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Biological system of neurotransmitters
The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, which are neurotransmitters that bind to cannabinoid receptors, and
Endocannabinoid_system
Transient state of euphoria from physical exertion
placing more importance in the endocannabinoids instead, which can cross this barrier. The release of endocannabinoids is greater during longer and more
Runner's_high
Effects of cannabis consumption during pregnancy
while breastfeeding. The endocannabinoid system (ECS) has wide-ranging effects on the central and peripheral nervous systems and is deeply involved in
Cannabis_in_pregnancy
Compounds found in cannabis
receptors than any other G protein-coupled receptor (GPCR) type. The endocannabinoid system (ECS) regulates multiple functions, including movement, motor coordination
Cannabinoid
Class of chemical compounds
when the body is physically and psychologically active,. The endocannabinoid signaling system (ECS) is the major pathway by which NAEs exerts its physiological
N-Acylethanolamine
Chemical compound (fatty acid neurotransmitter)
plus amide. Anandamide, the first discovered endocannabinoid, engages with the body's endocannabinoid system by binding to the same cannabinoid receptors
Anandamide
Israeli chemist (1930–2023)
from peripheral organs. His work has led to the discovery of the endocannabinoid system, which has effects on many important aspects of human health. Mechoulam
Raphael_Mechoulam
Acronym for lipoxygenase interaction product
enhancing AEA signaling and thereby potentiating the effects of this endocannabinoid both in vitro and in vivo. In addition to this, LXA4 displays a CB1
Lipoxin
Protein family
Kolakowski A, Chabowski A, Konstantynowicz-Nowicka K (March 2022). "The Endocannabinoid System and Physical Activity-A Robust Duo in the Novel Therapeutic Approach
Fatty_acid_desaturase
Group of receptors to cannabinoid compounds
Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system of vertebrates– a class of cell membrane receptors in the G protein-coupled
Cannabinoid_receptor
Type of cannabinoidergic drug
An endocannabinoid enhancer (eCBE) is a type of cannabinoidergic drug that enhances the activity of the endocannabinoid system by increasing extracellular
Endocannabinoid_enhancer
Patient with little to no pain or negative affect
involved in the metabolism of endocannabinoids like anandamide. Cameron has high levels of anandamide and other endocannabinoids. She was first presented as
Jo_Cameron
Intravenous medication used in anesthesia
amide hydrolase, which metabolizes the endocannabinoid anandamide (AEA). Activation of the endocannabinoid system by propofol, possibly via inhibition of
Propofol
First stage of pregnancy
implantation that enables successful implantation of a viable embryo. The endocannabinoid system plays a vital role in this synchrony in the uterus, influencing
Implantation_(embryology)
The endocannabinoid transporters (eCBTs) are transport proteins for the endocannabinoids. Most neurotransmitters are water-soluble and require transmembrane
Endocannabinoid_transporter
Medical theory
Clinical endocannabinoid deficiency (CECD) is a medical theory that proposes that a deficiency of endocannabinoids is the underlying pathophysiology of
Clinical endocannabinoid deficiency syndrome
Clinical_endocannabinoid_deficiency_syndrome
Compounds that inhibit or block the activity of cannabinoid receptors
activation by endocannabinoids. They include antagonists, inverse agonists, and antibodies of CBRs. The discovery of the endocannabinoid system led to the
Cannabinoid receptor antagonist
Cannabinoid_receptor_antagonist
Brain region
between the endocannabinoid system and orexin system within the central nervous system. Through the diverse outputs of the orexin system, the orexin neurons
Lateral_hypothalamus
Area of study within psychosomatic medicine
system, by which cannabinoid CB1 receptors modulate the excitability of dorsal raphe serotonin neurons. Data suggest that the endocannabinoid system in
Psychoneuroimmunology
Class of drugs
UCM-707 VDM-11 WOBE437 Endocannabinoid enhancer Endocannabinoid system Reuptake inhibitor Cannabinoid receptor antagonist Endocannabinoid transporters FAAH
Endocannabinoid reuptake inhibitor
Endocannabinoid_reuptake_inhibitor
Pharmacologist and bioanalyst
and pharmacological evaluation of compounds interacting with the endocannabinoid system. He obtained his Ph.D. in 2005 under the guidance of Prof. Didier
Giulio_Muccioli
Chemical compound
environmentally relevant concentrations of DINP in zebrafish disrupt the endocannabinoid system (ECS) and affect reproduction in a gender specific manner, and have
Diisononyl_phthalate
