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Protein-coding gene in the species Homo sapiens
sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene. SOS1 is a guanine nucleotide exchange factor (GEF) which interacts with
SOS1
Set of genes in cell signalling
each ommatidium fails to form. Similarly, the mammalian orthologues of Sos, SOS1 and SOS2, function downstream of many growth factor and adhesion receptors
Son_of_Sevenless
Genetic condition involving facial, heart, blood and skeletal features
key ones being PTPN11 accounting for 50% of genetically diagnosed cases, SOS1 responsible for 10-13% of cases, and RAF1 or RIT1 - each contributing to
Noonan_syndrome
Medical condition
mutation in the SOS1 gene localized on chromosome 2p21-p22 HGF2 - Caused by a mutation in the SOS1 gene localized on chromosome 5q13-q22[[[SOS1
Hereditary gingival fibromatosis
Hereditary_gingival_fibromatosis
Medical condition
pathway at or above the level of SOS1. SOS1 in turn regulates the activities of RAS, RAF, MEK, ERK, and p90RSK. SOS1 has been demonstrated to be a target
Cardiofaciocutaneous_syndrome
Pharmaceutical compound
factor protein SOS1, increasing the rate at which it catalyzes the exchange of GDP for GTP on its target protein KRAS. While inhibitors of SOS1 have been more
VUBI1
Autoimmune disease in which the immune system attacks healthy tissue
and PRKCD and 28 other genes, i.e., NEIL3, TMEM173, ADAR1, NRAS, SAMHD1, SOS1, FASLG, FAS receptor gene, RAG1, RAG2, DNASE1, SHOC2, KRAS, PTPN11, PTEN
Lupus
Proteins which remove GDP from GTPases
(SOS1) is an important GEF in the cell growth-regulatory MAPK/ERK pathway. SOS1 binds GRB2 at the plasma membrane after EGF receptor activation. SOS1 activates
Guanine nucleotide exchange factor
Guanine_nucleotide_exchange_factor
Family of protein kinases
phosphorylation of SOS1 (Son of Sevenless) at Serines 1134 and 1161 creates 14-3-3 docking site. This interaction of phospho SOS1 and 14-3-3 negatively
Ribosomal_s6_kinase
Cascade of intracellular and molecular events for transmission/amplification of signals
small G proteins that activate guanine nucleotide exchange factors such as SOS1. Once activated, these exchange factors can activate more small G proteins
Signal_transduction
Pharmaceutical compound
that acts as an inhibitor of the guanine nucleotide exchange factor protein SOS1, and prevents it from binding to its target protein KRAS. It has potential
BI-3406
Pharmaceutical compound
against the protein SOS1, acting by targeting this protein for destruction by cell maintenance enzymes. It was derived from the selective SOS1 inhibitor BI-3406
SIAIS562055
Pulp science fiction character
衛星ヌーンの決戦 Masahiro Sasaki Masaki Tsuji 5 時のロスト‧ワールド (The Lost World of Time) SOS1億年前 Kozo Morishita Masaki Tsuji 6 聖なる星クウムの謎 Tomoharu Katsumata Masaki Tsuji
Captain_Future
Pharmaceutical compound
inhibitor of the guanine nucleotide exchange factor protein SOS1. It acts by preventing SOS1 from binding to its target protein KRAS. It has potential applications
BAY-293
Family of genetic conditions caused by mutations affecting Ras genes
more types of RASopathy: HRAS KRAS NRAS RRAS RIT1 NF1 RASA1 RASA2 SYNGAP1 SOS1 SOS2 CBL PTPN11 BRAF RAF1 MAP2K1 MAP2K2 MAP3K8 SPRED1 SPRY1 MYST4 LZTR1 A2ML1
