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Protein complexes which degrade ubiquitin-tagged proteins by proteolysis
Proteasomes are essential protein complexes responsible for the degradation of proteins by proteolysis, a chemical reaction that breaks peptide bonds
Proteasome
Drug
Proteasome inhibitors (INN stem –zomib) are drugs that block the action of proteasomes. Proteasomes are large proteins complexes that are used to break
Proteasome_inhibitor
Class of enzymes
In enzymology, a proteasome ATPase (EC 3.6.4.8) is an enzyme that catalyzes the chemical reaction ATP + H2O ⇌ {\displaystyle \rightleftharpoons } ADP +
Proteasome_ATPase
Class of enzymes
prosome, multicatalytic proteinase (complex), MCP, proteasome, large multicatalytic protease, proteasome organelle, alkaline protease, 26S protease, tricorn
Proteasome endopeptidase complex
Proteasome_endopeptidase_complex
Proteasome accessory factor E (abbreviated PafE, also known as bacterial proteasome activator or Bpa) is an ATP-independent proteasome activator of Mycobacterium
Proteasome_accessory_factor_E
Type of cellular stress response
enough to prevent incorrect folding, the protein may be degraded by the proteasome or autophagy to remove any potentially toxic aggregates. Misfolded proteins
Heat_shock_response
Protein found in humans
Proteasome subunit beta type-2 also known as 20S proteasome subunit beta-4 (based on systematic nomenclature) is a protein that in humans is encoded by
PSMB2
An immunoproteasome is a type of proteasome that degrades ubiquitin-labeled proteins found in the cytoplasm in cells exposed to oxidative stress and proinflammatory
Immunoproteasome
Protein found in humans
Proteasome subunit beta type-5 also known as 20S proteasome subunit beta-5 is a protein that in humans is encoded by the PSMB5 gene. This protein is one
PSMB5
Protein found in humans
Proteasome subunit beta type-8 as known as 20S proteasome subunit beta-5i is a protein that in humans is encoded by the PSMB8 gene. This protein is one
PSMB8
Protein-coding gene in the species Homo sapiens
Proteasome subunit alpha type-1 is a protein that in humans is encoded by the PSMA1 gene. This protein is one of the 17 essential subunits (alpha subunits
Proteasome (prosome, macropain) subunit, alpha 1
Proteasome_(prosome,_macropain)_subunit,_alpha_1
Protein-coding gene in the species Homo sapiens
Proteasome maturation protein is a protein that in humans is encoded by the POMP gene. It is a short-lived maturation factor required for 20S proteasome
POMP
Protein found in humans
Proteasome subunit beta type-10 as known as 20S proteasome subunit beta-2i is a protein that in humans is encoded by the PSMB10 gene. This protein has
PSMB10
Chemical compound
the proteasome on the basis of its affinity for certain catalytic subunits of the proteasome by Fenteany and co-workers in 1995. The proteasome is a
Lactacystin
Defunct American pharmaceutical company owned by Onyx Pharmaceuticals
carfilzomib works by preventing proteasomes from breaking down other proteins. Proteolix focused primarily on the proteasome as a therapeutic target. At the
Proteolix
Protein found in humans
Proteasome subunit beta type-9 as known as 20S proteasome subunit beta-1i is a protein that in humans is encoded by the PSMB9 gene. This protein is one
PSMB9
Enzyme found in humans
26S proteasome non-ATPase regulatory subunit 10 or gankyrin is an enzyme that in humans is encoded by the PSMD10 gene. First isolated in 1998 by Tanaka
PSMD10
Basic unit of life forms
organelles include the nucleolus in the nucleus, centrosomes, ribosomes, proteasomes, and vaults. The cell nucleus is the largest organelle in the animal
Cell_(biology)
Cellular process
and subsequent degradation by a protein-degrading complex, called the proteasome. The process of ERAD can be divided into three steps: The recognition
Endoplasmic-reticulum-associated protein degradation
Endoplasmic-reticulum-associated_protein_degradation
Small molecule (PROTAC)
ubiquitination and subsequent degradation of the target protein via the proteasome. Because PROTACs need only to bind their targets with high selectivity
