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Physiological molecule and therapeutic drug
Hyaluronic acid (/ˌhaɪ.əljʊəˈrɒnɪk/; HA; conjugate base hyaluronate), also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed
Hyaluronic_acid
Microbial hyaluronic acid production refers to the process by which microorganisms, such as bacteria and yeast, are utilized in fermentation to synthesize
Microbial hyaluronic acid production
Microbial_hyaluronic_acid_production
Fillers for cosmetic skin smoothing
expanding their functionality beyond structural augmentation. Hyaluronic acid Hyaluronic acid is one of the most common materials used for injectable filler
Injectable_filler
Polysaccharides found in animal tissue
N-linked glycosylation or O-linked glycosylation of the proteoglycan Hyaluronic acid (also known as hyaluronan), which is synthesized by integral membrane
Glycosaminoglycan
Structural support for biological cells
Hyaluronic acid is thus found in abundance in the ECM of load-bearing joints. It is also a chief component of the interstitial gel. Hyaluronic acid is
Extracellular_matrix
Chemical compound
salt of hyaluronic acid, a glycosaminoglycan found in various connective tissue of humans. Sodium hyaluronate is the sodium salt of hyaluronic acid. It is
Sodium_hyaluronate
Injectable cosmetic filler
reduce wrinkles in the faces of patients. The substance is largely hyaluronic acid, a substance normally found in the skin, muscles, and tendons of mammals
Juvéderm
Folds of throat tissues that help to create n through vocalization
hyaluronic acid (HA) content is high. HA is a bulky, negatively charged glycosaminoglycan, whose strong affinity with water procures hyaluronic acid its
Vocal_cords
Form of arthritis caused by degeneration of joints
studies for hyaluronic acid injections of the hip and knee only showed a minor benefit. In other studies, injections of hyaluronic acid have not produced
Osteoarthritis
Species of bacterium
zooepidemicus is encapsulated, with a capsular polysaccharide containing hyaluronic acid, as well as being facultative anaerobes. The cells usually form in
Streptococcus_zooepidemicus
Class of enzymes
Hyaluronidases are a family of enzymes that catalyse the degradation of hyaluronic acid. Karl Meyer classified these enzymes in 1971, into three distinct groups
Hyaluronidase
prostaglandin E2, increase glycosaminoglycan production, and may increase hyaluronic acid production. The degree of these effects in horses after intramuscular
Treatment_of_equine_lameness
Inflammation of the knee joint
viscosupplementation (including hyaluronic acid injections), and glucosamine and chondroitin sulphate. Hyaluronic acid is normally present in joints (including
Knee_arthritis
Injectable cosmetic filler
fillers with a specific formulation of hyaluronic acid (HA). In the United States, Restylane was the first hyaluronic acid filler to be approved by the U.S
Restylane
Fluid found in the cavities of synovial joints
fluid contains 3–4 mg/ml hyaluronan (hyaluronic acid), a polymer of disaccharides composed of D-glucuronic acid and D-N-acetylglucosamine joined by alternating
Synovial_fluid
Polysaccharide found in brown algae
distribution and suitability for encapsulating cells or labile biomolecules. Hyaluronic acid: a polysaccharide in animals. Agar Davies, Jane C. (June 2002). "Pseudomonas
Alginic_acid
Method of delivering drugs into a joint
anti-inflammatory agents, the most common of which are corticosteroids. Hyaluronic acid, because of its high viscosity, is sometimes used to replace bursa
Joint_injection
Natural water-soluble glycoprotein
applications. Acetyl hexapeptide-3 GHK-Cu Glycyl-prolyl-hydroxyproline Hyaluronic acid KPV tripeptide Matrikine Palmitoyl pentapeptide-4 Polydeoxyribonucleotide
Silk_peptides
Protein allowing tissue in the body to resume shape after stretching
a skin-booster formulation containing amino acids, copper sulfate, and non-cross-linked hyaluronic acid (Elastic Lab). In five participants receiving
Elastin
Medical condition
topical hyaluronic acid can be used as another option which has been shown to be safe and effective. For mild atrophic vaginitis, hyaluronic acid can be
Atrophic_vaginitis
