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Recurrence of stenosis, a narrowing of a blood vessel
Restenosis is the recurrence of stenosis, a narrowing of a blood vessel, leading to restricted blood flow. Restenosis usually pertains to an artery or
Restenosis
Chemical compound
to counteract restenosis. Restenosis is typically described by clinical trials in a binary approach, otherwise known as "binary restenosis" or just "binary
Zotarolimus
Medical condition
synonym, but is commonly used only in the context of aortic coarctation. Restenosis is the recurrence of stenosis after a procedure. Examples of vascular
Stenosis
Medical implant to treat narrowed arteries
artery can close up again, which is a condition known as restenosis. Restenosis, or in-stent restenosis, is a blockage or narrowing that comes back in the portion
Drug-eluting_stent
Type of medical device
medication to prevent complications such as blood clot formation and restenosis (re-narrowing). Stenting is performed through a procedure called percutaneous
Stent
Medical stent implanted into coronary arteries
adverse reactions/effects of the dye used in the procedure, infection, restenosis, clotting, blood vessel damage, and bleeding at catheter insertion site
Coronary_stent
Pharmaceutical drug
has a use in cardiovascular drug-eluting stent technologies to inhibit restenosis. It is produced by the bacterium Streptomyces hygroscopicus and was isolated
Sirolimus
Medication used for cancer
Paclitaxel is used as an antiproliferative agent for the prevention of restenosis (recurrent narrowing) of coronary and peripheral stents; locally delivered
Paclitaxel
Chemical compound
has a use in cardiovascular drug-eluting stent technologies to inhibit restenosis.[medical citation needed] It is the 40-O-(2-hydroxyethyl) derivative of
Everolimus
Procedure to widen narrow arteries or veins
to restenosis relative to vascular bypass or coronary artery bypass grafting. Drug-eluting balloon angioplasty has significantly less restenosis, late
Angioplasty
Radiography of heart and blood vessels
procedures have been plagued by restenosis due to the formation of endothelial tissue overgrowth at the lesion site. Restenosis is the body's response to the
Coronary_catheterization
Chest discomfort due to disorder of the heart muscles
flow-limiting lesions are left unaddressed) or stent failure (including restenosis and thrombosis), and non-obstructive causes, such as coronary microvascular
Angina
decreased arterial lumen space. Neointimal hyperplasia is the major cause of restenosis after percutaneous coronary interventions such as stenting or angioplasty
Neointimal_hyperplasia
German cardiologist
implantations. Grüntzig had already recognized the problem of abrupt closure and restenosis after angioplasty. The need for a suitable form of intraluminal support
Ulrich_Sigwart
Argentine doctor
restenosis after angioplasty, and improved procedures continue to be sought. The drug-eluting stent, which releases chemicals that inhibit restenosis
Julio_Palmaz
area (in-stent restenosis). By the late 1990s, it was generally acknowledged among cardiologists that the incidence of in-stent restenosis was between 15
History of invasive and interventional cardiology
History_of_invasive_and_interventional_cardiology
Spanish cardiologist (born 1943)
prompting the introduction of drug-eluting stents (DES) to prevent PCI restenosis. 2000s: Following upon experience with CABG and DES for revascularization
Valentín_Fuster
Therapy using ionizing radiation, usually to treat cancer
villonodular synovitis, and prevention of keloid scar growth, vascular restenosis, and heterotopic ossification. The use of radiation therapy in non-malignant
Radiation_therapy
Medical intervention
preferred over bare-metal stents because the latter carry a higher risk of restenosis, the growth of tissue into the stent resulting in vessel narrowing. However
Bare-metal_stent
Large artery in the thigh
by compressive or torsional forces, leading to stent fracture and/or restenosis. On the other hand, lithoplasty balloon angioplasty may represent a safe