Proteolysis_targeting_chimera
Protein found in humans
Proteasome subunit alpha type-3 also known as macropain subunit C8 and proteasome component C8 is a protein that in humans is encoded by the PSMA3 gene
PSMA3
Regulatory protein found in most eukaryotic tissues
affects proteins in many ways: it can mark them for degradation via the 26S proteasome, alter their cellular location, affect their activity, and promote or
Ubiquitin
Protein found in humans
Proteasome assembly chaperone 1 is a protein that in humans is encoded by the PSMG1 gene. Proteasome Chaperone GRCh38: Ensembl release 89: ENSG00000183527
PSMG1
Protein found in humans
Proteasome subunit beta type-1 also known as 20S proteasome subunit beta-6 (based on systematic nomenclature) is a protein that in humans is encoded by
PSMB1
Protein of the immune system
peptides generated mainly from the degradation of cytosolic proteins by the proteasome. The MHC I: peptide complex is then inserted via the endoplasmic reticulum
MHC_class_I
Class of enzymes
prototype members of this class of enzymes are the catalytic subunits of the proteasome, however, the acyltransferases convergently evolved the same active site
Threonine_protease
Enzyme found in humans
26S proteasome non-ATPase regulatory subunit 9 is an enzyme that in humans is encoded by the PSMD9 gene. The 26S proteasome is a multicatalytic proteinase
PSMD9
Grossman School of Medicine. Her research interests include the bacterial proteasome and the antimicrobial effects of host-produced effectors including nitric
Heran_Darwin
Protein found in humans
Proteasome subunit alpha type-6 is a protein that in humans is encoded by the PSMA6 gene. This protein is one of the 17 essential subunits (alpha subunits
PSMA6
Chemical compound
syndrome. It is in the class of medications known as proteasome inhibitor. It works by inhibiting proteasomes, cellular complexes that break down proteins. Bortezomib
Bortezomib
Protein found in humans
Proteasome subunit beta type-3, also known as 20S proteasome subunit beta-3, is a protein that in humans is encoded by the PSMB3 gene. This protein is
PSMB3
Protein found in humans
Proteasome subunit beta type-6 also known as 20S proteasome subunit beta-1 (based on systematic nomenclature) is a protein that in humans is encoded by
PSMB6
Protein-coding gene in the species Homo sapiens
participates in protein turnover by targeting substrates for degradation by the proteasome. The UBD gene is located within the human major histocompatibility complex
Ubiquitin_D
Enzyme found in humans
26S protease regulatory subunit 7, also known as 26S proteasome AAA-ATPase subunit Rpt1, is an enzyme that in humans is encoded by the PSMC2 gene This
PSMC2
Pharmaceutical compound
proteolysis targeting chimera (PROTAC) that acts by using the ubiquitin-proteasome system to target Bruton's tyrosine kinase (BTK) for degradation. Salvaris
BGB-16673
Protein family
Like ubiquitin, Pup serves to direct proteins to the proteasome for degradation in the Pup-proteasome system (PPS). However, the enzymology of ubiquitylation
Prokaryotic ubiquitin-like protein
Prokaryotic_ubiquitin-like_protein
Cancer of plasma cells
an anti-CD38 monoclonal antibody, a proteasome inhibitor, and an immunomodulatory agent. carfilzomib: a proteasome inhibitor that is indicated: as a single
Multiple_myeloma
Protein family
the 20S proteasome or specific cofactors (e.g., Ufd1/Npl4). This interaction facilitates substrate transfer from Cdc48p/p97 to the proteasome, ensuring
AAA_proteins
Protein family
ubiquitination reaction that targets a protein for degradation via the proteasome. The ubiquitination process covalently attaches ubiquitin, a short protein
Ubiquitin-conjugating_enzyme
Protein found in humans
Proteasome subunit beta type-4 also known as 20S proteasome subunit beta-7 (based on systematic nomenclature) is a protein that in humans is encoded by
PSMB4
Breakdown of proteins into smaller polypeptides or amino acids
lysosome, or a ubiquitin-dependent process that targets unwanted proteins to proteasome. The autophagy-lysosomal pathway is normally a non-selective process,
