous leg ulcers, arterial ulcers, diabetic foot ulcers, pressure ulcers, and malignant wounds can have an enormous impact
Chronic_wound_pain
Group of endocrine diseases characterized by high blood sugar levels
footwear is widely used to reduce the risk of diabetic foot ulcers by relieving the pressure on the foot. Foot examination for patients living with diabetes
Diabetes
Medical specialty that focuses on the design and application of orthoses
prevention of diabetic foot ulcers. A real-time weight bearing orthotic can be created using a neutral position casting device and the Vertical Foot Alignment
Orthotics
Use of a curette to remove tissue
subsequent culture is more accurate than ulcer base swan culture or aspiration and culture for diabetic foot ulcers.[citation needed] Curettage is also used
Curettage
Device manufacturing company
IDRT received premarket approval from the FDA for the treatment of diabetic foot ulcers. In 2018, Integra LifeSciences was included in Fortune’s list of
Integra_LifeSciences
Pharmaceutical compound
topical use. It is in clinical trials for infections secondary to diabetic foot ulcer. Baker B (December 2020). "1289. Pravibismane is a Potent, Broad
Pravibismane
South Korean biotechnology company
and HGF 723. In addition to DPN, Engensis is also being studied in diabetic foot ulcers (DFU), amyotrophic lateral sclerosis (ALS), coronary artery disease
Helixmith
Wound that does not heal quickly
revascularization, for example in diabetic ulcers, and patients with venous ulcers may undergo surgery to correct vein dysfunction. Diabetics that are not candidates
Chronic_wound
Topics referred to by the same term
Dartmouth College Device Firmware Upgrade mechanism, for USB devices Diabetic foot ulcer Drain fixture unit, a unit of measure in plumbing This disambiguation
DFU
Infection of the bones
drug users. Diabetic neuropathy Smoking (in patients with diabetes and healing fractures) History of multiple foot ulcers, larger foot ulcers and inflammation
Osteomyelitis
Medical condition
Scott G (March–April 2013). "The diabetic foot examination: A positive step in the prevention of diabetic foot ulcers and amputation". Osteopathic Family
Complications_of_diabetes
Wound care by maggot therapy
chronic ulcers. In diabetic foot ulcers there is tentative evidence of benefit. A Cochrane review of methods for the debridement of venous leg ulcers found
Maggot_therapy
Type of self-adhesive pad for wounds
donor sites, burns, and cutaneous ulcers (including pressure ulcers or "bed sores", venous ulcers, and diabetic foot ulcers). Small hydrocolloid patches are
Hydrocolloid_dressing
Chemical compound
and tissue repair, demonstrated in treatment of tendinopathy and diabetic foot ulcers. The mechanism involves activation of adenosine A2A receptors, upregulating
Polydeoxyribonucleotide
Degeneration of a weight-bearing joint due to loss of sensation
of the Charcot-foot (active stage grade 0), which is potentially reversible, was not part of Eichenholtz's scheme. Diabetic foot ulcers should be treated
Neuropathic_arthropathy
Indian diabetologist
infection guidelines in 2015 and recommendations for footwear for diabetic foot ulcers in 2019. He will be part of the wound healing and offloading working
Vijay_Viswanathan
Type of tissue death by ischemia
effectiveness of hyperbaric oxygenation therapy in the management of chronic diabetic foot ulcers". Mayo Clinic Proceedings. 88 (2): 166–175. doi:10.1016/j.mayocp
Gangrene
Disruption or damage to living tissue
consideration in many chronic wounds, such as diabetic foot ulcers, pressure ulcers, and venous ulcers. Acute wounds will be located in areas consistent
Wound
Pharmaceutical compound
wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions
Polyhexanide
Neurological complication of persistently high blood sugar
monofilament for the insensate diabetic foot: a systematic review of randomized trials to prevent the occurrence of plantar foot ulcers in patients with diabetes"
Diabetic_neuropathy
Medical condition
a long-lasting, usually painless ulcer that penetrates deep into or through the skin, usually on the sole of the foot (in which case it may be called malum
