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Protein-coding gene in humans
transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 gene. It is a member of the STAT protein family. STAT3 is a member
STAT3
Biological signaling pathway h
phosphate groups to) proteins. There are seven STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. STAT proteins contain many different domains
JAK-STAT_signaling_pathway
Medical condition
STAT3 gain-of function (GOF) is a rare genetic disorder of the immune system, leading to early-onset autoimmunity and a variety of multi-organ disorders
STAT3_GOF
nucleus. STAT3 regulates several genes in response to growth factors and cytokines and play an important role in cell growth. Therefore, STAT3 facilitates
Protein_acetylation
Family of DNA viruses
between PI3K and JAK in Stat3 phosphorylation is that PI3K phosphorylates Stat3 on the S727 residue whereas JAK phosphorylates Stat3 on the Y705 residue.
Herpesviridae
Pharmaceutical compound
which acts as a proteolysis targeting chimera (PROTAC) against the protein STAT3, acting by targeting this protein for destruction by cell maintenance enzymes
SD36
Signaling within the same cell
STAT3 (pSTAT3), found in 50% of lung adenocarcinomas, and IL-6. Further investigation revealed that mutant EGFR could activate the oncogenic STAT3 pathway
Autocrine_signaling
Pharmaceutical compound
impetiginosus, that acts as an inhibitor of the transcription factor protein STAT3. It has potential applications in the treatment of cancer, acting as a stemness
Napabucasin
Family of intracellular transcription factors
mammalian STAT family members that have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6. STAT1 homodimers are involved
STAT_protein
Medical condition
dominant or autosomal recessive. Many patients with autosomal dominant STAT3 hyper-IgE syndrome have characteristic facial and dental abnormalities,
Hyperimmunoglobulin E syndrome
Hyperimmunoglobulin_E_syndrome
Chemical compound
activity, nifuroxazide has been predicted to possess properties of inhibiting STAT3, so it can potentially interfere with a specific cell signaling pathway
Nifuroxazide
Aggressive type of brain cancer
STAT3 locus, directly regulates STAT3 expression, a key driver of temozolomide (TMZ) resistance in glioblastoma. Silencing TMZR1-eRNA reduced STAT3 mRNA
Glioblastoma
Anti-inflammatory cytokine
receptor consists of four IL-10 receptor molecules. IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor
Interleukin_10
The STAT3-Ser/Hes3 signaling axis is a specific type of intracellular signaling pathway that regulates several fundamental properties of cells. Cells
Hes3_signaling_axis
Pharmaceutical compound
is a drug that acts as an inhibitor of the transcription factor protein STAT3. It has potential applications in the treatment of cancer and autoimmune
Stattic
Protein-coding gene in humans
degradation product of GnRH. GnRH-(1-5) was found to induce STAT3 phosphorylation (pSTAT3) in GN11 cells. GnRH-(1-5) was not found to affect cAMP levels
GPR173
Medication mainly used for depression and smoking cessation
bupropion anti-inflammatory action: involvement of the TLR2/TLR4 and JAK2/STAT3". Inflammopharmacology. 29 (4): 1101–1109. doi:10.1007/s10787-021-00829-4
Bupropion
Chemical compound
molecule JAK2 (Janus kinase) inhibitor, with additional minor inhibition of STAT3. In phase I trial, 16% of patients receiving the drug developed tumor lysis
Gandotinib
Marker in embryonic stem cells
turn, inhibits proliferation. Rex1 was also found to inhibit NOTCH and STAT3, two transcription factors which lead to differentiation. Therefore, Rex1
Rex1
Human prostate cancer cell line
3 (STAT3) inhibitor to induce apoptotic cell death and decrease DU-145 cancer cell proliferation. DU-145 cells consistently express activated STAT3 and
DU145
Subset of pro-inflammatory T helper cells
Th17 cells are signal transducer and the activator of transcription 3 (Stat3) and retinoic acid receptor-related orphan receptors gamma (RORγ) and alpha
T_helper_17_cell
Family of interleukins
IL-10RA IL-10RB Stat3, Stat1, Stat5 IL-19/20/24 IL-20RA IL-20RB Stat3, Stat5 IL-20/24 IL-22R IL-20RB Stat3, Stat5 IL-22 IL-22R IL-10RB Stat3, Stat1, Stat5
IL-10_family
Medical condition
molecule inhibitors of JAK3 (e.g. tofacitinib), JAK1/JAK2 (e.g. AZD1480), STAT3 (e.g. WP1066), and DDX3X (e.g. RK-33) are being study in pre-clinical in
Extranodal NK/T-cell lymphoma, nasal type
Extranodal_NK/T-cell_lymphoma,_nasal_type
Type of blood and immune-system cancer
expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha". Blood.