Proteolysis
American biochemist and cell biologist
focus on how proteins are conjugated with ubiquitin and degraded by the proteasome. Deshaies was born in Waterbury, Connecticut, on September 25, 1961. He
Raymond_J._Deshaies
Chemical compound
such proteins called the proteasome. However, in Alzheimer's disease and some other conditions the activity of these proteasomes is impaired leading to
Rolipram
American cell biologist-biochemist (1942–2023)
reticulocytes. He named it the 26S proteasome to distinguish it from the smaller particle, which he named the 20S proteasome, and which they later showed comprises
Alfred_L._Goldberg
Chemical compound
kinetoplastid parasites, which share similar biology. GNF6702 acts as allosteric proteasome inhibitor which was effective against infection with any of the three
GNF6702
Gene which maintains basic cellular functions
NM_002792 Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 7 (PSMA7), PSMB1 NM_002793 Homo sapiens proteasome (prosome, macropain) subunit
Housekeeping_gene
Chemical compound
brand name Kyprolis, is an anti-cancer medication acting as a selective proteasome inhibitor. Chemically, it is a tetrapeptide epoxyketone and an analog
Carfilzomib
Immunity, proteasome, thymus, T cells
Thymoproteasome is a special kind of proteasome, which is present in vertebrates. In the body it is located in thymus, exclusively in cortical thymic epithelial
Thymoproteasome
Topics referred to by the same term
transmembrane sensor protein of bacteria Modified citrus pectin, a form of pectin Proteasome endopeptidase complex, an enzyme Metoclopramide, a medication to treat
MCP
Protein-coding gene in the species Homo sapiens
PSME3 to the 20S proteasome, and is also involved in regulating its activity. In particular, it inhibits the break-down of certain proteasome substrates, and
PSME3-interacting_protein
Set of three coordinated amino acids
instead of serine at the acid location. Threonine proteases, such as the proteasome protease subunit and ornithine acyltransferases use the secondary hydroxyl
Catalytic_triad
Class of enzymes
which (among other things) can target a protein for degradation via a proteasome. This covalent bond of ubiquitin or ubiquitin-like proteins to targeted
Ubiquitin-activating_enzyme
Protein-coding gene in the species Homo sapiens
Proteasome adapter and scaffold protein ECM29 is a protein that in humans is encoded by the ECPAS gene. The protein ECM29 is a scaffold protein that binds
Proteasome adapter and scaffold protein ECM29
Proteasome_adapter_and_scaffold_protein_ECM29
Class of bacterial heat shock proteins
core subunits of proteasomes. Both proteins are encoded on the same operon within the bacterial genome. Unlike many eukaryotic proteasomes, which have several
HslVU
Protein found in humans
Proteasome activator complex subunit 1 is a protein that in humans is encoded by the PSME1 gene. The 26S proteasome is a multicatalytic proteinase complex
PSME1
Liquid found in cells
together and take part in metabolic pathways, and protein complexes such as proteasomes, and carboxysomes (in bacteria) that enclose and separate parts of the
Cytosol
Protein-coding gene in the species Homo sapiens
CXCR4. IU1 and related compounds VLX1570 (non selective inhibitor of proteasome deubiquitinases) Degrasyn (WP1130) (non selective deubiquitinase inhibitor
USP14
Chemical compound
radical cyclization, producing an ageliferin skeleton. Palau'amine is a proteasome inhibitor. Rohde S, Gochfeld DJ, Ankisetty S, Avula B, Schupp PJ, Slattery
Palau'amine
Medical condition
CIPN: platinum-based compounds, taxanes, vinca alkaloids, epothilones, proteasome inhibitors and immunomodulatory drugs. Platinum-based compounds, namely
Chemotherapy-induced peripheral neuropathy
Chemotherapy-induced_peripheral_neuropathy
Topics referred to by the same term
unsynthesized chemical element with atomic number 157 and symbol Ups Ubiquitin-proteasome system Ultraviolet photoelectron spectroscopy Universal Polar Stereographic
UPS
Protein-coding gene in the species Homo sapiens
