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See searches and references containing ORIGIN OF-REPLICATION!ORIGIN OF-REPLICATION
Sequence in a genome
The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated. Propagation of the
Origin_of_replication
Biological process
replication. DNA replication usually begins at specific locations known as origins of replication which are scattered across the genome. Unwinding of
DNA_replication
DNA replication in eukaryotic organisms
Eukaryotic DNA replication is a conserved mechanism that restricts DNA replication to once per cell cycle. Eukaryotic DNA replication of chromosomal DNA
Eukaryotic_DNA_replication
DNA replication in prokaryotes
starts replicating its DNA for grand daughter cell. For the same reason, the initiation of DNA replication is highly regulated. Bacterial origins regulate
Prokaryotic_DNA_replication
Protein complex formed during initiation of DNA replication
pre-replication complex (pre-RC) is a protein complex that forms at the origin of replication during the initiation step of DNA replication. Formation of
Pre-replication_complex
DNA region replicating from a single origin
A replicon is a region of an organism's genome that is independently replicated from a single origin of replication[citation needed]. A bacterial chromosome
Replicon_(genetics)
Protein family
initiation of DNA replication, including blocking reinitiation in G2/M phase. The ORC is present throughout the cell cycle bound to replication origins, but
Origin_recognition_complex
DNA-based cloning vector
properties. These vectors carry, in addition to the origin of plasmid replication, an origin of replication derived from bacteriophage. Unlike commonly used
Phagemid
Type of behavior of a dynamical system
separate categories, including: (1) Replication Control, (2) Replication Information, (3) Replication Substrate, (4) Replicator Structure, (5) Passive Parts
Self-replication
An autonomously replicating sequence (ARS or ars) contains the origin of replication in the yeast genome. The ARS of S. cerevisiae is a minimal 125 bp
Autonomously replicating sequence
Autonomously_replicating_sequence
Type of chromosome
proteins at the origin region of the chromosome, called oriC. These assembly stages are regulated to ensure that chromosome replication occurs only once
Circular_chromosome
Initiation site for the opening of the DNA double helix
replication bubble for DNA replication to then proceed. Archaea use a simpler homolog of the eukaryotic origin recognition complex to find the origin
DNA_unwinding_element
that recognize a specific DNA sequence within the origin of replication. The origin of replication is the site where the helicase attaches to the template
Initiator_protein
Protein domain
function of this protein is highly important in DNA replication. The protein negatively regulates the initiation of DNA replication at the origin of replication
SeqA_protein
DNA that does not code for proteins
synthesis. In most cases, replication proceeds in both directions from the replication origin. The main features of replication origins are sequences where
Non-coding_DNA
licensing factor is a protein or complex of proteins that allows an origin of replication to begin DNA replication at that site. Licensing factors primarily
Licensing_factor
Biological particle which transfers genetic material between cells
are capable of replication using the host cell's replication machinery. Plasmid vectors minimalistically consist of an origin of replication that allows
Vector_(molecular_biology)
Artificial plasmid
tetracycline resistance. It contains the origin of replication of pMB1, and the rop gene, which encodes a restrictor of plasmid copy number. The plasmid has
PBR322
Ability of a cell to take up DNA
origin of replication will generally have a higher transfection efficiency than one with a low copy number origin, using a plasmid with an origin of replication
Transformation_efficiency
Topics referred to by the same term
of the origin of concepts in the mind Origin of humanity, the study of human evolution Origin of replication, the location at which DNA replication is
Origin
Set of methods in molecular biology
sequences required for DNA replication, and the resulting recombinant DNA is introduced into the organism from which the replication sequences were obtained
Molecular_cloning
Undesirable occurrence in eukaryotic cells
successive generations. Replication of DNA always begins at an origin of replication. In yeast, the origins contain autonomously replicating sequences (ARS),
DNA_re-replication
Family of viruses
specific site situated within the origin of replication by the viral Rep protein in order to initiate replication. This process in a eukaryotic nucleus
Geminiviridae
RNA family
found in the 3′ UTR of various enteroviruses. The overall structure forms the origin of replication (OriR) for the initiation of (-) strand RNA synthesis
Enteroviral_3′_UTR_element
Number of copies of a plasmid in a cell