Cell-surface glycoprotein
and tumor metastasis. CD44 is a receptor for hyaluronic acid and internalizes metals bound to hyaluronic acid and can also interact with other ligands, such
CD44
Protein-coding gene in the species Homo sapiens
an enzyme that in humans is encoded by the HAS2 gene. Hyaluronan or hyaluronic acid is a high molecular weight unbranched polysaccharide synthesized by
HAS2
Japanese skin care brand
known for their hyaluronic acid products and for offering eco-friendly refill pouches. Their flagship offering, the Super Hyaluronic Acid Moisturizing Lotion
Hada_Labo
Cosmetic procedure
the lips using botulinum neurotoxin type A and occasionally adding hyaluronic acid fillers. The procedure is performed in order to increase the size of
Lip_flip
Bile acid
Deoxycholic acid is a bile acid. Deoxycholic acid is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. The two primary
Deoxycholic_acid
Injectable drug
as keratan sulfate and chondroitin sulfate attached to strands of hyaluronic acid. The glycosaminoglycan side chains are polyanionic, which causes adjacent
Polysulfated glycosaminoglycan
Polysulfated_glycosaminoglycan
Technique aimed to increase the size of a human penis
Administration (FDA) for use in the penis. Injectables such as hyaluronic acid and polyactic acid have shown some limited efficacy, however the Sexual Medicine
Penis_enlargement
Chinese biomaterial company
biomaterial company based in China. Bloomage primarily specializes in hyaluronic acid and other bioactive substance products. It is listed on the Shanghai
Bloomage
Tube surgically implanted in the body
for the injection of cosmetic wrinkle fillers like hyaluronic acid, collagen, poly-L-lactic acid, CaHA, etc., or for fat transfer (Liposuction). The
Cannula
Crest on the top of the head of some gallinaceous birds
characteristic jester's cap; a shape of pasta (creste di galli); and so on. Hyaluronic acid, which is used in skincare and medical treatments to hydrate and maintain
Comb_(anatomy)
Chemical compound
composites, hyaluronic acid is a delivery medium for OCP. Hyaluronic-OCP scaffolds are synthesized by simply mixing OCP granules with hyaluronic acid at a controlled
Octacalcium_phosphate
Medical surgical specialty
feature or section of the face. One type of dermal filler is hyaluronic acid. Hyaluronic acid is naturally found throughout the human body. It plays a vital
Plastic_surgery
Extracellular non-fibrous substance
substance include hyaluronic acid, heparan sulfate, dermatan sulfate, and chondroitin sulfate. With the exception of hyaluronic acid, GAGs are bound to
Ground_substance
Long carbohydrate polymers such as starch, glycogen, cellulose, and chitin
) Thiol groups are covalently attached to polysaccharides such as hyaluronic acid or chitosan. As thiolated polysaccharides can crosslink via disulfide
Polysaccharide
Chemical compound
reactive compounds. It is typically stored with a stabilizer in a weakly acidic solution in an opaque bottle. Hydrogen peroxide is found in biological systems
Hydrogen_peroxide
Broad term for specialties that focus on altering cosmetic appearance
today are botulinum neurotoxin, commonly referred to as botox, and hyaluronic acid fillers. According to statistics from an annual survey conducted by
Aesthetic_medicine
Hungarian biochemist (1920–2015)
He devoted seven decades to exploring the therapeutic potential of hyaluronic acid. He was inducted into the New Jersey Inventors Hall of Fame in 2012
Endre_Alexander_Balázs
Chemical compound
"Synthesis of hyaluronic acid hydrogels by crosslinking the mixture of high-molecular-weight hyaluronic acid and low-molecular-weight hyaluronic acid with 1
1,4-Butanediol diglycidyl ether
1,4-Butanediol_diglycidyl_ether
Blood product used in transfusion medicine
might be more effective in reducing pain and improving function than hyaluronic acid in knee arthritis. This therapeutic effect is not only considered to
Platelet-rich_plasma
American zoologist (1943–2022)
membrane structure. He is credited with discovering that adult cells make hyaluronic acid from glucosamine, which led the way to glucosamine being used to treat
Ronald_Cohn
Devices to replace damaged ligaments