RASopathy
Experimental anticancer drug
Eggerstorfer MT, Stickler S (2024). "Development of PROTACS degrading KRAS and SOS1". Oncology Research. 32 (8): 1257–1264. doi:10.32604/or.2024.051653. PMC 11267056
ACBI3
Transmembrane protein
alpha, PLCG1, PLSCR1, PTPN1, PTPN11, PTPN6, PTPRK, SH2D3A, SH3KBP1, SHC1, SOS1, Src, STAT1, STAT3, STAT5A, UBC, and WAS, PAR2. In fruitflies, the epidermal
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Protein found in humans
C, Saldanha J (Jul 1995). "Structural studies on the PH domains of Db1, Sos1, IRS-1, and beta ARK1 and their differential binding to G beta gamma subunits"
Ephrin_A1
GCSH recessive 1:60,000 Nonsyndromic deafness Noonan syndrome PTPN11, KRAS, SOS1, RAF1, NRAS, HRAS, BRAF, SHOC2, MAP2K1, MAP2K2, CBL dominant 1:1,000 Norman–Roberts
List_of_genetic_disorders
Protein-coding gene in humans
protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. GRAP has
GRAP
Family of conserved regulatory molecules
cytoplasm, inhibiting their function. Raf-1 Bad – see Bcl-2 Bax Cdc25 Akt SOS1 – see RSK YWHAB – "14-3-3 beta" YWHAE – "14-3-3 epsilon" YWHAG – "14-3-3
14-3-3_protein
Protein-coding gene in the species Homo sapiens
ABI1 gene. Abl interactor 1 has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to
ABI1
then activates SOS1. Finally, this causes the extrusion of any extra Sodium to the outside through Na+/H+ antiporter which is near SOS1. The SOS2-SOS3
Arabidopsis thaliana responses to salinity
Arabidopsis_thaliana_responses_to_salinity
Protein-coding gene in humans
proteins of the Guanine Nucleotide Exchange Factor (GEF) class (such as SOS1), which forces the release of bound nucleotide (GDP). Subsequently, KRAS
KRAS
Protein domain
RASGRF2; RASGRP1; RASGRP2; RASGRP3; RASGRP4; RGL1; RGL2; RGL3; RGL4/RGR; SOS1; SOS2; Boriack-Sjodin PA, Margarit SM, Bar-Sagi D, Kuriyan J (July 1998)
RasGEF_domain
to Sos1 during cell cycling. Sos1 and SHIP both bind to Shc competitively and by having an increased affinity for Shc during phosphorylation, Sos1 binding
MAFA
Pharmaceutical compound
1701963 is an investigational drug that blocks KRAS activation by binding to SOS1 proteins. The drug is thought to be effective in cancers with a KRAS mutation
BI_1701963
Human protein
immunity. MUC1 has been shown to interact with: CTNND1, ERBB2, GRB2, JUP, and SOS1. The ability of chemotherapeutic drugs to access the cancer cells is inhibited
Mucin_short_variant_S1
Researcher
Ishitani M, Kim C, Zhu JK. 2000. The Arabidopsis thaliana salt tolerance gene SOS1 encodes a putative Na+/H+ antiporter. Proc Natl Acad Sci USA. 97:6896-6901
Jian-Kang_Zhu
Protein found in humans
proteins SPRY1, SPRY2, SPRY3, and/or SPRY4 which in turn interact with GRB2, SOS1, and/or c-Raf to reduce or inhibit further cell stimulation by activated
Fibroblast growth factor receptor 1
Fibroblast_growth_factor_receptor_1
Protein-coding gene in the species Homo sapiens
"Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and
ZAP70
Cell signaling pathway
2006). "Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1". Molecular Biology of the Cell. 17 (8): 3591–7. doi:10.1091/mbc.E05-12-1104
