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Pharmaceutical drug
Hyftor (sirolimus gel) was authorized for topical treatment of facial angiofibroma in the European Union in May 2023. In the US, sirolimus, as Rapamune
Sirolimus
Drug that inhibits activity of immune system
Everolimus is an analog of sirolimus and also is an mTOR inhibitor. Zotarolimus is a semi-synthetic derivative of sirolimus used in drug-eluting stents
Immunosuppressive_drug
Class of pharmaceutical drugs
sites for mTOR and FKBP12. The bacterial natural product rapamycin or sirolimus, a cytostatic agent, has been used in combination therapy with corticosteroids
MTOR_inhibitors
Chemical compound
needed] It is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an inhibitor of mammalian target of rapamycin (mTOR)
Everolimus
Corticosteroid medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Methylprednisolone
Drug interactions with grapefruit juice
ratio remained unchanged. Quetiapine (Seroquel) Repaglinide (Prandin) Sirolimus (Rapamycin, Rapamune) Tamoxifen (Nolvadex): Tamoxifen is metabolized by
Grapefruit–drug_interactions
Medical implant to treat narrowed arteries
and the US Food and Drug Administration (FDA) were sirolimus-eluting stents (SES), releasing sirolimus, a natural immunosuppressant drug. SES were shown
Drug-eluting_stent
Skin disease characterized by red, raised, and itchy bumps
medications (dapsone, sulfasalazine), immunosuppressants (cyclosporin, sirolimus) or other medications like omalizumab can be used. These options are explained
Hives
Immunosuppressive drug
immunosuppressants discovered, preceded by the discovery of rapamycin (sirolimus) on Rapa Nui (Easter Island) in 1975. It is produced by a soil bacterium
Tacrolimus
Medical device company
of Swiss medical device company MedAlliance, adding the SELUTION SLR™ sirolimus drug-eluting balloon platform to its cardiovascular portfolio. Cordis
Cordis_(medical)
Type of drug-eluting stent
provide a "scaffold" to open the artery. An anti-rejection-type medication, sirolimus, helps to limit the overgrowth of normal cells while the artery heals
Cypher_stent
Progressive cystic lung disease
(mTORC1) led to successful use of rapamycin analog sirolimus in clinical trials and FDA approval of sirolimus for treatment of LAM. TSC1 and TSC2 form a tumor
Lymphangioleiomyomatosis
Indian-Canadian-American Scientist
scientist most widely known for his discovery and development of Rapamycin (Sirolimus), a immunosuppressant drug widely used in organ transplantation. Rapamycin
Surendra_Nath_Sehgal
Chemical compound
immunosuppressant, a macrocyclic lactone, a highly lipophilic derivative of sirolimus. This drug is proprietary to Biosensors International, which uses it in
Umirolimus
Chemical compound
Medicines Agency (EMA) in November 2007. It is a derivative and prodrug of sirolimus. Temsirolimus is a specific inhibitor of mTOR and interferes with the
Temsirolimus
Medication of the barbiturate type
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Phenobarbital
Benign nerve-sheath tumor in the peripheral nervous system
Sirolimus, a compound that inhibits mTOR signalling, is being studied to treat plexiform neurofibromas. The combination of erlotinib with sirolimus was
Neurofibroma
Medication
against IL-2 (Denileukin diftitox) mTOR inhibitors Everolimus Ridaforolimus Sirolimus Temsirolimus hedgehog inhibitors Glasdegib Sonidegib Vismodegib CDK inhibitors
Zilurgisertib
Malformations of the lymphatic system characterized by lesions that are thin-walled cysts
by damaging the endothelial lining of the abnormal lymphatic vessels. Sirolimus (rapamycin): An mTOR inhibitor that has emerged as an important medical
Lymphatic_malformations
Excessive production of lymphocytes by the immune system
usually caused by the prolonged use of T cell suppressant drugs, such as sirolimus, tacrolimus, or ciclosporin. The Epstein-Barr virus, which infects >90%
Lymphoproliferative_disorders
Medical condition
chemicals. DIP has also been associated with certain drugs like marijuana, sirolimus, macrolides, nitrofurantoin, tocainide, and sulfasalazine. Disorders,
