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Chemical compound
Platelet-activating factor, also known as PAF, PAF-acether or AGEPC (acetyl-glyceryl-ether-phosphorylcholine), is a potent phospholipid activator and
Platelet-activating_factor
Protein-coding gene in the species Homo sapiens
The platelet-activating factor receptor (PAF-R) is a G-protein coupled receptor which binds platelet-activating factor. It is encoded in the human by the
Platelet-activating factor receptor
Platelet-activating_factor_receptor
Process of formation of blood clots
vessel wall). Activation of platelets and platelet plug formation: Platelet activation: Platelet activators, such as platelet activating factor and thromboxane
Coagulation
Signaling glycoprotein regulating cell proliferation
Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In particular, PDGF plays a significant
Platelet-derived growth factor
Platelet-derived_growth_factor
Protein involved in blood clotting, wound healing and inflammation
Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . This
Platelet_factor_4
Second generation H1-antihistamine
Rupatadine is a second generation antihistamine and platelet-activating factor antagonist used to treat allergies. It was discovered and developed by Uriach [es]
Rupatadine
Class of enzymes
In enzymology, a platelet-activating factor acetyltransferase (EC 2.3.1.149) is an enzyme that catalyzes the chemical reaction 1-alkyl-2-acetyl-sn-gly
Platelet-activating factor acetyltransferase
Platelet-activating_factor_acetyltransferase
French immunologist and physician (1935–2004)
born in Paris. In 1979, he published a paper on the structure of platelet-activating factor and its relationship with histamine. He was head of allergy and
Jacques_Benveniste
Component of blood aiding in coagulation
(along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping to form a blood clot. Platelets have no cell nucleus; they
Platelet
Protein-coding gene in the species Homo sapiens
Platelet-activating factor acetylhydrolase IB subunit alpha or Lisencephaly protein-1 (LIS-1) is an enzyme that in humans is encoded by the PAFAH1B1 gene
PAFAH1B1
Protein-coding gene in the species Homo sapiens
Lipoprotein-associated phospholipase A2 (Lp-PLA2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A2 enzyme that in
Lipoprotein-associated phospholipase A2
Lipoprotein-associated_phospholipase_A2
Class of chemical compounds
(MAGEs) are also generated from 2-acetyl MAGEs (precursors of platelet-activating factor) by KIAA1363. Plasmalogens as well as some 1-O-alkyl lipids are
Ether_lipid
Mammalian protein found in Homo sapiens
danger activating thrifty genes in order to store fat and to avoid starvation. BAFF shares many activities with PAF (Platelet Activating Factor) and they
B-cell_activating_factor
Chemical compound
a potent and selective inhibitor of the phospholipid mediator platelet-activating factor (PAF). It was developed by structural modification of the
Apafant
Protein-coding gene in the species Homo sapiens
Platelet-activating factor acetylhydrolase IB subunit gamma is an enzyme that in humans is encoded by the PAFAH1B3 gene. PAFAH1B3 has been shown to interact
PAFAH1B3
Protein-coding gene in the species Homo sapiens
substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both
PAFAH2
Overreaction of the immune system to an antigen
Chisei; Okayama, Yoshimichi (May 2010). "Activation of human mast cells through the platelet-activating factor receptor". Journal of Allergy and Clinical
Hypersensitivity
Protein-coding gene in the species Homo sapiens
Platelet-activating factor acetylhydrolase IB subunit beta is an enzyme that in humans is encoded by the PAFAH1B2 gene. PAFAH1B2 has been shown to interact
PAFAH1B2
Class of enzymes
acyltransferase, blood platelet-activating factor acetyltransferase, lyso-GPC:acetyl CoA acetyltransferase, lyso-platelet activating factor:acetyl-CoA acetyltransferase
1-alkylglycerophosphocholine O-acetyltransferase
1-alkylglycerophosphocholine_O-acetyltransferase
Surface protein important to the immune system
proteases. Activated mast cells also synthesize and secrete lipid-derived mediators (such as prostaglandins, leukotrienes, and platelet-activating factor) and
Fc_receptor