Femoral_artery
Type of drug-eluting stent
which reduces the chance of re-blockage in the treated area known as restenosis, and reduces the chances that another procedure is required. The Cypher
Cypher_stent
Indian American cardiologist (born 1941)
for medical inventions including the use of red laser light to prevent restenosis, multi-lobe balloons, fibrin-coated stents, and hemostats to stop bleeding
Harvinder_Sahota
Organic compound
Lange Christian (1 December 2012). "Paclitaxel-Coated Balloons Reduce Restenosis After Femoro-Popliteal Angioplasty". Circulation: Cardiovascular Interventions
Urea
Radioactive isotope of strontium
89 Sr can be used in treatment of bone cancer, and to treat coronary restenosis via vascular brachytherapy. It is also used as a radioactive tracer in
Strontium-90
Medical intervention
(cutting plaque out) Brachytherapy (use of radioactive source to inhibit restenosis) Coronary intravascular lithotripsy (IVL), or using sonic waves to break
Percutaneous coronary intervention
Percutaneous_coronary_intervention
endothelial layer over the stent to protect against thrombus and minimize restenosis. The Genous Stent is a bio-engineered coronary stent coated with immobilized
Genous
Heart disease with narrowing of valve
to detect restenosis. Long-term follow-up data from patients undergoing PBMV indicates that up to 70–75% individuals can be free of restenosis 10 years
Mitral_stenosis
Chemical compound
trial) by SmithKline Beecham in partnership with Kissei for prevention of restenosis after percutaneous transluminal coronary revascularization, but was not
Tranilast
American cardiologist
a drug-coated stent (now known as a drug-eluting stent) could prevent restenosis. His research interests include delivery of stem cells to the heart for
Alan_Heldman
RNA family
factor for cardiovascular disease, including atherosclerosis, carotid restenosis after endarterectomy, and myocardial infarction. Translational silencing
GAIT_element
Class of drugs
thrombosis Mechanical heart valves Myocardial infarction Pulmonary embolism Restenosis from stents Cardiopulmonary bypass (or any other surgeries requiring temporary
Anticoagulant
aggregation, tearing, arterial recoil, and restenosis. Thus, coronary artery stents were created to prevent restenosis after balloon dilation. There are three
Dual_therapy_stent
Swirling and reverse current in a turbulent flow regime
atherosclerotic lesions, postsurgical neointimal hyperplasia, in-stent restenosis, vein bypass graft failure, transplant vasculopathy, and aortic valve
Eddy_(fluid_dynamics)
Medical condition
hyperplasia is the universal response of a vessel to injury. It is a restenosis and this is an important reason of late bypass graft failure, particularly
Intimal_hyperplasia
Cholesterol-lowering medication
morning versus evening intake of atorvastatin on major cardiac event and restenosis rates in patients undergoing first elective percutaneous coronary intervention"
Atorvastatin
Narrowing of the pulmonary artery
of vessel wall tearing, the rate of restenosis is between 15 and 44%. Studies reported that the rate of restenosis increases as time from the procedure
Pulmonary_artery_stenosis
American pharmaceutical company
tested for a wide range of applications including prevention of cardiac restenosis after angioplasty, treatment of coronary artery bypass grafts, treatment
Sarepta_Therapeutics
Topics referred to by the same term
Statistical Review International Studies Review Israel Studies Review In-stent restenosis, recurrence of stenosis after stenting Plant-induced systemic resistance
ISR
Type of radiation therapy
in-stent restenosis, in which a catheter is placed inside blood vessels, through which sources are inserted and removed. In treating In-stent restenosis (ISR)
Brachytherapy
Surgical procedure
high blood pressure following surgery. Long term complications include restenosis of the endarterectomy bed, although the clinical significance of this
Carotid_endarterectomy
Stroke resulting from lack of blood flow
of major peri-procedural complications ranged from 4-10%. The rates of restenosis and/or stroke following the treatment were also favorable. This data suggests
