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Connective tissue cell of any organ
Stromal cells, or mesenchymal stromal cells, are differentiating cells found in abundance within bone marrow but can also be seen all around the body.
Stromal_cell
Multipotent adult stem cells present in multiple tissues
Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or medicinal signaling cells, are multipotent stromal cells that can differentiate
Mesenchymal_stem_cell
Lymph node stromal cells are essential to the structure and function of the lymph node whose functions include: creating an internal tissue scaffold for
Lymph_node_stromal_cell
Human disease (cancer)
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs arise in the smooth muscle pacemaker
Gastrointestinal stromal tumor
Gastrointestinal_stromal_tumor
Thymus stromal cells are subsets of specialized cells located in different areas of the thymus. They include all non-T-lineage cells, such as thymic epithelial
Thymus_stromal_cells
Part of a tissue or organ with a structural or connective role
thymus stroma of bone marrow lymph node stromal cell multipotent stromal cell (mesenchymal stem cell) Stromal connective tissues are found in the stroma;
Stroma_(tissue)
Mammalian protein found in Homo sapiens
The stromal cell-derived factor 1 (SDF-1), also known as C-X-C motif chemokine 12 (CXCL12), is a chemokine protein that in humans is encoded by the CXCL12
Stromal_cell-derived_factor_1
Topics referred to by the same term
Stromal cell-derived factor may refer to: Stromal cell-derived factor 1 (SDF-1, SDF1, Sdf1) Stromal cell-derived factor 4 (SDF-4, SDF4, Sdf4) This disambiguation
Stromal_cell-derived_factor
The list of human cell types provides an enumeration and description of the various specialized cells found within the human body, highlighting their
List_of_human_cell_types
Group of tumors derived from ovarian and testicular stromal cells
cord–gonadal stromal tumour is a group of tumours derived from the stromal component of the ovary and testis, which comprises the granulosa, thecal cells and fibrocytes
Sex cord–gonadal stromal tumour
Sex_cord–gonadal_stromal_tumour
Cytokine, alarmin, and growth factor
discovered as a growth factor derived from the supernatant of a mouse thymic stromal cell line that was found to promote the survival and proliferation of B lymphocytes
Thymic_stromal_lymphopoietin
Semi-solid tissue in the spongy portions of bones
new blood cell production (or haematopoiesis). It is composed of hematopoietic cells, marrow adipose tissue, and supportive stromal cells. In adult humans
Bone_marrow
Pharmacologic substance
mesenchymal stromal cell therapy used for the treatment of graft-versus-host disease. Remestemcel contains mesenchymal stromal cells, which are a type of cell that
Remestemcel
Bone tumor composed of agglomerated osteoclast-like cells
populations. The giant-cell tumour stromal cells (GCTSC) constitute the neoplastic cells, which are from a mesenchymal stem cell origin and are classified based
Giant-cell_tumor_of_bone
Physiological process in the endometrium
changes (the decidual reaction) to endometrial stromal cells, the presence of decidual white blood cells (leukocytes), and vascular changes to maternal
Decidualization
Use of stem cells to treat or prevent a disease or condition
grown together with stromal cells, creating an environment that mimics the conditions of bone marrow, the natural site of red-blood-cell growth. Erythropoietin
Stem-cell_therapy
Surroundings of tumors including nearby cells and blood vessels
ecosystem surrounding a tumor, composed of cancer cells, stromal tissue (including blood vessels, immune cells, fibroblasts and signaling molecules) and the
Tumor_microenvironment
Process to preserve biological matter
Waller EK, Galipeau J (February 2012). "Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock
Cryopreservation
Connective tissue cell which produces reticular fibers
reticular cells can be traced back to mesenchymal stromal precursors. These precursors can differentiate into varying structural support cells depending