the ER membrane of aberrant proteins destined for degradation by the proteasome. BiP is an abundant protein under all growth conditions, but its synthesis
Binding immunoglobulin protein
Binding_immunoglobulin_protein
Protein-coding gene in the species Homo sapiens
response) in response to proteasome inhibition. This compensatory up-regulation of proteasome genes in response to proteasome inhibition has also been
NFE2L1
Group of innate immune system disorders
dysfunction of the proteasome. This syndrome is caused by a mutation in the gene that encodes subunit β type-8 of the proteasome (PSMB8 gene). Due to
Autoinflammatory_disease
Protein found in humans
Proteasome subunit alpha type-5 also known as 20S proteasome subunit alpha-5 is a protein that in humans is encoded by the PSMA5 gene. This protein is
PSMA5
Partial or complete wasting away of a part of the body
K+ channel induces skeletal muscle atrophy by activating the ubiquitin proteasome pathway". FASEB J. 20 (9): 1531–3. doi:10.1096/fj.05-5350fje. PMID 16723379
Atrophy
Women American scientist
biomedical sciences. Known for her research on lipopolysaccharides (LPS), proteasomes, and inflammatory diseases, Dr. Qureshi has contributed significantly
Nilofer_Qureshi
Medication
myeloma who have received at least three prior therapies, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody
Linvoseltamab
Medical condition
associated with a deletion in the transcription gene POMP, which codes proteasome maturation protein. This prevents the correct formation of filaggrin from
Keratosis linearis with ichthyosis congenita and sclerosing keratoderma syndrome
Keratosis_linearis_with_ichthyosis_congenita_and_sclerosing_keratoderma_syndrome
American biologist
Matouschek currently studies the proteasome, the degradation machinery of eukaryotic cells, and the mechanisms by which the proteasome is able to unfold and translocate
Andreas_Matouschek
Protein containing at least one F-box domain
mediates ubiquitination of proteins targeted for degradation by the 26S proteasome. F-box domain is a protein structural motif of about 50 amino acids that
F-box_protein
Type of cancer
Bortezomib (Velcade) Proteasome inhibitors inhibit the NF-κB pathway. Since this pathway is not a significant factor in GCB DLBCL, proteasome inhibitors have
Germinal center B-cell like diffuse large B-cell lymphoma
Germinal_center_B-cell_like_diffuse_large_B-cell_lymphoma
Enzyme found in humans
26S protease regulatory subunit S10B, also known as 26S proteasome AAA-ATPase subunit Rpt4, is an enzyme that in humans is encoded by the PSMC6 gene. This
PSMC6
Protein-coding gene in the species Homo sapiens
protein binding polyubiquitin modification-dependent protein binding proteasome binding protein binding ubiquitin-specific protease binding ubiquitin
Large proline-rich protein BAG6
Large_proline-rich_protein_BAG6
Spherical inclusion commonly found in damaged neurons
believed to occur when a large amount of misfolded proteins in the ubiquitin-proteasome pathway are incorporated into an aggresome. Since Lewy bodies contain
Lewy_body
Protein-coding gene in the species Homo sapiens
protein ligase binding calcium-dependent protein binding calmodulin binding proteasome binding Cellular component integral component of membrane endoplasmic
WFS1
American chemist
protein substrates. As a non-peptidic proteasome inhibitor lactacysin has proven useful in the study of proteasome function. Lactacystin modifies the amino-terminal
Stuart_Schreiber
Loss of skeletal muscle mass
consistently seen in muscle atrophy due to disuse. The ATP-dependent ubiquitin/proteasome pathway is one mechanism by which proteins are degraded in muscle. This
Muscle_atrophy
Chemical element with atomic number 5 (B)
the proteasome inhibitor, for treating myeloma and one form of lymphoma. The boron atom in bortezomib binds the catalytic site of the 26S proteasome. A
Boron
Chemical compound
2008). "The value of proteasome inhibition in cancer. Can the old drug, disulfiram, have a bright new future as a novel proteasome inhibitor?". Drug Discovery
Disulfiram