Malum_perforans
Thickened and hardened area of skin
; Meneses, Patricio; Ennis, William J. (January–February 1999). "Diabetic foot ulcers: A framework for prevention and care" (PDF). Wound Repair and Regeneration
Callus
Chemical compound
management of radiation cystitis, is effective in the treatment of diabetic foot ulcers, and is used in wound healing, where the mechanism of action is activation
Tetrachlorodecaoxide
Skin sore sustained by a vasculatory disease
such as squamous cell carcinoma (Marjolin's ulcer) or myelodysplastic syndrome; neuropathy (e.g., diabetic peripheral neuropathy); or atypical infections
Venous_ulcer
Medical procedure
such as high-grade bone sarcomas, and vascular conditions such as diabetic foot ulcers. As the techniques in chemotherapy, radiation, and diagnostic modalities
Limb-sparing_techniques
Therapeutic technique
open fractures, pressure injuries or pressure ulcers, diabetic foot ulcers, venous insufficiency ulcers, some types of skin grafts, burns, and sternal
Negative-pressure wound therapy
Negative-pressure_wound_therapy
Severe form of peripheral artery disease
2025-03-26 Packer, Corrine F.; Ali, Syed Awab; Manna, Biagio (2025), "Diabetic Foot Ulcer", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 29763062
Chronic limb threatening ischemia
Chronic_limb_threatening_ischemia
Group of pore-formng peptides from the skin and intestines of frogs
(MSI-78) that the company developed as a topical agent for infected diabetic foot ulcers; in 1999 the FDA rejected the application because pexiganan was not
Magainin
Protein that stimulates cell division and differentiation
factor, sold under the brand name Heberprot-P, is used to treat diabetic foot ulcers. It can be given by injection into the wound site, or may be used
Epidermal_growth_factor
Species of bacterium
lactolyticus along A. vaginalis can be a dominant species in Diabetic foot and pressure ulcers. It can also participate in polymicrobial infections of the
Anaerococcus_lactolyticus
Medical treatment at raised ambient pressure
tinnitus presenting in the same time frame. HBOT in diabetic foot ulcers increased the rate of early ulcer healing but does not appear to provide any benefit
Hyperbaric_medicine
Natural wound dressing
power. There is no evidence of superior effectiveness in those with diabetic foot ulcers. The gelling properties of alginates are attributed to the presence
Alginate_dressing
Medical condition
Advanced trench foot often involves blisters and open sores, which lead to fungal infections; this is sometimes called tropical ulcer (jungle rot). If
Immersion_foot_syndromes
Medical condition
required as the metabolic problems are corrected. Efforts to prevent diabetic foot ulcers are also important. It typically takes a few days for the person
Hyperosmolar hyperglycemic state
Hyperosmolar_hyperglycemic_state
Chemical compound
for acne. The drug was also under development for the treatment of diabetic foot ulcers, but development for this indication was discontinued. Pyrilutamide
Pyrilutamide
American podiatric surgeon and researcher
Assessment Guidelines, and the concept of "the diabetic foot in remission," an effort to maximize ulcer-free, hospital-free, and activity-rich days for
David_G._Armstrong
Management of diabetes
anyone considering the procedure. Foot monitoring can help in predicting the likelihood of developing diabetic foot ulcers, a common complication in persistent
Diabetes_management
Series of events that restore integrity to damaged tissue after an injury
healing of acute wounds. Additionally, diabetic individuals are susceptible to developing chronic diabetic foot ulcers, a serious complication of diabetes
Wound_healing
Medical garment
A diabetic sock is a non-restrictive, but close fitting garment designed to alleviate internal pressures on the foot or leg. Typically sufferers of diabetes
Diabetic_sock
Pharmaceutical drug
diabetic neuropathic ulcers. It is also known as "platelet-derived growth factor BB". Becaplermin is used for the treatment of diabetic foot ulcers.