Cerebral_infarction
Indian cardiologist
Weighing less than a gram, the gold stent also helped lower the risk of restenosis, marking a significant advancement in interventional cardiology. In February
Purshotam_Lal
verb stems to form abstract nouns or nouns of action, result or process restenosis, stenosis steth- of or pertaining to the upper chest, the area above the
List of medical roots and affixes
List_of_medical_roots_and_affixes
Protein-coding gene in humans
smooth muscle cell migration and division, causing atherosclerosis and restenosis. Note : In all these diseases we can observe the expression of the AAMP
AAMP_(gene)
Protein-coding gene in the species Homo sapiens
Wight TN, Merrilees MJ (2004). "Proteoglycans in atherosclerosis and restenosis: key roles for versican". Circ. Res. 94 (9): 1158–67. doi:10.1161/01.RES
Versican
Chinese-American bioengineer
introduced: Research could improve prevention and treatment option for restenosis", Discovery files, National Science Foundation, 7 August 2014, retrieved
Linxia_Gu
Monoclonal antibody
treatment for cerebral vasospasm, head trauma, kidney transplantation, and restenosis. Multiple companies have tried to develop anti-CD18 drugs, but none of
Rovelizumab
Impaired function of the inner lining of blood/lymph vessels
stents were previously used because they showed low rates of in-stent restenosis, but further investigation showed that they often impair endothelial function
Endothelial_dysfunction
Language used to describe the human body
verb stems to form abstract nouns or nouns of action, result or process restenosis, stenosis stom-, stomat-, -stomy mouth; an artificially created opening
Medical_terminology
Australian medical scientist
common diseases or complications including skin cancer, post-angioplasty restenosis, macular degeneration and asthma. Khachigian was born to Armenian parents
Levon_Khachigian
Medical condition
Type III is subdivided now to stent thrombosis (subtype a) and stent restenosis (subtype b). The management of these patients may be challenging for clinicians
Kounis_syndrome
Catheter-based treatment of structural heart diseases
year) Interventional radiology Vascular surgery Catheter Cannula Stent Restenosis Lakhan SE, Kaplan A, Laird C, Leiter Y (2009). "The interventionalism
Interventional_cardiology
Pharmaceutical drug
and early clinical experience with reviparin-sodium for prevention of restenosis after percutaneous transluminal coronary angioplasty". Blood Coagul. Fibrinolysis
Reviparin_sodium
Protein-coding gene in the species Homo sapiens
major vascular pathogenic transcription factor in atherosclerosis and restenosis". Reviews in Endocrine & Metabolic Disorders. 5 (3): 249–254. doi:10.1023/B:REMD
EGR1
Chemical compound
(October 2016). "Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway". Scientific Reports
Indatraline
Chemical compound
(triazolopyrimidine), a platelet-derived growth factor antagonist, reduces restenosis after percutaneous transluminal coronary angioplasty. Results of the randomized
Trapidil
Chemical compound
to drug-eluting stents, to prevent the occurrence of coronary artery restenosis. The first application of this approach for use of stents evolved from
Phosphorylcholine
Chemical compound
antithrombotic-drug regimens after coronary-artery stenting. Stent Anticoagulation Restenosis Study Investigators". The New England Journal of Medicine. 339 (23): 1665–1671
Ticlopidine
Human arterial disease
after this procedure to ensure adequate renal velocities. Stents have a restenosis rate of 10–20%, and may make surgical revascularization more difficult
Fibromuscular_dysplasia
American cardiologist
University. His current research interests include brachytherapy for restenosis prevention bioabsorbable/ biodegradable stents, HDL therapy, intracoronary
Ron_Waksman
Protein-coding gene in the species Homo sapiens
et al. (2005). "High plasma heparin cofactor II activity protects from restenosis after femoropopliteal stenting". Thrombosis and Haemostasis. 92 (5): 1108–1113
Heparin_cofactor_II
