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Protein-coding gene in the species Homo sapiens
Interferon alpha-1 is a protein that in humans is encoded by the IFNA1 gene. Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon
Interferon_alpha-1
Cytokine
The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses
Interferon_type_I
Pharmaceutical drug
Interferon alfa (INN) or HuIFN-alpha-Le, trade name Multiferon, is a pharmaceutical drug composed of natural interferon alpha (IFN-α), obtained from the
Interferon_alfa
Signaling proteins released by host cells in response to the presence of pathogens
4E-binding protein 1 (EIF4EBP1) in order to deactivate it. Interferons can disrupt signaling by other stimuli. For example, interferon alpha induces RIG-G
Interferon
Heterodimeric receptor
The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. Endogenous human
Interferon-alpha/beta receptor
Interferon-alpha/beta_receptor
Pharmaceutical drug
Interferon alpha-n3 (Alferon-N) is a medication consisting of purified natural human interferon alpha proteins used for the treatment of genital warts
Interferon_alpha-n3
InterPro Family
Interferon gamma (IFN-γ) is a family of dimerized soluble cytokines in the type II class of interferons. In humans, IFN-γ is the only type II family and
Interferon_gamma
Veterinary medication
feline interferon omega (RFeIFN-ω), sold under the brand name Virbagen Omega among others, is a recombinant version of a cat interferon alpha. It is used
Recombinant feline interferon omega
Recombinant_feline_interferon_omega
Protein-coding gene in the species Homo sapiens
Interferon alpha-1/13, also known as IFN-alpha-1/13, is a protein that in humans is encoded by the IFNA1 and IFNA13 genes. GRCh38: Ensembl release 89:
IFNA13
Pharmaceutical drug
Interferon alfa-2b is an antiviral or antineoplastic drug. It is a recombinant form of the protein interferon alpha-2 that was originally sequenced and
Interferon_alfa-2b
Protein-coding gene in the species Homo sapiens
encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages. IFNGR2, encodes
Interferon_gamma_receptor_1
constant alpha 1 Importin alpha 1 Interferon, alpha 1 Interleukin 13 receptor, alpha 1 Karyopherin alpha 1 Laminin, alpha 1 Major histocompatibility complex
List of A1 genes, proteins or receptors
List_of_A1_genes,_proteins_or_receptors
Cytokine in the interferon family
Interferon beta-1a (also interferon beta 1-alpha) is a cytokine in the interferon family used to treat multiple sclerosis (MS). It is produced by mammalian
Interferon_beta-1a
Protein found in humans
Interferon lambda receptor 1 is a subunit for the interferon lambda receptor encoded by the IFNLR1 gene. It was formerly known as interleukin 28 receptor
Interferon_lambda_receptor_1
Pharmaceutical drug
Pegylated interferon alfa-2a is in the alpha interferon family of medications. It is pegylated to protect the molecule from breakdown. Pegylated interferon alfa-2a
Peginterferon_alfa-2a
Transmembrane proteins
and limiting of interferon signaling. interferon-alpha/beta receptor interferon-gamma receptor Interferon type III receptor Interleukin-10 receptor Interleukin-20
Type_II_cytokine_receptor
Mammalian protein found in Homo sapiens
Interferon alpha-2 is a protein that in humans is encoded by the IFNA2 gene. Human interferon alpha-2 (IFNα2) is a cytokine belonging to the family of
IFNA2
Mammalian protein found in humans
pattern recognition receptor (PRR) that can mediate induction of a type-I interferon (IFN1) response. RIG-I is an essential molecule in the innate immune system
RIG-I
Protein-coding gene in the species Homo sapiens
Interleukin-1 alpha (IL-1 alpha or IL-1α) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that is encoded by the IL1A gene in humans
Interleukin_1-alpha
Protein-coding gene in the species Homo sapiens
Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the IFNAR2 gene. The protein encoded by this gene is a type I membrane
IFNAR2
Protein-coding gene in the species Homo sapiens
Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene. The protein encoded by this gene is a type I membrane
IFNAR1
Sendai virus, virus of rodents
proteins: inhibition of Toll-like receptor 7/9-dependent alpha interferon induction". FEBS Letters. 588 (1): 28–34. Bibcode:2014FEBSL.588...28Y. doi:10.1016/j
Murine_respirovirus
Pharmaceutical drug
Interferon alfacon-1 is a interferon drug that is used to treat hepatitis C infections. In chronic hepatitis C, multiple phase II and III trials showed
Interferon_alfacon-1
Protein-coding gene in the species Homo sapiens
Interferon lambda 3 encodes the IFNL3 protein. IFNL3 was formerly named IL28B, but the Human Genome Organization Gene Nomenclature Committee renamed this
Interferon_lambda_3
Protein-coding gene in the species Homo sapiens
Interferon alpha-8 is a protein that in humans is encoded by the IFNA8 gene. GRCh38: Ensembl release 89: ENSG00000120242 – Ensembl, May 2017 GRCm38: Ensembl
IFNA8
Type of immune cell in the blood
type of immune cell that are known to secrete large quantities of type 1 interferon (IFNs) in response to a viral infection. They circulate in the blood
Plasmacytoid_dendritic_cell
Protein-coding gene in the species Homo sapiens
Interferon lambda 4 (gene symbol: IFNL4) is one of the most recently discovered human genes and the newest addition to the interferon lambda protein family
Interferon_lambda_4
Protein-coding gene in the species Homo sapiens
PMID 15481145. Bekisz J, Schmeisser H, Hernandez J, et al. (2005). "Human interferons alpha, beta and omega". Growth Factors. 22 (4): 243–51. doi:10.1080/08977190400000833
IFNB1
disulfide bridges (1–99, 29–139) and amino terminal proline. Similar to other Type I interferons, IFN-τ binds to the Interferon-alpha/beta receptor (IFNAR)
Interferon_tau
Mammalian protein found in humans
(1993). "The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction". Nature. 366 (6451): 129–35. Bibcode:1993Natur
Janus_kinase_1
Protein-coding gene in the species Homo sapiens
induce interferon β and more than 10 forms of interferon α production. Type I interferon produced by infected cells can find and bind to Interferon-alpha/beta
Stimulator of interferon genes
Stimulator_of_interferon_genes
Protein family
Members of this family include: The human (bony fish in general) interferon gamma receptor 1, which is a member of the hematopoietic cytokine receptor superfamily
Interferon gamma receptor (IFNGR1) family
Interferon_gamma_receptor_(IFNGR1)_family
Group of anti-viral cytokines
The type III interferon group is a group of anti-viral cytokines that in humans consists of a singular family, IFN-λ (lambda). Their function is similar
Interferon_type_III
Medical condition
intraventricular interferon alfa, amantadine, ribavirin, and others. Immunoglobulin therapy (IVIG) is also used. Isoprinosine is sometimes combined with interferon alfa
Subacute sclerosing panencephalitis
Subacute_sclerosing_panencephalitis
Protein-coding gene in Homo sapiens
Lim JT, Schreiber RD, et al. (March 1996). "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of
STAT2
Topics referred to by the same term
the free dictionary. 1B may refer to: Alpha-1B adrenergic receptor Arginine vasopressin receptor 1B Interferon beta-1b Melatonin receptor 1B The ASCII
1B
Class of immunosuppressive drug
antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice". International Immunopharmacology. 6 (6): 903–907
TNF_inhibitor
Pharmaceutical drug
Subcutaneous injection is the preferred delivery method. Belonging to the alpha interferon family of medications, the molecule is PEGylated to prevent breakdown
Peginterferon_alfa-2b
Category of small signaling proteins
cancer patients. Interferon gamma is used to treat chronic granulomatous disease and osteopetrosis Interferon-alpha, an interferon type I, was identified
Cytokine
Topics referred to by the same term
obsolete designation for the group 1 elements AMY1A, a human gene Alpha-1A adrenergic receptor, a human gene Interferon beta-1a, a drug Meltwater pulse 1A