Desquamative interstitial pneumonia
Desquamative_interstitial_pneumonia
Surgical replacement of a patient's lungs
in the US demonstrated significantly improved long-term survival using sirolimus + tacrolimus (median survival 8.9 years) instead of mycophenolate mofetil
Lung_transplantation
Medical study concerned with the kidneys
cyclophosphamide, ciclosporin, tacrolimus, everolimus, thymoglobulin and sirolimus. Newer, so-called "biologic drugs" or monoclonal antibodies, are also
Nephrology
Island in the southeastern Pacific
island View of Rano Kau and Pacific Ocean The immunosuppressant drug sirolimus was first discovered in the bacterium Streptomyces hygroscopicus in a
Easter_Island
Medical condition
after transplantation and on detection of CAV. Medications including sirolimus and everolimus can slow disease progression. A repeat heart transplantation
Cardiac allograft vasculopathy
Cardiac_allograft_vasculopathy
Antibiotic derived from Penicillin
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Flucloxacillin
Antibiotic medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Rifaximin
Spanish cardiologist (born 1943)
Jose; Fuster, Valentin (2002). "Viewpoint Overcoming restenosis with sirolimus: From alphabet soup to clinical reality". The Lancet. 359 (9306): 619–622
Valentín_Fuster
Medication to treat gastroesophageal reflux disease and other conditions
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Omeprazole
Opioid medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Fentanyl
Medical intervention
drug-eluting stents to be utilized were the paclitaxel-eluting stent and the sirolimus-eluting stent, both of which have received approval from the U.S. Food
Percutaneous coronary intervention
Percutaneous_coronary_intervention
American multinational pharmaceutical and biotechnology corporation
acquired by Pfizer in 2009, alleging that the company illegally marketed sirolimus (Rapamune) for off-label uses, targeted specific doctors and medical facilities
Pfizer
Medical condition
after, in particular, high-dose therapy. Immunosuppressive drugs, such as sirolimus, mycophenolate mofetil, tacrolimus, ciclosporin, leflunomide and TNF inhibitors
Leukopenia
Medical condition
Akbal, Erdem; Can, Murat; Duranay, Murat (April 15, 2012). "Effect of sirolimus on the regression of peritoneal sclerosis in an experimental rat model"
Encapsulating peritoneal sclerosis
Encapsulating_peritoneal_sclerosis
Antiretroviral medication
disopyramide, immunosuppressants such as tacrolimus, voclosporin and sirolimus, neuroleptics like lurasidone and pimozide, as well as some chemotherapeutic
Ritonavir
Antibiotic
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Tetracycline
Rare genetic medical disorder with abnormal lymphocyte survival
drugs; however, sirolimus requires therapeutic drug monitoring and can cause mucositis. The goal serum trough is 5–15 ng/ml with Sirolimus and PCP prophylaxis
Autoimmune lymphoproliferative syndrome
Autoimmune_lymphoproliferative_syndrome
Medical condition
cryoablation may offer an effective control of pain in FAVA lesions. Sirolimus has been effective in improving the quality of life in some people with
Fibro-adipose vascular anomaly
Fibro-adipose_vascular_anomaly
Chemical stimulant produced by some plants
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Nicotine
Typical antipsychotic medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Chlorpromazine
Triazole antifungical drug
Voriconazole should not be used in conjunction with many drugs (including sirolimus, rifampicin, rifabutin, carbamazepine, quinidine and ergot alkaloids)
Voriconazole
Condition in which a male has abnormally low semen volume
of scientific evidence are still insufficient (with the exception of Sirolimus, Sulfasalazine, exogenous testosterone, Finasteride and Cyproterone acetate
Hypospermia
Chemical compound
is running a clinical trial to research the effects of auranofin and sirolimus on squamous, ras mutated lung adenocarcinoma, and small cell lung cancer
Auranofin
Chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Clotrimazole