Hodgkin_lymphoma
Chemical compound
Anatabine has anti-inflammatory activity partly through inhibition of STAT3 phosphorylation in vitro and in vivo. On a biochemical level, it appears
Anatabine
Protein-coding gene in the species Homo sapiens
the transcription factor STAT3 binds to IL20RA and STAT3 becomes activated.[1] IL20RA has multiple docking sites for STAT3. Research indicates that IL20RA
Interleukin 20 receptor, alpha subunit
Interleukin_20_receptor,_alpha_subunit
Protein-coding gene in humans
receptor-α, capable of stimulating cell proliferation through activation of STAT3, STAT5 and JAK2 pathways and is implicated in the development of the hematopoietic
CRLF2
Human disease
06.010. PMID 16210110. Wu R, Sun S, Steinberg BM (2003). "Requirement of STAT3 activation for differentiation of mucosal stratified squamous epithelium"
Human papillomavirus infection
Human_papillomavirus_infection
Mammalian protein found in Homo sapiens
AR, GR, E2F and STAT3. PELP1 participates in activation of ESR1 extra-nuclear actions by coupling ESR1 with Src kinase PI3K STAT3 ILK1 and mTOR PELP1
PELP-1
Medication for psoriasis
with a dissociation constant (KD) of 7.1 pM and inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells with an IC50 of 5
Icotrokinra
Protein-coding gene in the species Homo sapiens
(September 2009). "New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain"
IL22RA1
Protein-coding gene in humans
unknown mechanism of protein stabilisation and transcriptional regulation of Stat3. Other pathways influenced by Bcl3 activity include phosphorylation of AKT
BCL3
Polish American cancer researcher and immunologist
National Medical Center in Duarte, California. His research has shown that the STAT3 protein plays a role in protecting cancers from immune responses and contributes
Marcin_Kortylewski
Mammalian protein found in humans
dependent on IL-6 amplifier activation, which is dependent on NF-κB and STAT3 activation. This research provides evidence for a critical role for CCL20
CCL20
Chemical compound
apoptosis and cell cycle arrest in lung squamous cancer cells suppresses STAT3 activation has antiinflammatory effects by inhibiting chemokine production
Helenin
Cell surface receptor for interleukin-10
portions of the α subunit. This recruits STAT3, which is additionally phosphorylated by JAK1 and TYK2. STAT3 homodimerizes, moves to the cellular nucleus
Interleukin-10_receptor
White blood cell
anti-apoptotic genes prevents LLPCs from undergoing programmed cell death. STAT3 (Signal transducer and activator of transcription 3): LLPCs respond to interleukin
Long-lived_plasma_cell
Professor of pathology, immunology, biology, and surgery
, et al. IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L
Weiping_Zou
Pharmaceutical compound
α-Pyrrolidinooctanophenone promotes activation of human microglial cells via a ROS/STAT3-dependent pathway. α-Pyrrolidinooctanophenone was metabolized into hydroxy-derivatives
Α-Pyrrolidinooctanophenone
Protein-coding gene in the species Homo sapiens
of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-κB pathways and promotes cell survival in human cancer cells". Cancer
C1QTNF4_(gene)
Protein-coding gene in the species Homo sapiens
multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene
Interleukin-21_receptor
to inhibit STAT. For example, PIAS1 inhibited STAT1, and PIAS3 inhibited STAT3. When it was discovered that PIAS proteins did far more than simply inhibit
Protein inhibitor of activated STAT
Protein_inhibitor_of_activated_STAT
Group of proteins
production. In the absence of SOCS3, IL-23-induced STAT3 phosphorylation is enhanced, and phosphorylated STAT3 binds to the promoter regions of both IL-17A
Interleukin_17
Protein-coding gene in the species Homo sapiens
factor belonging to the STAT protein family, composed of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6. STAT proteins are key activators of gene
STAT4
Protein-coding gene in the species Homo sapiens
may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. IL13RA1 expression has been linked to
