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Anticoagulant
Heparin, also known as unfractionated heparin (UFH), is a medication and naturally occurring glycosaminoglycan. It is one of the most studied sulfated
Heparin
Anticoagulant medication
Low-molecular-weight heparin (LMWH) is a class of anticoagulant medications. They are used in the prevention of blood clots and, in the treatment of venous
Low-molecular-weight_heparin
Low platelet count due to heparin, associated with a risk of thrombosis
Heparin-induced thrombocytopenia (HIT) is the development of thrombocytopenia (a low platelet count), due to the administration of various forms of heparin
Heparin-induced thrombocytopenia
Heparin-induced_thrombocytopenia
Class of drugs
aggregated platelet products. Common anticoagulants include warfarin and heparin. The use of anticoagulants is a decision based on the risks and benefits
Anticoagulant
Medical equipment capable of exchanging oxygen and carbon dioxide in human blood
uncoated CPB circuits require a high dose of systemic heparin. Although the effects of heparin are reversible by administering protamine, there are a
Oxygenator
Medical condition
Heparin necrosis (also known as heparin-induced skin necrosis) is an adverse reaction that can occur on skin after initiation of heparin treatment.[page needed]
Heparin_necrosis
Medicine contamination incidents
2008 Chinese heparin adulteration, refers to heparin adulteration incidents that occurred in the United States of America in 2008. Pharmaceutical company
2008 Chinese heparin adulteration
2008_Chinese_heparin_adulteration
Protein-coding gene in the species Homo sapiens
Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. HB-EGF-like growth
Heparin-binding EGF-like growth factor
Heparin-binding_EGF-like_growth_factor
Synthetic compound and anticoagulant
Heparin mimicking polymers are synthetic compounds that possess similar characteristics to heparin, that is it can be used clinically as an anticoagulant
Heparin_mimicking_polymers
Enzyme
The enzyme heparin lyase (EC 4.2.2.7) catalyzes the following process: Eliminative cleavage of polysaccharides containing (1→4)-linked D-glucuronate or
Heparin_lyase
Protein-coding gene in the species Homo sapiens
Heparin cofactor II (HCII), a protein encoded by the SERPIND1 gene, is a coagulation factor that inhibits IIa, and is a cofactor for heparin and dermatan
Heparin_cofactor_II
Macromolecule
to heparin. Both consist of a variably sulfated repeating disaccharide unit. The main disaccharide units that occur in heparan sulfate and heparin are
Heparan_sulfate
Blockage of an artery in the lungs
types of surgery. Treatment is with anticoagulant medications such as heparin, warfarin, or one of the direct-acting oral anticoagulants (DOACs). These
Pulmonary_embolism
Protein in humans
known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity
Pleiotrophin
Mammalian protein found in humans
β-antithrombin. Its activity is increased manyfold by the anticoagulant drug heparin, which enhances the binding of antithrombin to factor IIa (thrombin) and
Antithrombin
Medication
Taurolidine/heparin, sold under the brand name Defencath, is a fixed-dose combination catheter lock solution used for central venous catheter instillation
Taurolidine/heparin
Catalytic chemical
The enzyme heparin-sulfate lyase (EC 4.2.2.8) catalyzes the chemical reaction Elimination of sulfate; appears to act on linkages between N-acetyl-D-lucosamine
Heparin-sulfate_lyase
Pharmaceutical drug
effects of heparin. It is specifically used in heparin overdose, in low molecular weight heparin overdose, and to reverse the effects of heparin during delivery
Protamine_sulfate
Pharmaceutical drug
Administration (FDA) for prophylaxis or treatment of thrombosis in people with heparin-induced thrombocytopenia (HIT). In 2002, it was approved for use during
Argatroban
Class of polysaccharides
