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Protein found in humans
The platelet-activating factor receptor (PAF-R) is a G-protein coupled receptor which binds platelet-activating factor. It is encoded in the human by the
Platelet-activating factor receptor
Platelet-activating_factor_receptor
Chemical compound
Platelet-activating factor, also known as PAF, PAF-acether or AGEPC (acetyl-glyceryl-ether-phosphorylcholine), is a potent phospholipid activator and
Platelet-activating_factor
Signaling glycoprotein regulating cell proliferation
Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In particular, PDGF plays a significant
Platelet-derived growth factor
Platelet-derived_growth_factor
Human protein-coding gene
Platelet-derived growth factor receptor A, also termed CD140a, is a receptor located on the surface of a wide range of cell types. The protein is encoded
Platelet-derived growth factor receptor A
Platelet-derived_growth_factor_receptor_A
Process of formation of blood clots
vessel wall). Activation of platelets and platelet plug formation: Platelet activation: Platelet activators, such as platelet activating factor and thromboxane
Coagulation
Component of blood aiding in coagulation
Platelet GP1b-IX-V receptor binds with VWF; and GPVI receptor and integrin α2β1 bind with collagen. Factors from the lining of vessels stop platelets
Platelet
Cell surface receptors
Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family
Platelet-derived growth factor receptor
Platelet-derived_growth_factor_receptor
Mammalian protein involved in blood clotting
Von Willebrand factor (VWF) (German: [fɔn ˈvɪləbʁant]) is a blood glycoprotein that promotes primary hemostasis, specifically, platelet adhesion. It is
Von_Willebrand_factor
Class of enzymes
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90
Receptor_tyrosine_kinase
Protein found in humans
blocked by of the basic helix–loop–helix transcription factor protein 2 (BHLHB2). NMDA receptor activation triggers the release of the regulatory inhibitor
Brain-derived neurotrophic factor
Brain-derived_neurotrophic_factor
Protein that stimulates cell division and differentiation
Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has
Epidermal_growth_factor
Transmembrane protein
growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Mammalian protein found in humans
N-terminal of the beta subunit, thereby activating the protein into functional NGF. The term nerve growth factor usually refers to the 2.5S, 26-kDa beta
Nerve_growth_factor
Protein involved in coagulation
Tissue factor, also called platelet tissue factor or Coagulation factor III, is a protein present in subendothelial tissue and leukocytes which plays a
Tissue_factor
Class of ligand activated receptors localized in surface of plama cell membrane
Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the plasma membrane of cells. They act in cell
Cell_surface_receptor
Second generation H1-antihistamine
Rupatadine is a second generation antihistamine and platelet-activating factor antagonist used to treat allergies. It was discovered and developed by Uriach [es]
Rupatadine
Subfamily of related G protein-coupled receptors
thrombin receptor expression in platelets and other cell types, in which differences in thrombin concentrations may considerably affect platelet activation of
Protease-activated_receptor
Mammalian protein found in Homo sapiens
Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity
Hepatocyte growth factor receptor
Hepatocyte_growth_factor_receptor
Protein or other substance that stimulates cellular proliferation
hepatocyte growth factor-like protein (HGFLP) Myostatin (GDF-8) Neuregulins Neurotrophins Placental growth factor (PGF) Platelet-derived growth factor (PDGF) Transforming
Growth_factor
Class of cell surface receptors coupled to G-protein-associated intracellular signaling
mediators of inflammation (e.g., prostaglandins, prostanoids, platelet-activating factor, and leukotrienes); peptide hormones (e.g., calcitonin, C5a anaphylatoxin
G_protein-coupled_receptor
Chemical compound
(Y-24180) is a drug which acts as a selective antagonist for the platelet-activating factor receptor, and was originally developed for the treatment of asthma
Israpafant
Family of biomolecules
maturation factor, insulin, insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), platelet-derived
Neurotrophic_factors
Mammalian protein found in humans
Proteinase-activated receptor 1 (PAR1) also known as protease-activated receptor 1, coagulation factor II receptor and thrombin receptor is a protein
Proteinase-activated receptor 1
Proteinase-activated_receptor_1
Mammalian protein found in Homo sapiens
B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B and CD257 among other names, is a protein that in humans
B-cell_activating_factor
Surface glycoproteins involved in hemostasis
GPIa/IIa, GPVI and probably GPIV as well, function as collagen receptors, engaged in platelet adhesion to collagen. The leading role in the elimination of