Interleukin 13 receptor, alpha 1
Interleukin_13_receptor,_alpha_1
Medication
progression by blocking E-selectin expression in endothelial cells via STAT3". Cancer Letters. 510: 13–23. doi:10.1016/j.canlet.2021.04.005. hdl:2318/1791282
Cimetidine
Chromatin remodeling complex
loop between IL-6, STAT3 and NFkB. Namely, when ARID1A and PIK3CA are mutated, there is a promotion of IL-6 and activation of STAT3 because of the newly
Mammalian SWI/SNF (BAF) complex
Mammalian_SWI/SNF_(BAF)_complex
Class of enzymes important in regulating DNA transcription
STAT3 – Embryonic lethal, increased histone acetylation, increase in p21 and p27 HDAC2 1 Nucleus Ubiquitous Glucocorticoid receptor, YY1, BCL6, STAT3
Histone_deacetylase
Type of immune cell
and IL-10 CD4 T cells. The key THαβ transcription factors are STAT1 and STAT3 as well as IRFs. IL-10 from CD4 T cells activate NK cells' ADCC to apoptose
T_helper_cell
Excess number of eosinophil cells in the blood
hypereosinophilia or eosinophilia due to mutations in any one of the following genes: STAT3, DOCK8, PGM3, SPINK5, and TYK2 (see mutations in the hymperimmoglobulin
Eosinophilia
Class of compounds
breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways". Molecular Cancer. 16 (1): 57. doi:10
Proteoglycan
Intravenous transference of blood products
cytotoxic T lymphocytes (CD8+/CTL), temporal response of Tregs, and the STAT3 signaling pathway. The role of the antitumor immune response in cancer therapeutics
Blood_transfusion
Medical condition
patients with CD4+ T-cell disease carried a STAT3-JAK2 fusion gene. This gene consists of a fusion between the STAT3 gene at position 2.2 on the long (or "g")
Indolent T cell lymphoproliferative disorder of the gastrointestinal tract
Indolent_T_cell_lymphoproliferative_disorder_of_the_gastrointestinal_tract
Mammalian protein found in humans
EIF4EBP1, FKBP1A, GPHN, KIAA1303, PRKCD, RHEB, RICTOR, RPS6KB1, STAT1, STAT3, Two-pore channels: TPCN1; TPCN2, and UBQLN1. GRCh38: Ensembl release 89:
MTOR
Mammalian protein found in Homo sapiens
et al. (2005). "STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation"
NLK
Pharmaceutical compound
UC-514321 is an experimental drug which acts as an inhibitor of the proteins STAT3 and STAT5. This blocks the transcription of the enzyme Tet methylcytosine
UC-514321
Type of drug intended to protect the brain after stroke onset
Granulocytecolony stimulating factor (G-CSF) 2003 activator of transcription-3 (STAT3) in the periphery of the infarction 53 1 No effect - G-CSF did not improve
Cerebroprotectant
Signaling proteins released by host cells in response to the presence of pathogens
and phosphorylation. RIG-G has shown the capacity to inhibit NF-κB and STAT3 signaling in lung cancer cells, which demonstrates the potential of type
Interferon
Form of treatment for genetic disorders and other illnesses
liver disease, Parkinson's disease, prostate cancer, Stargardt disease, STAT3-expressing cancers, Usher syndrome. Several ASOs are currently being investigated
Antisense_therapy
Protein in immune system
STAT1 and STAT3 transcription factors that bind specifically to the receptor subunits, IL-27ɑ and glycoprotein. IL-27 is able to activate STAT3 signaling
Interleukin_27
Transformation of a stem cell to a more specialized cell
undifferentiated state. This is achieved through its activation of the Jak-STAT3 pathway, which has been shown to be necessary and sufficient towards maintaining
Cellular_differentiation
Cytokine with structural similarity to Interleukin-2
phosphorylation and activation of signal transducer and activator of transcription 3 (STAT3) and STAT5. Due to sharing of receptor subunits between IL-2 and IL-15,
Interleukin_15
gene Gfap is repressed during early neurogenesis due to methylation of its STAT3 binding sites. Research published in 2001 demonstrated that DNMT3a maintains
Epigenetic regulation of neurogenesis
Epigenetic_regulation_of_neurogenesis
Species of flowering plant
