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Chemical compound in leeches
Hirudin is a naturally occurring peptide in the salivary glands of blood-sucking leeches (such as Hirudo medicinalis) that has a blood anticoagulant property
Hirudin
Canadian electronic music band
studio albums—Feel It Break (2011), Olympia (2013), Future Politics (2017), Hirudin (2020) and Chin Up Buttercup (2025). In 2004, Stelmanis and Postepski played
Austra_(band)
Species of annelid worm
while injecting blood thinners similar to Anophelins; anticoagulants (hirudin). Large adults can consume up to ten times their body weight in a single
Hirudo_medicinalis
Parasitic or predatory annelid worms
with a sucker and feeding on blood, having first secreted the peptide hirudin to prevent the blood from clotting. The jaws used to pierce the skin are
Leech
2020 studio album by Austra
Hirudin (stylized as HiRUDiN) is the fourth studio album by Canadian electronic music band Austra, released on May 1, 2020, by Domino worldwide and by
Hirudin_(album)
Drug discovery
technological advances in genetic engineering the production of recombinant hirudin was made possible which opened the door to this new group of drugs. Before
Discovery and development of direct thrombin inhibitors
Discovery_and_development_of_direct_thrombin_inhibitors
Ecological niche involving feeding on blood
substances in the saliva of several hematophagous species, such as leeches (hirudin). Hematophagy is classified as either obligatory or facultative. Obligatory
Hematophagy
Laboratory test
laboratory test used to monitor anticoagulation during treatment with hirudin, an anticoagulant medication which was originally isolated from leech saliva
Ecarin_clotting_time
Pharmaceutical drug
injection. Lepirudin is a recombinant hirudin derived from yeast cells. Lepirudin is almost identical to hirudin extracted from Hirudo medicinalis, having
Lepirudin
Species of leech
Parasitology compared hirudin and decorsin from M. decora, as well as hirudin and "hirudin-like factors" – substances which resemble hirudin but are not known
Macrobdella_decora
2017 studio album by Austra
Katie Stelmanis Austra chronology Olympia (2013) Future Politics (2017) Hirudin (2020) Singles from Future Politics "Utopia" Released: October 20, 2016
Future_Politics
Anticoagulant medication taken by mouth
recently, is the allosteric inhibitors. Hirudin and derivatives were originally discovered in Hirudo medicinalis: Hirudin Bivalirudin (transient inhibition
Direct_thrombin_inhibitor
Hard structure of the mouth
inside of a circle. After piercing the skin and injecting anticoagulants (hirudin) and anaesthetics, they suck out blood, consuming up to ten times their
Tooth
Anticoagulant drug
Chemically, it is a synthetic congener of the naturally occurring drug hirudin, found in the saliva of the medicinal leech Hirudo medicinalis. It is manufactured
Bivalirudin
Laboratory blood test
the reptilase time is not prolonged in blood samples containing heparin, hirudin, or direct thrombin inhibitors, whereas the thrombin time will be prolonged
Reptilase_time
Species of snake
(ECT) test, which is used to monitor anticoagulation during treatment with hirudin. Yet another drug produced from E. carinatus venom is Aggrastat (Tirofiban)
Echis_carinatus
Genre Label Ref. May 1 American Aquarium Lamentations New West Austra Hirudin Electronic Domino Boston Manor Glue Alternative rock Pure Noise Caleb Landry
List_of_2020_albums
Class of drugs
thrombin inhibitor. Current members of this class include the bivalent drugs hirudin, lepirudin, and bivalirudin and the monovalent drugs argatroban and dabigatran
Anticoagulant
German medical doctor
the town of Giessen, Germany. The procedure lasted only 15 minutes, and hirudin served as the anticoagulant. Haas was able to develop a dialyzer consisting
Georg_Haas_(physician)
Blood thinning drugs
paved way for the first successful synthetic anticoagulants including hirudin. The monitoring of warfarin and keeping the international normalized ratio
Direct_factor_Xa_inhibitors
Method of medication administration
and itching reaction. Leeches can inject an anticoagulant peptide called hirudin after attaching to prevent blood from clotting during feeding. This property
Injection_(medicine)
College in Birmingham, England
Haycraft, discovered an anticoagulant created by the leech, which he named hirudin John Rippiner Heath, physician and composer Micaiah John Muller Hill, FRS
Mason_Science_College
Specialised attachment organ of an animal
those six segments) to stay attached and secrete an anti-clotting enzyme, hirudin, into the host's blood stream. The medicinal leech (Hirudo medicinalis)
Sucker_(zoology)
Canadian musician (born 1985)
(2008) Austra Feel It Break (2011) Olympia (2013) Future Politics (2017) Hirudin (2019) Chin Up Buttercup (2025) Compilation appearances Friends in Bellwoods
Katie_Stelmanis
Pharmaceutical discovery procedure