Platelet membrane glycoprotein
Platelet_membrane_glycoprotein
Subtype of serotonin receptor
is a cell surface receptor that activates multiple intracellular signalling cascades. Like all 5-HT2 receptors, the 5-HT2A receptor is coupled to the
5-HT2A_receptor
Surface protein important to the immune system
proteases. Activated mast cells also synthesize and secrete lipid-derived mediators (such as prostaglandins, leukotrienes, and platelet-activating factor) and
Fc_receptor
Protein-coding gene in humans
Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with
PDGFRB
Class of enzymes
as platelet-activating factor. There are multiple enzymes with this function: Lipoprotein-associated phospholipase A2 Platelet-activating factor acetylhydrolase
1-alkyl-2-acetylglycerophosphocholine esterase
1-alkyl-2-acetylglycerophosphocholine_esterase
Protein-coding gene in the species Homo sapiens
sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor". Science. 238 (4827): 650–656. Bibcode:1987Sci...238..650K
Alpha-2A_adrenergic_receptor
Integrin complex found on platelets
integrin complex found on platelets. It is a transmembrane receptor for fibrinogen and von Willebrand factor, and aids platelet activation. The complex is formed
Glycoprotein_IIb/IIIa
Protein involved in blood clotting, wound healing and inflammation
chemokine receptor CXCR3, known as CXCR3-B. There are a set of prothrombotic conditions caused by monoclonal antibodies against Platelet factor 4 (anti-PF4)
Platelet_factor_4
Protein found in humans
growth factor (IGF) system. This system consists of three ligands (insulin, IGF1 and IGF-2), two tyrosine kinase receptors (insulin receptor and IGF1R
Insulin-like_growth_factor_1
Class of pharmaceuticals
hypertension. Glycoprotein IIb/IIIa receptor antagonists block a receptor on the platelet for fibrinogen and von Willebrand factor. 3 classes: Murine-human chimeric
Antiplatelet_drug
Family of proteins that bind to fibroblast growth factors
fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins
Fibroblast growth factor receptor
Fibroblast_growth_factor_receptor
Protein family
VEGF receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending
VEGF_receptor
Cell-surface receptors which bind angiopoietin
agonistic or activating ligands for Tie2, whereas Ang2 and Ang3 behave as competitive antagonists. They function by binding their physiologic receptors, Tie-1
Angiopoietin_receptor
Cell surface receptor found in humans
Toll-like receptor 4 (TLR4), also designated as CD284 (cluster of differentiation 284), is a key activator of the innate immune response and plays a central
Toll-like_receptor_4
Type of white blood cell
day two after injury. Attracted to the wound site by growth factors released by platelets and other cells, monocytes from the bloodstream enter the area
Macrophage
Antihistamine medication
not always directly related to only the H1 receptor potency, as the concentration of free drug at the receptor must also be considered. Loratadine also
Loratadine
Mammalian protein found in humans
the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptors". The Journal of Biological Chemistry
Beta-2_adrenergic_receptor
Mammalian protein found in Homo sapiens
cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by platelets, and mesenchymal cells and acts as a multi-functional
Hepatocyte_growth_factor
Mammalian protein involved in blood clotting
thrombin-induced activation of factor XI. Polyphosphate forms calcium-rich nanoparticles in vivo, which accumulate on platelets and activate FXII. The regulation
Factor_XII
Protein found in humans
internalization of the platelet-activating factor receptor is dependent on arrestins but independent of G-protein activation. Role of the C terminus
Arrestin_beta_2
Antihistamine medication
because second-generation antihistamines are more selective for the H1 receptor. Compared to other second-generation antihistamines, cetirizine can cause
Cetirizine
Enzyme involved in blood coagulation in humans
also promotes platelet activation and aggregation via activation of protease-activated receptors on the cell membrane of the platelet. Thrombin bound
Thrombin
Biologically active terpenic lactone
molecules has been studied for its potential to act as a platelet-activating factor receptor antagonist. Ginkgolide B has been investigated for its potential
Ginkgolide
Protein-coding gene in the species Homo sapiens
Lodish HF, Orkin SH (December 1991). "Activation of the erythropoietin receptor promoter by transcription factor GATA-1". Proceedings of the National Academy
Erythropoietin_receptor
Protein-coding gene in the species Homo sapiens
Lipoprotein-associated phospholipase A2 (Lp-PLA2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A2 enzyme that in
Lipoprotein-associated phospholipase A2
Lipoprotein-associated_phospholipase_A2
Protein and coding gene in humans
Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type
Tropomyosin_receptor_kinase_B
Protein-coding gene in the species Homo sapiens
Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene. Platelet-derived growth
PDGFC
Proteins similar to insulin that stimulate cell proliferation
activation of osteocytes, and thus may be an anabolic factor for bone. Since at high concentrations it is capable of activating the insulin receptor,
Insulin-like_growth_factor
Family of proteins
Colony-stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of committed progenitors in the bone marrow
Colony-stimulating_factor
Drug class of antiplatelet agents
P2Y12 platelet receptors and therefore prevent the binding of ADP to the P2Y12 receptor. This leads to a decrease in aggregation of platelets, prohibiting
Adenosine diphosphate receptor inhibitor
Adenosine_diphosphate_receptor_inhibitor
Protein-coding gene in the species Homo sapiens
Platelet-activating factor acetylhydrolase IB subunit gamma is an enzyme that in humans is encoded by the PAFAH1B3 gene. PAFAH1B3 has been shown to interact
PAFAH1B3
Aggregation of platelets formed during early stage of coagulation
such as the platelet-derived growth factor, fibrinogen, and the von Willebrand factor (vWF), a glycoprotein critical in platelet activation and adhesion
Platelet_plug
Mammalian protein found in humans
tissue factor released from damaged tissues, it is converted to factor VIIa (or blood-coagulation factor VIIa, activated blood coagulation factor VII),
Factor_VII
Biological signaling using lipid molecules
concentrations induces sudden cardiac death by an S1P3-receptor specific mechanism. PAF is a potent activator of platelet aggregation, inflammation, and anaphylaxis
Lipid_signaling
Group of protein families
Neurotrophic factor receptors or neurotrophin receptors are a group of growth factor receptors which specifically bind to neurotrophins (neurotrophic factors). Two
Neurotrophic_factor_receptor
Mammalian protein found in Homo sapiens
cells in part by activating the Gq family of G proteins. In at least certain cell types, however, TPα also stimulates cells by activating the Gs family of
Thromboxane_receptor
Family of proteins involved in anatomical development
These growth factors typically act as a systemic or locally circulating molecules of extracellular origin that activate cell surface receptors. A defining
Fibroblast_growth_factor
G protein-coupled receptor
G protein-coupled receptors (GPCRs) called vasopressin receptors that are classified into the V1 (V1A), V2, and V3 (V1B) receptor subtypes. These three
Vasopressin_receptor
Protein-coding gene in the species Homo sapiens
Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene. The protein encoded by this gene is a member of the
PDGFB
Type of protein or peptide
anti-mitogen, transforming growth factor (TGF-𝝱). TGF-𝝱 works by binding to cell-surface receptors and activating the Smad gene regulatory proteins
Mitogen
Mammalian protein found in humans
protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis
C-fos-induced_growth_factor
Refractive eye surgery procedure
N; Bazan, NG; Esquenazi, I; Bazan, HE (2009). "A novel platelet activating factor receptor antagonist reduces cell infiltration and expression of inflammatory
Photorefractive_keratectomy
Protein-coding gene in the species Homo sapiens
the receptors themselves become tyrosine phosphorylated. Receptor for thrombopoietin which is the major regulator of megakaryocytopoiesis and platelet formation
Thrombopoietin_receptor
Activation of coagulation cascade
reciprocal activation of FXII and PK occurs, forming FXIIa and PKa. FXIIa can initiate the coagulation cascade by cleaving and activating factor XI (FXI)
Contact_activation_system
Form of localized cell signaling
fibroblast growth factors, epidermal growth factors, platelet-derived growth factors, and stem cell factor. This dimerizes the transmembrane receptor to another
Paracrine_signaling
Chemical compound
critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor". Journal of Biological Chemistry. 285 (8): 5931–40. doi:10
Thienotriazolodiazepine
Protein-coding gene in humans
substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both
PAFAH2
Chemical compound
v t e PAF receptor modulators PAFRTooltip Platelet-activating factor receptor Agonists C-PAF Edelfosine PAF Antagonists A-85783 ABT-491 Apafant BN-50739
Phosphocholine
(February 2006). "Platelet-activating factor acetylhydrolase activity affects sperm motility and serves as a decapacitation factor". Fertility and Sterility
Decapacitation_factor
Cell receptor protein found in humans
insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone
Insulin-like growth factor 1 receptor
Insulin-like_growth_factor_1_receptor
Class of compounds
studied in young smokers. Evidence pointed towards smoking as a major risk factor for increased levels of PLA2, due to tobacco smoke's impact on oxidation
Lysophosphatidylcholine
Gene involved in the most common form of dwarfism
Fibroblast growth factor receptor 3 (FGFR-3) is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 (cluster
Fibroblast growth factor receptor 3
