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Type of protein or peptide
A mitogen is a small bioactive protein or peptide that induces a cell to begin cell division, or enhances the rate of division (mitosis). Mitogenesis
Mitogen
Type of protein
Pokeweed mitogen is a mitogen derived from the roots of Phytolacca americana. It functions as a lectin and a mitotic stimulus for the division of lymphocytes
Pokeweed_mitogen
Cell signaling pathway
cell, such as cell division. The pathway includes many proteins, such as mitogen-activated protein kinases (MAPKs), originally called extracellular signal-regulated
MAPK/ERK_pathway
P38 mitogen-activated protein kinases
A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of serine/threonine-specific protein kinases involved in directing cellular responses
Mitogen-activated protein kinase
Mitogen-activated_protein_kinase
Class of enzymes
"extracellular signal-regulated kinases", is sometimes used as a synonym for mitogen-activated protein kinase (MAPK), but has more recently been adopted for
Extracellular signal-regulated kinases
Extracellular_signal-regulated_kinases
Protein family
p38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines
P38 mitogen-activated protein kinases
P38_mitogen-activated_protein_kinases
Protein-coding gene in humans
Mitogen-activated protein kinase 14, also called p38-α, is an enzyme that in humans is encoded by the MAPK14 gene. MAPK14 encodes p38α mitogen-activated
MAPK14
Protein-coding gene in the species Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene. The protein encoded by this gene
MAP2K1
Enzyme catalyzing transfer of phosphate groups onto specific substrates
Mohamed S.H.; Sebaiy, Mahmoud M.; Elgawish, Mohamed Saleh (2024), "p38 mitogen-activated protein kinase inhibitors", Current Molecular Targets of Heterocyclic
Kinase
Class of enzymes
Mitogen Activated Protein (MAP) kinase kinase kinase (MAPKKK, MKKK, M3K, or, MAP3K) is a serine/threonine-specific protein kinase which acts upon MAP
MAP_kinase_kinase_kinase
Species of bacterium
effects. YopJ, which shares an operon with YpkA, "...interferes with the mitogen-activated protein (MAP) kinase activities of c-Jun N-terminal kinase (JNK)
Yersinia_pseudotuberculosis
Pharmaceutical compound
various types of cancer. It is a selective, orally administered inhibitor of mitogen-activated protein kinase kinases 1 and 2 (MEK1/MEK2), developed by Fosun
Luvometinib
Chemical compounds
Ser-73 within its transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli,
C-Jun_N-terminal_kinases
Kinase enzyme
Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a dual-specificity kinase enzyme which phosphorylates mitogen-activated protein
Mitogen-activated protein kinase kinase
Mitogen-activated_protein_kinase_kinase
Species of flowering plant
for some utility in biomedical research (e.g., in studies of pokeweed mitogen). In the wild, it is easily found growing in pastures, recently cleared
Phytolacca_americana
Animal cell cycle checkpoint
cycle completion is no longer dependent on the presence of mitogens. Sustained mitogen signaling promotes cell cycle entry largely through regulation
Restriction_point
Protein found in humans
also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5) is a member of MAP kinase family and as such a part of mitogen-activated protein
ASK1
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 3, also known as p44MAPK and ERK1, is an enzyme that in humans is encoded by the MAPK3 gene. The protein encoded by this
MAPK3
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 8 (also known as JNK1) is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene. The protein encoded by this
MAPK8
American actress
pharmacology from Yale University, where she studied regulation of oncogenic mitogen-activated protein kinase signaling. Her Erdős-Bacon number is 5. Little
Eunice_Cho
Protein-coding gene in the species Homo sapiens
Epigen also known as epithelial mitogen is a protein that in humans is encoded by the EPGN gene. The protein encoded by this gene is a member of the epidermal
Epigen
Protein-coding gene in humans
Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene. The protein encoded by this
MAPK1
Enzyme found in humans
Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene. The protein encoded by this gene is a member of the MAP kinase
Mitogen-activated protein kinase 9
Mitogen-activated_protein_kinase_9