"handcuffing" them at the origin of replication and inhibiting replication. Plasmids can be incompatible if they share the same replication control mechanism
Plasmid_copy_number
Small DNA molecule within a cell
plasmids to replicate independently within a cell, they must possess a stretch of DNA that can act as an origin of replication. The self-replicating unit, in
Plasmid
Type of repeated DNA sequence
repressing the formation of the Rep proteins. Since these proteins work to promote binding of replication machinery, replication can be halted in this form
Iteron
Species of red algae
plasmids can replicate in its cell nucleus unchanged: the bacterial origin of replication "just works". This could explain the extensive presence of bacterial
Porphyridium_purpureum
Observed inability to reproduce scientific studies
The replication crisis, also known as the reproducibility or replicability crisis, is a widespread phenomenon in which published scientific results cannot
Replication_crisis
Type of hybrid plasmid
kb of DNA, limits based on the normal bacteriophage packaging size. They can replicate as plasmids if they have a suitable origin of replication (ori):
Cosmid
Parts of lagging strand in DNA replication
single origin of replication. In eukaryotes, these replicating forks, which are numerous all along the DNA, form "bubbles" in the DNA during replication. The
Okazaki_fragments
Species of bacterium
it challenging to engineer. Sp245 can be transformed with OriV origin of replication plasmids through conjugation and electroporation. The strain is
Azospirillum_brasilense
methods. Typically, the vectors used in DNA constructs contain an origin of replication, a multiple cloning site, and a selectable marker. Certain vectors
DNA_construct
for replication and selection in both E. coli cells and yeast cells. The E. coli component of a yeast shuttle vector includes an origin of replication and
Shuttle_vector
Organelle in eukaryotic cells responsible for respiration
(TAS). The origin of replication for the L strand (OriL) is localized on the H strand 11,000 bp downstream of OriH, located within a cluster of genes coding
Mitochondria
Hypothetical DNA replication mechanism used by some circular chromosomes
D-loop contains an origin of replication for the heavy strand. Full circular DNA replication is initiated at that origin and replicates in only one direction
D-loop_replication
Cell line derived from human embryonic kidney cells
Due to the expression of SV40 large T antigen, transfected plasmid DNAs that carry the SV40 origin of replication can replicate in 293T and will transiently
HEK_293_cells
Biological process
In general, mitosis (division of the nucleus) is preceded by the S stage of interphase (during which the DNA replication occurs) and is followed by telophase
Cell_division
Small piece of maintainable DNA
maintenance in E. coli, such as a functional origin of replication (ori). The ColE1 origin of replication is found in many plasmids. Some vectors also
Cloning_vector
Protein-coding gene in humans
archaea. The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic
ORC1
expected for replication origin sites. This and other similar studies were used to generate a program that could predict the origins of replication using the
Z_curve
polyomavirus genome replication relies on the DNA replication machinery of the host cell, the cell must be in S phase (the part of the cell cycle in which
Large_tumor_antigen
Over- or under-abundance of guanine and cytosine in a particular region of DNA or RNA
strand, lagging strand, replication origin, and replication terminal. Most bacteria and archaea contain only one DNA replication origin. The GC skew is positive
GC_skew
Protein-coding gene in the species Homo sapiens
initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves
ORC2
Genus of bacteria and the disease it can cause
independent origin of replication, and are conserved together over time in the genus. Recent phylogenies have been constructed based on a suite of genes (multilocus
Vibrio
Unit of chromosome length
end of the DNA molecule, but must be some point that has some easily determinable unique characteristic. Often this point is the origin of replication, although
Centisome
Rolling hairpin replication (RHR) is a unidirectional, strand displacement form of DNA replication used by parvoviruses, a group of viruses that constitute
Rolling_hairpin_replication
In DNA replication, replication timing refers to the order in which segments of DNA along the length of a chromosome are duplicated. In eukaryotic cells
Replication_timing
DNA replication occurs only once per cell cycle. A key feature of the DNA replication mechanism in eukaryotes is that it is designed to replicate relatively
Control of chromosome duplication
Control_of_chromosome_duplication
Protein-coding gene in the species Homo sapiens
initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves
ORC4
Collection of the total genomic DNA from a single organism