like heparin, act by interacting with heparin binding proteins, generally through ionic interactions or hydrogen bonding. Some examples of heparin binding
Heparinoid
Anticoagulant drug
predictable antithrombotic response. There is no risk for heparin-induced thrombocytopenia or heparin-induced thrombosis-thrombocytopenia syndrome. It does
Bivalirudin
Localized bleeding outside of blood vessels
seepage and collection of blood may occur if heparin is given via an intramuscular route; to avoid this, heparin must be given intravenously or subcutaneously
Hematoma
Anticoagulant medication (blood thinner)
appears to be safe for the fetus. Enoxaparin is in the low molecular weight heparin family of medications. Enoxaparin was first made in 1981 and approved for
Enoxaparin_sodium
Insertion of medication under the skin
site due to their anticoagulant effect. This includes heparin and low molecular weight heparin products such as enoxaparin. There is some low certainty
Subcutaneous_administration
Technique that temporarily takes over the function of the heart and lungs during surgery
Because heparin is typically used in CPB, patients who are known to have the antibodies responsible for heparin-induced thrombocytopenia and heparin-induced
Cardiopulmonary_bypass
American multinational healthcare company
suspended the manufacture of heparin, and launched an investigation. The investigation into the contamination has focused on raw heparin produced by one of Baxter's
Baxter_International
Medication administered into a vein
or saline lock, a needleless connection filled with a small amount of heparin or saline solution to prevent clotting, between uses of the catheter. Ported
Intravenous_therapy
Blood clot (thrombus) that forms within a vein
low-molecular-weight heparin (LMWH) or unfractionated heparin, or increasingly with direct acting oral anticoagulants (DOAC). Those initially treated with heparins can
Venous_thrombosis
American serial killer (born 1950)
find whether heparin (a blood thinner) was present in the boy's system. The results came that same day, showing abnormal levels of heparin in the blood
Genene_Jones
Medical condition
appearing months to years before the tumor would be otherwise detected. Heparin therapy is recommended to prevent future clots. The Trousseau sign of malignancy
Trousseau_sign_of_malignancy
Czech serial killer
others between May and December, 2006. He killed with a hidden vial of heparin — a blood-thinning drug causing internal bleeding when administered in
Petr_Zelenka_(serial_killer)
Protein-coding gene in the species Homo sapiens
Azurocidin also known as cationic antimicrobial protein CAP37 or heparin-binding protein (HBP) is a protein that in humans is encoded by the AZU1 gene
Azurocidin_1
lock solution developed by Cormedix/Cormedix GmbH. Neutrolin contains heparin and citrate (1000 U/mL and 3.5% respectively), two compounds commonly used
Catheter_lock_solution
Formation of a blood clot in a deep vein
treatment requires an additional non-oral anticoagulant, often injections of heparin. Prevention of VTE in the general population includes avoiding obesity
Deep_vein_thrombosis
Type of blood collection equipment for medical testing
nozzle. The additives may include anticoagulants (EDTA, sodium citrate, heparin) or a gel with density between those of blood cells and blood plasma. Additionally
Vacutainer
Viscoelastic method for hemostasis testing in whole blood
differential assays. They allow testing in the presence of therapeutic heparin concentrations and provide differential diagnostic information to support
Thromboelastometry
Indian researcher
identified oversulfated chondroitin sulfate as a contaminant in the US heparin supply in 2007 and 2008, he had developed antibodies for dengue, yellow
Ram_Sasisekharan
Chemical compound
an anticoagulant medication chemically related to low molecular weight heparins. It is marketed by Viatris. A generic version developed by Alchemia is
Fondaparinux