Protein-coding gene in the species Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene. The protein encoded by this gene
MAP2K5
Protein found in humans
Mitogen-activated protein kinase kinase kinase 6 is a protein that in humans is encoded by the MAP3K6 gene. This gene encodes a serine/threonine protein
Mitogen-activated protein kinase kinase kinase 6
Mitogen-activated_protein_kinase_kinase_kinase_6
Family of proteins
Mitogen-activated protein kinase kinase kinase kinase (MAP4K) is a family of proteins involved in cellular signal transduction. MAP4Ks are involved in
MAP kinase kinase kinase kinase
MAP_kinase_kinase_kinase_kinase
Topics referred to by the same term
MKK is mitogen-activated protein kinase kinase, an enzyme. MKK may also refer to: Malmö KK, Swedish swim team from Malmö Main-Kinzig-Kreis, a kreis (district)
MKK_(disambiguation)
Protein-produced toxins that create pores in cell membrane
zinc-metalloprotease, which shows specificity for a conserved family of mitogen-activated protein kinases. The loss of these proteins results in a breakdown
Pore-forming_toxin
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the TAB1 gene. The protein encoded by
TAB1
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene. It is also known as HPK1 (Hematopoietic
MAP4K1
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene, which is located on the long arm of chromosome
MAP3K3
Protein-coding gene in the species Homo sapiens
Mitogen-Activated Protein Kinase Kinase Kinase 2 (MAP3K2), also known as MEKK2 (MEK/ERK Kinase 2), is an enzyme that in humans is encoded by the MAP3K2
MAP3K2
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 11 is an enzyme that in humans is encoded by the MAPK11 gene. The protein encoded by this gene is a member of the MAP
MAPK11
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene. MAPK7 is a member of the MAP kinase
MAPK7
(MKPs) are the largest class of phosphatases involved in down-regulating Mitogen-activated protein kinases (MAPK) signaling. MAPK signalling pathways regulate
MAPK_phosphatase
Protein-coding gene in humans
Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene. The protein encoded by this gene is called
MAP3K11
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 15 is a protein that in humans is encoded by the MAP3K15 gene. The protein encoded by this gene is a member
MAP3K15
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 6 is an enzyme that in humans is encoded by the MAPK6 gene. The protein encoded by this gene is a member of the Ser/Thr
MAPK6
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene. TAK1 is an evolutionarily
MAP3K7
Protein in humans
Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1
Pleiotrophin
Mitogen-activated protein kinase (MAPK) networks are the pathways and signaling of MAPK, which is a type of serine/threonine-specific protein kinase.
MAPK_networks
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene. The gene was identified by its oncogenic transforming
MAP3K8
Protein-coding gene in the species Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene. It is more commonly known as MEK2
MAP2K2
post-phagocytosis. Epithelial immunity is achieved predominantly through mitogen-activated protein kinase (MAPK) signaling, more specifically the p38 pathway
Candidalysin
Chemical compound
muscular dystrophy (FSHD). Losmapimod selectively inhibits enzymes p38α/β mitogen-activated protein kinases (MAPKs), which are modulators of DUX4 expression
Losmapimod
Pharmaceutical drug classification
ATC code L01 Antineoplastic agents is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes
ATC_code_L01
Protein-coding gene in the species Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene. The protein encoded by this gene
MAP2K3
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14), also known as NF-kappa-B-inducing kinase (NIK), is a MAP kinase kinase kinase enzyme that
MAP3K14
Investigational drug
the treatment of pancreatic cancer. It is a dual MEK1/MEK2 inhibitor of mitogen-activated protein kinase kinase. Clinical trial number NCT05585320 for
Atebimetinib
Chemical compound
NJK14047 is a drug which acts as a selective inhibitor of the enzyme p38 mitogen-activated protein kinase (p38 MAPK). It has antiviral and antiinflammatory
NJK14047
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 19 is a protein that in humans is encoded by the MAP3K19 gene. GRCh38: Ensembl release 89: ENSG00000176601