Fibroblast_growth_factor_receptor_3
Mammalian protein found in Homo sapiens
5-Hydroxytryptamine receptor 2B (5-HT2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the HTR2B gene. 5-HT2B is a member
5-HT2B_receptor
Family of protein kinases
some tyrosine kinase receptors, including the receptor for platelet-derived growth factor (PDGF) and insulin-like growth factor (IGF). GRKs also regulate
G protein-coupled receptor kinase
G_protein-coupled_receptor_kinase
Overreaction of the immune system to an antigen
Chisei; Okayama, Yoshimichi (May 2010). "Activation of human mast cells through the platelet-activating factor receptor". Journal of Allergy and Clinical Immunology
Hypersensitivity
Mammalian protein found in Homo sapiens
Platelet-derived growth factor subunit A is a protein that in humans is encoded by the PDGFA gene. The protein encoded by this gene is a member of the
PDGFA
Protein involved in blood vessel growth
verification] This gene is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and encodes a protein that
Vascular endothelial growth factor A
Vascular_endothelial_growth_factor_A
Mammalian protein found in Homo sapiens
development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor necessary for megakaryocyte proliferation
Thrombopoietin
Family of proteins
family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member
ErbB
Process of preventing and stopping bleeding
certain receptors, some of which are used for the adhesion of platelets to collagen. When platelets are activated, they express glycoprotein receptors that
Hemostasis
Protein-coding gene in the species Homo sapiens
growth factor, beta 1". Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB (June 1983). "Transforming growth factor-beta in human platelets. Identification
TGF_beta_1
Medical condition
of von Willebrand factor (VWF), a protein required for platelet adhesion through the binding to other proteins, particularly factor VIII. The disease
Von_Willebrand_disease
Mammalian protein found in humans
epidermal growth factor receptor 2) or CD340 (cluster of differentiation 340). HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB)
HER2
Human protein
that the PDPN-expressing vesicles activated platelets by binding to their CLEC-2 receptors. Similar platelet-activating effects were seen in cultures of
Podoplanin
Protein-coding gene in the species Homo sapiens
(In contrast, activation of either the EP2 or EP3 receptor inhibits platelet activation) Inhibition of EP3 with the selective EP3 receptor antagonist, DG-041
Prostaglandin_EP3_receptor
Class of phospholipids
Phosphatidylcholine also plays a role in membrane-mediated cell signaling and PCTP activation of other enzymes. This phospholipid is composed of a choline head group
Phosphatidylcholine
Protein found in humans
Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming
Tropomyosin_receptor_kinase_A
Type-1 transmembrane protein
(CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial
P-selectin
Mammalian protein found in Homo sapiens
prostanoids have the following relative efficacies as receptor ligands in binding to and activating IP: PGI2>>PGD2=PGE2=PGF2α>TXA2. In typical binding studies
Prostacyclin_receptor
Protein found in humans
The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded
Granulocyte colony-stimulating factor receptor
Granulocyte_colony-stimulating_factor_receptor
Protein found in humans
Fibroblast growth factor receptor 1 (FGFR-1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome
Fibroblast growth factor receptor 1
Fibroblast_growth_factor_receptor_1
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor receptor 4 (FGFR-4) is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334 (cluster
Fibroblast growth factor receptor 4
Fibroblast_growth_factor_receptor_4
Protein
becomes activated when binding to receptors capable of protein kinase activity for cellular signaling. TGF-α is a transforming growth factor that is a
TGF_alpha
Bone marrow cell which produces platelets
production of regulatory factors such as CXCL4 (platelet factor 4), transforming growth factor-β1, and fibroblast growth factor 1. Cycling megakaryocytes:
Megakaryocyte
Family of cell surface receptors
DNGR1/CLEC9A, Myeloid C‑type lectin‑like receptor (MICL) (CLEC12A), CLEC2 (also called CLEC1B)- the platelet activation receptor for podoplanin on lymphatic endothelial
Pattern_recognition_receptor
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor receptor 2 (FGFR-2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2
Fibroblast growth factor receptor 2
Fibroblast_growth_factor_receptor_2
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PLATELET ACTIVATING-FACTOR-RECEPTOR
PLATELET ACTIVATING-FACTOR-RECEPTOR
PLATELET ACTIVATING-FACTOR-RECEPTOR
PLATELET ACTIVATING-FACTOR-RECEPTOR
PLATELET ACTIVATING-FACTOR-RECEPTOR
PLATELET ACTIVATING-FACTOR-RECEPTOR
PLATELET ACTIVATING-FACTOR-RECEPTOR
PLATELET ACTIVATING-FACTOR-RECEPTOR
PLATELET ACTIVATING-FACTOR-RECEPTOR
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