American microbiologist and genetic researcher
put him at odds with mainstream academia. An expert on the human endocannabinoid system, Melamede contended that marijuana has anti-aging properties, and
Robert_Melamede
Naturally-occurring cannabinoid
low affinity partial agonist at the CB1 and CB2 receptors of the endocannabinoid system (ECS). Although CBN shares the same mechanism of action as other
Cannabinol
American researcher into cannabinoids
Biotechnology. His research has focused on the biochemical basis of the endocannabinoid system and on the development of synthetic cannabinoids. Makriyannis studied
Alexandros_Makriyannis
Black truffle
symbiosis. Truffles contain the endocannabinoid anandamide (AEA) and the major metabolic enzymes of the endocannabinoid system (ECS). The AEA content increases
Tuber_melanosporum
American chemical biologist
activity-based proteomics and a substantial contributor to research on the endocannabinoid system, he is a prominent figure in the field of chemical biology. Cravatt
Benjamin_Cravatt_III
Impulse transmission between neurons
the postsynaptic neuron release retrograde neurotransmitters (e.g., endocannabinoids; synthesized in response to a rise in intracellular calcium levels)
Neurotransmission
Cannabis law reform organisation
hyperemesis syndrome (CHS) Clinical endocannabinoid deficiency syndrome Entourage effect Endocannabinoid system Impaired driving Time perception Long-term
NORML_New_Zealand
Defense of Cannabis plant from pathogens
cause psychological and physical impairment in the user, via the endocannabinoid system and unique receptors. THC increases dopamine levels in the brain
Chemical_defenses_in_Cannabis
Homologue of tetrahydrocannabinol
of GPR55 and l-α-lysophosphatidylinositol (LPI), and beyond the endocannabinoid system, THCV also activate 5-HT1A receptors to produce an antipsychotic
Tetrahydrocannabivarin
Molecule involved in neural activity
neurotransmitters because it is not released in the same way. Endocannabinoids act in the endocannabinoid system to control neurotransmitter release in a host of neuronal
Neurochemical
Pre-modern drug and alcohol abuse
344–55. Crocq, Marc-Antoine (2020). "History of cannabis and the endocannabinoid system". Dialogues in Clinical Neuroscience. 22 (3): 225. doi:10.31887/DCNS
Substance abuse in ancient Rome
Substance_abuse_in_ancient_Rome
Alcoholic extract of cannabis
(Australia 1977, UK 1970s). The pharmacological target for cannabis, the endocannabinoid system, has been researched since its discovery in the 1980s. The tincture
Tincture_of_cannabis
Uncomfortable skin sensation
2007). "Attenuation of allergic contact dermatitis through the endocannabinoid system". Science. 316 (5830): 1494–1497. Bibcode:2007Sci...316.1494K. doi:10
Itch
Peptide hormone
Gatta-Cherifi B, Cota D (February 2016). "New insights on the role of the endocannabinoid system in the regulation of energy balance". International Journal of Obesity
Insulin
Species of fish
commonly used in a large variety of plastic items, disrupt the endocannabinoid system, disrupt cranio-facial cartilage of offsprings, and thereby affect
Zebrafish
Group of neural structures responsible for motivation and desire
the liking component is thought to be controlled by opiate-GABA-endocannabinoids systems. Koob & Le Moal proposed that there exists a separate circuit responsible
Reward_system
Medical condition
suppressing the overactive immune system and reducing inflammation by mopping up excess cells. Activation of the endocannabinoid system was found efficient in ameliorating
Inflammatory_bowel_disease
Name for the cannabis plant
hyperemesis syndrome (CHS) Clinical endocannabinoid deficiency syndrome Entourage effect Endocannabinoid system Impaired driving Time perception Long-term
Ganja
cannabis plant or synthetic compounds that can interact with the endocannabinoid system. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol
Comparison of phytocannabinoids
Comparison_of_phytocannabinoids
State of steady internal conditions maintained by living things
Timothy H.; Willets, Jonathon M.; Konje, Justin C. (2013). "The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers". International Journal
Homeostasis
hyperemesis syndrome (CHS) Clinical endocannabinoid deficiency syndrome Entourage effect Endocannabinoid system Impaired driving Time perception Long-term
List of slang names for cannabis
List_of_slang_names_for_cannabis
Medical condition for inability to feel pain
Ahmed M, Boileau I, Le Foll B, Carvalho AF, Kloiber S (2022). "The endocannabinoid system in social anxiety disorder: from pathophysiology to novel therapeutics"
Congenital insensitivity to pain
Congenital_insensitivity_to_pain
Steroid acid in the bile of animals
phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) of the endocannabinoid system. Bile acids are essential confactors for the biogenesis of lipid
Bile_acid
Ahmed M, Boileau I, Le Foll B, Carvalho AF, Kloiber S (2022). "The endocannabinoid system in social anxiety disorder: from pathophysiology to novel therapeutics"
List of investigational social anxiety disorder drugs
List_of_investigational_social_anxiety_disorder_drugs
Psychotic disorder caused by cannabis
hyperemesis syndrome (CHS) Clinical endocannabinoid deficiency syndrome Entourage effect Endocannabinoid system Impaired driving Time perception Long-term
Cannabis-induced psychotic disorder
Cannabis-induced_psychotic_disorder
Class of therapeutic drug
drugs interact with the endocannabinoid system and its endocannabinoids, as COX-2 have been shown to utilize endocannabinoids as substrates, and may have
Nonsteroidal anti-inflammatory drug
Nonsteroidal_anti-inflammatory_drug
Functions of nitric oxide in organisms
and growing evidence suggests that the biological actions of the endocannabinoid system (ECS) may, in part, be mediated through its ability to regulate
Biological functions of nitric oxide
Biological_functions_of_nitric_oxide
Paired structure within the brain temporal lobe
incentive salience is dependent upon dopamine receptor D1. The endocannabinoid system that produces lipoid neuromodulators has its specific receptors
Amygdala
Functional gastrointestinal disorder
secretion, and inflammation in the gut are all modulated by the ECS (Endocannabinoid system), providing a rationale for cannabinoids as treatment candidates
Irritable_bowel_syndrome
Recollection of odors
behaviour in the rat. The cat odor induced an inhibition of the endocannabinoid system in the amygdala which has been suggested to induce anxiety-related
Olfactory_memory
Exercise toy for hamsters and other rodents
running-wheel activity without suppressing general locomotion. The endocannabinoid system also contributes to wheel running in a sex-specific manner in rodents
Hamster_wheel
Research tools for understanding depressive symptoms in non-human animals
microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system". Nature Communications. 11 (1): 6363. Bibcode:2020NatCo..11.6363C
Animal_models_of_depression
cannabinoid receptors that make up a part of the endocannabinoid system. Such effects within the nervous system may vary among individuals. Cannabis influences
Cannabis_and_sex
American author and activist (1939–2010)
Books (with Al Emmanuel) G.R.A.S.S.: Great Revolutionary American Standard System: The Official Guide for Assessing the Quality of Marijuana on the 1 to 10
Jack_Herer
Global epidemic
Monalisa; Sharma, Arun K.; Sharma, Manju (1 July 2021). "Targeting the endocannabinoid system in diabesity: Fact or fiction?". Drug Discovery Today. 26 (7): 1750–1758
Diabesity
Mental illnesses and their treatments in Ancient Rome
Crocq, Marc-Antoine (September 2020). "History of cannabis and the endocannabinoid system". Dialogues in Clinical Neuroscience. 22 (3): 223–228. doi:10.31887/DCNS
Mental illness in ancient Rome
Mental_illness_in_ancient_Rome
Structure in nervous systems
"Modulating the Neuromodulators: Dopamine, Serotonin, and the Endocannabinoid System". Trends in Neurosciences. 44 (6): 464–477. doi:10.1016/j.tins.2021
Neural_network_(biology)
Primary female sex hormone
the endocannabinoid system activity, primarily through the regulation of fatty acid amide hydrolase (FAAH) enzyme expression and the endocannabinoid receptor
Estrogen
Species of plant
Ligresti A, Villano R, Allarà M, et al. (2012). "Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB₁ receptor ligand". Pharmacol
Kava
Physical activity that improves health
Gasperi V, Maccarrone M (July 2014). "Physical activity and the endocannabinoid system: an overview". Cellular and Molecular Life Sciences. 71 (14): 2681–2698
Exercise
Spice and hallucinogen
Akati S, Abourashed EA (December 2016). "Indirect modulation of the endocannabinoid system by specific fractions of nutmeg total extract". Pharm Biol. 54 (12):
Nutmeg_(drug)
Species of plant
hyperemesis syndrome (CHS) Clinical endocannabinoid deficiency syndrome Entourage effect Endocannabinoid system Impaired driving Time perception Long-term
Cannabis_indica
Continued use of cannabis despite clinically significant impairment
Strait Islanders and people with mental health conditions. The endocannabinoid system is directly involved in adolescent brain development. Adolescent
Cannabis_use_disorder
Psychoactive drug from the cannabis plant
general, irrespective of their age. Parsons LH, Hurd YL (October 2015). "Endocannabinoid signalling in reward and addiction". Nature Reviews. Neuroscience.
