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Cancer of plasma cells
Multiple myeloma (MM), also known as plasma cell myeloma and simply myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces
Multiple_myeloma
Medical condition
plasma cell dyscrasias. There is a risk of eventual progression to multiple myeloma, a malignant hematological disease. At the milder end of the spectrum
Smouldering_myeloma
Spectrum of blood disorders
a myeloma protein, i.e. an abnormal monoclonal antibody or portion thereof. The exception to this rule is the disorder termed non-secretory multiple myeloma;
Plasma_cell_dyscrasias
Abnormal immunoglobulin fragment
an abnormal monoclonal proliferation of plasma cells, typically in multiple myeloma or Monoclonal gammopathy of undetermined significance. Other terms
Myeloma_protein
Non-profit organization in the U.S.
The Multiple Myeloma Research Foundation (MMRF) is a charitable organization dedicated to multiple myeloma, an incurable blood cancer. The MMRF runs as
Multiple Myeloma Research Foundation
Multiple_Myeloma_Research_Foundation
American non-profit organization
diagnosed with myeloma each year in the U.S. The IMF was established in 1990 following Brian D. Novis's diagnosis with multiple myeloma at age 33. Novis
International Myeloma Foundation
International_Myeloma_Foundation
Medical condition
urine tests. It is a type of monoclonal gammopathy. MGUS resembles multiple myeloma and similar diseases, but the levels of antibodies are lower, the number
Monoclonal gammopathy of undetermined significance
Monoclonal_gammopathy_of_undetermined_significance
Pair of enantiomers
used to treat multiple myeloma, smoldering myeloma, various indolent lymphomas, and myelodysplastic syndromes (MDS). For multiple myeloma, it is a first-line
Lenalidomide
Genetically engineered T cell
acute myeloid leukemia (AML); and BCMA in multiple myeloma. Aside from CD19, CARs targeting the multiple myeloma antigen B-cell maturation antigen (BCMA)
CAR_T_cell
Monoclonal antibody
monoclonal antibody medication. It binds to CD38, which is overexpressed in multiple myeloma cells. Daratumumab was originally developed by Genmab, but it is now
Daratumumab
The mission of the Multiple Myeloma Research Consortium (MMRC) is to champion collaboration with and integration across academia and industry and to focus
Multiple Myeloma Research Consortium
Multiple_Myeloma_Research_Consortium
Medication
the brand name Elrexfio, is a medication used for the treatment of multiple myeloma. Elranatamab is a bispecific B-cell maturation antigen (BCMA)-directed
Elranatamab
Pharmaceutical drug
adults that have received 1 to 3 prior therapies for the treatment of multiple myeloma. It is also indicated for adult patients in combination with pomalidomide
Elotuzumab
Class of immunomodulatory drugs
U.S. Food and Drug Administration (FDA) for use in newly diagnosed multiple myeloma (MM) under strict regulations. This has led to the development of a
Cereblon_E3_ligase_modulator
Oncology Division of Takeda Pharmaceuticals
through clinical trials to approval for treatment of patients with multiple myeloma by the U.S. FDA, but has a growing clinical development pipeline of
Takeda_Oncology
Medical condition
kidney failure in the context of multiple myeloma. It is the most common cause of kidney injury in myeloma. In myeloma cast nephropathy, filtered κ or
Myeloma_cast_nephropathy
Softened section of a bone
formed as a symptom of specific diseases, including breast cancer and multiple myeloma. This softened area appears as a hole on X-ray scans due to decreased
Osteolytic_lesion
Immunomodulatory drug which can cause birth defects
oral administered medication used to treat a number of cancers (e.g., multiple myeloma), graft-versus-host disease, and many skin disorders (e.g., complications