Reticular_cell
Cancer originating in or on the ovary
cell types including epithelial cells, germ cells, and stromal cells. When these cells become abnormal, they can divide and form tumors. These cells can
Ovarian_cancer
Medical condition
endometrial stromal nodule is a noninfiltrative, circumscribed proliferation of endometrial stromal cells and is a benign subtype of endometrial stromal tumor
Endometrial_stromal_nodule
Cell-surface glycoprotein
vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone". Nature Medicine. 14 (2): 181–187. doi:10.1038/nm1703
CD44
Stem cells that give rise to other blood cells
hematopoietic stem cells creep between the gaps (even though the stromal cells are touching each other) and eventually settle between the stromal cells and the substratum
Hematopoietic_stem_cell
Cell with a large vacuole
follicular signet ring cell Signet ring adenocarcinoma cell Signet ring melanoma cell Signet ring stromal cell The name of the cell comes from its appearance;
Signet_ring_cell
Mammalian protein found in Homo sapiens
as a biologically active 42-amino acid peptide. It is synthesized by K cells, which are found in the mucosa of the duodenum and the jejunum of the gastrointestinal
Gastric inhibitory polypeptide
Gastric_inhibitory_polypeptide
Protein-coding gene in the species Homo sapiens
"Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering"
Galectin-1
Medical condition
prognoses than older patients. Epithelial-stromal tumors are classified on the basis of the epithelial cell type, the relative amounts of epithelium and
Surface epithelial-stromal tumor
Surface_epithelial-stromal_tumor
Swedish biopharmaceutical company
cluster south of Stockholm. The company develops allogeneic mesenchymal stromal cell (MSC) therapies, with its lead candidate aimed at preserving insulin
Nextcell_Pharma_AB
Protein-coding gene in the species Homo sapiens
interact with AP2 by direct binding to beta2 subunit". Molecular Biology of the Cell. 13 (11): 4001–12. doi:10.1091/mbc.02-07-0104. PMC 133610. PMID 12429842
AP2B1
Therapy in which cellular material is injected into a patient
adherent stromal cells or mature endothelial cells to treat peripheral artery disease and arteriovenous access complications. A combination of both cell engraftment
Cell_therapy
Endothelial cell Mesangial cell Intraglomerular Extraglomerular Juxtaglomerular cell Macula densa cell Stromal cell → Interstitial cell → Telocytes Kidney
List of human cell types derived from the germ layers
List_of_human_cell_types_derived_from_the_germ_layers
Aspect of medical care
oxide donor upregulation of stromal cell-derived factor-1/chemokine (CXC motif) receptor 4 enhances bone marrow stromal cell migration into ischemic brain
Stroke_recovery
Paracrine soluble factors produced by stem cells
stem cell secretome (also referred to as the stromal cell secretome) is a collective term for the paracrine soluble factors produced by stem cells and
Stem_cell_secretome
Topics referred to by the same term
photosynthetic plant cells Stromal cell, a connective tissue cell of any organ; supports the function of the parenchyma The nonmalignant cells which are present
Stroma
Type of connective tissue
with blood vessels, consisting for the most part of spindle-shaped stromal cells. These appear similar to fibroblasts. The stroma also contains ordinary
Ovarian_stroma
Growth of fibrous or connective tissue
tissues, epithelial cells, or parenchymal cells of epithelia, are highly organized, polar cells. These cells are separated from stromal cells by a basement
Desmoplasia
Protein family and hormone
manner and as an important regulator of the immune system. It has important cell cycle-related functions as a growth-, differentiating- and anti-apoptotic
Prolactin
Organelle in eukaryotic cells responsible for respiration
damaged cells Endothelial cell donation to cancer cells can increase chemoresistance or tumorigenic potential. Following acute lung injury, stromal cells can
Mitochondria
