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Ste5 is a MAPK scaffold protein involved in the mating of yeast. The active complex is formed by interactions with the MAPK Fus3, the MAPK kinase (MAPKK)
Ste5
mating decision of yeast. The dissociation of Fus3 from scaffold protein Ste5 results in the switch-like mating decision observed in yeast. During this
Fus3
Type of protein, regulators of signalling pathways
discovered was the Ste5 protein from the yeast Saccharomyces cerevisiae. The first signaling scaffold protein discovered was the Ste5 protein from the yeast
Scaffold_protein
P38 mitogen-activated protein kinases
help of a scaffold protein Ste5 that is selectively recruited by the G-proteins of the mating pathway. The trick is that Ste5 can associate with and "unlock"
Mitogen-activated protein kinase
Mitogen-activated_protein_kinase
phosphorylation sites on the scaffold protein Ste5. Presence of the mating pheromone α-factor causes Ptc1 to be recruited to Ste5. This recruitment takes place via
Ptc1
Biological process of yeast
recruitment of Ptc1 to Ste5 via a four-amino acid motif located within the Ste5 phosphosites. Ptc1 then dephosphorylates Ste5, resulting in the dissociation
Mating_of_yeast
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Colombia Medellín Ayacucho Tram 15 October 2015 4.3 km (2.7 mi) 09 12 STE5 France Clermont-Ferrand Clermont-Ferrand tramway 14 October 2006 15.4 km
Translohr
Major cell cycle checkpoint in yeast
pathway consists of a MAPK (mitogen-activated protein kinase) cascade, where Ste5 intermediates the pheromone signal and the downstream kinase responses by
Start_point_(yeast)
South Korean biotechnologist
studied cell signaling mechanisms. His research on the Saccharomyces protein Ste5, which mediates pheromone response through the MAP kinase pathway, was among
Kang-Yell_Choi
alpha-factor activates receptor, Ste2, and Ste4 and activated Ste4 recruits Ste5 complex to membrane, allowing PAK-like kinase Ste20 (membrane-localized)
Ultrasensitivity
American molecular biologist (born 1947)
Marcus, S; Polverino, A; Barr, M; Wigler, M (1994). "Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase
Michael_Wigler
Matthew C; Bashor, Caleb J; Falick, Arnold M; Lim, Wendell A (2006). "The Ste5 Scaffold Allosterically Modulates Signaling Output of the Yeast Mating Pathway"
Fuzzy_complex
states. For instance, it has been estimated that the yeast scaffold protein Ste5 can be a part of 25666 unique protein complexes. In E. coli, chemotaxis receptors
Multi-state modeling of biomolecules
Multi-state_modeling_of_biomolecules
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