Cannabis_(drug)
Organic compound that is soluble in nonpolar solvents
Maccarrone M (2008). "Fatty Acid Amide Hydrolase: A Gate-Keeper of the Endocannabinoid System". Lipids in Health and Disease. Subcellular Biochemistry. Vol. 49
Lipid
Use of drugs with the primary intention to alter the state of consciousness
and 11-OH-THC are partial agonist at CB1 and CB2 receptors of the endocannabinoid system. Cocaine: It is available as a white powder, which is insufflated
Recreational_drug_use
Protein-coding gene in humans
proposed as the focus of new drugs used to treat prostate cancer. Endocannabinoid system TRPM Ruthenium red GRCh38: Ensembl release 89: ENSG00000144481 –
TRPM8
Process in which an embryo and later fetus develops during gestation
Correia-da-Silva, G.; Almada, M.; Costa, M. A.; Teixeira, N. A. (2013). "The Endocannabinoid System in the Postimplantation Period: A Role during Decidualization and
Prenatal_development
abbreviated CBD. [See cannabinoids.] cannabinoid receptors Parts of the endocannabinoid system located in cells throughout the body that are activated by cannabinoids
Glossary_of_cannabis_terms
cannabinoids are contraindicated in pregnancy as it may interact with the endocannabinoid system. No fatal overdoses associated with cannabis use have ever been
Long-term_effects_of_cannabis
Diminished or absent ability of a female to achieve conception
Cannabis smoking, such as of marijuana, causes disturbances in the endocannabinoid system, potentially causing infertility Radiation, such as in radiation
Female_infertility
Mammalian protein found in humans
receptor 1 (CB1), which is largely responsible for the efficacy of endocannabinoid-mediated presynaptic-inhibition, the psychoactive properties of tetrahydrocannabinol
Cannabinoid_receptor_2
Mammalian protein found in humans
Anandamide (N-arachidonoylethanolamine), an endocannabinoid 2-arachidonoylglycerol (2-AG), an endocannabinoid. Other N-acylethanolamines, such as N-oleoylethanolamine
Fatty-acid_amide_hydrolase_1
hyperemesis syndrome (CHS) Clinical endocannabinoid deficiency syndrome Entourage effect Endocannabinoid system Impaired driving Time perception Long-term
List_of_names_for_cannabis
Abnormal condition of the mind
nervous system, such as Parkinson's disease, which involved reduced, rather than increased, dopaminergic activity. The endocannabinoid system is also
Psychosis
Professor of Behavioral Medicine and Neuroscience
hypothalamic–pituitary–adrenal axis, the endogenous opioid system, the sympathoadrenal system, and the endocannabinoid system. The research has demonstrated that dysregulated
Mustafa_al'Absi
Minnesota political party advocating cannabis legalization
hyperemesis syndrome (CHS) Clinical endocannabinoid deficiency syndrome Entourage effect Endocannabinoid system Impaired driving Time perception Long-term
Minnesota Legal Marijuana Now! Party
Minnesota_Legal_Marijuana_Now!_Party
Physiological tolerance to similar drugs
(2012). "A Review of the Interactions between Alcohol and the Endocannabinoid System: Implications for Alcohol Dependence and Future Directions for Research"
Cross-tolerance
Class of chemical compounds
(N-acyl phosphatidylethanolamine-specific phospholipase D) of the endocannabinoid system is a renal and extrarenal target of "thiazide-type" (e.g., hydrochlorothiazide)
Thiazide
American neuroscientist, researcher and entrepreneur
neuroscientist, innovator, and entrepreneur known for her research with the endocannabinoid system in stress-induced maladaptations of the brain. She is an Adjunct
Joyonna_Gamble-George
Pharmaceutical company headquartered in Portugal
clinical trial for BIA 10-2474, an FAAH inhibitor that targets the endocannabinoid system. The research in Rennes commenced in July 2015, evaluating male
Bial