capable of carrying inserts up to 15kb. Plasmids contain an origin of replication allowing them to replicate inside a bacterium independently of the host
Genomic_library
DNA inside the nucleus of eukaryotic cells
cell contains the full amount of DNA material. The process of DNA duplication is usually called replication. The replication is termed semiconservative since
Nuclear_DNA
DNA molecule containing genetic material of a cell
have a one-point (the origin of replication) from which replication starts, whereas some archaea contain multiple replication origins. The genes in prokaryotes
Chromosome
Protein found in humans
the assembly of pre-replication complexes (pre-RC), which occurs during the G1 phase of the cell cycle. In the assembly of pre-RCs, origin recognition
DNA_replication_factor_CDT1
Protein-coding gene in the species Homo sapiens
initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves
ORC6
for download. Origin of replication Siow, CC; Nieduszynska, SR; Müller, CA; Nieduszynski, CA (Jan 2012). "OriDB, the DNA replication origin database updated
OriDB
DNA synthesis technique
circle replication (RCR) is a process of unidirectional nucleic acid replication that can rapidly synthesize multiple copies of circular molecules of DNA
Rolling_circle_replication
Study of the human mitochondrial genome
continues until replication reaches the origin of replication on the other strand, at which point the other strand begins replicating in the opposite
Human_mitochondrial_genetics
Protein-coding gene in the species Homo sapiens
initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves
ORC5
Molecular complex
bidirectional replication. The two replisomes continue replication at both forks in the middle of the cell. Finally, as the termination site replicates, the two
Replisome
Non-coding region of the mitochondrial DNA
with differing amounts of conservation. The mtDNA control region contains the origin of replication of one strand, and the origin of transcription for both
MtDNA_control_region
Process of copying a segment of DNA into RNA
viral messenger RNA - a necessary step in the synthesis of viral proteins needed for viral replication. This process is catalyzed by a viral RNA dependent
Transcription_(biology)
Chemical compound
of DNA replication of plasmids with different replication origins and found that certain plasmids exhibited a delay in the inhibition of replication when
Hypochlorous_acid
Plasmid cloning vector
The origin of replication (ori) is derived from the plasmid pMB1. pUC19 is a high copy number plasmid. The high copy number is a result of the lack of the
PUC19
Topics referred to by the same term
Korea Orion (constellation) (standard astronomical abbreviation) Origin of replication, in cellular biology ori, OR Immediate, an RISC-V instruction Orientation
Ori
Branch of virology
susceptible host cell capable of supporting its replication is available. As of March 2020, the full-length genome sequences of 9,240 different viruses, including
Synthetic_virology
Biological process
replication. SeqA binds to the origin of replication, sequestering it and thus preventing methylation. Because hemimethylated origins of replication are
DNA_methylation
The ori is the "origin of replication", a site on the plasmid at which the two DNA strands begin to unwind to allow for DNA replication during cell division
Transfer_DNA_binary_system
Type of plasmid
HJ (January 1999). "A vector based on the SV40 origin of replication and chromosomal S/MARs replicates episomally in CHO cells". Nucleic Acids Research
Episome
Life arising from non-living matter
further RNA replication, i.e. it is autocatalytic. Some catalytic RNAs can link smaller RNA sequences together, enabling self-replication. Natural selection
Abiogenesis
Species of bacterium
chromosome carries a canonical origin of replication. It has notably more cell structure, DNA replication, recombination, and repair of genes than obligate endosymbionts
Hamiltonella_defensa
Class of enzymes
polymerase III. The firing of the origin of replication (oriC) in bacteria cells is highly controlled to ensure DNA replication occurs only once during each
DNA_adenine_methylase
Mechanism of DNA replication
Semiconservative replication is the process by which DNA is replicated in all living cells. DNA replication involves separation (unwinding) of the two strands of the
Semiconservative_replication
Class of enzymes
RNA primer, Pol α starts replication elongating the primer with ~20 nucleotides. In addition to its role during DNA replication, POLA1 plays a role in type
DNA polymerase alpha catalytic subunit
DNA_polymerase_alpha_catalytic_subunit
DNA sequences with no known biological function
genes for ribosomal RNA and transfer RNA, regulatory sequences, origins of replication, centromeres, telomeres, and scaffold attachment regions are considered
Junk_DNA
Genetic material
replicate in a wide variety of single-celled organisms, which makes it suitable as a genetic engineering tool. It is capable of transfer, replication
RK2_plasmid
Type of hybrid plasmid