hydrophilicity. Hyaluronic acid coatings can reduce hydrophobicity and have been shown to reduce scar tissue formation and inflammation in vivo. Hyaluronic acid and
Artificial_ligament
Medical intervention
medical aesthetic procedure in which injectable fillers, most commonly hyaluronic acid ones like Restylane and Juvederm or calcium hydroxyapatite (Radiesse)
Non-surgical_rhinoplasty
In vitro fertilization procedure
receptor for hyaluronic acid, which they need because this acid can be found surrounding the oocytes, and sperm need to be able to bind to this acid and digest
Intracytoplasmic sperm injection
Intracytoplasmic_sperm_injection
Gelatinous substance within the umbilical cord
within the umbilical cord, largely made up of mucopolysaccharides (hyaluronic acid and chondroitin sulfate). It acts as a mucous connective tissue containing
Wharton's_jelly
Polysaccharide layer that lies outside the cell envelope in many bacteria
polysaccharides. Bacillus anthracis Streptococcus pyogenes synthesizes a hyaluronic acid capsule. Streptococcus pneumoniae has at least 91 different capsular
Bacterial_capsule
Nonsteroidal anti-inflammatory drug
United States, with more than 9 million prescriptions. It is available as its acid or in two salts, as either diclofenac sodium or potassium. Diclofenac is
Diclofenac
Polymers that break down by bacterial decomposition
chitosan, hyaluronic acid, and hydrogels. In particular, poly(2-hydroxyethyl-methacrylate), polyethylene glycol, chitosan, and hyaluronic acid have been
Biodegradable_polymer
Chemical compound
4-Aminobenzoic acid (also known as para-aminobenzoic acid or PABA because the two functional groups are attached to the benzene ring across from one another
4-Aminobenzoic_acid
Cosmetic procedure
a non-animal, clear gel that is reported to be very close to the hyaluronic acid found naturally in the body. According to the American Society of Plastic
Lip_augmentation
Biomedical engineering discipline
have all proved suitable in terms of cell compatibility. Among GAGs, hyaluronic acid, possibly in combination with cross linking agents (e.g. glutaraldehyde
Tissue_engineering
Chemical compound
Italian study evaluated the effects of a nutraceutical composed of MSM, hyaluronic acid, and L-carnosine. The results from RCT showed broad improvements in
Methylsulfonylmethane
as hyaluronan-binding proteins, are proteins capable of binding to hyaluronic acid. Most hyaladherins belong to the Link module superfamily, including
Hyaladherin
Chemical compound used as an antihemorrhagic
capillary membranes by polymerizing hyaluronic acid. Etamsylate limits capillary bleeding through its action on hyaluronic acid and initial studies showed a
Etamsylate
Insertion of medication under the skin
medications such as apomorphine and hyaluronic acid injected as a filler, which may cause the area to appear bruised. Hyaluronic acid "bruising" may be treated
Subcutaneous_administration
Method of medication administration
complete replacement of the synovial fluid with a compound such as hyaluronic acid. The injection of a steroid into a joint is used to reduce inflammation
Injection_(medicine)
Medical condition
fibroblasts producing abnormally large amounts of acid mucopolysaccharides (i.e. mucin), usually hyaluronic acid. Cutaneous mucinosis is a group of conditions
Mucinosis
Species of bacterium
tissue layers. A carbohydrate-based bacterial capsule composed of hyaluronic acid surrounds the bacterium, protecting it from phagocytosis by neutrophils
Streptococcus_pyogenes
Medical intervention
expressing pluripotency markers and with added advantage of enriched hyaluronic acid (HA) expression by the cells have been reported which will contribute
Knee cartilage replacement therapy
Knee_cartilage_replacement_therapy
Topics referred to by the same term
abbreviation HA) Hahnium, an element now called Dubnium Hyaluronan (Hyaluronic acid), a carbohydrate structure Hydroxylapatite, a mineral Hyperandrogenic
Ha
Non-invasive non-surgical technique
hormones, plant extracts, vitamins, and/or other ingredients such as hyaluronic acid. It has no proven clinical efficacy and poor scientific backing. Mesotherapy
Mesotherapy
