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Abnormally increased sensitivity to pain
Hyperalgesia (/ˌhaɪpərælˈdʒiːziə/ or /-siə/; hyper from Greek ὑπέρ (huper) 'over' + -algesia from Greek ἄλγος (algos) 'pain') is an abnormally increased
Hyperalgesia
Pain caused by opioid addiction
Opioid-induced hyperalgesia (OIH) or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia, is an uncommon condition of generalized
Opioid-induced_hyperalgesia
Array of painful conditions in humans
pinprick stimulation of a CRPS affected limb was painful (mechanical hyperalgesia) and showed a "significantly increased activation" of not just the S1
Complex regional pain syndrome
Complex_regional_pain_syndrome
Muscle pain after exercise
characteristic symptom of DOMS, is also referred to as "muscular mechanical hyperalgesia". Although there is variance among exercises and individuals, the soreness
Delayed_onset_muscle_soreness
Transduction of mechanical stimuli into neural signals
responsible for hearing and balance. States of neuropathic pain, such as hyperalgesia and allodynia, are also directly related to mechanosensation. A wide
Mechanosensation
Feeling of pain from stimuli which do not normally elicit pain
cold or warm water over it, can be very painful. It is different from hyperalgesia, an exaggerated response from a normally painful stimulus. The term comes
Allodynia
Abnormal increase in sensitivity to sensory stimuli
refer to an increase in sensitivity where there is both allodynia and hyperalgesia. In psychology, Jeanne Siaud-Facchin uses the term by defining it as
Hyperesthesia
Psychoactive chemical
unwanted side effects. Long-term opioid use can cause opioid-induced hyperalgesia, which is a condition in which the patient has increased sensitivity
Opioid
Uncomfortable skin sensation
(punctuate hyperalgesia). Touch-evoked hyperalgesia requires continuous firing of primary afferent nociceptors, and punctuate hyperalgesia does not require
Itch
2015 studio album by Victorian Halls
Hyperalgesia is the second full-length studio album by American alternative rock band Victorian Halls. The album, that contains 11-tracks, was recorded
Hyperalgesia_(album)
Extreme perception of pain from normally painful stimuli
inclusion of hyperalgesia explicitly. Previously hyperalgesia was implied, since hyperesthesia was mentioned in the previous note and hyperalgesia is a special
Hyperpathia
Drugs used to achieve relief from pain
opioid-induced hyperalgesia. The symptoms of these two conditions can appear very similar but the mechanism of action is different. Opioid-induced hyperalgesia is
Analgesic
Human protein for regulating body temperature
stimuli. This manifests as an increased sensitivity to painful stimuli (hyperalgesia) or pain sensation in response to non-painful stimuli (allodynia). Most
TRPV1
Group of neurons in medulla of brain
a dermorphin-saporin conjugate reduced the duration of allodynia and hyperalgesia caused by a nerve injury. Treatment with the dermorphin-saporin conjugate
Rostral_ventromedial_medulla
Type of pain in the organs
affected by secondary hyperalgesia - especially when the causative visceral pain has been recurrent or chronic. Secondary hyperalgesia may persist after the
Visceral_pain
Spectrum of disorders
severe sensitivity to light (photophobia) in the worst cases, to mild hyperalgesia or dysesthesia such as a sensation of dryness, stinging, or foreign body
Ocular_neuropathic_pain
Dissociative anesthetic and anti-depressant
and the control of procedural pain. It may also prevent opioid-induced hyperalgesia and postanesthetic shivering. For chronic pain, ketamine is used as an
Ketamine
Species of mammal
edema (swelling via fluid buildup) which can lead to an excruciating hyperalgesia (heightened sensitivity to pain) that can last as long as months. The
Platypus
Aspect of psychology
lethargy, depression, anxiety, malaise, loss of appetite, sleepiness, hyperalgesia, reduction in grooming and failure to concentrate. Sickness behavior
Sickness_behavior
General anesthesia method
patients may be subjected to an elevated risk of anesthesia awareness, hyperalgesia and neurotoxicity. Considering these risks, special consideration is
Total_intravenous_anaesthesia
Chronic medical condition
