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Chemical compound
ERX-11, also known as ERα coregulator-binding modulator-11, is a novel antiestrogen and experimental hormonal antineoplastic agent which is being researched
ERX-11
ERx is a putative membrane estrogen receptor (mER) of which little is currently known. It was discovered as a gene transcription signature induced by
ERx
Human hormone
in urinary hormone profile". Clinical Chemistry. 43 (11): 2091–2098. doi:10.1093/clinchem/43.11.2091. PMID 9365393. Marks LS (2004). "5alpha-reductase:
Dihydrotestosterone
Anti-seizure medication
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Phenytoin
Polycyclic organic compound having sterane as a core structure
"11-oxyandrogens" as an abbreviation for 11-oxygenated androgens, to emphasize that they all have an oxygen atom attached to carbon at position 11. However
Steroid
Infertility treatment for women
-". Drugs.com. Archived from the original on 20 September 2016. Retrieved 11 September 2016. Kim MJ, Byeon JY, Kim YH, Kim SH, Lee CM, Jung EH, et al.
Clomifene
Chemical used in plastics, xenoestrogen
alternatives to this compound". Fertility and Sterility. 103 (1): 11–21. doi:10.1016/j.fertnstert.2014.11.005. PMID 25475787. See: А. Дианина (1891) "О продуктахъ
Bisphenol_A
Herbicide
Medicines Authority. 2014-05-28. Archived from the original on 2015-02-11. Retrieved 2015-02-11. Brovini, Emília Marques; de Deus, Beatriz Corrêa Thomé; Vilas-Boas
Atrazine
Type of steroid hormone
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Sex_hormone
Primary male sex hormone
The Journal of Clinical Endocrinology & Metabolism. 25 (11): 1441–50. doi:10.1210/jcem-25-11-1441. PMID 5843701. Dabbs JM, Dabbs MG (2000). Heroes, rogues
Testosterone
Organochloride known as an insecticide
arabiensis in Nouakchott, Mauritania". Parasites & Vectors. 11 (1) 344. Bibcode:2018PVec...11..344M. doi:10.1186/s13071-018-2923-4. PMC 5998517. PMID 29895314
DDT
Vitamer of Vitamin B3
on 30 December 2016. Blum R (2015). "Vitamins, 11. Niacin (Nicotinic Acid, Nicotinamide)". Vitamins, 11. Niacin (Nicotinic Acid, Nicotinamide. Ullmann's
Nicotinamide
Polyphenol with a stilbene skeleton
no effect on systolic or diastolic blood pressure; a sub-analysis found an 11.90 mmHg reduction in systolic blood pressure from resveratrol doses of 150 mg
Resveratrol
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
4-Hydroxyestriol
Androgenic Anabolic steroid
2010-11-13. Richardson M (2004-02-19). "Athletics: Mark Richardson explains how he felt at his disciplinary hearing". The Guardian. Retrieved 2010-11-13
Nandrolone
Chemical compound
ingestion. Taken together, the quercetin glucuronides have a half-life around 11–12 hours. In rats, quercetin did not undergo any significant phase I metabolism
Quercetin
Chemical compound
1016/j.jsbmb.2005.11.011. PMID 16524719. S2CID 30489004. Scott T (1996). Concise Encyclopedia Biology. Walter de Gruyter. p. 49. ISBN 978-3-11-010661-9. Retrieved
Dehydroepiandrosterone
Chemical compound
Taylor & Francis. January 2000. pp. 856–. ISBN 978-3-88763-075-1. Mosby (11 February 2009). Mosby's Pocket Dictionary of Medicine, Nursing & Health Professions
Polyestradiol_phosphate
Chemical compound
Administration. Archived from the original (PDF) on 2017-02-16. Retrieved 2017-12-11. Nieschlag E, Behre HM, Nieschlag S (26 July 2012). Testosterone: Action,
Testosterone_cypionate
Chemical compound
of 4′-Methoxypropiophenone to Anethole". ChemSusChem. 11 (17): 3007–3017. Bibcode:2018ChSCh..11.3007Z. doi:10.1002/cssc.201801340. ISSN 1864-564X. PMID 29927044
Anethole
Progestin medication
tips.2003.11.009. PMID 14723979. Rudel HW (September 1968). "Pharmacology of oral contraceptives". Clinical Obstetrics and Gynecology. 11 (3): 632–44
Norethisterone
Plant-derived xenoestrogen
clover, and isoflavones and breast cancer: a systematic review". PLOS ONE. 8 (11) e81968. Bibcode:2013PLoSO...881968F. doi:10.1371/journal.pone.0081968. PMC 3842968
Phytoestrogen
Primary female sex hormone
replacement therapy". Genetic Testing and Molecular Biomarkers. 15 (1–2): 11–15. doi:10.1089/gtmb.2010.0106. PMID 21117950. Lauwers J, Shinskie D (2004)