Cosmetics brand
fair to deep skin tones, and features ingredients like niacinamide, hyaluronic acid, and vitamin E. In May 2022, the cosmetic company won the award for
R.E.M._Beauty
Method of nerve regeneration
for reinnervation of the target in vivo after a spinal cord injury. Hyaluronic acid (HA) is a widely used biomaterial as a result of its excellent biocompatibility
Nerve_guidance_conduit
Skin condition characterized by pimples
depth of acne scars. Examples of fillers used for this purpose include hyaluronic acid; poly(methyl methacrylate) microspheres with collagen; human and bovine
Acne
Species of bacterium
red blood cells, while N-acetyl-D-glucosamine is present in human hyaluronic acid. The presence of these residues on A. muciniphila LOS may thus mediate
Akkermansia_muciniphila
Fluid surrounding a fetus within the amnion
(ECM) components including collagens and glycosaminoglycans, including hyaluronic acid and chondroitin sulfate, all of which aid in the growth of the fetus
Amniotic_fluid
Medical intervention
Non-surgical rhinoplasty (liquid rhinoplasty) is a method that incorporates hyaluronic acid dermal fillers and other non-surgical devices, which act as alternatives
Nasal_surgery
Aesthetic technique
skin with the purpose of stimulating cutaneous collagen, elastin and hyaluronic acid production in order to reduce the appearance of fine lines and loose
Radio-frequency skin tightening
Radio-frequency_skin_tightening
Chemical compound
Cromoglicic acid (INN)—also referred to as cromolyn (USAN), cromoglycate (former BAN), or cromoglicate—is traditionally described as a mast cell stabilizer
Cromoglicic_acid
Class of enzymes
domain; an aspartic acid to asparagine mutation at position 196 (D196N) leads to loss of GlcUA-transferase activity, and an aspartic acid to lysine mutation
Hyaluronan_synthase
Pharmaceutical compound
claimed to stimulate endogenous biosynthesis of collagens, fibronectin, hyaluronic acid and laminin, and is used in skincare products for its purported anti-aging
Palmitoyl_tripeptide-38
Catalase-positive bacterium
lower-cost PHA production.[citation needed] It is used to produce hyaluronic acid, which is used in the joint-care sector in healthcare and cosmetics
Bacillus_subtilis
Crease on otherwise smooth surface
maintain structural integrity in tissues and to maintain fluid balance. Hyaluronic acid is a type of GAG that promotes collagen synthesis, repair, and hydration
Wrinkle
Viscoelatic materials used in ophthalmic surgery to maintain eye shape
Palmer isolated hyaluronic acid from the vitreous cortex in 1934. Also in 1934, Endre A. Balazs extracted and purified hyaluronic acid from rooster combs
Ophthalmic viscosurgical device
Ophthalmic_viscosurgical_device
Medical condition
(poly-L-lactic acid)). Two published medical journals appear to show Hyaluronidase injections (Hyaluronidase is an enzyme used to dissolve hyaluronic acid which
Cutis_verticis_gyrata
Scar formation in the uterus
polypectomy or septum removal. Mechanical barriers such as Womed Leaf or hyaluronic acid gels can be used to prevent formation of IUA after such adhesiogenic
Asherman's_syndrome
Brazilian digital influencer (born 1999)
of taking care of the skin due to its minimal level of vitamin E, hyaluronic acid and nicotinamide, all of which were claimed by Virginia to be of a
Virginia_Fonseca
Appearance of swelling around the eyes
periorbital swelling occur due to infiltration with the mucopolysaccharides hyaluronic acid and chondroitin sulfate, pulling fluid into the interstitial space
Periorbital_puffiness
Mesenchymal progenitor cell that forms a chondrocyte
matrix secreted by chondroblasts is composed of fibers, collagen, hyaluronic acid, proteoglycans, glycoproteins, water, and a host of macromolecules
Chondroblast
occur in the peripheral part of the vitreous body, and may produce hyaluronic acid and collagen fibrils, Hyalocytes are star-shaped (stellate) cells with
Hyalocyte
Extreme hypothyroidism
glycosaminoglycans (GAGs) in the dermal tissues consists characteristically of hyaluronic acid with very little change in the dermatan sulfate abundance and perhaps
Myxedema
Region of a specific protein