Class of enzymes
as platelet-activating factor. There are multiple enzymes with this function: Lipoprotein-associated phospholipase A2 Platelet-activating factor acetylhydrolase
1-alkyl-2-acetylglycerophosphocholine esterase
1-alkyl-2-acetylglycerophosphocholine_esterase
Protein-coding gene in the species Homo sapiens
phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis. Platelet-activating factor ENSG00000153395 GRCh38: Ensembl release 89: ENSG00000275079, ENSG00000153395
LPCAT1
American biotechnology company
developed to treat severe sepsis. Pafase is the recombinant form of platelet-activating factor acetylhydrolase (PAF-AH, also known as lipoprotein-associated
Icos
Topics referred to by the same term
language for the CAB 500 computer Paroxysmal atrial fibrillation Platelet-activating factor Population attributable fraction (epidemiology) Pure autonomic
PAF
Medical condition
tissue trauma. Mast cell granules contain histamine, heparin, platelet-activating factor, and other substances. Disseminated mastocytosis is rarely seen
Mastocytoma
Protein found in humans
internalization of the platelet-activating factor receptor is dependent on arrestins but independent of G-protein activation. Role of the C terminus
Arrestin_beta_2
Chemical compound
and muscle relaxant effects, and also acts as an inhibitor of platelet-activating factor (PAF). Brotizolam Etizolam Flubrotizolam Fluclotizolam Deschloroclotizolam
Clotizolam
MeSH D23.469.050.375.925 – urotensins MeSH D23.469.050.600 – platelet activating factor MeSH D23.469.050.650 – serotonin MeSH D23.469.200.070 – beta-thromboglobulin
List_of_MeSH_codes_(D23)
Chemical compound
(Y-24180) is a drug which acts as a selective antagonist for the platelet-activating factor receptor, and was originally developed for the treatment of asthma
Israpafant
Mammalian protein involved in blood clotting
Von Willebrand factor (VWF) (German: [fɔn ˈvɪləbʁant]) is a blood glycoprotein that promotes primary hemostasis, specifically, platelet adhesion. It is
Von_Willebrand_factor
Chemical compound
and hydrogels, and for positron emission tomography. Hexadecyl platelet-activating factor has profound effects on the lung, and hexadecyl glyceryl ether
Hexadecane
Protein-coding gene in humans
Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with
PDGFRB
(February 2006). "Platelet-activating factor acetylhydrolase activity affects sperm motility and serves as a decapacitation factor". Fertility and Sterility
Decapacitation_factor
Human protein-coding gene
Platelet-derived growth factor receptor A, also termed CD140a, is a receptor located on the surface of a wide range of cell types. The protein is encoded
Platelet-derived growth factor receptor A
Platelet-derived_growth_factor_receptor_A
Biologically active terpenic lactone
class of molecules has been studied for its potential to act as a platelet-activating factor receptor antagonist. Ginkgolide B has been investigated for its
Ginkgolide
Biological signaling using lipid molecules
primarily by activation of ceramidase by growth-inducing proteins such as platelet-derived growth factor and insulin-like growth factor, is consistent
Lipid_signaling
Birth defect of abnormally large or thick brain folds
encoding the alpha subunit of the intracellular Ib isoform of platelet-activating factor acetylhydrolase. It is located on chromosome 17p13.3 and has 11
Pachygyria
Widening of blood vessels
causing degranulation. Granules in these cells contain histamine, platelet-activating factor, and other compounds causing clinical manifestation of anaphylaxis-
Vasodilation
"The role of transacylases in the metabolism of arachidonate and platelet activating factor". Prog. Lipid Res. 31 (1): 65–86. doi:10.1016/0163-7827(92)90016-C
Glycerophospholipid acyltransferase (CoA-dependent)
Glycerophospholipid_acyltransferase_(CoA-dependent)
Refractive eye surgery procedure
hazing after surgery is also decreased with brush technique. The platelet activating factor blocker LAU-0901 has shown effect in mitigating dry eye in mouse
Photorefractive_keratectomy
Chemical compound
This will change platelet's shape and induce release of serotonin, ADP, vWF (Von Willebrand factor), PAF (Platelet-activating factor) to promote further
Carbazochrome
