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STE5

  • Ste5
  • Ste5 is a MAPK scaffold protein involved in the mating of yeast. The active complex is formed by interactions with the MAPK Fus3, the MAPK kinase (MAPKK)

    Ste5

    Ste5

    Ste5

  • Fus3
  • mating decision of yeast. The dissociation of Fus3 from scaffold protein Ste5 results in the switch-like mating decision observed in yeast. During this

    Fus3

    Fus3

    Fus3

  • Scaffold protein
  • Type of protein, regulators of signalling pathways

    discovered was the Ste5 protein from the yeast Saccharomyces cerevisiae. The first signaling scaffold protein discovered was the Ste5 protein from the yeast

    Scaffold protein

    Scaffold protein

    Scaffold_protein

  • Mitogen-activated protein kinase
  • P38 mitogen-activated protein kinases

    help of a scaffold protein Ste5 that is selectively recruited by the G-proteins of the mating pathway. The trick is that Ste5 can associate with and "unlock"

    Mitogen-activated protein kinase

    Mitogen-activated_protein_kinase

  • Ptc1
  • phosphorylation sites on the scaffold protein Ste5. Presence of the mating pheromone α-factor causes Ptc1 to be recruited to Ste5. This recruitment takes place via

    Ptc1

    Ptc1

  • Mating of yeast
  • Biological process of yeast

    recruitment of Ptc1 to Ste5 via a four-amino acid motif located within the Ste5 phosphosites. Ptc1 then dephosphorylates Ste5, resulting in the dissociation

    Mating of yeast

    Mating of yeast

    Mating_of_yeast

  • Translohr
  • Rubber-tyred tramway technology

     Colombia Medellín Ayacucho Tram 15 October 2015 4.3 km (2.7 mi) 09 12 STE5  France Clermont-Ferrand Clermont-Ferrand tramway 14 October 2006 15.4 km

    Translohr

    Translohr

    Translohr

  • Start point (yeast)
  • Major cell cycle checkpoint in yeast

    pathway consists of a MAPK (mitogen-activated protein kinase) cascade, where Ste5 intermediates the pheromone signal and the downstream kinase responses by

    Start point (yeast)

    Start_point_(yeast)

  • Kang-Yell Choi
  • South Korean biotechnologist

    studied cell signaling mechanisms. His research on the Saccharomyces protein Ste5, which mediates pheromone response through the MAP kinase pathway, was among

    Kang-Yell Choi

    Kang-Yell_Choi

  • Ultrasensitivity
  • alpha-factor activates receptor, Ste2, and Ste4 and activated Ste4 recruits Ste5 complex to membrane, allowing PAK-like kinase Ste20 (membrane-localized)

    Ultrasensitivity

    Ultrasensitivity

    Ultrasensitivity

  • Michael Wigler
  • American molecular biologist (born 1947)

    Marcus, S; Polverino, A; Barr, M; Wigler, M (1994). "Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase

    Michael Wigler

    Michael_Wigler

  • Fuzzy complex
  • Matthew C; Bashor, Caleb J; Falick, Arnold M; Lim, Wendell A (2006). "The Ste5 Scaffold Allosterically Modulates Signaling Output of the Yeast Mating Pathway"

    Fuzzy complex

    Fuzzy complex

    Fuzzy_complex

  • Multi-state modeling of biomolecules
  • states. For instance, it has been estimated that the yeast scaffold protein Ste5 can be a part of 25666 unique protein complexes. In E. coli, chemotaxis receptors

    Multi-state modeling of biomolecules

    Multi-state_modeling_of_biomolecules

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