Estrogen
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Boldenone_undecylenate
Selective estrogen receptor modulator
long elimination half-life of typically 5 to 7 days, with a range of 4 to 11 days. Similarly, the half-life of afimoxifene is 14 days. Conversely, the
Tamoxifen
Chemical compound
such as estrone and estriol. Additional mERs besides GPER include ER-X, ERx, and Gq-mER. ERα/ERβ are in inactive state trapped in multimolecular chaperone
Estradiol
Endogenous weak androgen
scant evidence that androstenedione itself is anabolic in nature. On April 11, 2004, the United States Food and Drug Administration banned the sale of androstenedione
Androstenedione
Class of drugs
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Antiestrogen
Chemical compound
2024. "Jatenzo- testosterone undecanoate capsule, liquid filled". DailyMed. 11 January 2021. Archived from the original on 5 January 2022. Retrieved 27 May
Testosterone_undecanoate
Chemical compound
and future prospects". F&S Reviews. 2 (1): 32–42. doi:10.1016/j.xfnr.2020.11.001. PMC 7894643. PMID 33615283. Yazdani N, Matthews Branch S (March 2018)
Enclomifene
Vitamer of Vitamin B3
ISBN 978-3-0348-6542-5. PMID 6357846. Blum R (2015). "Vitamins, 11. Niacin (Nicotinic Acid, Nicotinamide)". Vitamins, 11. Niacin (Nicotinic Acid, Nicotinamide. Ullmann's
Nicotinic_acid
Chemical compound
315-37-7) ≥98% | AASraw". aasraw. Archived from the original on 2022-11-20. Retrieved 2022-11-20. "DELATESTRYL Package Insert" (PDF). Indevus Pharmaceuticals
Testosterone_enanthate
Steroidal antiandrogen and antimineralocorticoid
The Journal of Clinical Endocrinology and Metabolism. 22 (11): 1156–1159. doi:10.1210/jcem-22-11-1156. PMID 13991036. Omar HR, Komarova I, El-Ghonemi M,
Spironolactone
Catechin (polyphenol) in tea
and individual variability". Cancer Epidemiology, Biomarkers & Prevention. 11 (10 Pt 1): 1025–1032. PMID 12376503. Manach, C; Williamson, G; Morand, C;
Epigallocatechin_gallate
Estrogen medication
11. ISBN 978-94-009-8195-9. Pschyrembel W (1968). Praktische Gynäkologie: für Studierende und Ärzte. Walter de Gruyter. pp. 598–599. ISBN 978-3-11-150424-7
Conjugated_estrogens
Anabolic steroid
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Nandrolone_phenylpropionate
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Fluoroestradiol_(18F)
The receptor is insensitive to the antiestrogen ICI-182,780 (fulvestrant). ERx GPER (GPR30) Gq-mER Estrogen receptor Toran-Allerand CD, Guan X, MacLusky
ER-X
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
17α-Dihydroequilenin
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
ZK-283197
Drugs acting on the estrogen receptor
1007/3-540-34742-9_11. ISBN 978-3-540-24227-7. "Senshio (ospemifene)". The European Medicines Agency (EMA). Archived from the original on 2018-06-20. Retrieved 2015-11-02
Selective estrogen receptor modulator
Selective_estrogen_receptor_modulator
Chemical compound
benzoate, 7.5 mg estradiol dienanthate in oil), and control group in 20, 11, and 11 ovariectomized women, respectively. Assays were performed using RIA. Source
Estradiol_valerate
Chemical compound
studies of estradiol enantate in menopausic women". Arzneimittel-Forschung. 36 (11): 1674–1677. PMID 3814225. Sang GW (April 1994). "Pharmacodynamic effects
Estradiol_enanthate
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
O-Desmethylangolensin
Pharmaceutical birth control combination
despite experts' safety concerns". St. Louis Post-Dispatch. Retrieved March 11, 2014. Food and Drug Administration (United States) (2001). "Nuvaring NDA
Ethinylestradiol/etonogestrel
Mineralocorticoid steroid hormone
quantitative NMR (qNMR) spectroscopy: a curious case of aldosterone". RSC Adv. 11 (38): 23627–23630. Bibcode:2021RSCAd..1123627S. doi:10.1039/D1RA03472C. PMC 9036601
Aldosterone
Chemical compound
a methyl group and undergoes an allylic isomerization to form gramisterol 11. This step is catalyzed by sterol C-14 demethylase (E4), sterol Δ14-reductase
Β-Sitosterol
Chemical compound
of norethandrolone and testosterone as a contraceptive agent for men". Contraception. 11 (2): 193–207. doi:10.1016/0010-7824(75)90030-x. PMID 1112088.