orthostatic hypotension, a drop in blood pressure after standing. Pain and hyperalgesia (an abnormally increased sensitivity to pain) are common in ME/CFS. The
Myalgic encephalomyelitis/chronic fatigue syndrome
Myalgic_encephalomyelitis/chronic_fatigue_syndrome
Medical condition
in central sensitization, which manifests clinically as allodynia and hyperalgesia of CTTH. Additionally, CTTH patients exhibit decreased thermal and pain
Tension_headache
One of three classes of nerve fiber in the nervous system
can be caused by an increased neuronal response to a noxious stimulus (hyperalgesia), a larger neuronal receptive field, or spread of the hyper-excitability
Group_C_nerve_fiber
Chemical compound
activity. Yangonin significantly reduces nociception and inflammatory hyperalgesia via spinal CB1 receptors in rats, highlighting its potential as a promising
Yangonin
Form of sickle cell crisis in sickle cell anaemia
vaso-occlusive crisis present with pain (mild to severe) and a history of sickle cell anemia. Differential diagnosis Neuropathic pain, hyperalgesia, osteomyelitis
Vaso-occlusive_crisis
Pharmaceutical compound
analgesic effects, showing efficacy against atypical pain syndromes such as hyperalgesia and allodynia. It is being researched as a potential treatment for neuropathy
ART26.12
Drug
receptor in as yet poorly understood processes such as allodynia and hyperalgesia. AS-19 E-55888 LP-44 LP-211 Godínez-Chaparro B, Barragán-Iglesias P,
LP-12
Dopamine agonist medication
Common side effects of pramipexole include: Headache Peripheral edema Hyperalgesia (body aches and pains) Nausea and vomiting Sedation and somnolence Decreased
Pramipexole
Neurological disorder
Rolan, Paul (2012). "Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach
Cluster_headache
Injury caused by a bullet
early dementia, amputations, chronic pain and pain with light touch (hyperalgesia), deep venous thrombosis with pulmonary embolus, limb swelling and debility
Gunshot_wound
Harmful effect from negative belief
hypersensitivity are caused by the nocebo effect. Verbal suggestion can cause hyperalgesia (increased sensitivity to pain) and allodynia (perception of a tactile
Nocebo
distress in the context of opioid abuse. Hyperkatifeia and opioid-induced hyperalgesia can be seen with long-term use of illicit street opioids e.g. heroin
Hyperkatifeia
Gamma-aminobutyric acid analog
an inpatient therapy program, particularly by reducing opioid-induced hyperalgesia and drug craving. There is insufficient evidence for its use in cannabis
Gabapentin
Nerve cell that converts environmental stimuli into corresponding internal stimuli
pain - a severe pain condition resulting from a damaged sensory nerve Hyperalgesia - an increased sensitivity to pain caused by sensory ion channel, TRPM8
Sensory_neuron
Group of physiologically active lipid compounds
release of histamine (increasing allergy response) ↑ pain perception hyperalgesia (wild type EP3 expression) ↑ autonomic neurotransmitters ↑ platelet response
Prostaglandin
Pharmaceutical compound
nitroglycerin-evoked hyperalgesia model in rodents used to screen candidates for potential utility in acute migraine [16], TRV250 significantly reduced hyperalgesia (Data
TRV250
Substance derived from opium
morphine, and thus M3G, are associated with neurotoxic side effects such as hyperalgesia, allodynia and myoclonus. Oxymorphone is a congener of morphine. It is
Opiate
2011 studio album by Victorian Halls
Producer Victorian Halls Victorian Halls chronology Charlatan (2011) Hyperalgesia (2015) Singles from Victorian Halls "A Crush is a Crush" Released: 2011
Charlatan_(album)
Raised body temperature caused by disease
which consists of lethargy, depression, loss of appetite, sleepiness, hyperalgesia, dehydration, and the inability to concentrate. Sleeping with a fever
Fever
Drug discovery
in these sites is a key factor in the development of inflammation and hyperalgesia. COX-2 inhibitors have analgesic and anti-inflammatory activity by blocking
Discovery and development of cyclooxygenase 2 inhibitors
Discovery_and_development_of_cyclooxygenase_2_inhibitors
Chemical compound
anti-inflammatory and analgesic effects in carrageenan-evoked thermal hyperalgesia. Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-α