Antibiotic medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Rifampicin
Rejection of host tissue by a transplanted organ's immune cells
substances that have been studied for GvHD treatment include, for example: sirolimus, pentostatin, etanercept, and alemtuzumab. In August 2017, the US FDA
Graft-versus-host_disease
Tumor originating in adipose (fat) tissue
trial is nearing completion to evaluate the efficacy of sirolimus (an inhibitor of MTOR; sirolimus is also known as rapamycin) plus cyclophosphamide (a chemotherapy
Liposarcoma
Medical condition
cyclosporine and tacrolimus, and least with mTOR inhibitors, such as sirolimus and everolimus. The antimetabolites azathioprine and mycophenolic acid
Cutaneous squamous-cell carcinoma
Cutaneous_squamous-cell_carcinoma
Medical condition
vincristine, propranolol, octreotide, aminocaproic acid, bevacizumab, and/or sirolimus are available. Skin lesion List of cutaneous conditions Rapini, Ronald
Multifocal lymphangioendotheliomatosis
Multifocal_lymphangioendotheliomatosis
Medication used for cancer
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Paclitaxel
Group of autoimmune diseases resulting in abnormal growth of connective tissue
cyclophosphamide, mycophenolate, intravenous immunoglobulin, rituximab, sirolimus, alefacept, and the tyrosine kinase inhibitors, imatinib, nilotinib, and
Scleroderma
Multinational medical technology manufacturer
platform features a unique abluminal groove-filled design that delivers sirolimus using a biodegradable polymer, with a lower drug and polymer load compared
MicroPort
Medication and insecticide
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Permethrin
Transference of pancreatic islets
(Zenapax), sirolimus (Rapamune) and tacrolimus (Prograf). Daclizumab is given intravenously right after the transplant and then discontinued. Sirolimus and tacrolimus
Islet_cell_transplantation
Chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Fenbendazole
Chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Meclizine
Reduction of average diameter of a solid's particles
several U.S. Food and Drug Administration–approved products, including sirolimus (Rapamune oral tablet, approved 2000), aprepitant (Emend, 2003), fenofibrate
Micronization
Chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Cafestol
Israeli biotech company
Alternariol, Alternariol methyl ether Immunomodulators: Tacrolimus, Sirolimus, Ascomycin, Myriocin Ionophores: Valinomycin, Nonactin, Ionomycin Special
Fermentek
Antihistamine medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Loratadine
Group of drugs used against malaria
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Artemisinin
Species of bacterium
natalensis) are antifungals isolated from Streptomyces.[citation needed] Sirolimus (Rapamycin), ascomycin, and tacrolimus were isolated from Streptomyces
Streptomyces_isolates
antibody coating of the Genous Stent with antiproliferative sirolimus elution. The sirolimus drug reduces the risk of stent restenosis through inhibiting
Dual_therapy_stent
Atypical antidepressant
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Tianeptine
Efficacy of Sirolimus Trial (The MILES Trial)". ClinicalTrials.gov (NIH). 6 January 2007. Retrieved 10 January 2007. "Sirolimus in Treating Patients
Timeline of tuberous sclerosis
Timeline_of_tuberous_sclerosis
Italian American surgeon
long-term trial of tacrolimus/sirolimus versus tacrolimus/mycophenolate mofetil versus cyclosporine (NEORAL)/sirolimus in renal transplantation. Ii. Survival
Gaetano_Ciancio
Pharmaceutical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Indinavir
Chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Pregnenolone
Atypical antidepressant drug
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Nefazodone
Antibiotic
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Clindamycin
Antifungal chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Ketoconazole
Psychoactive component of cannabis
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Tetrahydrocannabinol
Corticosteroid medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Prednisolone
Health advocacy group
