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Mammalian protein found in Homo sapiens
Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor (CD117). SCF can exist both as a transmembrane
Stem_cell_factor
Pluripotent stem cell generated directly from a somatic cell
pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell. The iPSC
Induced_pluripotent_stem_cell
Stem cells that give rise to other blood cells
Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells. This process is called haematopoiesis. In vertebrates, the first
Hematopoietic_stem_cell
Unspecialized biological cell that can become specialized
multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can change into various types of cells and proliferate indefinitely
Stem_cell
Mammalian protein and protein-coding gene
tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). Multiple transcript variants encoding different
KIT_gene
Formation of blood cellular components
mouse haematopoietic progenitor cells, underlying stochastic variability in the distribution of Sca-1, a stem cell factor, subdivides the population into
Haematopoiesis
Use of stem cells to treat or prevent a disease or condition
Stem-cell therapy uses stem cells to treat or prevent a disease or condition. As of 2024[update], the only FDA-approved therapy using stem cells is hematopoietic
Stem-cell_therapy
Ability of a cell to differentiate into other cell types
transcription factor with enhanced capacity to dimerize with Oct4. The baseline stem cells commonly used in science that are referred as embryonic stem cells (ESCs)
Cell_potency
Specific location in the body containing stem cells
Stem-cell niche refers to a microenvironment, within the specific anatomic location where stem cells are found, which interacts with stem cells to regulate
Stem-cell_niche
Precursor cells of neurons and glia during embryonic development
Neural stem cells (NSCs) are self-renewing, multipotent cells that firstly generate the radial glial progenitor cells that generate the neurons and glia
Neural_stem_cell
Type of pluripotent blastocystic stem cell
Embryonic stem cells (ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo. Human
Embryonic_stem_cell
Mammalian protein found in humans
granulocytes and stem cells and release them into the bloodstream. Functionally, it is a cytokine and hormone, a type of colony-stimulating factor, and is produced
Granulocyte colony-stimulating factor
Granulocyte_colony-stimulating_factor
Multipotent stem cell in the adult body
Adult stem cells are undifferentiated cells, found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate
Adult_stem_cell
Hematopoietic stem cell (HSC) mobilization is the medical process of stimulating hematopoietic stem cells to move (or "mobilize") from their native microenvironment
Hematopoietic stem cell mobilization
Hematopoietic_stem_cell_mobilization
Colony forming unit that generates myeloid cells in the bone marrow
combination of both factors produces additive stimulatory effects upon CFU-GEMM. The growth of CFU-GEMM is stimulated by the stem cell factor, or SCF. SCF has
CFU-GEMM
Endogenous cardiac stem cells (eCSCs) are tissue-specific stem progenitor cells harboured within the adult mammalian heart. A scientific-misconduct scandal
Endogenous_cardiac_stem_cell
Multipotent adult stem cells present in multiple tissues
Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or medicinal signaling cells, are multipotent stromal cells that can differentiate
Mesenchymal_stem_cell
Culture of stem cells that can be propagated indefinitely
A stem cell line is a group of stem cells that is cultured in vitro and can be propagated indefinitely. Stem cell lines are derived from either animal
Stem-cell_line
Academic journal
Cell Stem Cell is a peer-reviewed scientific journal published by Cell Press, an imprint of Elsevier. The journal was established in 2007 and focuses on
Cell_Stem_Cell
Academic journal
to the Journal Citation Reports, the journal has a 2024 impact factor of 5.0. "Stem Cell Reports". 2024 Journal Citation Reports. Web of Science (Science ed
Stem_Cell_Reports
Pharmaceutical compound
Ancestim is a recombinant methionyl human stem cell factor, branded by Amgen as StemGen. It was developed by Amgen and sold to Biovitrium, now Swedish
Ancestim
Transcription factor
Elaine (2023-07-24). "The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates". Nature Cell Biology. 25 (8): 1185–1195. doi:10
Pioneer_factor
Cancer cells with features of normal cells
Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically
Cancer_stem_cell
Cancer tumor in dogs
mutation with phosphorylation of the stem cell factor receptor leading to activation without binding of the stem cell factor (ligand-independent) can occur
Mastocytoma_in_dogs
Family of proteins
"colony-stimulating factors" comes from the method by which they were discovered. Hematopoietic stem cells were cultured (see cell culture) on a so-called
Colony-stimulating_factor
Transformation of a stem cell to a more specialized cell
specification, is the process in which a stem cell changes from one type to a differentiated one. Usually, the cell changes to a more specialized type. Differentiation