based on compounds found in animals. For example, the anticoagulant drugs, hirudin and its synthetic congener, bivalirudin, are based on saliva chemistry
Drug_discovery
Enzyme involved in blood coagulation in humans
COMPLEXES OF HIRUDIN DERIVATIVES AND HUMAN ALPHA-THROMBIN DUE TO DIFFERENT CRYSTAL FORMS 1tmu: CHANGES IN INTERACTIONS IN COMPLEXES OF HIRUDIN DERIVATIVES
Thrombin
Canadian musician (born 1985)
Exactly" 2020 Kane West & Thomas Van Party —N/a "Mountain Baby" Austra Hirudin "Anywayz" Co-writer "Show Me What" A. G. Cook 7G Featured artist "Wish
Cecile_Believe
Belgian molecular biologist and entrepreneur (1947–1992)
candidates for schistosomiasis, toxoplasmosis and babesia canis; recombinant hirudin, α-1-antitrypsin, gamma-interferon and interleukins, and variants thereof
Jean-Pierre_Lecocq
Canadian musician (born 1991)
Arrangement "Get Up" 2018 TiKA Non-album single Co "Anywayz" 2020 Austra HiRUDiN Additional "It's Amazing" Additional "I Am Not Waiting" Additional "fall"
Casey_MQ
Protein family
to a superfamily (MEROPS IM) of protease inhibitors that also includes hirudin (MEROPS I14.001) and antistasin (MEROPS I15). Richardson JL, Kroger B,
Haemadin
Medical diagnostic method
against time on the computer screen. The manufacturer recommends the use of hirudin as anticoagulant for samples to be tested, but studies have shown that
Multiple electrode aggregometry
Multiple_electrode_aggregometry
College, discovered an anticoagulant created by the leech, which he named hirudin Lancelot Hogben, Professor of Zoology (1941–1947) and Professor of Medical
List of University of Birmingham academics
List_of_University_of_Birmingham_academics
British physiologist (1857–1922)
discovered that the leech secreted a powerful anticoagulant, which he named hirudin, although it was not isolated until the 1950s, nor its structure fully
John_Berry_Haycraft
Species of annelid worm
parasitization that he had observed, the leech did produce histamine or hirudin. The bite healed quickly, but itched for some time afterwards, and inflammation
Chtonobdella_limbata
Welsh musician, songwriter and producer
Marika Hackman Covers Mix Jack Garratt Love, Death & Dancing Mix Austra Hirudin Mix Elderbrook Why Do We Shake in the Cold? Mix Honne No Song Without You
David_Wrench_(music_producer)
inhibited by chlorpromazine, theophylline and mepacrine. However, neither hirudin, nor antithrombin III have any effect on cerastocytin-mediated clot formation
Cerastocytin
German biochemist and Nobel laureate (born 1937)
activation mechanism of this enzyme, and of the complex of thrombin with hirudin, which showed the molecular mechanism of inhibition of blood clotting by
Robert_Huber
Enzyme
Cholecystokinin (CCK), Factor V and Factor VIII, gastrin, the leech enzyme hirudin, fibrinogen, Complement component 4, follicle-stimulating hormone receptor
Tyrosylprotein sulfotransferase
Tyrosylprotein_sulfotransferase
Kurdish Iranian Kamancheh player and composer
most renowned works are: My Sunset-Land ROJAVA (2020). Of Shadows (2020). HiRUDin, Austra (band), (2020). Kamancello II: Voyage (2019). Kamancello (2017)
Shahriyar_Jamshidi
Vitamin K-dependent plasma glycoprotein synthesized in the liver
and C4b-binding protein levels in plasma anticoagulated with citrate or hirudin". Blood. 79 (12): 3203–3211. doi:10.1182/blood.V79.12.3203.bloodjournal79123203
Protein_S
Oligonucleotides which recognize the exosites of human thrombin
thrombin) is around 70 to 80 nmol/L, which is much lower than that of hirudin (~1.7 umol/L). Also, compared with heparin, TBA is more efficient in the
Anti-thrombin_aptamers
Protein family
families are named with an I followed by a number, for example, I14 contains hirudin-like inhibitors. Classes of proteases are: Aspartic protease inhibitors
Protease_inhibitor_(biology)
Ensemble, Ain't Got Long Rich Aucoin, United States – September 18 Austra, Hirudin – May 1 Backxwash, God Has Nothing to Do With This Leave Him Out of It
2020_in_Canadian_music
The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)
List_of_MeSH_codes_(D12.776)
discovers that the leech secretes a powerful anticoagulant, which he names hirudin. 1885: Birmingham School of Art becomes the first municipal school of art
Science and invention in Birmingham
Science_and_invention_in_Birmingham
Pure chemical substances produced by and for the chemical industry
ester) is also a dipeptide. At the high end, there is the anticoagulant hirudin, MW ≈ 7000, which is composed of 65 amino acids. Apart from pharmaceuticals
Fine_chemical
K, Unkrig C, Müller-Berghaus G (June 1997). "Monitoring of recombinant hirudin: assessment of a plasma-based ecarin clotting time assay". Thromb. Res
Ecarin
therapy MeSH E02.319.703.150 – antibiotic prophylaxis MeSH E02.319.913.500 – hirudin therapy MeSH E02.365.647.110 – cardiopulmonary resuscitation MeSH E02.365
List_of_MeSH_codes_(E02)
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