Chemical compound
targeting atherosclerosis treatment and prevention of post-angioplasty restenosis. In Japan, Probucol was available under both the Lorelco brand name, the
Probucol
Academic journal
] P. J., Casterella; Teirstein, P. S. (1999). "Prevention of Coronary Restenosis". Cardiology in Review. 7 (4): 219–231. doi:10.1097/00045415-199907000-00014
Cardiology_in_Review
Israeli biochemist (born 1940)
from nanoparticles or from a drug eluting stent can be used to inhibit restenosis after balloon angioplasty. In 2006 his research team developed a method
Alexander_Levitzki
Smooth muscle tissue in the walls of blood vessels
conditions, such as vascular inflammation, plaque formation, atherosclerosis, restenosis, and pulmonary hypertension. Recent studies have shown that the majority
Vascular_smooth_muscle
Genetic disorder group
S2CID 211082029. Appleby CE, Kingston PA (June 2004). "Gene therapy for restenosis--what now, what next?". Current Gene Therapy. 4 (2): 153–82. doi:10
Autophagic_vacuolar_myopathy
GPI-anchored signaling protein
T-cadherin is upregulated in atherosclerotic lesions and post-angioplasty restenosis —conditions associated with pathological angiogenesis. T-cadherin expression
T-cadherin
Public deemed university in Mumbai, India
stent: Potential strategy for the prevention of stent thrombosis and restenosis". International Journal of Pharmaceutics. 600 120403. doi:10.1016/j.ijpharm
Institute of Chemical Technology
Institute_of_Chemical_Technology
Combination of cancer diagnosis and treatment
delivery systems for the treatment of conditions such as atherosclerosis and restenosis, as well as image-guided interventions for precise stenting or catheter-based
Theranostics
The drug aims to combat a range of illnesses, including skin cancer, restenosis, arthritis and macular degeneration. Trials of Dz13 were suspended in
Dz13
American academic
vessels, a process important for the development of atherosclerosis and restenosis. Her vascular biology laboratory characterized the role of cell cycle
Elizabeth_Nabel
suggesting that laryngeal growth could continue after reconstruction without restenosis. Great advances in open airway reconstruction were made in the 1970s,
Laryngotracheal reconstruction
Laryngotracheal_reconstruction
Form of phototherapy
used successfully to treat the non-malignant conditions psoriasis and restenosis. Chlorins are distinguished from the parent porphyrins by a reduced exocyclic
Photodynamic_therapy
Cardiologist
W.; Leon, Martin B. (1999-11-02). "Angiographic Patterns of In-Stent Restenosis". Circulation. 100 (18): 1872–1878. doi:10.1161/01.CIR.100.18.1872. PMID 10545431
Roxana_Mehran
Enzyme
proliferating smooth muscle cells in atherosclerotic lesions or during restenosis. Lugnier C (March 2006). "Cyclic nucleotide phosphodiesterase (PDE) superfamily:
PDE1
Protein involved in blood vessel growth
factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results
Vascular endothelial growth factor A
Vascular_endothelial_growth_factor_A
American chemist
times more potent. Beta-cyclodextrin sulfate is also useful in limiting restenosis, growth of cells on artery walls that can lead to blockages at the site
Madeleine_M._Joullié
Medical condition
percutaneous coronary interventions for focal disease, but the likelihood of restenosis is high. A repeat heart transplantation may be considered. Once there
Cardiac allograft vasculopathy
Cardiac_allograft_vasculopathy
Blockage of a grafted vein
O'Brien, ER (September 1995). "The intima. Soil for atherosclerosis and restenosis". Circulation Research. 77 (3): 445–65. doi:10.1161/01.res.77.3.445. PMID 7641318
Vein_graft_failure
American cardiologist
smooth muscle cell proliferation: implications for atherosclerosis and restenosis". Seminars in Thrombosis and Hemostasis. 22 (2): 139–144. doi:10.1055/s-2007-999001
George_Stouffer
(2022-06-28). Cao, Jianlei (ed.). "Association between Oxidative Burden and Restenosis: A Case-Control Study". Oxidative Medicine and Cellular Longevity. 2022:
Amirhossein_Sahebkar
Chemical compound