Cellular_differentiation
Paracrine soluble factors produced by stem cells
The stem cell secretome (also referred to as the stromal cell secretome) is a collective term for the paracrine soluble factors produced by stem cells and
Stem_cell_secretome
Mammalian protein found in Homo sapiens
growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets
Hepatocyte_growth_factor
Spermatogonium that does not differentiate into a spermatocyte
A spermatogonial stem cell (SSC), also known as a type A spermatogonium, is a spermatogonium that does not differentiate into a spermatocyte, a precursor
Spermatogonial_stem_cell
Academic journal
journal has a 2018 impact factor of 3.147. Lin, Ching-Shwun; Lue, Tom F. (2013-04-01). "Defining vascular stem cells". Stem Cells and Development. 22 (7):
Stem_Cells_and_Development
Ethical concerns about embryonic stem cell research and medical use
stem cells. Not all stem cell research involves human embryos. For example, adult stem cells, amniotic stem cells, and induced pluripotent stem cells
Stem_cell_controversy
Medical procedure to replace blood or immune stem cells
Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral
Hematopoietic stem cell transplantation
Hematopoietic_stem_cell_transplantation
ligand 4), cytokines IL-7, TGFβ or stem cell factor and chemokines CCL25, CXCL12 or CCRL1 etc. Essential part of T cell development forms process called
Cortical thymic epithelial cells
Cortical_thymic_epithelial_cells
Stem cell in bone marrow that gives rise to endothelial cells
Endothelial stem cells (ESCs) are one of three types of stem cells found in bone marrow. They are multipotent, which describes the ability to give rise
Endothelial_stem_cell
Therapy in which cellular material is injected into a patient
transplanting T-cells capable of fighting cancer cells via cell-mediated immunity in the course of immunotherapy, or grafting stem cells to regenerate diseased
Cell_therapy
Form of localized cell signaling
fibroblast growth factors, epidermal growth factors, platelet-derived growth factors, and stem cell factor. This dimerizes the transmembrane receptor to
Paracrine_signaling
Japanese stem cell researcher (born 1962)
Japanese stem cell researcher and a Nobel Prize laureate. He is a professor and the director emeritus of the Center for iPS Cell (induced Pluripotent Stem Cell)
Shinya_Yamanaka
Academic journal
journal has a 2023 impact factor of 0.8. "Stem Cell Research: Abstracting and Indexing". Retrieved 2018-10-16. "Stem Cell Research (journal)". MIAR:
Stem_Cell_Research_(journal)
Protein that stimulates cell division and differentiation
Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has
Epidermal_growth_factor
Signaling glycoprotein regulating cell proliferation
Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In particular, PDGF plays a significant
Platelet-derived growth factor
Platelet-derived_growth_factor
Epigenetic phenomenon
pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors" (PDF). Cell. 126 (4): 663–676. doi:10.1016/j.cell.2006.07.024
Reprogramming
Protein found in humans
adhesion factor. It may also mediate the attachment of hematopoietic stem cells to bone marrow extracellular matrix or directly to stromal cells. Clinically
CD34
Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. Stem cells can also be identified by functional
Stem_cell_marker
Cell that differentiates into one or a few cell types
A progenitor cell is a biological cell that can differentiate into a specific cell type. Stem cells and progenitor cells have this ability in common.
Progenitor_cell
Pharmaceutical compound
Limbal stem cells, also known as corneal epithelial stem cells, are unipotent stem cells located in the basal epithelial layer of the corneal limbus.
Limbal_stem_cell
Precursor cell to a nucleated red blood cell
receptor), the erythropoietin receptor (EpoR), some c-Kit (stem cell factor receptor), and are Ter119 (cell surface molecule)-positive. Their proliferative capacity
Proerythroblast
Mammalian protein found in humans
transcription to promote cell survival. Alternatively, programmed cell death occurs when TRAF6 and neurotrophin receptor interacting factor (NRIF) are both recruited
Nerve_growth_factor
Endogenous non-cancerous pluripotent stem cell
A Muse cell (Multi-lineage differentiating stress-enduring cell) is an endogenous non-cancerous pluripotent stem cell. They reside in the connective tissue
Muse_cell
Family of biomolecules
(2) glial cell-line derived neurotrophic factor family ligands (GFLs), and (3) neuropoietic cytokines. Each family has its own distinct cell signaling
Neurotrophic_factors
Cancerous overproduction of T cells
T-cell lymphoma is not definitive, it has been associated with various risk factors and viruses such as Epstein–Barr virus (EBV) and human T-cell leukemia
T-cell_lymphoma
Cell produced by hematopoiesis
Blood cells with differentiation potential are called hematopoietic cells; the ones with the most such potential are hematopoietic stem cells. Red blood
Blood_cell
Japanese Thoroughbred broodmare (1996–2019)
the tyrosine kinase domain II of the stem cell factor receptor (SCFR). This disrupts melanocyte precursor cell migration, resulting in a white or spotted