Norethandrolone
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Acefluranol
Anabolic steroid
therapy in postmenopausal women". Mayo Clinic Proceedings. 72 (11): 1051–1055. doi:10.4065/72.11.1051. PMID 9374980. Meikle AW (24 April 2003). Endocrine Replacement
Nandrolone_decanoate
Androgen and anabolic steroid
International Sports Studies. 24: 42–76. Archived from the original (PDF) on 2017-11-23. Retrieved 2017-01-14. Lin GC, Erinoff L (1996-07-01). Anabolic Steroid
Metandienone
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
ERB-79
Chemical compound
fructose". Phytochemical Analysis. 11 (5): 327–329. Bibcode:2000PChAn..11..327H. doi:10.1002/1099-1565(200009/10)11:5<327::AID-PCA523>3.0.CO;2-0. Acosta
4-Hydroxybenzoic_acid
Chemical compound
Drugs and Substances Act (S.C. 1996, c. 19)". Justice Laws Website. 2016-11-30. "Summary Basis of Decision (SBD) for Tibella". Health Canada. 23 October
Tibolone
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
3β-Androstanediol
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Giredestrant
Type of pterocarpan found in the soybean
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Glyceollin_III
Dietary supplement range for menopause support
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Femarelle
Transdermal delivery system for estrogens
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Estrogen_patch
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Prolame
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Rhaponticin
Combination drug
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Bazedoxifene/conjugated estrogens
Bazedoxifene/conjugated_estrogens
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
PHTPP
Protein-coding gene in the species Homo sapiens
children with ADHD compared to controls. Membrane estrogen receptor Gq-mER ER-X ERx GRCh38: Ensembl release 89: ENSG00000164850 – Ensembl, May 2017 GRCm38: Ensembl
GPER
Mechanisms of action
enzyme is responsible for the transformation of 11-deoxycorticosterone into corticosterone and of 11-deoxycortisol into cortisol. The clinical significance
Pharmacodynamics of spironolactone
Pharmacodynamics_of_spironolactone
Chemical compound
from the University of Mainz center plus an additional 149 patients from 11 other centers, was published in 1982. The antitumor effectiveness of estradiol
Estradiol_undecylate
Chemical compound
an olive brine strain of Wickerhamomyces anomalus". FEMS Yeast Research. 11 (6): 487–493. doi:10.1111/j.1567-1364.2011.00738.x. ISSN 1567-1356. PMID 21575132
Oleuropein
Androgenic and anabolic steroid medication
in urinary hormone profile". Clinical Chemistry. 43 (11): 2091–2098. doi:10.1093/clinchem/43.11.2091. PMID 9365393. von Deutsch DA, Abukhalaf IK, Lapu-Bula
Androstanolone
Chemical compound
(PDF), American Fisheries Society, archived from the original (PDF) on 2017-11-07 Hayes W. J. (1991). Handbook on Pesticides. Vol. 1. Academic Press.