elements: oriT (Origin of Transfer): The sequence which marks the starting point of conjugative transfer. oriV (Origin of Replication): The sequence starting
Fosmid
DNA sequence whose position in the genome is variable
This reciprocal replication overlaps in time and occurs between duplicated segments of the replication element before replication is completed. The
Mobile_genetic_elements
Bacterial plasmid
inhibits RepA transcription. oriV: origin of replication. RepA is needed in order to initiate replication. ParM: this protein forms dynamic filaments that
R1_plasmid
for genome replication and other viral life cycle components. The ITRs located 5' and 3' of the viral genome serve as the origin of replication. Like the
Self-complementary adeno-associated virus
Self-complementary_adeno-associated_virus
Family of viruses
understanding is that viral DNA replication likely occurs in the G2 phase of the cell cycle and rely on recombination-dependent replication supported by DNA damage
Papillomaviridae
Theory that viruses predate cellular life
attempt to explain the origin and evolution of viruses. Modern viruses are obligate parasites that cannot replicate independently of their cellular hosts;
Virus_world_hypothesis
Engineered plasmid
plasmids, the pGLO plasmid contains an origin of replication (ori), which is a region of the plasmid where replication will originate. The pGLO plasmid was
PGLO
Class of enzymes
polymerase epsilon in the presence of PCNA (proliferating cell nuclear antigen), RFC (replication factor C) and RPA (replication protein A). Either DNA polymerase
DNA_polymerase_epsilon
Protein-coding gene in the species Homo sapiens
initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves
ORC3
Control mechanism in the eukaryotic cell cycle
fission) is relatively simple and quick: the chromosome replicates from the origin of replication, a new membrane is assembled, and the cell wall forms
Cell_cycle_checkpoint
Virus or plasmid designed for gene expression in cells
any vector may have, such as an origin of replication, a selectable marker, and a suitable site for the insertion of a gene like the multiple cloning
Expression_vector
Synthetic viral vector
called transfection. These plasmids contain either transgenic DNA or replication and capsid encoding DNA, plus helper DNA. Every cell that is successfully
Helper_dependent_virus
Proto-oncogene derived from polyomavirus SV40
the origin of replication directs transcription, and T-antigen directs transcription and replication. SV40 DNA replication is initiated by binding of large
SV40_large_T_antigen
of replication forks forms when helicases work in opposite directions from a single origin of replication, creating a replication eye. replication rate
Glossary of cellular and molecular biology (M–Z)
Glossary_of_cellular_and_molecular_biology_(M–Z)
Species of bacterium
some genes usually found on plasmids, including a P1 plastid-like origin of replication. CTXφ (also called CTXphi) is a filamentous phage that contains
Vibrio_cholerae
zipper domain, a characteristic of many transcription factors. ZEBRA binds to the oriLyt (lytic origin of replication) of the EBV genome. It acts as an
BZLF1
Family of protein complexes
plays a more limited role in replication. Pol α is responsible for the initiation of DNA replication at origins of replication (on both the leading and lagging
DNA_polymerase_alpha
Cellular process of protein synthesis
molecules as templates. The generated protein is a sequence of amino acids determined by the sequence of nucleotides in the RNA. The nucleotides are considered
Translation_(biology)
Informal grouping of viruses
segment that is 143–145kb. The origin of replication (often labeled as "oriLyt" in the literature) is where DNA replication begins. The direct repeat termini
Human_herpesvirus_6
is the replication initiation factor which causes DNA replication if present in sufficient concentration. When replication happens, the origin of replication
Gua_Operon
2013 video game
Batman: Arkham Origins is a 2013 action-adventure game developed by WB Games Montréal and published by Warner Bros. Interactive Entertainment. Based on
Batman:_Arkham_Origins
Protein complex in bacteria responsible for cell division
for synthesis of the division septum. DNA replication in bacteria is tightly linked to cell division. For instance, blocking replication in B. subtilis
Divisome
Species of virus
each cell cycle. Binding site I initiates DNA replication at the origin of replication. Early transcription gives two spliced RNAs that are both 19s. Late
SV40
Species of virus
separate origin of replication (oriL) that is activated during the lytic cycle. Replication begins by a regular bidirectional theta replication at oriL
P1_phage
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ORIGIN OF-REPLICATION
ORIGIN OF-REPLICATION
ORIGIN OF-REPLICATION
ORIGIN OF-REPLICATION
ORIGIN OF-REPLICATION
ORIGIN OF-REPLICATION
ORIGIN OF-REPLICATION
ORIGIN OF-REPLICATION
ORIGIN OF-REPLICATION
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