Anticoagulant drug
devoid of heparin. It consists of a mixture of heparan sulfate, dermatan sulfate, and chondroitin sulfate. It is chemically distinct from heparin, has different
Danaparoid
Abnormally high platelet count in the blood
Thrombocytopenic purpura: ITP Evans syndrome TM TTP Upshaw–Schulman syndrome Heparin-induced thrombocytopenia (HIT) May–Hegglin anomaly Monoclonal gammopathy
Thrombocythemia
Presence of a blood clot in the dural venous sinuses or cerebral veins
(medications that suppress blood clotting) such as low molecular weight heparin. Rarely, thrombolysis (enzymatic destruction of the blood clot) or mechanical
Cerebral venous sinus thrombosis
Cerebral_venous_sinus_thrombosis
Medical diagnostic method
also detect factor VIII inhibitors but is sensitive to unfractionated heparin as well. The KCT on whole blood is known as the "Activated Clotting Time"
Kaolin_clotting_time
Blood clot
mechanism of action of heparin and warfarin are different as they work on different pathways of the coagulation cascade. Heparin works by binding to and
Thrombus
Drug discovery
anticoagulation had stayed the same for over 50 years with the use of heparin derivatives and warfarin which have some well known disadvantages. DTIs
Discovery and development of direct thrombin inhibitors
Discovery_and_development_of_direct_thrombin_inhibitors
Polysaccharides found in animal tissue
classified into four groups, based on their core disaccharide structures: Heparin/heparan sulfate (HSGAGs) Chondroitin sulfate/dermatan sulfate (CSGAGs)
Glycosaminoglycan
Anticoagulant medication taken by mouth
clinical development. Several members of the class are expected to replace heparin (and derivatives) and warfarin in various clinical scenarios. There are
Direct_thrombin_inhibitor
Protein found in humans
matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). CTGF plays
CCN_family_member_2
Protein involved in blood clotting, wound healing and inflammation
aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is predicted to play a role in wound
Platelet_factor_4
Growth factor and signaling protein otherwise known as FGF2
1975; soon thereafter three variants were isolated: 'basic FGF' (FGF2); Heparin-binding growth factor-2; and Endothelial cell growth factor-2. Gene sequencing
Fibroblast_growth_factor_2
Pharmaceutical drug
Dalteparin is a low molecular weight heparin. It is marketed as Fragmin. Like other low molecular weight heparins, dalteparin is used for prophylaxis or
Dalteparin_sodium
Medical condition
intravenous insulin in those with significant ketones, low molecular weight heparin to decrease the risk of blood clotting, and antibiotics among those in
Hyperosmolar hyperglycemic state
Hyperosmolar_hyperglycemic_state
Abnormally low levels of platelets in the blood
who relapsed following splenectomy. Discontinuation of heparin is critical in a case of heparin-induced thrombocytopenia (HIT). Beyond that, however, clinicians
Thrombocytopenia
Type of white blood cell
responses, including histamine and serotonin that induce inflammation, and heparin that prevents blood clotting, although there are less than that found in
Basophil
Medical procedure involving an incision in a vein
(RST). Dark green Sodium heparin (anticoagulant) Chromosome testing, HLA typing, ammonia, lactate Light green Lithium heparin (anticoagulant) Plasma separator
Phlebotomy
American bioengineer
on a collaboration to bioengineer Heparin from E. coli. This is in part a response to the outbreak of adverse heparin reactions in 2007. This work helped
Robert_J._Linhardt
Medical procedure for purifying blood
effect cannot be easily reversed. Heparin can infrequently cause a low platelet count due to a reaction called heparin-induced thrombocytopenia (HIT). The
Hemodialysis
surgeon. He is most notable for his major contribution to the discovery of heparin. Born in San Francisco in 1890, he was the son of a physician, John T.