MAPK/ERK_pathway
Clinical Significance
SGEF, SH2B, SH2B1, SH2B2, SH2B3, SH3BP2, SKAP1, SKAP2, SNTA1, SNTB1, SNTB2, SOS1, SOS2, SPATA13, SPNB4, SPTBN1, SPTBN2, SPTBN4, SPTBN5, STAP1, SWAP70, SYNGAP1
Pleckstrin_homology_domain
GTP-binding proteins functioning on cell-cycle regulation
of conformations when binding GTP or GDP or no nucleotide (when bound to SOS1, which releases the nucleotide). Ras also binds a magnesium ion which helps
Ras_GTPase
Protein-coding gene in the species Homo sapiens
PTPN1, PTPN6, PTPRA, RAPGEF1, RET proto-oncogene, SH2B1, SH3KBP1, SHC1, SOS1, Src, Syk, TNK2, TrkA, VAV1, VAV2, VAV3, and Wiskott-Aldrich syndrome protein
GRB2
Protein found in humans
of activated T cells, Lymphocyte cytosolic protein 2, PDGFRA, PLD2, RHOA, SOS1, TUB, TrkA, TrkB, VAV1, and Wiskott-Aldrich syndrome protein. Phospholipase
PLCG1
Protein-coding gene in the species Homo sapiens
so far. ITSN1 has been shown to interact with: CDC42, SCAMP1 SNAP-25, and SOS1. GRCh38: Ensembl release 89: ENSG00000205726 – Ensembl, May 2017 GRCm38:
Intersectin_1
Protein-coding gene in humans
kinase 2, LAIR1, LRP1, PDGFRB, PI3K → Akt PLCG2, PTK2B, Ras SLAMF1, SOCS3, SOS1, STAT3, STAT5A, and STAT5B. Inhibitors Batoprotafib SHP099 Sitneprotafib
PTPN11
Special case of discrete optimization
There are two sorts of Special Ordered Sets: Special Ordered Sets of type 1 (SOS1 or S1): are a set of variables, at most one of which can take a non-zero
Special_ordered_set
Protein-coding gene in humans
proteins of the guanine nucleotide exchange factor (GEF) class (for example SOS1), which forces the release of bound nucleotide. Subsequently, GTP present
HRAS
Protein-coding gene in humans
(February 1996). "The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells". J. Biol. Chem. 271 (7): 3856–62. doi:10.1074/jbc
PTPN6
Protein-coding gene in the species Homo sapiens
PMID 12119179. S2CID 39778155. Chardin P, Camonis JH, Gale NW, et al. (1993). "Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2". Science
SPTBN5
Protein domain
CD117, CRKL FES, Grb2, GRB10, HCK, MLLT4, PXN, PIK3CG, PTPN6, PTPRT(PTPrho) SOS1, and XPB. A reciprocal translocation between chromosomes 22 and 9 produces
Breakpoint cluster region protein
Breakpoint_cluster_region_protein
Protein-coding gene in humans
deafness. EPS8 has been shown to interact with: ABI1, BAIAP2, DVL1, SHB, SHC1 SOS1, and Src. GRCh38: Ensembl release 89: ENSG00000151491 – Ensembl, May 2017
EPS8
Group of blood-based disorders
receptor remains continuously active in attracting docking proteins such as SOS1 and STAT proteins which drive cell growth, proliferation, and survival. PCM1-JAK2
Clonal_hypereosinophilia
American cancer biologist (born 1956)
he was one of the lead scientists who discovered that mutations in the SOS1 gene account for many cases of Noonan syndrome. In 2006, Neel was recruited
Benjamin_G._Neel
Protein found in humans
MAPK8, NEDD9, PDGFRA, PDGFRB, PTK2, Paxillin RAPGEF1, RICS, SH3KBP1, and SOS1. CrkL, "Crk-like" protein GRCh38: Ensembl release 89: ENSG00000167193 – Ensembl
Adapter_molecule_crk
Protein-coding gene in the species Homo sapiens
interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding". The Journal of Biological Chemistry. 275 (20): 15074–15081
RACGAP1
Series of biochemical reactions
recruited independently of p85. For example, Grb2 can also bind the Ras-GEF Sos1, leading to activation of Ras. Ras-GTP then activates the p110 subunit of
Akt/PKB_signaling_pathway
Fibrodysplasia ossificans progressiva; 135100; ACVR1 Fibromatosis, gingival; 135300; SOS1 Fibromatosis, gingival, 2; 135300; GINGF2 Fibromatosis, juvenile hyaline;
List_of_OMIM_disorder_codes
Public high school in Sarasota, Florida, United States
Archived from the original on January 16, 2017. Retrieved January 14, 2017. Sos1 (December 8, 2006). "SAVE Riverview: New York Team Films Documentary On Riverview
Riverview High School (Sarasota, Florida)
Riverview_High_School_(Sarasota,_Florida)
Protein
C (August 1999). "M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative
MRAS
Protein found in humans
of activated T cells, Lymphocyte cytosolic protein 2, PDGFRA, PLD2, RHOA, SOS1, TUB, TrkA, TrkB, VAV1, and Wiskott-Aldrich syndrome protein. GRCh38: Ensembl
BAG3
Medical condition
PRKCD genes and 29 other genes, i.e., NEIL3, TMEM173, ADAR1, NRAS, SAMHD1, SOS1, FASLG, FAS, RAG1, RAG2, DNASE1, SHOC2, KRAS, PTPN11, PTEN, BLK, RNASEH2A
Childhood-onset systemic lupus erythematosus
Childhood-onset_systemic_lupus_erythematosus
Protein-coding gene in the species Homo sapiens
Kucherlapati RS (January 2007). "Germline gain-of-function mutations in SOS1 cause Noonan syndrome". Nature Genetics. 39 (1): 70–4. doi:10.1038/ng1926
PAG1
Protein found in humans
Bi C (Aug 1999). "M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative
Afadin
Protein-coding gene in the species Homo sapiens
SH3GL3, SH3GL2, BCAR1, Epidermal growth factor receptor, CBLB, Cbl gene, SOS1, CRK and PAK2. GRCh38: Ensembl release 89: ENSG00000147010 – Ensembl, May
SH3KBP1
Protein-coding gene in humans
cancer. FRS2 has been shown to interact with: CBL FGFR1 GRB2 PRKCI PTPN11 SOS1 TrkA ALK GRCh38: Ensembl release 89: ENSG00000166225 – Ensembl, May 2017
FRS2
Q00796 15520 SORL1 HGNC:11185; Q92673 15521 SORT1 HGNC:11186; Q99523 15522 SOS1 HGNC:11187; Q07889 15523 SOS2 HGNC:11188; Q07890 15524 SOST HGNC:13771; Q9BQB4
List of human protein-coding genes 7
List_of_human_protein-coding_genes_7
Protein-coding gene in the species Homo sapiens
MINK1, NCKIPSD, NEDD9, PAK1, PDGFRB, PKN2, PTK2, RASA1, RICS, RRAS, SOCS7, SOS1, TBK1, WASL, WIPF1, and WAS. Signal transducing adaptor protein Receptor
NCK1
300.700.700 – son of sevenless proteins MeSH D12.776.402.300.700.700.330 – sos1 protein MeSH D12.776.402.300.700.700.600 – son of sevenless protein, drosophila
List_of_MeSH_codes_(D12.776)
of sevenless protein, drosophila MeSH D12.644.360.325.300.700.700.630 – sos1 protein MeSH D12.644.360.350 – guanylate cyclase MeSH D12.644.360.375 – heterotrimeric
List_of_MeSH_codes_(D12.644)
of sevenless protein, drosophila MeSH D12.776.476.325.300.700.700.630 – sos1 protein MeSH D12.776.476.375.100.100 – gtp-binding protein alpha subunits
List of MeSH codes (D12.776.476)
List_of_MeSH_codes_(D12.776.476)
travel, tourism, insurance
SOS1
SOS1
SOS1
SOS1
SOS1
SOS1
SOS1
SOS1
SOS1
travel, tourism, insurance