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HBYX MOTIFS

  • HbYX motifs
  • HbYX motif is a short, evolutionarily conserved peptide sequence found at the C‑termini of several proteasome activators. The "Hb" at the beginning of

    HbYX motifs

    HbYX motifs

    HbYX_motifs

  • PSMC2
  • Enzyme found in humans

    interface between the 19S RP and the 20S CP. Three C-terminal tails with HbYX motifs of distinct Rpt ATPases insert into pockets between two defined alpha

    PSMC2

    PSMC2

    PSMC2

  • PSMC6
  • Enzyme found in humans

    interface between the 19S RP and the 20S CP. Three C-terminal tails with HbYX motifs of distinct Rpt ATPases insert into pockets between two defined alpha

    PSMC6

    PSMC6

    PSMC6

  • PSMC5
  • Enzyme found in humans

    interface between the 19S RP and the 20S CP. Three C-terminal tails with HbYX motifs of distinct Rpt ATPases insert into pockets between two defined alpha

    PSMC5

    PSMC5

    PSMC5

  • PSMC4
  • Enzyme found in humans

    interface between the 19S RP and the 20S CP. Three C-terminal tails with HbYX motifs of distinct Rpt ATPases insert into pockets between two defined alpha

    PSMC4

    PSMC4

    PSMC4

  • AAA proteins
  • Protein family

    conformational changes required for protein unfolding and extraction. The HbYX motif plays a crucial role in regulating this process by mediating interactions

    AAA proteins

    AAA proteins

    AAA_proteins

  • PSMC3
  • Enzyme found in humans

    interface between the 19S RP and the 20S CP. Three C-terminal tails with HbYX motifs of distinct Rpt ATPases insert into pockets between two defined alpha

    PSMC3

    PSMC3

    PSMC3

  • PSMC1
  • Enzyme found in humans

    interface between the 19S RP and the 20S CP. Three C-terminal tails with HbYX motifs of distinct Rpt ATPases insert into pockets between two defined alpha

    PSMC1

    PSMC1

    PSMC1

  • Proteasome
  • Protein complexes which degrade ubiquitin-tagged proteins by proteolysis

    C-termini of the proteasomal ATPases, which contains a specific motif (i.e., HbYX motif). The ATPases C-termini bind into pockets in the top of the 20S

    Proteasome

    Proteasome

    Proteasome

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