Shirayukihime
Early form of hematopoietic stem cells
hematopoietic stem cells from the many other differentiated cells in the bone marrow. Kit (CD117) is the receptor of Stem Cell Factor. Sca-1 is a murine
KSL_cells
Protein-coding gene in the species Homo sapiens
folding. It represents a major stem cell factor, that is involved in crucial processes during brain but also stem cell development. Trnp1 controls gene
TRNP1
Academic journal
According to Journal Citation Reports, the journal has a 2021 impact factor of 6.692. Stem Cell Reviews homepage. Accessed July 23, 2008. "Journal Citation Reports"
Stem_Cell_Reviews_and_Reports
Mixture of stem cells that can be obtained from amniotic fluid
Amniotic stem cells are the mixture of stem cells that can be obtained from the amniotic fluid as well as the amniotic membrane. They can develop into
Amniotic_stem_cells
Mammalian protein found in humans
is a transcriptional factor that helps embryonic stem cells (ESCs) maintain pluripotency by suppressing cell determination factors. hNanog is encoded in
Homeobox_protein_NANOG
Growth factor and signaling protein otherwise known as FGF2
a critical component of human embryonic stem cell culture medium; the growth factor is necessary for the cells to remain in an undifferentiated state,
Fibroblast_growth_factor_2
Biological term
blood cells, such as red blood cells (RBCs), immune cells, and even platelets all originate from the same progenitor cell, the hematopoietic stem cell (HSC)
Hematopoietic_stem_cell_niche
Protein found in humans
neuroprotection and neuroregeneration. As a major growth factor, IGF1 is responsible for stimulating growth of all cell types, and causing significant metabolic effects
Insulin-like_growth_factor_1
Mammalian protein found in Homo sapiens
homeodomain transcription factor of the POU family. It is critically involved in the self-renewal of undifferentiated embryonic stem cells. As such, it is frequently
Oct-4
Method of replacing blood-forming stem cells
blood stem cell transplantation (PBSCT), also called "Peripheral stem cell support", is a method of replacing blood-forming stem cells. Stem cells can be
Peripheral stem cell transplantation
Peripheral_stem_cell_transplantation
Plant stem cells are innately undifferentiated cells located in the meristems of plants. Plant stem cells serve as the origin of plant vitality, as they
Plant_stem_cell
Group of signal transduction pathways involved in embryonic development
differentiation and is a major factor in self-renewal of neural stem cells. This allows for regeneration of nervous system cells, which is further evidence
Wnt_signaling_pathway
Protein found in humans
of the adult brain retain the ability to grow new neurons from neural stem cells in a process known as neurogenesis. Neurotrophins are proteins that help
Brain-derived neurotrophic factor
Brain-derived_neurotrophic_factor
Introduction of foreign genetic material into a host
effective pluripotent stem cell (PSC) transgenesis. The manipulated gene construct is inserted into totipotent stem cells, cells which can develop into
Transgenesis
Types of irreversible biochemical changes
functioning cells are unable to divide when necessary.[citation needed] An enzyme called telomerase elongates telomeres in gametes and stem cells. Telomerase
Hallmarks_of_aging
Overview article
Embryonic stem cells are capable of self-renewing and differentiating to the desired fate depending on their position in the body. Stem cell homeostasis
Epigenetics in stem-cell differentiation
Epigenetics_in_stem-cell_differentiation
Stem cells
of stem cell differentiation are cell fate and cell state. Cell fate is the likelihood a cell will differentiate into a particular type of cell. Cell state
Stem_cell_proteomics
Precursor cell of skeletal muscle cells
Myosatellite cells, also known as satellite cells, muscle stem cells or MuSCs, are small multipotent cells with very little cytoplasm found in mature
Myosatellite_cell
Method of creating a cloned embryo by replacing the egg nucleus with a body cell nucleus
embryonic stem cells (ESCs) and the destruction of viable embryos for medical use, though questions remain on how homologous the two cell types truly
Somatic_cell_nuclear_transfer
Human protein-coding gene
Platelet-derived growth factor receptor A, also termed CD140a, is a receptor located on the surface of a wide range of cell types. The protein is encoded
Platelet-derived growth factor receptor A
Platelet-derived_growth_factor_receptor_A
Academic journal
currently edited by Jan Nolta (University of California). Stem Cells currently has an impact factor of 6.277. The journal is abstracted and indexed in the
Stem_Cells_(journal)
Since haematopoietic stem cells cannot be isolated as a pure population, it is not possible to identify them under a microscope.[citation needed] Therefore
Techniques to isolate haematopoietic stem cells
Techniques_to_isolate_haematopoietic_stem_cells
Analyzing the genes of stem cells
In biology and medicine, stem cell genomics is the analysis of the genomes of stem cells. Currently, this field is rapidly expanding due to the dramatic
Stem_cell_genomics