Thalidomide
Growth of a plasma cell tumour within soft tissue or the axial skeleton
International Myeloma Working Group lists three types: solitary plasmacytoma of bone (SPB); extramedullary plasmacytoma (EP), and multiple plasmacytomas
Plasmacytoma
Chemical compound
anti-cancer medication used to treat multiple myeloma and mantle cell lymphoma. This includes multiple myeloma in those who have and have not previously
Bortezomib
Gene therapy medication used to treat multiple myeloma
the brand name Carvykti, is an anti-cancer medication used to treat multiple myeloma. Ciltacabtagene autoleucel is a BCMA (B-cell maturation antigen)-directed
Ciltacabtagene_autoleucel
Monoclonal antibody
Sarclisa, is a monoclonal antibody (mAb) medication for the treatment of multiple myeloma. The most common side effects include neutropenia (low levels of neutrophils
Isatuximab
Monoclonal antibody
Talvey, is a humanized monoclonal antibody used for the treatment of multiple myeloma. It is a bispecific GPRC5D-directed CD3 T-cell engager. Talquetamab
Talquetamab
Medication
medication used for the treatment of people with relapsed or refractory multiple myeloma. Linvoseltamab is a bispecific monoclonal antibody that targets CD3
Linvoseltamab
Aspect of medicine
test. FLC tests can be used to diagnose and monitor diseases like multiple myeloma and amyloidosis. Each immunoglobulin light-chain molecule contains
Serum free light-chain measurement
Serum_free_light-chain_measurement
Mammalian protein found in Homo sapiens
g., in chronic lymphocytic leukemia (CLL) and multiple myeloma). Among patients with multiple myeloma, RANKL activity was greatly increased. In fact
RANKL
accelerated approval to linvoseltamab-gcpt for relapsed or refractory multiple myeloma". U.S. Food and Drug Administration (FDA). 2 July 2025. Retrieved 4
List of therapeutic monoclonal antibodies
List_of_therapeutic_monoclonal_antibodies
American biopharmaceutical company
product is Revlimid (lenalidomide), which is used in the treatment of multiple myeloma, and also in certain anemias. The company is incorporated in Delaware
Celgene
White blood cell that secretes large volumes of antibodies
human plasma cells. It is also expressed on malignant plasma cells in multiple myeloma. Compared with CD138, which disappears rapidly ex vivo, the expression
Plasma_cell
Chemical compound
The FDA approved carfilzomib in July 2012, for use in people with multiple myeloma who have received at least two prior therapies, including treatment
Carfilzomib
Medical term for the likely development of a disease
1001/virtualmentor.2013.15.1.mnar1-1301, PMID 23356812 "Multiple Myeloma Prognosis". Multiple Myeloma Prognosis. Tian, Yao; Yao, Yang; Zhou, Jing; Diao, Xin;
Prognosis
Mammalian protein found in Homo sapiens
resorption. Multiple myeloma is a type of cancer involving malignant plasma cells, called myeloma cells, within the bone marrow. Multiple myeloma is associated
Osteoprotegerin
Anti-cancer drug
dexamethasone for the treatment of adults with relapsed refractory multiple myeloma (RRMM) who have received at least four prior therapies and whose disease
Selinexor
Monoclonal antibody
monoclonal antibody used for the treatment of relapsed and refractory multiple myeloma. It is a bispecific antibody that targets the CD3 receptor expressed
Teclistamab
American entertainment lawyer and producer
supported fundraising and benefit efforts for organizations including the Multiple Myeloma Research Foundation, the Drug Policy Alliance, City of Hope, and the
Doug_Davis_(producer)
American actor (1935–2006)
New York Presbyterian Hospital in New York City after suffering from multiple myeloma and heart disease. At the time of his death, he had completed his roles
Peter_Boyle
Protein-coding gene in the species Homo sapiens