Designer drugs
synthetic phytocannabinoids (obtained by chemical synthesis) or synthetic endocannabinoids from which they are distinct in many aspects. Typically, synthetic
Synthetic_cannabinoids
Chemical compound
pharmaceutical company Bial-Portela & Ca. SA. It interacts with the human endocannabinoid system. The drug was in development for the treatment of a range of different
BIA_10-2474
Vitamin
N-acyl phosphatidylethanolamine-specific phospholipase D of the endocannabinoid system. In the presence of bile acids (e.g., digestion), NAPE-PLD with
Pyridoxal_phosphate
Fatty acids required for biological processes
0254-4725 Maccarrone, M; Finazzi-Agró, A (22 August 2003). "The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis". Cell
Essential_fatty_acid
Overview of and topical guide to cannabis
Miscellaneous products Cannabis flower essential oil Emerald Triangle Endocannabinoid system Cannabinoid receptor Cannabinoid receptor type 1 (CB1) Cannabinoid
Outline_of_cannabis
Group of chemical compounds
R, Allarà M, Ujváry I, Di Marzo V (2012). "Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB₁ receptor ligand". Pharmacol
Kavalactone
Human protein for regulating body temperature
antagonists Ruthenium red Thermoreceptor Category:Somatosensory system Endocannabinoid system GRCh38: Ensembl release 89: ENSG00000196689 – Ensembl, May 2017
TRPV1
Nebraska political party advocating cannabis legalization
of disgusting. I decided to go with this new party and just support the system how it’s supposed to be. We’re supposed to work together to make things
Nebraska Legal Marijuana NOW Party
Nebraska_Legal_Marijuana_NOW_Party
Chemical compound
2-Arachidonoylglycerol (2-AG) is an endocannabinoid, an endogenous agonist of the CB1 receptor and the primary endogenous ligand for the CB2 receptor
2-Arachidonoylglycerol
Topics referred to by the same term
Electrochemical Society, a learned society Embodied cognitive science Endocannabinoid system Erosion control structures used in stream restoration Equilibrium
ECS
Chemical compound
University, synthesized a variety of chemical compounds that affect the endocannabinoid system. JWH-018 is one of these compounds, with studies showing an affinity
JWH-018
American physician (1954–2015)
alleged abnormal gene expression in autistic children involving the endocannabinoid system could be corrected with GcMAF and that more studies should be conducted
Jeff_Bradstreet
American political party advocating cannabis legalization
hyperemesis syndrome (CHS) Clinical endocannabinoid deficiency syndrome Entourage effect Endocannabinoid system Impaired driving Time perception Long-term
Legal_Marijuana_Now_Party
Italian neurologist (1909–2012)
its mechanisms and benefits, a far better understanding of the endocannabinoid system and new liposomal palmitoylethanolamide product formulations designed
Rita_Levi-Montalcini
Chemical compound
an agonist at the CB1 receptor. This affinity suggests that the endocannabinoid system may play a role in the complex psychopharmacological effects of
Yangonin
Enzyme that breaks down diacylglycerol
2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid in tissues. The endocannabinoid system has been identified to have considerable involvement
Diacylglycerol_lipase
Pavlovian conditioning
receptor knockout mice, implicating a possible contribution of the endocannabinoid system. Genetic knockouts of the dopamine D2 receptor, vesicular monoamine
Conditioned_place_preference
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ENDOCANNABINOID SYSTEM
ENDOCANNABINOID SYSTEM
ENDOCANNABINOID SYSTEM
ENDOCANNABINOID SYSTEM
ENDOCANNABINOID SYSTEM
ENDOCANNABINOID SYSTEM
ENDOCANNABINOID SYSTEM
ENDOCANNABINOID SYSTEM
ENDOCANNABINOID SYSTEM
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