Cell surface receptors
Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family
Platelet-derived growth factor receptor
Platelet-derived_growth_factor_receptor
Antibody isotype
receptor FcεRI, stimulating the release of both histamine and platelet activating factor (PAF). In the alternative pathway, antigens form complexes with
Immunoglobulin_G
Antihistamine medication
v t e PAF receptor modulators PAFRTooltip Platelet-activating factor receptor Agonists C-PAF Edelfosine PAF Antagonists A-85783 ABT-491 Apafant BN-50739
Cetirizine
"Effects of Calaguala and an active principle, adenosine, on platelet activating factor". Planta Med. 58 (4): 306–10. doi:10.1055/s-2006-961472. PMID 1438589
Calaguala
Biological process
in a generated list of candidates including carbon monoxide, platelet-activating factor, arachidonic acid, and nitric oxide. Nitric oxide has received
Retrograde_signaling
Aggregation of platelets formed during early stage of coagulation
such as the platelet-derived growth factor, fibrinogen, and the von Willebrand factor (vWF), a glycoprotein critical in platelet activation and adhesion
Platelet_plug
Argentine neuroscientist
transmission by platelet-activating factor. Neuron 9:1211-1216, 1992 Kato K, Clark GD, Bazan NG, Zorumski CF: Platelet activating factor as a potential
Nicolas_Bazan
Organ dysfunction in an acutely ill person requiring medical intervention
are: tumor necrosis factor-alpha (TNF-α), interleukin-1, interleukin-6, thromboxane A2, prostacyclin, platelet activating factor, and nitric oxide. As
Multiple organ dysfunction syndrome
Multiple_organ_dysfunction_syndrome
Excess number of eosinophil cells in the blood
cytokines, chemokines, growth factors, lipid mediators (e.g. leukotrienes, prostaglandins, platelet activating factor), and toxic proteins (e.g. metalloproteinases
Eosinophilia
Complex formed by blood clotting factors X and V
coagulation, the coagulation factor X can be activated into factor Xa in two ways: either extrinsically or intrinsically. The activating complexes are together
Tenase
Blood product used in transfusion medicine
Platelet-rich plasma (PRP), also known as autologous conditioned plasma, is a concentrate of plasma protein derived from whole blood, centrifuged to remove
Platelet-rich_plasma
Protein that stimulates cell division and differentiation
profile of total protein and six angiogenically-active growth factors in three platelet products". GMS Interdisciplinary Plastic and Reconstructive Surgery
Epidermal_growth_factor
Mammalian protein found in humans
hours. Factor V is able to bind to activated platelets and is activated by thrombin. On activation, factor V is spliced in two chains (heavy and light
Factor_V
Index of enzymes associated with the same name
following enzymes: 1-alkylglycerophosphocholine O-acetyltransferase Platelet-activating factor acetyltransferase This set index page lists enzyme articles associated
PAF_acetyltransferase
Protein-coding gene in the species Homo sapiens
Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene. The protein encoded by this gene is a member of the
PDGFB
Nasal inflammation due to allergens in the air
release inflammatory molecules including histamine, leukotrienes, platelet activating factor, prostaglandins and thromboxane with these inflammatory molecules'
Allergic_rhinitis
Abnormally increased sensitivity to pain
discontinuation of opioid treatment. Hyperalgesia is induced by platelet-activating factor (PAF), which comes about in an inflammatory or an allergic response
Hyperalgesia
Integrin complex found on platelets
integrin complex found on platelets. It is a transmembrane receptor for fibrinogen and von Willebrand factor, and aids platelet activation. The complex is formed
Glycoprotein_IIb/IIIa
Pockets on both sides of the head of some mammals
"Inhibition of endotoxin-induced microvascular leakage by a platelet-activating factor antagonist and 5-lipoxygenase inhibitor". Shock. 4 (5): 368–72
Cheek_pouch
Process by which cells lose secretory granules
receptors on the surface of mast cells to induce degranulation, via the activation of tyrosine kinases within the cell. The mast cell releases a mixture
Degranulation
Class of proteins involved in inflammation