rheumatoid arthritis-related inflammation by inhibiting the NF-κB and JAK2/STAT3 signal pathways". Phytochemistry. 194. doi:10.1016/j.phytochem.2021.113018
Kadsura_coccinea
Form of diabetes mellitus
(causing autoimmune polyglandular syndrome), FoxP3 (causing IPEX syndrome), or STAT3 include type 1 diabetes in their effects. There is ongoing research for
Type_1_diabetes
Protein-coding gene in the species Homo sapiens
its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. IL-20 has a broad range of functions and is involved
Interleukin_20
Receptor to which cortisol and other glucocorticoids bind
NCOR1, NCOA1, NCOA2, NCOA3, POU2F1, RANBP9, RELA, SMAD3, SMARCD1, SMARCA4 STAT3, STAT5B, Thioredoxin, TRIM28, and YWHAH. Membrane glucocorticoid receptor
Glucocorticoid_receptor
Precursor microRNA family
FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution". Dev Biol. 333 (2): 238–50. doi:10
Mir-17 microRNA precursor family
Mir-17_microRNA_precursor_family
Egyptian cancer biologist
breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways". Molecular Cancer. 16 (1): 57. doi:10
Mona_Mostafa_Mohamed
Progressive cystic lung disease
cell growth and increases LAM cell viability. Upregulation of STAT1 and STAT3 and autophagy are known mediators of LAM cell viability and survival. LAM
Lymphangioleiomyomatosis
Protein-coding gene in the species Homo sapiens
IL-26 induces rapid phosphorylation of the transcription factors STAT1 and STAT3, which enhance IL-10 and IL-8 secretion and as expression of the CD54 molecule
Interleukin_26
included chronic granulomatous disease, Job's syndrome (autosomal dominant STAT3 deficiency) and the genetic conditions predisposing people to mycobacterial
Steven_M._Holland_(physician)
Series of chemical reactions resulting in a cell response
transcription control. There are some signaling pathways, such as LIF/JAK/STAT3 (Leukemia inhibitory factor/Janus kinase/Signal transducer and activator
Biochemical_cascade
Medical condition
Many cases of AML-M5 are seen to have enhanced phosphorylation of the STAT3 protein due to increased induction of cytokines thus increasing cell proliferation
Acute_monocytic_leukemia
Mammalian protein found in Homo sapiens
transcription 3 (Stat3). Stat3 is recruited to the activated LIF receptor and phosphorylated by Janus kinase. It bears noting that LIF and Stat3 are not sufficient
Leukemia_inhibitory_factor
Cytokine
activated dendritic cells, which serves to activate the transcription factor STAT3, is required in addition to TGF-β1 for the differentiation of Th17 cells
Transforming growth factor beta
Transforming_growth_factor_beta
Protein found in humans
factor for primary astrocytes and its expression is controlled by NFI-X3, STAT3, and AP-1. CHI3l1 is induced by a variety of cancers and in the presence
CHI3L1
Protein found in humans
0811902106. PMC 2626610. PMID 19144919. Katoh M, Katoh M (February 2007). "STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues
Protein_Wnt-5a
Biological process
damage-induced hair cell regeneration has been demonstrated in the inner ear. The Stat3/SOCS3 pathway has been identified as key in promoting hair cell regeneration
Inner_ear_regeneration
Family of transcription factor protein complexes
PMID 22985997. Grivennikov SI, Karin M (February 2010). "Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer". Cytokine & Growth
NF-κB
Protein found in humans
2001). "Requirement for high mobility group protein HMGI-C interaction with STAT3 inhibitor PIAS3 in repression of alpha-subunit of epithelial Na+ channel
HMGA2
Catalytic subunit of the enzyme telomerase
expression of hTERT via signal transducer and activation of transcription 3 (STAT3), proposing a mechanism for increased cancer incidence in obese individuals
Telomerase reverse transcriptase
Telomerase_reverse_transcriptase
Protein-coding gene in the species Homo sapiens
and capsular invasion. Overexpression of AGK sustains constitutive JAK2/STAT3 activation, consequently promoting the cancer stem cell population and augmenting
Acylglycerol kinase, mitochondrial
Acylglycerol_kinase,_mitochondrial