the serum of normal patients and generally elevated in patients with multiple myeloma (MM). The protein encoded by this gene is a member of the TNF-receptor
B-cell_maturation_antigen
English film, stage and television actress (1939–2011)
Harwood's Quartet. She died at the Royal Marsden Hospital in London from multiple myeloma on 15 January 2011, aged 72. "UPI Almanac for Thursday, Jan. 9, 2020"
Susannah_York
Laboratory test
for a serum protein electrophoresis test are to diagnose or monitor multiple myeloma, a monoclonal gammopathy of uncertain significance (MGUS), or further
Serum_protein_electrophoresis
Chemical compound
cereblon E3 ligase modulator developed by Bristol Myers Squibb to treat multiple myeloma. Richardson, Paul G.; Trudel, Suzanne; Quach, Hang; Popat, Rakesh;
Mezigdomide
Excess myeloma protein or monoclonal gamma globulin in the blood
immunoproliferative disorder or hematologic neoplasms, especially multiple myeloma. It is sometimes considered equivalent to plasma cell dyscrasia. The
Monoclonal_gammopathy
American actress, comedian, writer and director (born 1961)
7 victory during the 2016 World Series. Hunt is a supporter of the Multiple Myeloma Research Foundation, of which she is an honorary board member. "About
Bonnie_Hunt
Gene therapy medication
under the brand name Abecma, is a cell-based gene therapy to treat multiple myeloma. The most common side effects include cytokine release syndrome (CRS)
Idecabtagene_vicleucel
Condition or cell change indicating increased cancer risk
monoclonal gammopathy of undetermined significance, which can progress into multiple myeloma or myelodysplastic syndrome, and cervical dysplasia, which can progress
Precancerous_condition
Experimental bispecific antibody for multiple myeloma treatment
investigational bispecific antibody designed for the treatment of multiple myeloma. Developed by Genentech, a member of the Roche group, cevostamab is
Cevostamab
Monoclonal antibody
2 trial of mapatumumab in combination with bortezomib in advanced multiple myeloma. However, in 2010, mapatumumab failed in a midstage study. There was
Mapatumumab
Semi-solid tissue in the spongy portions of bones
can be damaged or displaced by aplastic anemia, malignancies such as multiple myeloma, or infections such as tuberculosis, leading to a decrease in the production
Bone_marrow
High protein concentration in the blood
in the blood. This can occur due to monoclonal gammopathies such as multiple myeloma and after intravenous immunoglobulin has been given. It can result
Hyperproteinemia
American model and actress (born 1966)
the best care possible. She is also an honorary board member of the Multiple Myeloma Research Foundation. In 2007, she became an official supporter of the
Cindy_Crawford
Canadian actress (born 1972)
best-conceived queer films of the past year." In 2009, Ray was diagnosed with multiple myeloma, an incurable form of blood cancer. She began writing The Yellow Diaries
Lisa_Ray
American-Egyptian physician and academic
of multiple myeloma. She is interested in why certain patients with monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma
Irene_Ghobrial
American journalist (born 1957)
Retrieved October 7, 2015. "MMRF Events - Multiple Myeloma Races - Myeloma Fundraising Events". Multiple Myeloma Research Foundation. Archived from the original
Katie_Couric
Medical condition
cell disorders, such as multiple myeloma and Waldenström's macroglobulinemia. About 10% to 15% of patients with multiple myeloma may develop overt AL amyloidosis
AL_amyloidosis
Type of blood cancer
similar to other plasma cell dyscrasias that, for example, lead to multiple myeloma. Waldenström macroglobulinemia is commonly preceded by two clinically
Waldenström_macroglobulinemia
Pharmaceutical drug