Jay_McLean
Test for coagulation of blood
partial thromboplastin time is also used to monitor the treatment effect of heparin, a widely prescribed drug that reduces blood's tendency to clot. The PTT
Partial_thromboplastin_time
TrkA and TrkB positive modulator
Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen Epiregulin Heparin-binding EGF-like growth factor (HB-EGF) Murodermin Nepidermin Transforming
ACD856
Canadian hematologist
recognized as an expert in heparin-induced thrombocytopenia and is renowned for developing a diagnostic test for heparin-induced thrombocytopenia in
John_G._Kelton
Colorimetric method used in clinical chemistry
interferent; if the sample is plasma, care needs to be taken that ammonium heparin has not been used as an anticoagulant. Nonspecificity is markedly decreased
Jaffe_reaction
Tubular device placed in a vein to administer medicines
flushing with saline or a heparin-containing solution keeps the line open and prevents blood clots. There is no evidence that heparin is better than saline
Central_venous_catheter
Process of obtaining intravenous access
these cases, but will delay testing. Tubes containing lithium heparin or sodium heparin are also commonly used for a variety of chemistry tests, as they
Venipuncture
Medical treatment to prevent clotting within blood vessels
A 2021 review found that low molecular weight heparin (LMWH) was superior to unfractionated heparin in the initial treatment of venous thromboembolism
Thrombosis_prevention
Obstruction of a blood vessel by a clot
anticoagulants, such as vitamin K antagonists (VKAs) and low-molecular-weight heparins (LMWHs), due to their rapid onset of action, predictable pharmacokinetics
Thromboembolism
Canadian public health entity
international standard for insulin production. Efforts at Connaught to purify heparin for human clinical trials laid the foundation for various critical surgeries
Connaught_Laboratories
Medical condition
antibiotic therapy is being administered.[citation needed] Anticoagulation with heparin is controversial. Retrospective studies show conflicting data. This decision
Cavernous_sinus_thrombosis
Medical diagnostic test
(dysfunctional fibrinogen) defect is present. In blood samples suspected to contain heparin, a substance derived from snake venom called batroxobin (formerly reptilase)
Thrombin_time
American actor (born 1954)
Cedars-Sinai Medical Center mistakenly gave Quaid's 10-day-old twins a dosage of heparin (a blood thinner) that was 1,000 times the common dosage for infants. The
Dennis_Quaid
2006 7 21[title missing] Killed his victims with a lethal injection of heparin from May to September 2006. Ten people survived his murder attempt. Suspected
List of serial killers by number of victims
List_of_serial_killers_by_number_of_victims
Family of proteins involved in anatomical development
cell surface receptors. A defining property of FGFs is that they bind to heparin and to heparan sulfate. Thus, some are sequestered in the extracellular
Fibroblast_growth_factor
Canadian co-discoverer of insulin (1899–1978)
of Toronto and was further involved in research concerning choline and heparin. Charles Herbert Best was born in Pembroke, Maine, on February 27, 1899
Charles Best (medical scientist)
Charles_Best_(medical_scientist)
Assisted reproductive technology procedure
adjuncts with IVF (screening hysteroscopy, DHEA, testosterone, GH, aspirin, heparin, antioxidants, seminal plasma, and PRP) suggested that (except for hysteroscopy)
In_vitro_fertilisation
Species of fungus
contain atromentin, a pigment with anticoagulant properties similar to heparin. The species was first described scientifically by American mycologist
Hydnellum_peckii
Anticoagulant solution often used in blood samples
typing. It is also used during procedures such as plasmapheresis instead of heparin. Two solutions (A and B) are defined by the United States Pharmacopeia
Acid-citrate-dextrose
Toxicity in the kidneys
kidneys needing their dose adjusted for the decreased kidney function (e.g., heparin, lithium). General: diuretics, β-blockers, vasodilator agents Local: ACE
Nephrotoxicity
Organic compounds of the form R–O–SO3 (charge –1)
Examples include keratan sulfate, chondroitin sulfate, and the anticoagulant heparin. Post-translational modifications of some proteins entail sulfation, often
Organosulfate
Laboratory blood test
detect deficiency or abnormalities in fibrinogen, especially in cases of heparin contamination. Reptilase, an enzyme found in the venom of Bothrops snakes
Reptilase_time
Medical procedure
prepacked with a small amount of heparin to prevent coagulation, or must be heparinised, by drawing up a small amount of heparin and squirting it out again
