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Protein-coding gene in the species Homo sapiens
maturation protein-1 (BLIMP-1), is a protein in humans encoded by the gene PRDM1 located on chromosome 6q21. BLIMP-1 is considered a 'master regulator' of
PRDM1
One of three major types of muscle
Prdm1 gene down-regulates the formation of new slow twitch fibers through direct and indirect mechanisms such as Sox6 (indirect). In mice, the Prdm1 gene
Skeletal_muscle
White blood cell that secretes large volumes of antibodies
cells into plasma cells is dependent upon the transcription factors Blimp-1/PRDM1, BCL6, and IRF4. Unlike their precursors, plasma cells cannot switch antibody
Plasma_cell
Type of large B-cell lymphoma
and promotes malignancy); 2) loss in the expression of the PRDM1 gene whose product, PRDM1/BLMP1 protein, represses the expression of Myc protein;) 3)
Plasmablastic_lymphoma
Medical condition
(i.e. genes that protect cells from becoming malignant) such as HACE1, PRDM1, FOXO3, and PTPRK. Subsequent studies showed that the disease is also occasionally
Extranodal NK/T-cell lymphoma, nasal type
Extranodal_NK/T-cell_lymphoma,_nasal_type
Protein family
(FP13812), EHMT2 (BAT8), EZH1, EZH2 MLL, MLL2, MLL3, MLL5 NSD1, NSD2, NSD3 PRDM1, PRDM2, PRDM5 SETD1A, SETD2, SETD3, SETD4, SETD5, SETD6, SETD7, SETD8, SETDB1
SET_domain
Group of disorders
Translocations, amplifications, and other causes (e.g. mutations in the PRDM1 gene) lead to the overexpression of the MYC gene. PEL 90% possible I/II
Epstein–Barr virus–associated lymphoproliferative diseases
Epstein–Barr_virus–associated_lymphoproliferative_diseases
Transcription factor for converting Naive T cells to TFH
lymphomas. Normally, the action of BCL6 is negatively regulated by the gene PRDM1 encoding the transcription factor Blimp-1. The antagonistic effect with
BCL6
protein with 100% identical DBD – in vitro [728] VNTRMCCYANWDNRACCTWTNVCCYVNW PRDM1 ENSG00000057657 C2H2 ZF Known motif – High-throughput in vitro [729] RAAAGTGAAAGTD
List of human transcription factors
List_of_human_transcription_factors
Medical condition
epidermal differentiation. These transcription activators include: GRHL3, HOPX, PRDM1, KLF4, and ZNF750. Most notably, Hay-Wells-type p63 mutations cause irregular
Hay–Wells_syndrome
Protein-coding gene in the species Homo sapiens
L, Gregersen PK, Daly MJ, Plenge RM (2009). "Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk". Nat. Genet
T-cell activation RhoGTPase activating protein
T-cell_activation_RhoGTPase_activating_protein
Gamete-producing cell
signaling, which activates expression of the transcription factors Blimp-1/Prdm1 and Prdm14. It is speculated that induction was the ancestral mechanism
Germ_cell
E. K.; Robertson, E. J. (2011). "The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes". Proceedings
List of intestinal epithelial differentiation genes
List_of_intestinal_epithelial_differentiation_genes
Enzyme that creates mutations in DNA
transcription factors TCF3 (E47), HoxC4, Irf8 and Pax5, and inhibited by PRDM1 (Blimp1) and Id2. At the post-transcriptional level of regulation, AID expression
Activation-induced cytidine deaminase
Activation-induced_cytidine_deaminase
Medical condition
microglobulin genes; translocations of the BCL6 and BCL2 genes; and losses of PRDM1 and TNFAIP3 genes. There is an important distinction in DLBCL-RTs based
Richter's_transformation
Cancer originating in lymph nodes
member 14, aka Herpesvirus entry mediator, HVEM, or CD270); 3) mutations in PRDM1 (encodes the PR domain zinc finger protein which promotes the maturation
Follicular_lymphoma
RNA family
(September 2010). "Epigenetic down-regulation of the tumor suppressor gene PRDM1/Blimp-1 in diffuse large B cell lymphomas: a potential role of the microRNA
Let-7_microRNA_family
Complication of celiac disease
lymphocyte development); another gene involved in lymphocyte development, PRDM1; a gene promoting activation of the tumor suppressor p53, IRF1; DNA repair
Enteropathy-associated T-cell lymphoma
Enteropathy-associated_T-cell_lymphoma
which play key role in T cells exhaustion include TCF-1, T-bet, Eomes, PRDM1, NFAT, NR4A, IRF4 and BATF. According to the current differentiation model
T_memory_stem_cell
Specialized subtype of cytotoxic lymphocyte
IFNG gene, NKG2C+ adaptive NK cells also showed CpG demethylation of the PRDM1/BLIMP1 and ZBTB32/TZFP genes or hypermethylation of FCER1G (Fc fragment
Adaptive_NK_cell
Group of lymphomas
gene. FoxP1 protein stimulates production of transcription factors such as PRDM1, IRF4, and XBP1 which promote the maturation of B-cells to plasma cells
Marginal_zone_lymphoma
Protein-coding gene in the species Homo sapiens
complex, MTA3 regulates BCL6-dependent repression of target genes, including PRDM1, and modulates the differentiation of B-cells. The estrogen receptor-stimulates
MTA3
Joseph J; Xie, Gang; Stahl, Eli A (2009-11-08). "Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk". Nature Genetics
Gene Relationships Across Implicated Loci
Gene_Relationships_Across_Implicated_Loci
These proteins specify embryonic cells into PGCs expressing the genes PRDM1 and PRDM14 at embryonic day (E) 6.25. The PGCs which are positively stained
Gonocyte
Protein-coding gene in the species Homo sapiens
et al. (November 2009). "A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus"
TNIP1
Q92733 12762 PRCD HGNC:32528; Q00LT1 12763 PRCP HGNC:9344; P42785 12764 PRDM1 HGNC:9346; O75626 12765 PRDM2 HGNC:9347; Q13029 12766 PRDM4 HGNC:9348; Q9UKN5
List of human protein-coding genes 6
List_of_human_protein-coding_genes_6
PRDM1
PRDM1
PRDM1
PRDM1
Boy/Male
Italian Spanish
Abbreviation of Donatello 'gift from God.
Boy/Male
Indian, Sikh
Loyal
Boy/Male
Muslim
Generous, Noble, Friendly, Precious and distinguished, Kind
Boy/Male
Hindu
Master of Kapil
Surname or Lastname
English
English : variant of Toll.
Boy/Male
Hindu
Dark
Boy/Male
Arabic, Muslim
Servant of the Implementor
Biblical
nourishing
Girl/Female
Australian, British, Christian, English, French
Battle
Biblical
lady; mother of the multitude
PRDM1
PRDM1
PRDM1
PRDM1
PRDM1