MAP3K19
Enzyme
Mitogen-activated protein kinase 12 is an enzyme that in humans is encoded by the MAP3K12 gene. The protein encoded by this gene is a member of serine/threonine
MAP3K12
Drug class
A MEK inhibitor is a chemical or drug that inhibits the mitogen-activated protein kinase enzymes MEK1 and/or MEK2. They can be used to affect the MAPK/ERK
MEK_inhibitor
Protein-coding gene in the species Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is an enzyme that in humans
MAP2K6
Mammalian protein found in Homo sapiens
Drosophila ortholog of the mammalian NLK gene. This enzyme is a member of the Mitogen-activated protein kinase (MAPK) family, although not explicitly designated
NLK
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the
MAPK13
Protein-coding gene in humans
PT, et al. (December 1993). "The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2". The Biochemical
MAPKAPK2
Protein-coding gene in the species Homo sapiens
Sung HY, et al. (2004). "Human tribbles, a protein family controlling mitogen-activated protein kinase cascades" (PDF). J. Biol. Chem. 279 (41): 42703–8
TRIB2
Synthetic, cannabinoid-like compound
lowers blood pressure, and induces cell migration, cell proliferation and mitogen-activated protein kinase activation in microglia, but without producing
Abnormal_cannabidiol
the RAS-RAF-MEK-ERK signal transduction cascade, also referred to as the mitogen-activated protein kinase (MAPK) cascade. Activation of RAF kinases requires
RAF_kinase
Type of blood collection equipment for medical testing
Green, Yellow, Purple QuantiFERON 1. Grey (nil) tube 2. Green (TB1 antigen) tube 3. Yellow (TB2 antigen) tube 4. Purple (mitogen) tube Tuberculosis
Vacutainer
Protein-coding gene in the species Homo sapiens
encoded by the NMBR gene. Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal
Neuromedin_B_receptor
Protein-coding gene in the species Homo sapiens
RPS6KA5 RPS6KA4 P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated
GAK_(protein)
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP3K4 gene. The central core of each mitogen-activated
MAP3K4
Protein-coding gene in the species Homo sapiens
binding mitogen-activated protein kinase kinase binding vascular endothelial growth factor receptor 2 binding protein homodimerization activity mitogen-activated
DAB2IP
Peptide hormone in animals
Regulation of the CGRP gene is in part controlled by the expression of the mitogen-activated protein kinase (MAPK) signaling pathway and cytokines like TNFα
Calcitonin gene-related peptide
Calcitonin_gene-related_peptide
Protein-coding gene in the species Homo sapiens
screen for epidermal growth factor (EGF)-induced mRNAs and initially named mitogen-inducible gene 2 (Mig-2) protein. FERMT2 is a component of extracellular
FERMT2
Enzyme found in humans
RPS6KA5 RPS6KA4 P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated
Cyclin-dependent_kinase_19
Protein-coding gene in the species Homo sapiens
lymphocytes. Immune interferon (IFN-gamma; MIM 147570) is produced by mitogen- or antigen-stimulated T lymphocytes.[supplied by OMIM] The interferons
Interferon_alpha-1
Protein-coding gene in the species Homo sapiens
ion binding phosphoprotein phosphatase activity manganese ion binding mitogen-activated protein kinase kinase kinase binding protein serine/threonine
Protein phosphatase with EF-hand domain 2
Protein_phosphatase_with_EF-hand_domain_2
Protein-coding gene in humans
Molecular function MDM2/MDM4 family protein binding NF-kappaB binding mitogen-activated protein kinase binding protein binding ubiquitin-like protein
CDK5RAP3
Class of opioid peptides
not bind to opioid receptors, causes an increase in phosphorylated p38 mitogen-activated protein kinases (MAPK) in microglia in the dorsal horn of the
Dynorphin
Protein complex
significance in diabetes mellitus, which is due to insulin resistance. Mitogens, such as insulin like growth factor 1 (IGF1), can activate the MAPK/ERK
MTORC1
Mammalian protein found in humans
3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells". Cancer Research. 60 (13): 3504–13. PMID 10910062
MTOR
Enzyme found in humans
domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein
RPS6KA2
Species of protist
cascadensis employs several adaptations. Signalling pathways including calcium, mitogen-activated protein kinase, and Ras proteins are enriched in the amoeba.