1A
Protein-coding gene in the species Homo sapiens
Interferon alpha-21 is a protein that in humans is encoded by the IFNA21 gene. GRCh38: Ensembl release 89: ENSG00000137080 – Ensembl, May 2017 GRCm38:
IFNA21
Protein-coding gene in the species Homo sapiens
Interleukin-29 (IL-29) is a cytokine and it belongs to type III interferons group, also termed interferons λ (IFN-λ). IL-29 (alternative name IFNλ1) plays an important
Interleukin_29
Type of cytokine produced primarily by monocytes and macrophages
and macrophages. Some monokines are: interleukin 1 tumor necrosis factor-alpha alpha and beta interferon colony stimulating factors Monokines released from
Monokine
Type II cytokine receptor
Interferon-lambda receptor (IFNLR), formerly known as the interleukin-28 receptor (IL28R), is a type II cytokine receptor found largely in epithelial cells
Interferon-lambda_receptor
Slovak immunologist (born 1933)
leukocyte (alpha) and beta interferon are antigenically distinct, laying the groundwork for the later demonstration that these interferons are encoded
Jan_Vilček
Type of signaling molecule
inflammation. They include interleukin-1 (IL-1), IL-6, IL-12, and IL-18, tumor necrosis factor alpha (TNF-α), interferon gamma (IFNγ), and granulocyte-macrophage
Inflammatory_cytokine
Protein-coding gene in the species Homo sapiens
the nucleus for the transcriptional activation of interferons alpha and beta, and further interferon-induced genes. IRF3 plays an important role in the
IRF3
Autoimmune condition causing dysfunction of endocrine glands
tolerance. APS-1 causes considerable reactions with both interferon omega and interferon alpha. There may also be a reaction against interleukin 22. This
Autoimmune polyendocrine syndrome type 1
Autoimmune_polyendocrine_syndrome_type_1
Chemical compound
Journal of Chinese Medicine. 19 (1): 73–8. doi:10.1142/S0192415X91000119. PMID 1897494. Paeoniflorin ameliorates interferon-alpha-induced neuroinflammation and
Paeoniflorin
Protein-coding gene in the species Homo sapiens
Interferon alpha-16, also known as IFN-alpha-16, is a protein that in humans is encoded by theIFNA16 gene. GRCh38: Ensembl release 89: ENSG00000147885
IFNA16
Protein-coding gene in the species Homo sapiens
Interferon alpha-5 is a protein that in humans is encoded by the IFNA5 gene. GRCh38: Ensembl release 89: ENSG00000147873 – Ensembl, May 2017 GRCm38: Ensembl
IFNA5
(2005). "Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction". The
Interleukin-1 receptor associated kinase
Interleukin-1_receptor_associated_kinase
Mammalian protein found in Homo sapiens
The interferon-gamma receptor (IFNGR) protein complex is the heterodimer of two chains: IFNGR1 and IFNGR2. It binds interferon-γ, the sole member of interferon
Interferon-gamma_receptor
Cytokine produced by lymphocytes
Interleukin 5 Interleukin 6 Granulocyte-macrophage colony-stimulating factor Interferon-gamma The T helper cell secretes many lymphokines that are important when
Lymphokine
Protein-coding gene in the species Homo sapiens
Interferon alpha-10 is a protein that in humans is encoded by the IFNA10 gene. GRCh38: Ensembl release 89: ENSG00000186803 – Ensembl, May 2017 GRCm38:
IFNA10
Cell lineage used in cell cultures
become senescent. Vero cells are interferon-deficient; unlike normal mammalian cells, they do not secrete interferon alpha or beta when infected by viruses
Vero_cell
Type of cytokines secreted by adipose tissue
(SERPINA12) progranulin CTRP-4 Interleukin 8 (IL-8), interleukin 10 (IL-10), interferon gamma (IFN-γ) and inducible protein 10 (IP-10 or CXCL10) have been shown
Adipokine
Protein-coding gene in the species Homo sapiens
Interferon alpha-inducible protein 27 is a protein that in humans is encoded by the IFI27 gene. ENSG00000275214 GRCh38: Ensembl release 89: ENSG00000165949
IFI27
Protein-coding gene in the species Homo sapiens
Interferon alpha-17 is a protein that in humans is encoded by the IFNA17 gene. GRCh38: Ensembl release 89: ENSG00000234829 – Ensembl, May 2017 GRCm38:
IFNA17
Mammalian protein found in humans
promoter region has a response element to IRF-1, the interferon regulatory factor. Type I interferons can also upregulate PD-L1 on murine hepatocytes
PD-L1
Protein-coding gene in the species Homo sapiens
Interferon alpha-7 is a protein that in humans is encoded by the IFNA7 gene. GRCh38: Ensembl release 89: ENSG00000214042 – Ensembl, May 2017 GRCm38: Ensembl
IFNA7
Protein-coding gene in the species Homo sapiens
Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene. Interferon regulatory factor 1 was the first member of the interferon
IRF1
Cancer medication
RTKs, metastatic disease could only be treated with the cytokines interferon alpha (IFNα) or interleukin-2. However, these agents demonstrated low rates
Sunitinib
Protein-coding gene in the species Homo sapiens
Interferon alpha-14 is a protein that in humans is encoded by the IFNA14 gene. GRCh38: Ensembl release 89: ENSG00000228083 – Ensembl, May 2017 GRCm38:
IFNA14
Protein found in humans
Interferon-stimulated gene 15 (ISG15) is a 17 kDa secreted protein that in humans is encoded by the ISG15 gene. ISG15 is induced by type I interferon
ISG15
Chemical compound
name Albuferon) is a recombinant fusion protein drug consisting of interferon alpha (IFN-α) linked to human albumin. Conjugation to human albumin prolongs
Albinterferon
Protein-coding gene in the species Homo sapiens
virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. Constitutive expression of IRF7 is
IRF7
Group of cytokines
cytokines that mediate immune responses. Interleukin 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation
Interleukin
Monoclonal antibody
It binds to the type I interferon receptor, blocking the activity of type I interferons such as interferon-α and interferon-β.[medical citation needed]
Anifrolumab
Protein-coding gene in the species Homo sapiens
Interferon omega-1 is a protein that is encoded by the IFNW1 gene. Interferon omega-1 (IFN-ω) is a subtype of the Interferon type I family. The Interferon
IFNW1
Protein-coding gene in the species Homo sapiens
Interferon alpha-6 is a protein that in humans is encoded by the IFNA6 gene. GRCh38: Ensembl release 89: ENSG00000120235 – Ensembl, May 2017 GRCm38: Ensembl
IFNA6
Cytokine in the interferon family
Interferon beta-1b is a cytokine in the interferon family used to treat the relapsing-remitting and secondary-progressive forms of multiple sclerosis (MS)
Interferon_beta-1b
Mammalian protein found in Homo sapiens
the serine/threonine-protein kinase 1 (TBK1). This causes the phosphorylation and the transport of the interferon regulatory factors 3 and 7 (IRF3 and
MDA5
Chemical compound
2017). "Interferon targeted therapies in systemic lupus erythematosus". Mediterranean Journal of Rheumatology. 28 (1): 13–19. doi:10.31138/mjr.28.1.13. PMC 7045923
Rontalizumab
Protein family
In molecular biology, the protein family Dispanin is another name for Interferon-induced transmembrane protein (IFITM). This refers to a family of protein
Dispanin
Human monoclonal antibody
Wyost". Drug and Health Products Portal. 1 March 2024. Archived from the original on 1 April 2024. Retrieved 1 April 2024. "Wyost EPAR". European Medicines
Denosumab
Enzyme
immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions
OAS1
Immune modulating medication
hematological malignancies". Journal of Hematology & Oncology. 10 (1) 145. doi:10.1186/s13045-017-0512-1. PMC 5534090. PMID 28754125. Rocha CM, Alves AM, Bettanin
Janus_kinase_inhibitor
Interleukin
function of T cells. It stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T cells and natural killer (NK) cells
Interleukin_12
Medication
symptoms of pulmonary embolism. It is an inhibitor of the enzyme janus kinase 1 (JAK1) and janus kinase 3 (JAK 3), which means that it interferes with the
Tofacitinib
Protein-coding gene in humans
Interferon alpha-inducible protein 6 is a protein that in humans is encoded by the IFI6 gene. This gene was first identified as one of the many genes induced