Mammalian protein found in humans
strictly associated with cell proliferation. During interphase, the Ki-67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis
Proliferation marker protein Ki-67
Proliferation_marker_protein_Ki-67
testicle Achilles tendon gonad skeletal muscle tissue prefrontal cortex stromal cell of endometrium epithelium of colon superior frontal gyrus liver Top expressed
CDP-L-Ribitol Pyrophosphorylase A
CDP-L-Ribitol_Pyrophosphorylase_A
Protein-coding gene in the species Homo sapiens
"Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype". The International Journal of Biochemistry & Cell Biology
Thrombospondin-2
Protein found in humans
the adult brain retain the ability to grow new neurons from neural stem cells in a process known as neurogenesis. Neurotrophins are proteins that help
Brain-derived neurotrophic factor
Brain-derived_neurotrophic_factor
Protein-coding gene in the species Homo sapiens
Stromal interaction molecule 1 is a protein that in humans is encoded by the STIM1 gene. STIM1 has a single transmembrane domain, and is localized to
STIM1
Mammalian protein found in Homo sapiens
role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation
Thymosin_beta-4
Topics referred to by the same term
computer game FreeSpace 2 Single-cell protein Spheroidal carbonaceous particles Sterol carrier protein Stromal cell protein Superior cerebellar peduncle
SCP
Enzyme found in humans, implicated in neuropathy
in beta cell frontal pole Brodmann area 10 right frontal lobe middle frontal gyrus paraflocculus of cerebellum Brodmann area 9 stromal cell of endometrium
Alanine–tRNA ligase, cytoplasmic
Alanine–tRNA_ligase,_cytoplasmic
Protein-coding gene in the species Homo sapiens
apoptotic cells. Opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells, mediates the engulfment of the dead cell. GRCh38:
MFGE8
Enzyme found in humans
oocyte endothelial cell gonad mucosa of transverse colon ventricular zone endometrium gingival epithelium right adrenal cortex stromal cell of endometrium
Tyrosine–tRNA ligase, mitochondrial
Tyrosine–tRNA_ligase,_mitochondrial
Protein involved in the breakdown of blood clots
breakdown. It is a serine protease (EC 3.4.21.68) found on endothelial cells lining the blood vessels. Human tPA is encoded by the PLAT gene, and has
Tissue-type plasminogen activator
Tissue-type_plasminogen_activator
Enzyme
Top expressed in buccal mucosa cell tendon of biceps brachii liver right lobe of liver endothelial cell stromal cell of endometrium internal globus pallidus
Gamma-glutamyl_carboxylase
Accessory cell of the mammalian immune system
CXCR3 Ligands Control Plasmacytoid Dendritic Cell Responsiveness to the Constitutive Chemokine Stromal Cell–derived Factor 1 (SDF-1)/CXCL12". J. Exp. Med
Dendritic_cell
surface of HSCs and various other cell types. CXCL-12 (C-X-C motif chemokine 12), also known by SDF-1 (Stromal Cell-Derived Factor-1) is a chemokine protein
Hematopoietic stem cell mobilization
Hematopoietic_stem_cell_mobilization
Protein found in humans
of a novel protein (p137) which transcytoses bidirectionally in Caco-2 cells". The Journal of Biological Chemistry. 270 (35): 20717–20723. doi:10.1074/jbc
Caprin-1
Israeli biotechnology company
placental adherent stromal cells for commercial use in disease treatment. According to the company's website, it extracts adult stem cells exclusively from
Pluri_Inc.
Protein-coding gene in the species Homo sapiens
Bst1 (Bone marrow stromal cell antigen 1, ADP-ribosyl cyclase 2, CD157) is an enzyme that in humans is encoded by the BST1 gene. CD157 is a paralog of
BST1
Protein found in humans
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium ventricular zone ganglionic eminence apex of heart smooth
Selenoprotein_N
Protein-coding gene in the species Homo sapiens
was first isolated in 1990 from bone marrow-derived fibrocyte-like stromal cells. It was initially thought to be important for hematopoiesis, notably
Interleukin_11
Mammalian protein found in Homo sapiens
monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine.
