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HbYX motif is a short, evolutionarily conserved peptide sequence found at the C‑termini of several proteasome activators. The "Hb" at the beginning of
HbYX_motifs
Enzyme found in humans
interface between the 19S RP and the 20S CP. Three C-terminal tails with HbYX motifs of distinct Rpt ATPases insert into pockets between two defined alpha
PSMC2
Enzyme found in humans
interface between the 19S RP and the 20S CP. Three C-terminal tails with HbYX motifs of distinct Rpt ATPases insert into pockets between two defined alpha
PSMC6
Enzyme found in humans
interface between the 19S RP and the 20S CP. Three C-terminal tails with HbYX motifs of distinct Rpt ATPases insert into pockets between two defined alpha
PSMC5
Enzyme found in humans
interface between the 19S RP and the 20S CP. Three C-terminal tails with HbYX motifs of distinct Rpt ATPases insert into pockets between two defined alpha
PSMC4
Protein family
conformational changes required for protein unfolding and extraction. The HbYX motif plays a crucial role in regulating this process by mediating interactions
AAA_proteins
Enzyme found in humans
interface between the 19S RP and the 20S CP. Three C-terminal tails with HbYX motifs of distinct Rpt ATPases insert into pockets between two defined alpha
PSMC3
Enzyme found in humans
interface between the 19S RP and the 20S CP. Three C-terminal tails with HbYX motifs of distinct Rpt ATPases insert into pockets between two defined alpha
PSMC1
Protein complexes which degrade ubiquitin-tagged proteins by proteolysis
C-termini of the proteasomal ATPases, which contains a specific motif (i.e., HbYX motif). The ATPases C-termini bind into pockets in the top of the 20S
Proteasome
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