Paeonol
CR was opposite to the effects of morphine, and the rats experienced hyperalgesia. Siegel suggested that compensatory CRs allow the organism to maintain
Conditioned compensatory response
Conditioned_compensatory_response
Protein and coding gene in humans
Hepoxilin#Pain perception) directly activate TRPA1 and thereby contribute to the hyperalgesia and tactile allodynia responses of mice to skin inflammation. In this
TRPA1
Unpleasant, abnormal sense of touch
affected paws as well. These results indicate that the rats exhibited hyperalgesia, allodynia, and dysesthesia.[citation needed] In a study in which researchers
Dysesthesia
Type of unpleasant bodily feeling
medications can cause paradoxical side effects, such as opioid-induced hyperalgesia (severe generalized pain caused by long-term opioid use). Sugar (sucrose)
Pain
Musical group from the United States
Cameron Webb's recording studio. Their second full-length studio album, "Hyperalgesia" was recorded in Gossip Studios, Chicago, and released in May 2015 with
Victorian_Halls
Pharmaceutical compound
receptors. In animal studies, RF3286 potently inhibited the development of hyperalgesia produced by mu-opioid agonists while also increasing analgesia. Quillet
RF3286
Protein-coding gene in humans
sensitization increases the sensation of cold pain, also known as cold hyperalgesia. An experiment was done in a double-blind two-way crossover study by
TRPM8
Sensory neuron that detects pain
commonly known as hyperalgesia. Inflammation is one common cause that results in the sensitization of nociceptors. Normally hyperalgesia ceases when inflammation
Nociceptor
Venom produced by the platypus
obtained from case studies shows that the pain develops into a long-lasting hyperalgesia that can persist for months but usually lasts from a few days to a few
Platypus_venom
Pharmaceutical compound
effects of mu-opioid agonists while decreasing some side effects such as hyperalgesia. Simonin F, Schmitt M, Laulin JP, Laboureyras E, Jhamandas JH, MacTavish
RF9_(drug)
Chemical compound
accumulation of this metabolite include convulsions, agitation, hallucinations, hyperalgesia, and coma. The enzyme UDP-Glucuronosyltransferase-2B7 converts morphine
Morphine-3-glucuronide
Condition characterized by amplified and chronic pain
tolerance to pain. This can help with symptoms such as allodynia and hyperalgesia in AMPS, as well as indirectly help with other common symptoms by relieving
Amplified musculoskeletal pain syndrome
Amplified_musculoskeletal_pain_syndrome
Enzyme
novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action". The
Adenosine_kinase
Chemical compound
Ho WH, Pons J, Rosenthal A (July 2005). "Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis". Pain. 116 (1–2): 8–16. doi:10
Tanezumab
Medical condition
syndrome (CAPS) D2. Narcotic bowel syndrome (NBS)/ Opioid-induced GI hyperalgesia E1. Biliary pain E1a. Functional gallbladder disorder E1b. Functional
Functional gastrointestinal disorder
Functional_gastrointestinal_disorder
Brazilian physician and pharmacologist (1934–2016)
on the basic mechanisms involved in the development of inflammatory hyperalgesia led to the discovery that a select class of analgesics like metamizole
Sérgio_Henrique_Ferreira
Cluster of neurons in a dorsal root of a spinal nerve
compound that sensitizes neurons to mechanical stimuli and mechanical hyperalgesia), which further supports a role for HT channels in the transduction of
Dorsal_root_ganglion
Group of venomous snakes from Asia
protein component specific to this species, causes hypolocomotion and hyperalgesia in experimental mice. It is believed that it contributes to neurotoxicity
King_cobra
Heritable connective tissue disorder
joint movement. Chronic pain: Recurrent joint pain that can develop into hyperalgesia, with a higher rate of small fiber neuropathy in some individuals. Disturbed
Hypermobility spectrum disorder
Hypermobility_spectrum_disorder
Chronic multi-symptomatic pain disorder
resulting in cognitive problems. People with fibromyalgia may experience hyperalgesia (abnormally increased sensitivity to pain) and allodynia (pain from a
Fibromyalgia
Pharmaceutical compound