Granulocyte-macrophage colony-stimulating factor
Granulocyte-macrophage_colony-stimulating_factor
Cancer that originates in mammary glands
stromal cells and epithelial cells can facilitate malignant cell growth. In breast adipose tissue, overexpression of leptin leads to increased cell proliferation
Breast_cancer
Enzyme found in humans
Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa blood stromal cell of endometrium left lobe of thyroid gland granulocyte skin of leg prefrontal
Cysteine–tRNA ligase, cytoplasmic
Cysteine–tRNA_ligase,_cytoplasmic
Protein-coding gene in the species Homo sapiens
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right lobe of liver thoracic aorta ascending aorta Descending
VKORC1
Protein-coding gene in the species Homo sapiens
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium islet of Langerhans right adrenal gland right adrenal
TXNRD1
Protein-coding gene in humans
paraflocculus of cerebellum tail of epididymis bronchial epithelial cell stromal cell of endometrium Top expressed in spermatocyte zygote medial ganglionic
ARB2A
Protein-coding gene in the species Homo sapiens
Cheng Y (January 2014). "Down-regulation of stromal caveolin-1 expression in esophageal squamous cell carcinoma: a potent predictor of lymph node metastases
TANGO1/MIA3
Mammalian protein found in Homo sapiens
isoform and analysis of caldesmon expression in normal and transformed cells". J Biol Chem. 266 (25): 16917–24. doi:10.1016/S0021-9258(18)55390-4. PMID 1885618
Caldesmon
Protein-coding gene in the species Homo sapiens
the Golgi lumen". J Cell Biol. 133 (2): 257–68. doi:10.1083/jcb.133.2.257. PMC 2120788. PMID 8609160. "Entrez Gene: SDF4 stromal cell derived factor 4"
SDF4
Enzyme in humans
pancreatic alpha cells in multipotent bone marrow stromal cells (BM-MSC) and uterine stroma. FAP expression is high in reactive stromal fibroblasts of epithelial
Fibroblast activation protein, alpha
Fibroblast_activation_protein,_alpha
Protein-coding gene in the species Homo sapiens
"Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell. 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6
UPF1
Protein found in humans
Indeed, Skd3 solubilizes HAX1 in cells and the deletion of the CLPB gene in human cells has been shown to sensitize cells to apoptotic signals. In humans
CLPB
Protein involved in cell adhesion, cell growth, cell migration and differentiation
secreted by various cells, primarily fibroblasts, as a soluble protein dimer and is then assembled into an insoluble matrix in a complex cell-mediated process
Fibronectin
Protein-coding gene in the species Homo sapiens
critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine". Cell. 101 (2): 199–210. doi:10.1016/S0092-8674(00)80830-2. PMID 10786835. S2CID 18200460
Stress-induced-phosphoprotein 1
Stress-induced-phosphoprotein_1
White blood cell that secretes large volumes of antibodies
has yet to be properly defined, molecules such as IL-5, IL-6, TNF-α, stromal cell-derived factor-1α and signalling via CD44 have been shown to play a role
Plasma_cell
Formation of blood cellular components
HSCs are self-renewing cells: when they differentiate, at least some of their daughter cells remain as HSCs so the pool of stem cells is not depleted. This
Haematopoiesis
Protein-coding gene in humans
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium ventricular zone gallbladder canal of the cervix right
MFAP2
Protein-coding gene in the species Homo sapiens
tendon of biceps brachii cartilage tissue right lobe of liver oocyte stromal cell of endometrium secondary oocyte embryo body of pancreas tibia ganglionic
Serine hydroxymethyltransferase 2
Serine_hydroxymethyltransferase_2
Enzyme of the respiratory chain encoded by the mitochondrial genome
mitochondrion in a cell (a cell with MT-COI-deficient homoplasmy). There are about 100 to 700 mitochondria per cell, depending on cell type. Furthermore
Cytochrome c oxidase subunit I
Cytochrome_c_oxidase_subunit_I
Protein-coding gene in the species Homo sapiens
Sugar transporter SWEET1, also known as RAG1-activating protein 1 and stromal cell protein (SCP), is a membrane protein that in humans is encoded by the
Sugar_transporter_SWEET1
Gene and protein involved in Huntington's disease
aggregates in neurons, disrupting cellular processes and ultimately causing cell death. The 5'-end (five prime end) of the HTT gene has a sequence of three
Huntingtin
Protein-coding gene in humans