Type of herding dog
"Long-Term Treatment of Canine Cyclic Hematopoiesis With Recombinant Canine Stem Cell Factor". Blood. 85 (1): 74–79. doi:10.1182/blood.V85.1.74.bloodjournal85174
Collie
Cells forming the neural tube wall during embryogenesis
Neuroepithelial cells are the stem cells of the central nervous system, known as neural stem cells, and generate the intermediate progenitor cells known as radial
Neuroepithelial_cell
Medication which blocks growth of blood vessels
growth factor therapy, also known as anti-VEGF (/vɛdʒˈɛf/) therapy or medication, is the use of medications that block vascular endothelial growth factor. This
Anti-VEGF
Mammalian protein found in Homo sapiens
The stromal cell-derived factor 1 (SDF-1), also known as C-X-C motif chemokine 12 (CXCL12), is a chemokine protein that in humans is encoded by the CXCL12
Stromal_cell-derived_factor_1
Disease causing insufficient blood cells of all types
the body fails to make blood cells in sufficient numbers. Normally, blood cells are produced in the bone marrow by stem cells that reside there, but patients
Aplastic_anemia
Chemical compound
"Small-molecule-driven hepatocyte differentiation of human pluripotent stem cells". Stem Cell Reports. 4 (5): 939–952. doi:10.1016/j.stemcr.2015.04.001. PMC 4437467
Dihexa
previously damaged. Mesenchymal stem cells are able to differentiate, or mature from a less specialized cell to a more specialized cell type, to replace damaged
Clinical uses of mesenchymal stem cells
Clinical_uses_of_mesenchymal_stem_cells
Transmembrane protein
"Engineering toxin-resistant therapeutic stem cells to treat brain tumors". Stem Cells. 33 (2): 589–600. doi:10.1002/stem.1874. PMC 4305025. PMID 25346520. Roskoski
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Mammalian protein found in Homo sapiens
inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate
Leukemia_inhibitory_factor
Protein-coding gene in the species Homo sapiens
been shown that combination of IL-3, GM-CSF and stem cell factor enhances peripheral blood stem cells during high-dose chemotherapy. Other studies showed
Interleukin_3
Corticosteroid medication
"Bortezomib plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: results
Dexamethasone
Mammalian protein found in Homo sapiens
damaged tissues in an adult. However, cancer stem cells are thought to hijack the ability of normal stem cells to express MET, and thus become the cause
Hepatocyte growth factor receptor
Hepatocyte_growth_factor_receptor
Cells responsible for connecting and repairing skin layers
stem cells within the body. Like corneal fibroblasts, dermal fibroblast proliferation can be stimulated by the presence of fibroblast growth factor (FGF)
Dermal_fibroblast
Family of proteins
the hippocampus) retain the ability to grow new neurons from neural stem cells, a process known as neurogenesis. Neurotrophins are chemicals that help
Neurotrophin
Type of stem cell
Pancreatic progenitor cells are multipotent stem cells originating from the developing fore-gut endoderm which have the ability to differentiate into the
Pancreatic_progenitor_cell
Topics referred to by the same term
Kitl or KITL may refer to: Kittel, a Jewish ritual garment Stem cell factor, or KIT ligand KZTN-LD, a low-power television station (channel 20) licensed
Kitl
Family of proteins involved in anatomical development
Fibroblast growth factors (FGF) are a family of cell signalling proteins produced by the macrophages. They are involved in a wide variety of processes
Fibroblast_growth_factor
Laws governing the use or isolation of human stem cells
Stem cell laws are the law rules, and policy governance concerning the sources, research, and uses in treatment of stem cells in humans. These laws have
Stem_cell_laws
TrkA and TrkB positive modulator
ACD856 potentiates the effects of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). In addition to the tropomyosin receptor kinases,
ACD856
Immune disorder caused by proliferation of mast cells
too few mast cells.[citation needed] Mast cells express a cell surface receptor, c-kit (CD117), which is the receptor for stem cell factor (scf). In laboratory
Mastocytosis
Protein-coding gene in humans
domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex
GRAP
Protein involved in blood vessel growth
endothelial growth factor (VEGF, /vɛdʒˈɛf/), originally known as vascular permeability factor (VPF), is a signal protein produced by many cells that stimulates
Vascular endothelial growth factor
Vascular_endothelial_growth_factor
Mammalian protein found in humans
stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which causes hematopoietic stem cells to differentiate
Macrophage colony-stimulating factor
Macrophage_colony-stimulating_factor
Process in developmental biology
is a type of metaplasia, which includes all cell fate switches, including the interconversion of stem cells. Current uses of transdifferentiation include
Transdifferentiation
Protein or other substance that stimulates cellular proliferation
A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation
Growth_factor
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STEM CELL-FACTOR
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