prostaglandins and leukotrienes, and they also cause the production of platelet-activating factor and IL-6. After stimulation with proinflammatory cytokines, Kupffer
Acute-phase_protein
Class of pharmaceuticals
known as a platelet agglutination inhibitor or platelet aggregation inhibitor, is a member of a class of pharmaceuticals that decrease platelet aggregation
Antiplatelet_drug
Chemical compound
a potent and selective inhibitor of the phospholipid mediator platelet-activating factor (PAF). It was developed in the 1990s by British Biotech with several
Lexipafant
Class of lipids
generation of second messengers, such as prostaglandins, eicosanoids, platelet activating factor and diacylglycerol. Thus, neural membrane phospholipids are a
Glycerophospholipid
Protein-coding gene in humans
characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor". Proc Natl Acad Sci USA. 80 (3): 765–9
CXCL7
Chemical compound
of mediators such as various arachidonic acid metabolites and platelet-activating factor in human eosinophils, basophils, neutrophils, and monocytes. Furthermore
5-Oxo-eicosatetraenoic_acid
Passively Acquired anti-D PAE prostatic artery embolization PAF platelet-activating factor paroxysmal atrial fibrillation (meaning intermittent AF) PAH pulmonary
List of medical abbreviations: P
List_of_medical_abbreviations:_P
Organic compounds made of alkyl/aryl groups bound to oxygen (R–O–R')
alcohol: R–CH2–CH2(OH) → R–CH=CH2 + H2O Alcohols add to electrophilically activated alkenes. The method is atom-economical: R2C=CR2 + R–OH → R2CH–C(–O–R)–R2
Ether
Antihistamine medication
reuptake inhibitors v t e PAF receptor modulators PAFRTooltip Platelet-activating factor receptor Agonists C-PAF Edelfosine PAF Antagonists A-85783 ABT-491
Loratadine
Chemical compound
positively charged choline group. Phosphorylcholine is part of the platelet-activating factor; the phospholipid phosphatidylcholine and sphingomyelin, the only
Phosphorylcholine
Blood-clotting protein
cofactor for factor IXa, which, in the presence of Ca2+ and phospholipids, forms a complex that converts factor X to the activated form Xa. The factor VIII gene
Factor_VIII
Family of biomolecules
factor (VEGF), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), pituitary adenylate cyclase-activating peptide (PACAP), interleukin-1
Neurotrophic_factors
Topics referred to by the same term
Association Management, a Belgium-based consultancy for trade unions Platelet-activating factor, sometimes abbreviated as AGEPC This disambiguation page lists
AGEP
"The role of transacylases in the metabolism of arachidonate and platelet activating factor". Prog. Lipid Res. 31 (1): 65–86. doi:10.1016/0163-7827(92)90016-C
Glycerophospholipid arachidonoyl-transferase (CoA-independent)
Glycerophospholipid_arachidonoyl-transferase_(CoA-independent)
Protein
C, Perkins T, Clarke FM (Nov 1986). "Platelet-activating factor induces the expression of early pregnancy factor activity in female mice". Journal of
GroES
First stage of pregnancy
immunosuppressive agents. Such agents include platelet-activating factor, human chorionic gonadotropin, early pregnancy factor, prostaglandin E2, interleukin-1 alpha
Implantation_(embryology)
Peripheral membrane protein
(iPLA2) and lipoprotein-associated PLA2 (Lp-PLA2), also known as platelet activating factor acetylhydrolase (PAF-AH). The extracellular forms of phospholipases
Phospholipase_A2
Protein involved in coagulation
Tissue factor, also called platelet tissue factor or Coagulation factor III, is a protein present in subendothelial tissue and leukocytes which plays a
Tissue_factor
Class of enzymes
synergistically with another pro-allergic mediator, platelet-activating factor, to stimulate and otherwise activate eosinophils. ALOX5 contributes to non-allergic
Arachidonate_5-lipoxygenase
Category of white blood cells
abundant with histamine, heparin, chondroitin sulfate, peroxidase, platelet-activating factor, and other substances. When an infection occurs, mature basophils
Granulocyte
Plasma proteins arranged in a fibrin matrix
Platelet-rich fibrin (PRF) or leukocyte- and platelet-rich fibrin (L-PRF) is a derivative of PRP where autologous platelets and leukocytes are present
Platelet-rich_fibrin
Class of enzymes which cleave fats via hydrolysis