antisense oligonucleotides reduces neointimal formation in the porcine stent restenosis model". Journal of the American College of Cardiology. 39 (10): 1686–91
Morpholino_nucleic_acid
American biomedical engineer (born 1982)
achieved by the stent in the interest of preventing failures, such as restenosis or formation of a new blockage. Outstanding Postdoc Award (1 of 4 awarded
Lucas_Timmins
Argentine cardiologist, researcher, author
cardiology, with an interest in interventional cardiology including coronary restenosis as well as myocardial infarction and diabetes. He has published several
Alfredo_E._Rodríguez
Indian cardiologist and researcher
radiation therapy department at the hospital for the treatment of coronary restenosis. Later he moved to Kailash Group of Hospitals where he is the group director
Daljeet_Singh_Gambhir
Protein found in humans
vascular smooth muscle cells and to reduce neointima formation in mouse restenosis model. See also the PDB gallery below showing interactions with many inhibitors
Cyclin-dependent_kinase_2
and ventricular remodeling, study of ischemic heart disease, coronary restenosis, and atherosclerotic plaque, and impact of environmental toxins, particularly
Mihail_Popovici
Protein-coding gene in the species Homo sapiens
and occurrence of post-percutaneous transluminal coronary angioplasty restenosis: a prospective, angiography-based evaluation". Atherosclerosis. 171 (2):
Interleukin 36 receptor antagonist
Interleukin_36_receptor_antagonist
Family of zinc finger transcription factors
factor in disease states affected by shear stress, such as thrombosis, restenosis and atherosclerosis. Klf4 also mediates the vascular response to nitric
Kruppel-like_factors
Protein-coding gene in the species Homo sapiens
calcium-activated potassium channel as a new therapeutic strategy for restenosis". Circulation. 108 (9): 1119–25. doi:10.1161/01.CIR.0000086464.04719.DD
KCNN4
Protein-coding gene in the species Homo sapiens
pathological expression profiles shows implications as a predictive factor for restenosis". Circulation. 102 (20): 2528–34. doi:10.1161/01.cir.102.20.2528. PMID 11076828
KLF5
Type of medical imaging methodology
"Impact of intravascular ultrasound guidance in stent deployment on 6-month restenosis rate: a multicenter, randomized study comparing two strategies--with and
Intravascular_ultrasound
Spinal implants designed to preserve lumbar motion after posterior decompression
process fracture, implant loosening, heterotopic ossification, osteolysis, restenosis, and reoperation or conversion to fusion in some patients. The device
Posterior motion preservation devices
Posterior_motion_preservation_devices
Protein-coding gene in the species Homo sapiens
serum smooth muscle myosin heavy chain levels following PTCA may predict restenosis". Japanese Heart Journal. 41 (2): 131–40. doi:10.1536/jhj.41.131. PMID 10850529
Myosin-11
American cardiologist
D; Itescu, S; Rabbani, LE. "Anti-HLA antibodies are associated with restenosis after percutaneous coronary intervention for cardiac allograft vasculopathy"
Sean_P._Pinney
Scientist and philosopher (1718–1793)
Commentarius in Sylvam (A Commentary on Sylva; 1748–60) De Restenosis (Concerning Restenosis; 1755) De Febribus Acutis (Concerning High Fevers; 1756) Tractatus
Joseph_Demarco
American physician
inhibits neointimal hyperplasia at 4 weeks in a porcine model of coronary restenosis. Circulation. 2001; 103(18):2289-95. Abella BS, Zhao D, Alvarado J, Vanden
Benjamin_Abella
Medical stent that dissolves or is absorbed by the body
Serruys PW, Luijten HE, Beatt KJ, et al. (February 1988). "Incidence of restenosis after successful coronary angioplasty: a time-related phenomenon. A quantitative
Bioresorbable_stent
Restoring blood flow post-heart attack
stents is widespread because of the decreased rates of procedures to treat restenosis compared to balloon angioplasty. Adjuvant therapy during an angioplasty
Reperfusion_therapy
Human enzyme
stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis". The American Journal of Cardiology. 83 (6): 852–6. doi:10.1016/S0002-9149(98)01073-X
MMP3
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