Link domain-containing hyaladherin, a protein capable of binding to hyaluronic acid (HA), homologous to CD44, the main HA receptor. In humans it is encoded
LYVE1
Pharmaceutical compound
activity in hair follicle stem cells (HFSCs). As a result of this, lactic acid levels and glycolysis increase within the cells and more energy for cellular
Suvomipic
Chemical compound
radiation. In a rabbit-cornea study, eye drops combining actinoquinol with hyaluronic acid reduced changes in corneal optics and suppressed oxidative damage after
Actinoquinol
Medical symptoms including a sense of suffocation despite a clear airway
cows or from another part of the person's body is used. Sometimes hyaluronic acid is injected or tricalcium phosphate is used. Possible complications
Empty_nose_syndrome
Inorganic chemicals that either produce or become acid
the body, and are also useful in reducing metabolic alkalosis. Text Book of Pharmaceutical Inorganic Chemistry by VN RAJASEKARAN Hyaluronic Acid v t e
Acidifier
Most abundant structural protein in animals
Efficacy of an Elastin-Inducing Composition Containing Amino Acids, Copper, and Hyaluronic Acid: Results of an Open Single-Center Clinical Trial Study". Cosmetics
Collagen
Dark blemishes around the eyes
used. Low-level laser therapy, autologous fat transplantation and hyaluronic acid fillers are also alternative treatment options. In addition, many skin
Periorbital_dark_circles
Fluid-filled sac growth found on joints or tendon sheaths
tissues and liquefaction with chronic damage, increased production of hyaluronic acid by fibroblasts, and a proliferation of mesenchymal cells. Normal sized
Ganglion_cyst
Property of chemical biologic staining
the degree of stacking, the greater the metachromatic shift. Thus, hyaluronic acid, lacking sulphate groups and with only moderate charge density, causes
Metachromasia
Skin thinning due to prolonged exposure to topical steroids
fibroblasts and hyaluronan synthase 3 enzyme leads because of decreased hyaluronic acid. Atrophic effects begin within 3–14 days of consistent topical steroid
Steroid-induced_skin_atrophy
Multi-sport event in Italy
Crawford. "2026 Winter Olympics: Why rumors of penis injections of hyaluronic acid is doping concern for WADA". CBS Sports. Retrieved 16 February 2026
2026_Winter_Olympics
Eye drops for relieving dryness and irritation in the eye
methylcellulose (a.k.a. HPMC or hypromellose), hydroxypropyl cellulose and hyaluronic acid (a.k.a. hyaluronan, HA). Preparations can also contain preservatives
Artificial_tears
Protein-coding gene in the species Homo sapiens
PMID 10547355. Lokeshwar VB, Selzer MG (Sep 2000). "Differences in hyaluronic acid-mediated functions and signaling in arterial, microvessel, and vein-derived
Hyaluronan-mediated motility receptor
Hyaluronan-mediated_motility_receptor
Soft water-rich polymer gel
synthetic polymers. Natural polymers for hydrogel preparation include hyaluronic acid, chitosan, heparin, alginate, gelatin and fibrin. Common synthetic
Hydrogel
Type of cosmetics
agents like hyaluronic acid and glycerin help skin attract and retain moisture. Exfoliants – Alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs), like
Toner_(skin_care)
Enzyme
that in humans is encoded by the SPAM1 gene. Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and
SPAM1
Chemical Compound
both endogenous and synthetic chemicals. Endogenous molecules include hyaluronic acid, glucosamine, and chondroitin sulfate. Felson, David T.; Kim, Young-Jo
Chondroprotection
Protein that in humans is encoded by the ACAN gene
the function of joints. Functionally, the G1 domain interacts with hyaluronic acid and link protein, forming stable ternary complexes in the extracellular
Aggrecan
Medical intervention
As a further improvement of hyaluronic acid solution, usefulness of a mixture of high-molecular-weight hyaluronic acid, glycerin, and sugar has also
Endoscopic submucosal dissection
Endoscopic_submucosal_dissection
Genetic connective tissue disorder
with a collagen biosynthesis gene. A metabolic defect concerning the hyaluronic acid and the collagen of the 2-d type is assumed to be the cause of this
Stickler_syndrome
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