with a cytotoxic agent for the treatment of relapsed and refractory multiple myeloma. Belantamab mafodotin is a B-cell maturation antigen (BCMA)-directed
Belantamab_mafodotin
American actor (1909–1981)
primetime soap opera Dallas, a role he continued until he was too ill from multiple myeloma to perform. In 1981, his performance on the series earned him a posthumous
Jim_Davis_(actor)
American businessman (1898–1990)
Centuries of Masterpieces, published by the Armand Hammer Foundation in multiple editions, eventually became five centuries of masterpieces, sometimes in
Armand_Hammer
"FDA Grants RMAT Designation to ALLO-715 for Relapsed/Refractory Multiple Myeloma". OncLive. Archived from the original on 2021-07-09. Retrieved 2021-07-01
Regenerative medicine advanced therapy
Regenerative_medicine_advanced_therapy
Paraneoplastic syndrome
POEMS syndrome (also termed osteosclerotic myeloma, Crow–Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare paraneoplastic syndrome caused
POEMS_syndrome
Chemical compound
among others, is an anti-cancer medication used for the treatment of multiple myeloma and AIDS-related Kaposi sarcoma. It inhibits angiogenesis, the formation
Pomalidomide
American pharmaceutical company
of 2025 revenues); lenalidomide (Revlimid), used to treat multiple myeloma, smoldering myeloma, and myelodysplastic syndromes (6% of 2025 revenues); abatacept
Bristol_Myers_Squibb
American actor (1932–2008)
remained married until his death. In 2004, Scheider was diagnosed with multiple myeloma. In June 2005, he received a bone marrow transplant to treat the cancer
Roy_Scheider
be listed more than once since breakthrough therapy can be awarded for multiple indications. "CDER Breakthrough Therapy Designation Approvals". U.S. Food
List of drugs granted breakthrough therapy designation
List_of_drugs_granted_breakthrough_therapy_designation
American actress (1945–2010)
their son, McWilliams and Keaton have two grandchildren. She died from multiple myeloma at her home in Los Angeles, California, on February 11, 2010, aged
Caroline_McWilliams
American pharmaceutical company
compound is a BCMA-targeting immunotherapeutic for relapsed or refractory multiple myeloma. In March 2022, AbbVie acquired Syndesi Therapeutics for up to $1 billion
AbbVie
Physiological quantity
infections, some kidney diseases and some cancers (such as lymphoma and multiple myeloma). The ESR is decreased in polycythemia, hyperviscosity, sickle cell
Erythrocyte sedimentation rate
Erythrocyte_sedimentation_rate
American singer (born 1953)
Sam. In September 2024, Scialfa revealed that she was diagnosed with multiple myeloma in 2018. Rumble Doll (1993) 23rd Street Lullaby (2004) – (#152, US
Patti_Scialfa
American actor and musician (1944–2012)
married for 27 years, until Grady's death on June 27, 2012. He died of myeloma at age 68 in Thousand Oaks, California, and is buried at the Pierce Brothers
Don_Grady
Chemical compound
maytansinoid DM4. It is being investigated as part of a treatment for multiple myeloma. Preliminary data has been reported in 2013 from an early stage clinical
Indatuximab_ravtansine
American writer and filmmaker (1928–2017)
Blatty's case constituted "a well-founded complaint". Blatty died of multiple myeloma on January 12, 2017, at a hospital in Bethesda, five days after his
William_Peter_Blatty
psoriasis Skyrizi 17.6 6 apixaban anticoagulant Eliquis 14.7 7 daratumumab multiple myeloma Darzalex 14.4 8 Bictegravir/emtricitabine/ tenofovir alafenamide HIV/AIDS
List of largest selling pharmaceutical products
List_of_largest_selling_pharmaceutical_products
Drug
carfilzomib, and ixazomib are already approved for use in treating multiple myeloma and mantle cell lymphoma. They also work as immunosuppressants and
Proteasome_inhibitor
Protein family