McIntyre TM; Stafforini DM; Prescott SM; PW Gray (1995). "Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A2 with a catalytic
Lipase
Class of cell surface receptors coupled to G-protein-associated intracellular signaling
mediators of inflammation (e.g., prostaglandins, prostanoids, platelet-activating factor, and leukotrienes); peptide hormones (e.g., calcitonin, C5a anaphylatoxin
G_protein-coupled_receptor
Abnormally low levels of platelets in the blood
characterized by abnormally low levels of platelets (also known as thrombocytes) in the blood. Low levels of platelets in turn may lead to prolonged or excessive
Thrombocytopenia
Medical condition
cells release proteases, histamine, and cytokines along with platelet-activating factors and other metabolites of arachidonic acid. These mediators cause
Chronic_spontaneous_urticaria
Human bacterial infection
as a virulence factor. Theta toxin also promotes vascular degradation as does its counterpart alpha toxin. A platelet-activation factor is employed which
Gas_gangrene
Type of white blood cell
day two after injury. Attracted to the wound site by growth factors released by platelets and other cells, monocytes from the bloodstream enter the area
Macrophage
Medical condition
such as histamine, platelet activating factor, prostaglandins, leukotrienes, proteases, and cytokines. Mast cells can be activated in three ways during
Jellyfish_dermatitis
Mammalian protein involved in blood clotting
thrombin-induced activation of factor XI. Polyphosphate forms calcium-rich nanoparticles in vivo, which accumulate on platelets and activate FXII. The regulation
Factor_XII
Protein or other substance that stimulates cellular proliferation
hepatocyte growth factor-like protein (HGFLP) Myostatin (GDF-8) Neuregulins Neurotrophins Placental growth factor (PGF) Platelet-derived growth factor (PDGF) Renalase
Growth_factor
Protein-coding gene in the species Homo sapiens
produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation
PLA2G4A
Medical condition
as histamine, neutral proteases, arachidonic acid derivatives, platelet activating factor and a variety of cytokines and chemokines. These mediators can
Kounis_syndrome
Aspect of human sexuality
present at higher concentrations in semen of men with SCI, as is platelet-activating factor acetylhydrolase; both are harmful to sperm. Another immune-related
Sexuality after spinal cord injury
Sexuality_after_spinal_cord_injury
Human protein
transduction). CLEC-2 is also activated by the human immunodeficiency virus (i.e., HIV), rhodocytin (a platelet-activating snake venom also termed aggretin)
PDPN
Protein found in humans
capable of activating NR2A although this was not found in the hippocampus. Thus, BDNF can increase NMDA receptor activity through Fyn activation. This has
Brain-derived neurotrophic factor
Brain-derived_neurotrophic_factor
Excessive reactions to mosquito bites
or a drug with combined activity in inhibiting histamine and platelet-activating factor, e.g. rupatadine. Randomized, double-blinded, placebo-controlled
Mosquito_bite_allergy
Species of plant in the soursop family
and roots have been reported to inhibit platelet-activating factor receptor binding in tests with rabbit platelets. King, George (1893). "Anonaceae of British
Goniothalamus_tapis
Chemical compound
v t e PAF receptor modulators PAFRTooltip Platelet-activating factor receptor Agonists C-PAF Edelfosine PAF Antagonists A-85783 ABT-491 Apafant BN-50739
Phosphocholine
Class of compounds
from phosphatidylcholine to produce LPC. Among other properties, they activate endothelial cells during early atherosclerosis. LPC also acts as a find-me
Lysophosphatidylcholine
PLATELET ACTIVATING-FACTOR
PLATELET ACTIVATING-FACTOR
Boy/Male
Muslim
Captivating, Attractive
Boy/Male
Arabic, Muslim
Fascinating; Captivating
Girl/Female
Tamil
Captivating
Boy/Male
Arabic, Muslim, Parsi
Attractive; Captivating
Girl/Female
Arabic, Muslim
Attractive; Captivating
Boy/Male
Indian, Punjabi, Sikh
Captivating God
Girl/Female
Arabic, Muslim, Parsi
Captivating; Attractive
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Manifested; Looks Like; Well Known; Clear
Girl/Female
Arabic, Gujarati, Hindu, Indian, Kannada, Muslim
Captivating
Girl/Female
Hebrew
Captivating.