Radial_artery_puncture
Mammalian protein found in Homo sapiens
essential for the physiological activity. Heparin (unfractionated heparin) and its derivatives low molecular weight heparin (LMWH) bind to a plasma cofactor,
Factor_X
Combination drug
Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen Epiregulin Heparin-binding EGF-like growth factor (HB-EGF) Murodermin Nepidermin Transforming
Pertuzumab/trastuzumab/hyaluronidase
Pertuzumab/trastuzumab/hyaluronidase
Formation of blood clots inside the blood vessels
the brain is one of the causes of stroke.[citation needed] The use of heparin following surgery is common if there are no issues with bleeding. Generally
Thrombosis
Immune disorder leading to increased risk of blood clots
molecular weight heparin and low-dose aspirin are used instead of warfarin because of warfarin's ability to cause birth defects. Heparin and aspirin together
Antiphospholipid_syndrome
Swedish cardiovascular surgeon
October 1944, one year before Robert E. Gross. Crafoord also introduced heparin as thrombosis prophylaxis in the 1930s and he pioneered mechanical positive-pressure
Clarence_Crafoord
Medical procedure
medication used to keep blood from clotting. Heparin and regional citrate are often used, though heparin carries a higher risk of bleeding. However, a
Hemofiltration
Process of formation of blood clots
presence of heparan sulfate (a glycosaminoglycan) or the administration of heparins (different heparinoids increase affinity to FXa, thrombin, or both). Quantitative
Coagulation
Drug classification – antithrombotic agents
Clorindione B01AA10 Diphenadione B01AA11 Tioclomarol B01AA12 Fluindione B01AB01 Heparin B01AB02 Antithrombin III B01AB04 Dalteparin B01AB05 Enoxaparin B01AB06
ATC_code_B01
Bio-pharmaceutical company
along with other pharmaceutical companies, the 2008 Chinese heparin adulteration. "Heparin's Deadly Side Effects". Time magazine. 2008. Archived from the
Scientific Protein Laboratories
Scientific_Protein_Laboratories
Penultimate step in the activation of mammalian spermatozoa
with the acrosome and cortical reaction following this. Compounds such as heparin and progesterone can be used to induce capacitation. As a result of the
Capacitation
Medical condition
count due to drug-induced anti-platelet antibodies caused by drugs such as heparin, sulfonamides, digoxin, quinine, and quinidine. Idiopathic thrombocytopenic
Drug-induced thrombocytopenic purpura
Drug-induced_thrombocytopenic_purpura
Technique of providing both cardiac and respiratory support
management. Heparin-induced thrombocytopenia (HIT) is increasingly common among people receiving ECMO. When HIT is suspected, the heparin infusion is
Extracorporeal membrane oxygenation
Extracorporeal_membrane_oxygenation
Professor of pharmacy
His research interest is in the interface of chemistry and biology of heparin and heparan sulfate. His work covers the understanding of the biosynthetic
Jian_Liu_(academic)
Anticoagulant drug
monitoring; dietary restrictions are not needed. Unfractionated heparin, low molecular weight heparin, and fondaparinux also inhibit the activity of factor Xa
Rivaroxaban
Medical condition cause by blood clots
frozen plasma. Evidence to support these treatments, however, is poor. Heparin may be useful in the slowly developing form. About 1% of people admitted
Disseminated intravascular coagulation
Disseminated_intravascular_coagulation
Drugs for heart or blood vessels diseases
antithrombin. Heparin is a widely used anticoagulant. It is administered intravenously (into a vein) or subcutaneously (below the skin). Heparin can exert
Cardiovascular_agents
Protein-coding gene in the species Homo sapiens
soon afterwards others using different conditions isolated acidic FGF, Heparin-binding growth factor-1, and Endothelial cell growth factor-1. Gene sequencing
Fibroblast_growth_factor_1
Laboratory test
1992 by making it resistant to the widely used interfering anticoagulant heparin. A new LA resistant version with increased phospholipid was also released
Dilute Russell's viper venom time
Dilute_Russell's_viper_venom_time
Medical condition
resistance to unfractionated heparin, especially with continuous infusions. If large quantities of unfractionated heparin are required e.g. greater than
Antithrombin_III_deficiency
Topics referred to by the same term
HBDS may stand for : heparin-based delivery system various other acronyms. See also : HBD, Hemoglobin subunit delta honey bee deaths, due to colony collapse
HBDS
Swedish physician and biochemist. He identified the chemical structure of heparin and developed its clinical applications. Jorpes was the professor of medical
Erik_Jorpes
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