Becaplermin
American podiatric surgeon and television commentator (1979–2024)
Wound. American College of Foot and Ankle Surgeons. Providence, Rhode Island. Powers, Kelly (January 2012). Diabetic Foot Ulcer Complicated By Still's Disease:
Kelly_Powers
Medical removal of dead, damaged, or infected tissue
therapy. In podiatry, practitioners such as chiropodists, podiatrists and foot health practitioners remove conditions such as calluses and verrucas. Debridement
Debridement
Wound closure technique using external oxygen exposure
wounds treated with TCOT have become more common in diabetic foot ulcers, venous stasis and decubitus ulcers (pressure sores). TCOT involves inserting a thin
Transdermal continuous oxygen therapy
Transdermal_continuous_oxygen_therapy
Mammalian protein found in Homo sapiens
altered in non-cancer disease states. In diabetic foot ulcers (DFU), ITGA1 is upregulated in wound tissues from diabetic patients and in advanced glycation
Integrin_alpha-1
American Biomedical company
allografts for skin grafts to address persistent wounds such as diabetic foot ulcers that often result in amputation, burns, and other urgent health issues
MiMedx
Medical procedure that removes a part of the body
2008). "Mortality rates and diabetic foot ulcers: is it time to communicate mortality risk to patients with diabetic foot ulceration?". Journal of the
Amputation
American biotechnology firm (1981–2006)
active ingredient, becaplermin, in Regranex, a topical treatment for diabetic foot ulcers, manufactured by Ortho-McNeil Pharmaceutical Inc. In 2001, Chiron
Chiron_Corporation
Chemical compound
furuncles, carbuncles, cellulitis, paronychia, impetigo contagiosa, diabetic foot ulcers and abscesses caused by Staphylococcus aureus and Streptococcus pyogenes
Sultamicillin
Topical drug delivery dosage form
(January 2022). "Topical gel-based biomaterials for the treatment of diabetic foot ulcers". Acta Biomaterialia. 138: 73–91. doi:10.1016/j.actbio.2021.10.045
Topical_gels
Differences in foot structure and shape
Gayle E. (2005). "Relationship between foot type, foot deformity, and ulcer occurrence in the high-risk diabetic foot". The Journal of Rehabilitation Research
Foot_type
Ultrasonic, non-invasive, outpatient treatment
long-term outcomes in diabetic patients with foot ulcers. Randomised controlled trials into the use of ESWT for healing venous leg ulcers are needed as there
Extracorporeal shockwave therapy
Extracorporeal_shockwave_therapy
Chemical compound
numerous other diseases including heart failure, macular degeneration, diabetic foot ulcers and hypertension, though it is currently only medically approved
Elamipretide
Preventable adverse effect of medical care
Helgi B.; Klabukov, Ilya D. (October 29, 2021). "Misdiagnosis of diabetic foot ulcer in patients with undiagnosed skin malignancies". International Wound
Medical_error
Tissue damage after return of blood supply following ischemia or hypoxia
and failure to heal of chronic wounds such as pressure sores and diabetic foot ulcer. Continuous pressure limits blood supply and causes ischemia, and
Reperfusion_injury
receiving MPPT closed. MPPT has also been used on diabetic foot ulcers and venous leg ulcers, including ulcers that were chronic and non-healing and in all
Micropore_particle_technology
Physiological molecule and therapeutic drug
reviews of its effect on healing for chronic wounds including burns, diabetic foot ulcers or surgical skin repairs show either insufficient evidence or only
Hyaluronic_acid
Antibiotic derived from Penicillin
mastitis, skin infections, external ear infections, infections of leg ulcers, diabetic foot infections, and bone infections. It may be used together with other
Flucloxacillin
Regenerative medical device platform
the treatment of acute and chronic wounds, including diabetic foot ulcers (DFU) and venous leg ulcers (VLU). Endoform™ Natural has been shown to accelerate
Ovine_forestomach_matrix
Species of spider with venomous bite native to US
gangrenosum Infection by Staphylococcus Infection by Streptococcus Herpes Diabetic ulcers Fungal infection Chemical burns Toxicodendron dermatitis Squamous cell
Brown_recluse_spider
of surgical and other chronic wounds or ulcers such as diabetic foot ulcers, venous ulcers, pressure ulcers etc. Microbial synergy also helps with eliminating
Microbial_synergy
Form of diabetes mellitus
disease, stroke, kidney failure (Diabetic Nephropathy), foot ulcers, and damage to the eyes (diabetic retinopathy). As insulin lowers blood sugar levels,
Type_1_diabetes
Former vice-chancellor of King Edward Medical University (1954 - 2019)
Singapore Med J, Vol. 48, No. 3, 2007 Topical therapy for neuropathic diabetic foot ulcers, Esculapio: Vol. 1, No.4. Jan–March 2006 "Profile of Faisal Masud"
Faisal_Masud
Species of lichen
Escherichia coli and Staphylococcus aureus, which are common pathogens in diabetic foot ulcers. Furthermore, extracts from this species showed significant antiviral
Parmotrema_perlatum
Medical research company