Boy/Male
Hindu
Manifested, Confident
Boy/Male
Arabic, German, Indian, Muslim, Turkish
Captivating
Girl/Female
Australian, Hebrew
Captivating
Girl/Female
Arabic, Australian, French, German
Captivating
Girl/Female
Muslim
Captivating
Boy/Male
Arabic, Indian, Muslim
Captivating
Girl/Female
Indian
Captivating, Enchanting
Boy/Male
Indian
Captivating, Attractive
Girl/Female
Arabic, Indian, Muslim, Punjabi, Sikh
Captivating
Girl/Female
Muslim
Captivating, Enchanting
PLATELET ACTIVATING-FACTOR
PLATELET ACTIVATING-FACTOR
Boy/Male
Muslim
Sedate, Grave, Sober minded, Composed, Subtle
Boy/Male
Tamil
Surname or Lastname
English
English : variant of Perry 1.
Girl/Female
English
Girl/Female
Arabic, Gujarati, Hindu, Indian, Kannada, Muslim
Rich; Wealthy
Boy/Male
British, English
Life; Little
Boy/Male
Tamil
Leading
Surname or Lastname
English
English : apparently a habitational name from a place called Kenfield Hall in Kent, so named from Old English cyning ‘king’ (genitive plural cyninga ‘of the kings’) + feld ‘open country’.
Girl/Female
English Latin
A made famous by 1960s British singer CilIa Black, who was born Priscilla White.
Boy/Male
Hindu
Austerities
PLATELET ACTIVATING-FACTOR
PLATELET ACTIVATING-FACTOR
PLATELET ACTIVATING-FACTOR
PLATELET ACTIVATING-FACTOR
PLATELET ACTIVATING-FACTOR
n.
The body of factors in any place; as, a chaplain to a British factory.
n.
The art or practice of captivating the hearts of women.
a.
Literally, that kills; having power to kill; fatal; in a colloquial sense, conquering; captivating; irresistible.
a.
Moving in opposite directions; -- said of a lever, pulley, etc., in which the resistance and the actuating force are on opposite sides of the fulcrum or axis.
n.
A courting of favor or applause, by flattery or address; a captivating quality; an attraction.
n.
A little plant.
n.
A small plume.
a.
Having power to captivate or charm; fascinating; as, captivating smiles.
a.
Moving in the same direction; -- said of a lever or pulley in which the resistance and the actuating force are both on the same side of the fulcrum or axis.
n.
The act of captivating.
n.
A little castle.
a.
Captivating; alluring.
n.
A building, or collection of buildings, appropriated to the manufacture of goods; the place where workmen are employed in fabricating goods, wares, or utensils; a manufactory; as, a cotton factory.
n.
Any one of several species of wading birds of the genera Ajaja and Platalea, and allied genera, in which the long bill is broadly expanded and flattened at the tip.
p. pr. & vb. n.
of Captivate
p. pr. & vb. n.
of Actuate
a.
Having power to bewitch or fascinate; enchanting; captivating; charming.
n.
A small dish.
n.
A small flame.
n.
A little lake.