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Fus3 is a MAPK protein involved in the mating decision of yeast. The dissociation of Fus3 from scaffold protein Ste5 results in the switch-like mating
Fus3
mating of yeast. The active complex is formed by interactions with the MAPK Fus3, the MAPK kinase (MAPKK) Ste7, and the MAPKK kinase Ste11. After the induction
Ste5
Dependence of the state of a system on its history
receptor on another yeast cell promoting transcription of Fus3 and promoting mating. Fus3 further promotes Far1 which inhibits Cln1/2, activators of
Hysteresis
P38 mitogen-activated protein kinases
tiers (Ste11-Ste7-Fus3), but the MAP2 and MAP3 kinases are shared with another pathway, the Kss1 or filamentous growth pathway. While Fus3 and Kss1 are closely
Mitogen-activated protein kinase
Mitogen-activated_protein_kinase
Biological process of yeast
resulting in the phosphorylation of Fus3. The switching mechanism arises as a result of competition between the Fus3 protein (a MAPK protein) and the phosphatase
Mating_of_yeast
Type of protein, regulators of signalling pathways
of Ste5 were shown to associate with the protein kinases Ste11, Ste7, and Fus3 to form a multikinase complex. Scaffold proteins act in at least four ways:
Scaffold_protein
Class of plant hormones
inverse relationship and regulate seed development and germination. Levels of FUS3, an Arabidopsis transcription factor, are upregulated by ABA and downregulated
Gibberellin
Blast, fungal disease of rice & wheat
genetically close to one necessary for mating and cell morphology in yeasts, FUS3/KSS1. Defective mutant yeast are somewhat or entirely restored in mating
Magnaporthe_grisea
phosphatase involved in the mating decision of yeast. Ptc1 competes with Fus3 for control of the 4 phosphorylation sites on the scaffold protein Ste5.
Ptc1
Major cell cycle checkpoint in yeast
downstream kinase responses by Ste11, Ste7, and Fus3. From its downstream effects and even immediate ones, Fus3 ultimately activates Far1, which directly inhibits
Start_point_(yeast)
Mammalian protein found in Homo sapiens
MAP kinase pathways that are homologous to the mammalian ERK1/2 pathway (Fus3 and Kss1 in yeast) are activated by MEKK-related kinases (e.g. Ste11 in yeast)
C-Raf
to activate MAPKKK Ste11. Ste11 and downstream kinases, Ste7 (MAPKK) and Fus3 (MAPK), are colocalized on the scaffold and activation of cascade leads to
Ultrasensitivity
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