Protein-coding gene in the species Homo sapiens
degradation and its recycling. The sequence associates with the ubiquitin- proteasome system, UPS, required for the unique development of an autophagosomal
ATG7
Class of drugs used to treat malignant tumors
primarily consist of various small molecule kinase inhibitors, alongside proteasome inhibitors and some epigenetic drugs. The latter, represented by monoclonal
Antineoplastic
Protein-coding gene in the species Homo sapiens
polyubiquitination by the SCF complex and their subsequent degradation by the proteasome. The Fbxl3 gene function was independently identified in 2007 by three
FBXL3
Protein-coding gene in the species Homo sapiens
subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. The human version of this proteasome subunit is PSMD2
RPN1
Peptide sequence in short-lived proteins
ubiquitin-26S proteasome-mediated degradation. This pathway works by marking the protein with ubiquitin molecules that the 26S proteasome recognizes. The
PEST_sequence
Food product and protein supplement derived from Pisum sativum
Protein methods Structures Protein structure Protein structural domains Proteasome Types List of proteins Membrane protein Globular protein Globulin Edestin
Pea_protein
Protein found in humans
Proteasome subunit beta type-7 as known as 20S proteasome subunit beta-2 is a protein that in humans is encoded by the PSMB7 gene. This protein is one
PSMB7
Cell-cycle regulatory complex
ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin
Anaphase-promoting_complex
Process of regulating a functional proteome
ubiquitin tagged for degradation by ATP dependent proteases, such as the proteasome in eukaryotes or ClpXP in prokaryotes. Autophagy, or self engulfment,
Proteostasis
Protein-coding gene in the species Homo sapiens
associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to effect in
UBQLN1
whereby an effector protein, TRIM21, directs antibody bound virions to the proteasome where they are degraded. As yet, it has only been observed to act against
Intracellular antibody-mediated degradation
Intracellular_antibody-mediated_degradation
Overview of and topical guide to biochemistry
activity: enzyme kinetics – enzyme inhibition proteolysis – ubiquitin – proteasome kinase – dehydrogenase Membranes : fluid mosaic model – diffusion – osmosis
Outline_of_biochemistry
Protein-coding gene in humans
ERK. BRAF V600E is a determinant of sensitivity to proteasome inhibitors. Vulnerability to proteasome inhibitors is dependent on persistent BRAF signaling
BRAF_(gene)
Mammalian protein found in humans
the 20S proteasome, and finally, the 26S proteasome. Grey bars on the evolutionary tree represent the two significant transitions in proteasome structure
ClpX
Protein region lacking lysines
deserts have been studied in the context of ubiquitination, pupylation and proteasome-dependent protein degradation. The term lysine desert was introduced by
Lysine_desert
Protein found in humans
Proteasome subunit alpha type-4 also known as macropain subunit C9, proteasome component C9, and 20S proteasome subunit alpha-3 is a protein that in humans
PSMA4
Aggregation of misfolded proteins in cells
proteolytic degradation of the misfolded/damaged proteins involving ubiquitin–proteasome and autophagy–lysosome systems, and formation of detergent-insoluble aggresomes
Aggresome
Topics referred to by the same term
Wiktionary, the free dictionary. Pomp or pomps may refer to: POMP, a proteasome maturation protein Pomp, Kentucky, a community in the United States Pomps
Pomp
Combination drug
combination is called Vel/Dex (or Vel-Dex or Veldex). Bortezomib is a proteasome inhibitor and dexamethasone is a corticosteroid. Corso A, Barbarano L
Bortezomib/dexamethasone
Chemical compound
designed to selectively degrade specific proteins by hijacking the ubiquitin-proteasome system. Luxdegalutamide is a second-generation PROTAC AR degrader that
Luxdegalutamide
Medication
myeloma who have received at least four prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody
Elranatamab
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