Fajgenbaum discovered that "a drug that had been on the market for many years–Sirolimus–could be repurposed to fight Castleman Disease." The drug saved Fajgenbaum's
Castleman Disease Collaborative Network
Castleman_Disease_Collaborative_Network
Genetic disorder that causes early aging
rim, and it now has a more normal state.[citation needed] Studies of sirolimus, an mTOR Inhibitor, demonstrate that it can minimize the phenotypic effects
Progeria
Natural organic compounds derived from a [C(O)–CH2] chain
The immunosuppressants tacrolimus (FK506) (a calcineurin inhibitor) and sirolimus (rapamycin) (a mTOR inhibitor) Radicicol and the pochonin family (HSP90
Polyketide
Thyroid hormone medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Levothyroxine
Radiography of heart and blood vessels
to lower two-digit range with the introduction of drug-eluting stents. Sirolimus, paclitaxel, and everolimus are the three drugs used in coatings which
Coronary_catheterization
Protein-coding gene in humans
isomerase that binds to the immunosuppressants tacrolimus (FK506) and sirolimus (rapamycin). It is thought to mediate calcineurin inhibition. It also
FKBP5
Flowering plant in the St John's wort family
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Hypericum_perforatum
Dormant volcano in Easter Island
coming out of the crater wall. Geography portal List of volcanoes in Chile Sirolimus "Rano Kau". Rapa Nui Travel Guide. Retrieved 17 February 2026. "Volcanoes
Rano_Kau
Mammalian protein found in humans
respectively, leading to full activation of IGF-IR and InsR. Rapamycin (Sirolimus) inhibits mTORC1, resulting in the suppression of cellular senescence
MTOR
Anticonvulsant medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Carbamazepine
Medication against high blood pressure
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Amlodipine
Chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Lovastatin
Blood pressure medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Telmisartan
Species of bacterium
from soil from the Easter Island. Streptomyces rapamycinicus produces sirolimus. List of Streptomyces species LPSN bacterio.net UniProt Deutsche Sammlung
Streptomyces_rapamycinicus
Medical usage of the prasterone compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Prasterone
Anti-seizure medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Phenytoin
Sex hormone
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Progesterone
Medical device company based in Singapore
lactic acid. The Biolimus A9 drug, a highly lipophilic derivative of sirolimus. The S-Stent stent platform. An automated stent coating technology that
Biosensors_International
Medical condition
immunosuppressive drugs such as infliximab, tacrolimus, 6-mercaptopurine, sirolimus, azathioprine, mycophenolate mofetil, rituximab, and cyclosporine have
Autoimmune_enteropathy
Family of multi-domain enzymes that produce polyketides
by polyketide synthases. Other industrially important polyketides are sirolimus (immunosuppressant), erythromycin (antibiotic), lovastatin (anticholesterol
Polyketide_synthase
Laxatives/stool softeners
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Docusate
Genus of bacteria
317-326. Mawardi, H., Pavlakis, M., Mandelbrot, D., Woo, S. B. (2010). Sirolimus oral ulcer with Cedecea davisae superinfection.[dead link] Transpl Infect
Cedecea
Chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
5β-Dihydroprogesterone
Antibiotic medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Erythromycin
Single-blind study – Single-photon emission computed tomography – Siplizumab – Sirolimus – Small cell lung cancer – Small intestine – Smoldering leukemia – Smoldering
Index_of_oncology_articles
Chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
17α-Hydroxypregnenolone
Investigational long COVID drugs
[1] Sodium pyruvate (EmphyClear; N115) – various actions [2] low-dose Sirolimus (rapamycin; rapimune) AER-002 – monoclonal antibody against SARS-CoV-2
List of investigational long COVID drugs
List_of_investigational_long_COVID_drugs
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