Heterodimeric cytokine acting as mediator of inflammation
the signal and phosphorylate STAT3 and STAT4. STATs dimerise and activate transcription of target genes in nucleus. STAT3 is responsible for key Th17 development
Interleukin_23
Protein-coding gene in the species Homo sapiens
interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the
PTPN21
Nuclear protein that binds to CREB
the region more open and accessible for transcription. Acetylated p53 and STAT3 have been shown to bind to CBP's bromodomain. The 380 protein residue lysine
CREB-binding_protein
Protein-coding gene in humans
progression and mitosis, and it also modulates the transcription factors SRF, STAT3, and NFkB. It has been hypothesized that targeting Cdc42 in conjunction
CDC42
Thin connective tissue layer of mucous membranes
developing cancer. An example of this is the overactivation of the IL-6/STAT3 pathway, which has been linked to colitis-associated cancer. Basal lamina
Lamina_propria
Transmembrane proteins
activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3". The Biochemical Journal. 370 (Pt 2): 391–6. doi:10.1042/BJ20021935. PMC 1223207
Type_II_cytokine_receptor
Protein-coding gene in the species Homo sapiens
the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway". Journal of Genetics and Genomics. 51 (10): 1055–1065
GPR160
Mammalian protein found in humans
Reprimo[citation needed] RPA1, RPL11, S100B, SUMO1, SMARCA4, SMARCB1, SMN1, STAT3, TBP, TFAP2A, TFDP1, TIGAR, TOP1, TOP2A, TP53BP1, TP53BP2, TOP2B, TP53INP1
P53
Protein-coding gene in humans
implantation and this downregulation promotes trophoblast invasion by activating STAT3. Homeobox A10 has been shown to interact with PTPN6. Homeobox GRCh38: Ensembl
Homeobox_A10
Transcription factor protein
pathways, including Akt, signal transducer and activator of transcription 3 (STAT3), mitogen-activated protein kinase, Ras, and Wnt signaling. Activated Twist
Twist-related_protein_1
Complication of celiac disease
for both genes; and/or activating mutations in JAK1 (75% of cases) and STAT3 (25% of cases). In Type II RCD, the same types of abnormal ILE found in
Enteropathy-associated T-cell lymphoma
Enteropathy-associated_T-cell_lymphoma
Protein-coding gene in the species Homo sapiens
(December 2014). "Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity". Sci Rep. 4: 7330. Bibcode:2014NatSR
INPP5F
Transmembrane protein
PTPN1, PTPN11, PTPN6, PTPRK, SH2D3A, SH3KBP1, SHC1, SOS1, Src, STAT1, STAT3, STAT5A, UBC, and WAS, PAR2. In fruitflies, the epidermal growth factor
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Chemical compound
(2013), Oxymatrine protects against myocardial injury via inhibition of JAK2/STAT3 signaling in rat septic shock. Mol Mod Rep 7(4): 1293-1299. Cao Y, Shan
Oxymatrine
ENSG00000170581 STAT Known motif – In vivo/Misc source [886] TNRGTTTCDNTTYC STAT3 ENSG00000168610 STAT Known motif – In vivo/Misc source [887] HTTCCYRKMA
List of human transcription factors
List_of_human_transcription_factors
Genetic element in the species Homo sapiens
arm of chromosome 17. The phenotype may be associated with variation in STAT3 or ORMDL3 genes. Marla J. F. O'Neill (11 January 2022). "INFLAMMATORY BOWEL
Inflammatory_bowel_disease-22
Hormone that inhibits hunger
hypothalamic nuclei. Once leptin has bound to the Ob-Rb receptor, it activates the stat3, which is phosphorylated and travels to the nucleus to effect changes in
Leptin
STAT3
STAT3
STAT3
STAT3
Biblical
canopier
Male
Chinese
eternal years.
Boy/Male
Indian
A Person who Greater than Anyone
Boy/Male
Hindu, Indian, Punjabi, Sikh
Peaceful; Patient; Satisfaction; Contentment
Boy/Male
Muslim
Servant of the creator, Slave of the creator
Girl/Female
Tamil
Nithyadevi | நீதà¯à®¯à®¤à¯‡à®µà¯€Â
Eternal
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Tamil, Telugu
Lord Krishna
Male
Babylonian
, Apsu, the watery deep.
Male
Greek
(Γεννάδιος) Greek name derived from the word gennadas, GENNADIOS means "noble."
Boy/Male
English American
Earnest.
STAT3
STAT3
STAT3
STAT3
STAT3