syndecan 1 have been reported in the bone marrow of the patients with multiple myeloma, and high syndecan-1 serum concentrations have been associated with
Syndecan
Urinary protein
suggestive of multiple myeloma, or Waldenström's macroglobulinemia.[citation needed] Bence Jones proteins are particularly diagnostic of multiple myeloma in the
Bence_Jones_protein
Scottish hematologist
research and efforts regarding multiple myeloma and blood disorders, especially his development of the multiple myeloma staging system. He is the former
Brian_Durie
Low sodium concentration in the blood
low sodium measurements include high blood protein levels such as in multiple myeloma, high blood fat levels, and high blood sugar. Treatment is based on
Hyponatremia
American astronaut and politician (1931–1982)
John Leonard Swigert Jr. (August 30, 1931 – December 27, 1982) was an American NASA astronaut, test pilot, mechanical engineer, aerospace engineer, United
Jack_Swigert
Relationship between cancer and the consumption of alcohol
cell leukemia." Alcohol has been suggested as a possible cause of multiple myeloma, although a study found no association between MM in a comparison study
Alcohol_and_cancer
English musician (1944–2025)
ultimately cancelled due to Davies's health issues; he was battling multiple myeloma. In late August 2018 Davies gave a rare interview in which he expressed
Rick_Davies
Observation of the diversity of tumour cells
head and neck, bladder and gynecological carcinomas, liposarcoma, and multiple myeloma. There are two models used to explain the heterogeneity of tumour cells
Tumour_heterogeneity
United States Army Air Forces officer
Lieutenant Colonel Robert Rosenthal (June 11, 1917 – April 20, 2007) was an American lawyer and Army officer. A highly decorated B-17 commander of the
Robert Rosenthal (USAAF officer)
Robert_Rosenthal_(USAAF_officer)
French multinational pharmaceutical and healthcare company
peripheral blood stem cell mobilizer for non-Hodgkin's lymphoma and multiple myeloma in December 2008. Oforta (Fludarabine), for leukemia. Thymoglobulin
Sanofi
Medical condition
typical multiple myeloma case with its clinical features being a combination of those found in multiple myeloma and acute leukemia. Like multiple myeloma patients
Plasma_cell_leukemia
Medical procedure to replace blood or immune stem cells
patients with certain cancers of the blood or bone marrow, such as multiple myeloma, leukemia, some types of lymphoma and immune deficiencies. In these
Hematopoietic stem cell transplantation
Hematopoietic_stem_cell_transplantation
American broadcast journalist and author (born 1940)
taken half a dose of Ambien in the morning. He was diagnosed with multiple myeloma, a treatable but incurable blood cancer, in August 2013 at the Mayo
Tom_Brokaw
Indian musician (1964-2015)
Chitresh died in a car accident in 2011. Aadesh was diagnosed with multiple myeloma in December 2010 and underwent chemotherapy. It was reported in the
Aadesh_Shrivastava
Human blood group classification
increased incidence of Duffy antigen has been reported in patients with multiple myeloma compared with healthy controls. The Duffy antigen is present in the
Duffy_antigen_system
Clumping of abnormal cold-sensitive proteins in blood
main causes of cryoglobulinemia are Waldenstrom's macroglobulinemia, multiple myeloma, Non-Hodgkin's lymphoma, chronic lymphocytic leukemia (CLL), monoclonal
Cryoglobulinemia
Political socialite and Watergate whistleblower (1918–1976)
donations sent by sympathetic supporters. Suffering the advanced stages of multiple myeloma, on May 31, 1976, Mitchell slipped into a coma and died at Memorial
Martha_Mitchell
American actor (1924–1998)
(Thanksgiving Day), Fell was rushed to the hospital and diagnosed with multiple myeloma (plasma cell cancer) after becoming too weak to get out of bed at his
Norman_Fell