IFI6
gene. RSAD2 is a multifunctional protein in viral processes that is an interferon stimulated gene. It has been reported that viperin could be induced by
Viperin
Protein-coding gene in the species Homo sapiens
Lebon P (1999). "Aicardi-Goutières syndrome: an update and results of interferon-alpha studies". Ann. Neurol. 44 (6): 900–7. doi:10.1002/ana.410440608. PMID 9851434
TREX1
Protein-coding gene in the species Homo sapiens
Interferon alpha-4 is a protein that in humans is encoded by the IFNA4 gene. GRCh38: Ensembl release 89: ENSG00000236637 – Ensembl, May 2017 GRCm38: Ensembl
IFNA4
Mammalian protein found in humans
"Mechanism of interferon action: double-stranded RNA-specific adenosine deaminase from human cells is inducible by alpha and gamma interferons". Virology
ADAR
Human gene
org/wiki/Q18035986) codes for the interferon-induced protein 44-like protein (i.e., IFI44L protein). This gene is located in band 1, region 1 (see band and gene nomenclature)
IFI44L
Class of enzymes
addition to its role during DNA replication, POLA1 plays a role in type I interferon activation. The POLA1 gene was found to be the site of a mutation resulting
DNA polymerase alpha catalytic subunit
DNA_polymerase_alpha_catalytic_subunit
Gene in the species Homo sapiens
Medicine. "Entrez Gene: IFN1@ interferon, type 1, cluster". Ferrantini M, Capone I, Belardelli F (2007). "Interferon-alpha and cancer: mechanisms of action
IFN1@
Mammalian protein found in Homo sapiens
Interleukin-23 subunit alpha is a protein that in humans is encoded by the IL23A gene. The protein is also known as IL-23p19. It is one of the two subunits
Interleukin_23_subunit_alpha
Immune response that does not involve antibodies
which produce interferon gamma and lymphotoxin alpha. Th2 cells, which produce interleukin 4 (IL-4), interleukin 5 (IL-5), and interleukin 1 (IL-13). A third
Cell-mediated_immunity
Cancer treatment medicine
Fever Influenza-like illness Transient increase in transaminase Uncommon (0.1-1% frequency) Folliculitis Infection Hypersensitivity reactions Hypothyroidism
Sorafenib
Medical condition
(1): 46–57. doi:10.1111/j.1469-8749.2012.04437.x. PMID 23121296. S2CID 9146788. Lebon, P; et al. (1988). "Intrathecal synthesis of interferon-alpha in
Aicardi–Goutières_syndrome
Group of cytokine proteins
of interferon gamma (IFN-γ). It is a pro-inflammatory cytokine that shares similar biological effects to IL-12 and structural forms with the IL-1 family
Interleukin-1_family
Mammalian protein found in Homo sapiens
Biology. 109 (6 Pt 1): 3183–6. doi:10.1083/jcb.109.6.3183. PMC 2115918. PMID 2592421. Chang PL, Prince CW (April 1991). "1 alpha,25-dihydroxyvitamin
Osteopontin
Family of intracellular transcription factors
involved in type II interferon signalling, and bind to the GAS (Interferon-Gamma Activated Sequence) promoter to induce expression of interferon stimulated genes
STAT_protein
Enzyme and coding gene in humans
amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor". Proceedings of the National
Tyrosine_kinase_2
Protein found in humans
Lymphotoxin-alpha (LT-α) formerly known as tumor necrosis factor-beta (TNF-β) is an immune signalling protein (a cytokine) that in humans is encoded by
Lymphotoxin_alpha
Medication
2026. Retrieved 26 July 2026. "Nypozi- filgrastim-txid injection". DailyMed. 1 May 2025. Retrieved 26 July 2026. "Accofil EPAR". European Medicines Agency
Filgrastim
Class of biochemical compounds
the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity". Journal of Natural Products. 71 (1): 153–5. Bibcode:2008JNAtP..71..153C. doi:10.1021/np0704396
Cucurbitacin
Mammalian protein found in Homo sapiens
Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a
Integrin_alpha-1
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INTERFERON ALPHA-1
INTERFERON ALPHA-1
INTERFERON ALPHA-1
INTERFERON ALPHA-1
INTERFERON ALPHA-1
INTERFERON ALPHA-1
INTERFERON ALPHA-1
INTERFERON ALPHA-1
INTERFERON ALPHA-1
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