oocyte gonad ganglionic eminence testicle bone marrow stromal cell of endometrium bone marrow cell trabecular bone Top expressed in Ileal epithelium granulocyte
HJURP
Process by which cells are grown under controlled conditions
"A single bone marrow-derived stromal cell type supports the in vitro growth of early lymphoid and myeloid cells". Cell. 48 (6): 997–1007. doi:10
Cell_culture
Protein-coding gene in the species Homo sapiens
pattern Bgee Human Mouse (ortholog) Top expressed in testicle amygdala stromal cell of endometrium gonad prefrontal cortex nucleus accumbens sural nerve
AMZ1
Protein-coding gene in the species Homo sapiens
adrenal gland left adrenal cortex right adrenal cortex granulocyte spleen stromal cell of endometrium right uterine tube right lobe of thyroid gland left lobe
SGSH
Catalytic subunit of the enzyme telomerase
epithelial and stromal-derived cells, which are typically difficult to culture in vitro. hTERT introduction allows in vitro culture of these cells and available
Telomerase reverse transcriptase
Telomerase_reverse_transcriptase
Cancer of plasma cells
2019). "Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT)
Multiple_myeloma
Protein-coding gene in humans
testicle sperm bronchial epithelial cell Achilles tendon right uterine tube olfactory zone of nasal mucosa stromal cell of endometrium Top expressed in spermatocyte
CATSPERE
Protein-coding gene in the species Homo sapiens
Sgo1 is an excellent target for induction of apoptosis of transformed cells". Cell Cycle. 5 (8): 896–901. doi:10.4161/cc.5.8.2691. PMID 16628005. Tang Z
Shugoshin_1
Topics referred to by the same term
SDF-1 may refer to: Stromal cell-derived factor 1, a protein in cell biology SDF-1 Macross, a fictional spaceship from the anime series Super Dimension
SDF-1
Medical condition
Pathways and Targeted Therapies for Malignant Ovarian Germ Cell Tumors and Sex Cord-Stromal Tumors: A Contemporary Review". Cancers. 12 (6): 1398. doi:10
Germ_cell_tumor
Medullary thymic epithelial cells (mTECs) represent a unique stromal cell population of the thymus which plays an essential role in the establishment
Medullary thymic epithelial cells
Medullary_thymic_epithelial_cells
Chaperone protein
ER-mitochondrion interface regulate Ca(2+) signaling and cell survival". Cell. 131 (3): 596–610. doi:10.1016/j.cell.2007.08.036. PMID 17981125. S2CID 18885068. Kekuda
Sigma-1_receptor
Protein-coding gene in the species Homo sapiens
induces cell migration and proliferation in smooth muscle. In the case of T cells, PPIA regulates the T-cell-specific tyrosine kinase ITK upon T-cell receptor
Peptidylprolyl_isomerase_A
Protein found in humans
apoptosis is an intrinsic feature of DFNA5, shutting the gene down in tumor cells makes them more susceptible to uncontrolled cellular growth. Moreover, the
Gasdermin-E
Biological term
components of the "hematopoietic stem cell niche" that made this possible. Dexter observed that mesenchymal stromal cells could maintain early HSCs ex vivo
Hematopoietic_stem_cell_niche
Enzyme found in humans
tryptophanyl-tRNA synthetase in mammalian, prokaryotic and archaebacterial cells". European Journal of Cell Biology. 62 (2): 248–258. PMID 7925483. Børglum AD, Flint T
Tryptophan–tRNA ligase, cytoplasmic
Tryptophan–tRNA_ligase,_cytoplasmic
Protein-coding gene in the species Homo sapiens
gastric mucosa muscle of thigh gastrocnemius muscle islet of Langerhans stromal cell of endometrium hair follicle Top expressed in Region I of hippocampus
Serine_racemase
Protein-coding gene in humans
Ostman A, Micke P (November 2012). "CD99 is a novel prognostic stromal marker in non-small cell lung cancer". Int. J. Cancer. 131 (10): 2264–73. doi:10.1002/ijc
CD99
Aspartic protease protein and enzyme
microvessels of the kidney from specialized cells of the juxtaglomerular apparatus—the juxtaglomerular cells, in response to three stimuli: A decrease in
Renin
Specialized uterine tissue
Decidual cells are also thought to control the invasion of the endometrium by trophoblast cells. Experimentally, human endometrial stromal cells can be
Decidual_cells
Protein-coding gene in humans
CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. Expression in equine cutaneous tumors
CD47
Protein-coding gene in the species Homo sapiens
cystinotic renal tubular cell lines. Non-human protein homologs for cystinosin include ERS1 in Saccharomyces cerevisiae (yeast cells) and the Caenorhabditis
CTNS_(gene)
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