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Protein-coding gene in the species Homo sapiens
homolog C (S. cerevisiae), also known as RAD51C, is a protein which in humans is encoded by the RAD51C gene. The RAD51C protein is one of five paralogs of RAD51
RAD51C
Chemical compound
repair (HRR) deficiencies as a result of mutations in BRCA1, BRCA2, PALB2, RAD51C, or RAD51D genes. "Saruparib - AstraZeneca". AdisInsight. Springer Nature
Saruparib
Genetic disease causing anemia, birth defects, and cancers
FANCF, FANCG, FANCI, FANCJ (BRIP1), FANCL, FANCM, FANCN (PALB2), FANCO (RAD51C), FANCP (SLX4), FANCQ (XPF), FANCS (BRCA1), FANCT (UBE2T), FANCU (XRCC2)
Fanconi_anemia
Cereal grain and staple food
higher plants. For example, study using rice has shown that the gene OsRAD51C is necessary for the accurate repair of DNA double-strand breaks during
Rice
Protein-coding gene in the species Homo sapiens
three related paralogs: BCDX2 (RAD51B-RAD51C-RAD51D-XRCC2) while two paralogs form a second complex CX3 (RAD51C-XRCC3). These two complexes act at two
XRCC2
Protein-coding gene in the species Homo sapiens
paralogs form a complex designated CX3 (RAD51C-XRCC3). Four paralogs form a second complex designated BCDX2 (RAD51B-RAD51C-RAD51D-XRCC2). These two complexes
XRCC3
Protein-coding gene in the species Homo sapiens
determined. RAD51L3 has been shown to interact with: Bloom syndrome protein, RAD51C, and XRCC2. GRCh38: Ensembl release 89: ENSG00000185379 – Ensembl, May 2017
RAD51L3
Loss of the copy of a gene from one parent in a diploid organism
cancers was found for DNA repair genes BRCA1, BRCA2, BARD1, PALB2, FANCC, RAD51C and RAD51D. Reduced ability to accurately repair DNA damages by homologous
Loss_of_heterozygosity
Protein-coding gene in the species Homo sapiens
protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2
RAD51L1
FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM, FANCN, FANCP, FANCS, RAD51C, XPF 1:130,000 Fabry disease GLA (Xq22.1) P 1:117,000-476,000 Factor V Leiden
List_of_genetic_disorders
Protein-coding gene in the species Homo sapiens
a DNA double-strand break, and also binds to RAD51C, a member of the RAD51 paralog complex RAD51B-RAD51C-RAD51D-XRCC2 (BCDX2). The BCDX2 complex is responsible
Fanconi anemia group G protein
Fanconi_anemia_group_G_protein
Schinzel–Giedion syndrome: SETBP1 Fanconi anemia and related disorders: RAD51C Noonan syndrome: NRAS generalized lymph vessel dysplasia: CCBE1 brachydactyly-anonychia:
Malformative_syndrome
Protein-coding gene in the species Homo sapiens
a DNA double-strand break, and also binds to RAD51C, a member of the RAD51 paralog complex RAD51B-RAD51C-RAD51D-XRCC2 (BCDX2). The BCDX2 complex is responsible
PALB2
Cancer originating in or on the ovary
Other genes that have been associated with ovarian cancer are BRIP1, MSH6, RAD51C and RAD51D. CDH1, CHEK2, PALB2 and RAD50 have also been associated with
Ovarian_cancer
Protein involved in DNA repair
The paralogs form two identified complexes: BCDX2 (RAD51B-RAD51C-RAD51D-XRCC2) and CX3 (RAD51C-XRCC3). These two complexes act at two different stages of
RAD51
Gene which maintains basic cellular functions
checkpoint activation upon DNA damage RAD23B NM_002873 RAD50 NM_005732 RAD51C NM_002874 IST1 (locates to central dividing line of dividing cells) DAD1
Housekeeping_gene
Protein-coding gene in the species Homo sapiens
a DNA double-strand break, and also binds to RAD51C, a member of the RAD51 paralog complex RAD51B-RAD51C-RAD51D-XRCC2 (BCDX2). The BCDX2 complex is responsible
Fanconi anemia group D2 protein
Fanconi_anemia_group_D2_protein
Model of DNA repair in biology
a DNA double-strand break, and also binds to RAD51C, a member of the RAD51 paralog complex RAD51B-RAD51C-RAD51D-XRCC2 (BCDX2). The BCDX2 complex is responsible
Double-strand break repair model
Double-strand_break_repair_model
Tonin, Patricia N. (30 April 2022). "The Genetic and Molecular Analyses of RAD51C and RAD51D Identifies Rare Variants Implicated in Hereditary Ovarian Cancer
Shapiro–Senapathy_algorithm
Overview article
associated with lower risk of breast cancer.[better source needed] Mutations in RAD51C confer an increased risk for breast and ovarian cancer. People who have
Risk factors for breast cancer
Risk_factors_for_breast_cancer
Chemical compound
(ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11A, NBN, PALB2, or RAD51C) were assessed prospectively using tumor tissue and/or circulating tumor
Talazoparib
Gene known for its role in breast cancer
In addition, the four paralogs of RAD51, consisting of RAD51B (RAD51L1), RAD51C (RAD51L2), RAD51D (RAD51L3), XRCC2 form a complex called the BCDX2 complex
BRCA2
Protein-coding gene in the species Homo sapiens
In addition, the four paralogs of RAD51, consisting of RAD51B (RAD51L1), RAD51C (RAD51L2), RAD51D (RAD51L3), XRCC2 form a complex called the BCDX2 complex
RAD52
13361 RAD51AP2 HGNC:34417; Q09MP3 13362 RAD51B HGNC:9822; O15315 13363 RAD51C HGNC:9820; O43502 13364 RAD51D HGNC:9823; O75771 13365 RAD52 HGNC:9824;
List of human protein-coding genes 6
List_of_human_protein-coding_genes_6
British biochemist and molecular biologist
resolution structure of the two RAD51 paralog complexes (made up of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3) using cryo-electron microscopy and, in work considered
Stephen_C._West
fever, AR; 249100; MEFV Fanconi anemia, complementation group 0; 613390; RAD51C Fanconi anemia, complementation group A; 227650; FANCA Fanconi anemia, complementation
List_of_OMIM_disorder_codes
RNF-113 is involved in interstrand DNA crosslink repair and interacts with a RAD51C homolog". PLOS ONE. 8 (3) e60071. Bibcode:2013PLoSO...860071L. doi:10.1371/journal
RNF113A
Protein-coding gene in the species Homo sapiens
a DNA double-strand break, and also binds to RAD51C, a member of the RAD51 paralog complex RAD51B-RAD51C-RAD51D-XRCC2 (BCDX2). The BCDX2 complex is responsible
FANCL
Indian biochemistr and academic
Anup; Saxena, Sneha; Kaushal, Anjali; Nagaraju, Ganesh (1 February 2018). "RAD51C/XRCC3 Facilitates Mitochondrial DNA Replication and Maintains Integrity
Ganesh_Nagaraju
Group of proteins
protein FANCN is also known as PALB2. FANC protein FANCO is also known as RAD51C. FANC protein FANCP is also known as SLX4. FANC+Proteins at the U.S. National
FANC_proteins
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RAD51C
RAD51C
RAD51C
RAD51C
RAD51C
RAD51C
RAD51C
RAD51C
RAD51C
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