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Protein-coding gene in the species Homo sapiens
enzyme that in humans is encoded by the POLD3 gene. It is a component of the DNA polymerase delta complex. POLD3 has been shown to interact with PCNA. GRCh38:
POLD3
Enzyme complex
The DNA polymerase delta complex consists of 4 subunits: POLD1, POLD2, POLD3, and POLD4. DNA Pol δ is an enzyme used for both leading and lagging strand
DNA_polymerase_delta
Biological process
Eukaryotic DNA polymerase: alpha POLA1 POLA2 PRIM1 PRIM2 delta POLD1 POLD2 POLD3 POLD4 epsilon POLE POLE2 POLE3 POLE4 DNA clamp PCNA Control of chromosome
DNA_replication
Enzymes that catalyze DNA formation
Pol δ is expressed by genes POLD1, creating the catalytic subunit, POLD2, POLD3, and POLD4 creating the other subunits that interact with Proliferating
DNA_polymerase
polymerases in the process. However, other proteins, namely POLD3 and REV1, arrive as well. POLD3 assists the polymerases overall, but REV1 targets the Pol ζ
Mitotic_DNA_Synthesis
DNA region replicating from a single origin
Eukaryotic DNA polymerase: alpha POLA1 POLA2 PRIM1 PRIM2 delta POLD1 POLD2 POLD3 POLD4 epsilon POLE POLE2 POLE3 POLE4 DNA clamp PCNA Control of chromosome
Replicon_(genetics)
Sequence in a genome
Eukaryotic DNA polymerase: alpha POLA1 POLA2 PRIM1 PRIM2 delta POLD1 POLD2 POLD3 POLD4 epsilon POLE POLE2 POLE3 POLE4 DNA clamp PCNA Control of chromosome
Origin_of_replication
Class of enzymes
Eukaryotic DNA polymerase: alpha POLA1 POLA2 PRIM1 PRIM2 delta POLD1 POLD2 POLD3 POLD4 epsilon POLE POLE2 POLE3 POLE4 DNA clamp PCNA Control of chromosome
DNA_polymerase_epsilon
Protein-coding gene in the species Homo sapiens
human DNA Polδ is a heterotetramer. The four subunits are: (POLD1/ p125), (POLD3/ p66), (POLD2/ p50) and (POLD4/ p12), with the alternative names reflecting
POLD1
Protein-coding gene in the species Homo sapiens
Eukaryotic DNA polymerase: alpha POLA1 POLA2 PRIM1 PRIM2 delta POLD1 POLD2 POLD3 POLD4 epsilon POLE POLE2 POLE3 POLE4 DNA clamp PCNA Control of chromosome
POLE2
Protein-coding gene in humans
Eukaryotic DNA polymerase: alpha POLA1 POLA2 PRIM1 PRIM2 delta POLD1 POLD2 POLD3 POLD4 epsilon POLE POLE2 POLE3 POLE4 DNA clamp PCNA Control of chromosome
POLE_(gene)
DNA replication in eukaryotic organisms
protein known as RAD52, which then recruits enzymes, including MUS81 and POLD3. These enzymes work to promote MiDAS, operating outside of ATR, BRCA2, and
Eukaryotic_DNA_replication
Mammalian protein found in Homo sapiens
HDAC1 HUS1 ING1 KCTD13 KIAA0101 Ku70 Ku80 MCL1 MSH3 MSH6 MUTYH P21 POLD2 POLD3 POLDIP2 POLH POLL RFC1 RFC2 RFC3 RFC4 RFC5 Ubiquitin C Werner syndrome ATP-dependent
Proliferating cell nuclear antigen
Proliferating_cell_nuclear_antigen
Protein-coding gene in the species Homo sapiens
Eukaryotic DNA polymerase: alpha POLA1 POLA2 PRIM1 PRIM2 delta POLD1 POLD2 POLD3 POLD4 epsilon POLE POLE2 POLE3 POLE4 DNA clamp PCNA Control of chromosome
POLE4
P06746 12469 POLD1 HGNC:9175; P28340 12470 POLD2 HGNC:9176; P49005 12471 POLD3 HGNC:20932; Q15054 12472 POLD4 HGNC:14106; Q9HCU8 12473 POLDIP2 HGNC:23781;
List of human protein-coding genes 6
List_of_human_protein-coding_genes_6
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POLD3
POLD3
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POLD3
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POLD3
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