In animal studies it reduced tolerance to morphine but also produced hyperalgesia and anxiety. Related compounds such as AC-099 with Cl or CF3 replacing
AC-263093
Condition negatively affecting an organism
illness can include lethargy, depression, loss of appetite, sleepiness, hyperalgesia, and inability to concentrate. Disorder A disorder is a functional abnormality
Disease
Glutamate receptor and ion channel protein found in nerve cells
NCT00188383 for "Effects of N-Methyl-D-Aspartate (NMDA)-Receptor Antagonism on Hyperalgesia, Opioid Use, and Pain After Radical Prostatectomy" at ClinicalTrials
NMDA_receptor
Symptom
referring to a hyperexcitability of the nervous system, usually including hyperalgesia (increased sensitivity to pain), and allodynia (painful perception of
Nociplastic_pain
How an organism receives and responds to painful stimuli
increases as the pain stimulus continues, leading to a condition called hyperalgesia. Nociception can also cause generalized autonomic responses before or
Nociception
Chemical compound
preventing the development of tolerance to morphine, the prevention of hyperalgesia induced by intracerebroventricular administration of nociceptin (orphanin
J-113,397
Drug
tolerance and dependence, as well as the development of side effects such as hyperalgesia and allodynia, which can cause long-term use of opioid analgesics to
(+)-Naloxone
Opioid medication used for pain relief
produce excitatory neurotoxic effects such as restlessness, myoclonus and hyperalgesia. Patients with compromised kidney function and older patients are at
Hydromorphone
Chemical compound
neuropathic pain model, LF22-0542 reversed the thermal hyperalgesia, but not the mechanical hyperalgesia. "Safotibant INN". Mednet. Retrieved 31 March 2016
Safotibant
Pain that lasts longer than three months
abnormally changed due to continuous stimulation and can cause allodynia or hyperalgesia. In chronic pain, this process is difficult to reverse or stop once established
Chronic_pain
Cranial nerve responsible for the face's senses and motor functions
mechanisms leading to sensory symptoms such as parasthesias, dysesthesias, or hyperalgesia in the affected nerve distribution including the distribution of the
Trigeminal_nerve
Functional gastrointestinal disorder
in the colon of IBS patients. A role of 5-HT7 receptor in intestinal hyperalgesia was demonstrated in mouse models with visceral hypersensitivity, of which
Irritable_bowel_syndrome
Protein-coding gene in the species Homo sapiens, named for ketazocine
pain reversal and chronic stimulation leads to receptor tolerance and hyperalgesia with allodynia. Mechanisms such as activation of NMDA receptors on spinal
Κ-opioid_receptor
Synthetic opioid analgesic
increase in the dosage in cats can achieve analgesia and anti-nociception. Hyperalgesia and tolerance has been demonstrated in rodents and rabbits but not dogs
Remifentanil
Protein-coding gene in the species Homo sapiens
after detecting a noxious stimulus. Therefore, Nav1.8 contributes to hyperalgesia (increased sensitivity to pain) and allodynia (pain from stimuli that
Nav1.8
Peripheral vascular disease
dependence Opioids SID Opioid overdose Opioid withdrawal Opioid-induced hyperalgesia (OIH) Opioid-induced endocrinopathy (OIE) Opioid-induced constipation
Cannabis_arteritis
Opiate and prodrug of morphine used to treat pain
Like morphine, codeine causes TLR4 signaling which causes allodynia and hyperalgesia. It does not need to be converted to morphine to increase pain sensitivity
Codeine
Fear of pain
anything actually happens to them. People with this problem probably have hyperalgesia. The Fear of Pain Questionnaire (currently the FPQ-III), a mental health
Algophobia
InterPro Family
Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia". Journal of Medicinal Chemistry. 64 (11): 7555–7564. doi:10.1021/acs
Neuropeptide_FF_receptor
Medical condition
sensitivity and field of peripheral receptors, the latter of which causes hyperalgesia by recruiting and activating nociceptors that were previously silent
Functional abdominal pain syndrome
Functional_abdominal_pain_syndrome
characteristic of pain (in mammals at least) is that pain can result in hyperalgesia (a heightened sensitivity to noxious stimuli) and allodynia (a heightened
Pain_in_fish
Continual use of drugs despite negative consequences