Rotenone
Chemical compound
central compartment was 0.043 L/kg and for the peripheral compartment was 0.11 L/kg. The plasma protein binding of EMP is high. Estramustine is accumulated
Estramustine_phosphate
Human glycoprotein that binds to androgens and estrogens
study): a case control study". Cardiovascular Diabetology. 11 130. doi:10.1186/1475-2840-11-130. PMC 3537568. PMID 23066943. Unit Code 91215 Archived 2011-07-20
Sex_hormone–binding_globulin
Chemical compound
(RBA) for the ERs compared to estradiol, it was found in one study to possess 11 to 14% of the RBA for the human ERα and 18 to 21% of the RBA for the human
Estriol_(medication)
Chemical compound
nonylphenol for babies". Chemosphere. 82 (11): 1533–1540. Bibcode:2011Chmsp..82.1533R. doi:10.1016/j.chemosphere.2010.11.065. PMID 21185059. Ademollo, N.; Ferrara
Nonylphenol
Chemical compound
dog". Theriogenology. 75 (7): 1271–1279. doi:10.1016/j.theriogenology.2010.11.041. PMID 21295836. Reusch CE (2006). "Trilostane-5 Years of Clinical Experience
Trilostane
Androgen and anabolic steroid
under the Controlled Substances Act. "Anabolic steroid misuse". nhs.uk. 2022-11-04. Retrieved 2024-07-12. Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias
Oxymetholone
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
4-Hydroxyestradiol
Chemical compound
1210/jcem-62-3-536. PMID 3080464. Kloosterboer HJ, Schoonen WG, Verheul HA (11 April 2008). "Proliferation of Breast Cells by Steroid Hormones and Their
Estrone
Chemical compound
Prostate Cancer: Abiraterone Acetate and Enzalutamide". Clin Pharmacokinet. 55 (11): 1369–1380. doi:10.1007/s40262-016-0403-6. PMC 5069300. PMID 27106175. Sternberg
Abiraterone_acetate
Chemical compound
Family Welfare (MoHFW). Government of India. Archived from the original on 11 May 2021. Retrieved 29 June 2020. Correspondent HT (10 July 2018). "Contraception
Ormeloxifene
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Estradiol_salicylate
Selective estrogen receptor modulator
lipid levels in elderly men". J. Bone Miner. Res. 16 (11): 2118–25. doi:10.1359/jbmr.2001.16.11.2118. PMID 11697809. S2CID 28216610. Dimaraki EV, Symons
Raloxifene
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Broparestrol
Chemical compound
11. ISBN 978-94-009-8195-9. Pschyrembel W (1968). Praktische Gynäkologie: für Studierende und Ärzte. Walter de Gruyter. pp. 598–599. ISBN 978-3-11-150424-7
Diethylstilbestrol
Medication and naturally occurring steroid hormone
1016/j.jsxm.2015.11.015. PMID 26944462. Stone L (November 2017). "Sexual medicine: Transdermal oestrogen is effective". Nat Rev Urol. 14 (11): 638. doi:10
Testosterone_(medication)
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Pentolame
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Β-LGND2
Combined oral contraceptive medication
57 (2): 117–160. doi:10.1093/jhmas/57.2.117. PMID 11995593. Retrieved 2023-11-29. Winter IC (March 1965). "The incidence of thromboembolism in Enovid users"
Mestranol/noretynodrel
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Cloxestradiol
Chemical compound
Science & Business Media. pp. 13, 401, 454. doi:10.1007/978-3-642-66353-6_11. ISBN 978-3-642-66353-6. Thieme D, Hemmersbach P (18 December 2009). Doping
Methyltestosterone
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Testosterone_propionate
Steroidal hormone medication
receptor, Gq-mERTooltip Gq-coupled membrane estrogen receptor, ER-X, and ERx. Estradiol is highly selective for these ERs and mERs, and does not interact
Estradiol_(medication)
Antimicrobial agent
Antimicrobial Soaps". Journal of Food Protection. 74 (11): 1875–82. doi:10.4315/0362-028X.JFP-11-122. PMID 22054188. "Triclosan: What Consumers Should
Triclosan
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Photoanethole
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Dimethylstilbestrol
Combination drug
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Estradiol benzoate butyrate/algestone acetophenide
Estradiol_benzoate_butyrate/algestone_acetophenide
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Etamestrol
Chemical compound
TAS-108 (SR-16234) ZB716 ZK-164015 ZK-191703 Coregulator-binding modulators: ERX-11 Noncompetitive inhibitors: Trilostane GPERTooltip G protein-coupled estrogen
Androstenediol
Chemical compound
biomarker for breast cancer". American Journal of Translational Research. 11 (8): 4992–5007. ISSN 1943-8141. PMC 6731443. PMID 31497216. Wang, Hongge;
4-Hydroxyestrone
Chemical compound
Base (Clark Air Base, Philippines). CLEAN Air, Soil, Water Journal 36 (10–11), 870–874. International Programme on Chemical Safety CDC - NIOSH Pocket Guide
Dieldrin
Chemical compound
the study), estradiol cypionate had the longest duration, at approximately 11 days, whereas estradiol benzoate and estradiol valerate were found to last
Estradiol_cypionate
travel, tourism, insurance
ERX 11
ERX 11
ERX 11
ERX 11
ERX 11
ERX 11
ERX 11
ERX 11
ERX 11
travel, tourism, insurance