Wound Journal reported the efficacy of Grafix for the treatment of diabetic foot ulcers. CEO Lode Debrabandere resigned in 2016 in conjunction with activities
Osiris_Therapeutics
ulcers including diabetic foot ulcers and venous foot ulcers. It received premarket approval from the FDA in 2001 for the treatment of diabetic foot ulcers
Dermal_equivalent
Disease of the blood vessels
stroke and peripheral vascular disease which contributes to the diabetic foot ulcers and the risk of amputation. In microangiopathy, the walls of the
Angiopathy
Genus of bacteria
to be linked with an impairment of wound-healing in patients with diabetic foot ulcers if present in abundance during the initial infection. The currently
Peptoniphilus
Hospital in Baden-Württemberg, Germany
recognised for type 1 and type 2 diabetics (stage 1 and 2) and as an in-patient treatment centre for complicated diabetic foot ulcers according to the guidelines
German Diabetes Center Mergentheim
German_Diabetes_Center_Mergentheim
Gene editing method
large-scale EVs (Extracellular vesicles) to reduce angiogenesis for diabetic foot ulcers, thus reducing death danger. Combination of CRISPR-Cas9 with integrases
CRISPR_gene_editing
Interdisciplinary research center
Bibliography (2007) Quality of Life of Adults with Unhealed and Healed Diabetic Foot Ulcers (2006) Depressive symptoms among older adults in urban and rural
Alberta_Centre_on_Aging
Family of zinc-dependent metalloendopeptidases
MMP-1 releases growth factors that enhance cancer metastasis, and in diabetic foot ulcers it slows healing by over-degrading tissues. MMP-8 levels rise in
Matrix_metalloproteinase
Species of bacterium
that has been isolated from human wounds. In the reported case of a diabetic foot ulcer, there was no evidence supporting a causative role for the organism
Bordetella_trematum
Infection caused by anaerobic bacteria
often polymicrobial in nature, and sometimes (i.e. decubitus ulcers, diabetic foot ulcer) they are complicated by bacteremia and/or osteomyelitis. Infections
Anaerobic_infection
Medical field involved in regenerating tissues
substitutes and advanced wound dressings to treat deep third-degree burns, diabetic foot ulcers, and extensive chronic wounds. Unlike traditional occlusive dressings
Regenerative_medicine
American podiatrist (born 1978)
lower-extremity amputation rate. His other notable works include the Diabetic Foot Ulcer Guidelines from the Wound Healing Society and a co-author of the
Lee_Rogers_(podiatrist)
Indian-American scientist
Closure Is Associated With Increased Recurrence of Diabetic Foot Ulcers: The NIDDK Diabetic Foot Consortium TEWL Study". Diabetes Care. 48 (7): 1233–1240
Chandan_K._Sen
Unfavorable result of disease or medical treatment
foot with inadequate blood flow can progress to ulcers and become infected. Individuals with diabetic neuropathy may not notice the damage and may develop
Complication_(medicine)
Class of chemical substances
phosphatidylcholine – trans-resveratrol: promotes foot ulcer regeneration in patients with diabetes 2. Diabetic foot ulcer images before and after 60-day trans-resveratrol
Carotenoid_complex
Unspecialized biological cell that can become specialized
(2022-04-27). "Stem and Somatic Cell Monotherapy for the Treatment of Diabetic Foot Ulcers: Review of Clinical Studies and Mechanisms of Action". Stem Cell
Stem_cell
Organomercuric antiseptic for external use on minor cuts
antisepsis of wounds with inhibited scar formation, such as neuropathic ulcers and diabetic foot sores. When applied on a wound, it stains the skin a distinctive
Merbromin
American chemist
(2016-01-10). "Association of diabetic foot ulcer and death in a population-based cohort from the United Kingdom". Diabetic Medicine. 33 (11): 1493–1498
Millicent_Sullivan
British scientist
Footwear and Other Removable Off-loading Devices in the Treatment of Diabetic Foot Ulcers: A Systematic Review". Current Diabetes Reviews. 10 (4): 215–230
Nachiappan_Chockalingam
American biomedical engineering professor
team developed a regenerative bandage which is designed to heal diabetic foot ulcers. The bandage is a liquid that upon contact with the injured tissue
Guillermo_Ameer
Hospital in New York, United States
is not only prescribed for patients with wounds, such as diabetic foot ulcers or venous ulcers, but is also an effective treatment for such conditions
Northern_Westchester_Hospital
Medical dressing based on hydrogels
Sohan; Speak, Katharine (2013-07-12). "Hydrogel dressings for healing diabetic foot ulcers". Cochrane Database of Systematic Reviews. 2013 (7) CD009101. doi:10
Hydrogel_dressing
Study of pressure fields between foot and a supporting surface
biomechanical function of the foot. The most widely researched clinical application of pedobarography is diabetic foot ulceration, a condition which can
Pedobarography
Bacterial infection
circulation in the legs, leading to diabetic foot or foot ulcers. Neural degeneration in diabetes may cause these ulcers not to be painful, and so remain
Cellulitis
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