dependence Opioids SID Opioid overdose Opioid withdrawal Opioid-induced hyperalgesia (OIH) Opioid-induced endocrinopathy (OIE) Opioid-induced constipation
Substance_use_disorder
Semi-synthetic opioid
and causes". Mayo Clinic. Retrieved 5 September 2022. "Opioid-Induced Hyperalgesia: How Opioids Can Increase Pain". Hospital for Special Surgery. Retrieved
Dihydrocodeine
Chemical compound
was developed as a potential analgesic, and blocks the development of hyperalgesia following exposure to cold temperatures or chronic morphine administration
RQ-00203078
Protein-coding gene in the species Homo sapiens
expressing these mutant channels, thus causing extreme sensitivity to pain (hyperalgesia). While the expression of PE Nav1.7 mutations produces hyperexcitability
Sodium voltage-gated channel alpha subunit 9
Sodium_voltage-gated_channel_alpha_subunit_9
Distress in human infants
rendering the scale unreliable in acute or prolonged cases. In addition, hyperalgesia and allodynia, occur more quickly and more extensively in babies than
Pain_in_babies
Medical condition
jeans nerve compression syndrome neurectomy paresthesia dysesthesia hyperalgesia Pearce JM (2006). "Meralgia paraesthetica (Bernhardt-Roth syndrome)"
Meralgia_paraesthetica
Physical effects resulting from activation of the immune system
released mediators such as bradykinin increase the sensitivity to pain (hyperalgesia, dolor). The mediator molecules also alter the blood vessels to permit
Inflammation
Sensation and perception of temperature
Hyperesthesia Hypoesthesia Paresthesia Tactile hallucination Nociception (pain) Hyperalgesia Hypoalgesia Pain dissociation Phantom pain Proprioception Asomatognosia
Thermoception
Therapeutic technique
"Effectiveness of transcutaneous electrical nerve stimulation for treatment of hyperalgesia and pain". Current Rheumatology Reports. 10 (6): 492–499. doi:10.1007/s11926-008-0080-z
Transcutaneous electrical nerve stimulation
Transcutaneous_electrical_nerve_stimulation
Phytocannabinoid discovered in 1940
2004). "Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin". The Journal of Pharmacology and Experimental
Cannabidiol
Conclusion of the human pregnancy
actually increase sensitivity to pain through the process of nocebo hyperalgesia. At the same time positive expectations can reduce pain through placebo
Childbirth
Type of brain cell
transmitters, which in turn control synaptic activity. In the past, hyperalgesia was thought to be modulated by the release of substance P and excitatory
Astrocyte
intrinsic anterograde amnesia effect. Barbiturates are known to induce hyperalgesia, i.e. aggravation of pain and for sleeplessness due to pain, if barbiturates
Automatism_(toxicology)
Pharmaceutical compound
Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats". eNeuro. 5 (3). doi:10.1523/ENEURO.0153-18
JNJ-63533054
Chemical compound
the human thromboxane receptor. HXA3 and HXB3 appear responsible for hyperalgesia and tactile allodynia (pain caused by a normally non-painful stimulus)
Hepoxilin
Canadian neurobiologist
motor spasticity, stress, anxiety, schizophrenia, and morphine-induced hyperalgesia. Marc Bergeron received a CIHR Brain Star Award for this publication
Yves_De_Koninck
Chemical compound
modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy". Nature Medicine. 18 (6): 926–33. doi:10.1038/nm
Methylglyoxal
Class of anesthetics
PMID 8901001. "Effects of N-Methyl-D-Aspartate (NMDA)-Receptor Antagonism on Hyperalgesia, Opioid Use, and Pain After Radical Prostatectomy", University Health
NMDA_receptor_antagonist
HYPERALGESIA
HYPERALGESIA
HYPERALGESIA
HYPERALGESIA
Girl/Female
Biblical
The house of grace or mercy.
Boy/Male
Hindu
One whose wealth is his wisdom
Biblical
rebellious; bitter; set with trees
Boy/Male
Indian
Respectable Man, Intelligent
Boy/Male
American, Australian, British, Chinese, Christian, English
Three
Boy/Male
Biblical
Mountainous country.
Boy/Male
Indian, Sikh
A Partition in the World
Girl/Female
Danish, Finnish, German, Swedish, Teutonic
Desire; Protection; Will; Helmet
Girl/Female
British, English
Female Version of Anseim; Introduced from Germany by 11th Century St Anselm
Boy/Male
Indian
God
HYPERALGESIA
HYPERALGESIA
HYPERALGESIA
HYPERALGESIA
HYPERALGESIA