Incendiamoeba_cascadensis
Protein-coding gene in the species Homo sapiens
in humans is encoded by the SIPA1 gene. The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity
SIPA1
Chemical compound
PH-797804 is a drug which acts as a selective inhibitor of the enzyme p38 mitogen-activated protein kinase (p38 MAPK). It has antiinflammatory effects and
PH-797804
Protein-coding gene in the species Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 7, also known as MAP kinase kinase 7 or MKK7, is an enzyme that in humans is encoded by the MAP2K7
MAP2K7
Medical procedure involving an incision in a vein
Green, Yellow, Purple QuantiFERON 1. Grey (nil) tube 2. Green (TB1 antigen) tube 3. Yellow (TB2 antigen) tube 4. Purple (mitogen) tube Tuberculosis
Phlebotomy
Protein-coding gene in the species Homo sapiens
RPS6KA5 RPS6KA4 P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated
SMG1
Chemical compound
smooth muscle cells through inducing p21Cip1 expression: Involvement of p38 mitogen activated protein kinase". Journal of Cellular Physiology. 198 (2): 310–23
Pyrrolidine_dithiocarbamate
Enzyme involved in glycogenolysis
RPS6KA5 RPS6KA4 P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated
Phosphorylase_kinase
Protein-coding gene in humans
enzyme that in humans is encoded by the DUSP16 gene. The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular
DUSP16
Lectin (carbohydrate-binding protein)
physiological function in plants, however, is still unknown. ConA is a plant mitogen, and is known for its ability to stimulate mouse T-cell subsets giving
Concanavalin_A
Genus of fungi
suppresses mast cell-mediated allergic inflammation: Role of calcium, mitogen-activated protein kinase and nuclear factor-κB". Int. J. Mol. Med. 30 (2):
Sparassis
Protein-coding gene in the species Homo sapiens
serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal
CILK1
Class of protein kinase enzymes
messenger requirements. EC 2.7.11.24 Mitogen-activated protein kinases (MAPKs) respond to extracellular stimuli (mitogens) and regulate various cellular activities
Serine/threonine-specific protein kinase
Serine/threonine-specific_protein_kinase
Protein-coding gene in the species Homo sapiens
RPS6KA5 RPS6KA4 P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated
STK11
Protein-coding gene in the species Homo sapiens
et al. (October 2004). "Human tribbles, a protein family controlling mitogen-activated protein kinase cascades". The Journal of Biological Chemistry
TRIB1
Chemical compound
drug in development by Eli Lilly. Although originally thought to be a p38 mitogen-activated protein kinase (MAPK) inhibitor, it has since been reported that
Ralimetinib
American information scientist and health services researcher
School of Public Health Thesis Characterization of betacellulin: a novel mitogen from pancreatic beta cell tumors Academic work Institutions Weill Cornell
Rainu_Kaushal
Protein-coding gene in the species Homo sapiens
RPS6KA5 RPS6KA4 P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated
PKMYT1
Energy-carrying molecule in living cells
Phosphorylation of a protein by a kinase can activate a cascade such as the mitogen-activated protein kinase cascade. ATP is also a substrate of adenylate
Adenosine_triphosphate
Protein-coding gene in humans
Mitogen-activated protein kinase kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP4K2 gene. The protein encoded by this gene is
MAP4K2
compared to sigmoidal curves for cooperative (ultrasensitive) enzymes. In mitogen-activated protein kinase (MAPK) signaling (see example below), the ultrasensitivity
Ultrasensitivity
Peptide hormone that stimulates growth
increases the concentration of glucose and free fatty acid. It is a type of mitogen which is specific only to the receptors on certain types of cells. GH is
Growth_hormone
Protein family
RPS6KA5 RPS6KA4 P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated
Phosphatidylinositol 3-kinase-related kinase
Phosphatidylinositol_3-kinase-related_kinase
Protein-coding gene in the species Homo sapiens
reference expression data Gene ontology Molecular function protein binding mitogen-activated protein kinase binding identical protein binding polyubiquitin
TNIP1
Protein-coding gene in the species Homo sapiens
MAP-kinase scaffold activity protein kinase activity signal transducer activity mitogen-activated protein kinase kinase binding chaperone binding Hsp90 protein
KSR1
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