American hematologist and oncologist
advances in the treatment of multiple myeloma. He directs the Lebow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center at Dana–Farber Cancer
Kenneth C. Anderson (physician)
Kenneth_C._Anderson_(physician)
Canadian jazz singer and pianist (born 1964)
father-in-law was the singer Ross MacManus. Krall's mother died of multiple myeloma in 2002, within months of the deaths of Krall's mentors Ray Brown and
Diana_Krall
American actor (1924–1996)
after a lifetime apart. Koenig played Sawyer. Lenard died aged 72, of multiple myeloma in New York City. The Greatest Story Ever Told (1965) - Balthazar Hang
Mark_Lenard
Chemical compound
Patients With Relapsed/Refractory Multiple Myeloma (RRMM): Phase 1/2 DREAMM-5 Platform Sub-Study 3". Clinical Lymphoma, Myeloma & Leukemia. 23: S507–S508. doi:10
Nirogacestat
Persistence of some cancer cells during remission
used, particularly in hematological malignancies like leukemia and multiple myeloma, as a powerful prognostic marker and to help guide treatment decisions
Minimal_residual_disease
Chemical compound
antineoplastic agent. It is part of the approved drug belantamab mafodotin in multiple myeloma and some experimental anti-cancer antibody-drug conjugates such as
Monomethyl_auristatin_F
American actor (1935–2021)
stay-at-home dad to his children. On May 18, 2021, Grodin died from multiple myeloma at his home in Wilton, Connecticut, at age 86. Plays Grodin, Charles
Charles_Grodin
Swedish footballer and manager (1968-2014)
On 14 May 2009, Ingesson announced that he had been diagnosed with multiple myeloma. The treatment was at the start said to be going "in the right direction"
Klas_Ingesson
American actor (1950–2016)
2015, fifteen years after they first met. Polito was diagnosed with multiple myeloma in 2010. He fell into a coma and later was taken off life support on
Jon_Polito
Prime Minister of India from 1990 to 1991
afterward. Chandra Shekhar died on 8 July 2007. He had been suffering with multiple myeloma for some time and had been in the Apollo Hospital at New Delhi since
Chandra_Shekhar
MULTIPLE MYELOMA
MULTIPLE MYELOMA
Boy/Male
Hebrew
God will multiply.
Girl/Female
Hebrew
God will multiply.
Boy/Male
Hebrew Gaelic
God will multiply.
Boy/Male
Muslim
Multiple lights. Luster.
Boy/Male
Hebrew
God will multiply.
Girl/Female
Hebrew
God will multiply.
Girl/Female
Hebrew
God will multiply.
Girl/Female
Hebrew
God will multiply.
Boy/Male
Australian, Vietnamese
Many; Multiple
Boy/Male
Hindu, Indian, Tamil
Multiple
Boy/Male
Hindu, Indian
Un Countable; Multiple; Countless
Boy/Male
Hebrew
God will multiply.
Boy/Male
Hebrew Spanish
God will multiply.
Boy/Male
Hebrew
God will multiply.
Boy/Male
Dutch, German, Hebrew
God will Multiply
Boy/Male
Hebrew
God will multiply.
Boy/Male
Hebrew
God shall multiply.
Boy/Male
Hebrew
God will multiply.
Boy/Male
Hebrew Spanish
God will multiply.
Boy/Male
Hebrew American Latin
God will multiply.
MULTIPLE MYELOMA
MULTIPLE MYELOMA
Boy/Male
Muslim
Beloved
Girl/Female
American, British, Danish, Dutch, English, Finnish, French, German, Gujarati, Hebrew, Hindu, Indian, Japanese, Kannada, Latin, Malayalam, Marathi, Sanskrit, Scandinavian, Sindhi, Swedish, Tamil, Telugu
Grace; Sweet Faced; Different; God is Gracious; God has Shown Favour; Goddess Durga
Boy/Male
British, English
Son of Walter
Surname or Lastname
English
English : patronymic from Deemer.French : habitational name apparently associated with a specific domain; the source is unclear, because of the wide range of local variants.
Boy/Male
Indian, Punjabi, Sikh
True and Immaculate One
Boy/Male
Arabic
Calmness; Patience; Intelligence; Dream
Male
Ukrainian
, ruling the world.
Surname or Lastname
English (northern) and Scottish
English (northern) and Scottish : variant of Town.
Girl/Female
Arabic
Greatest. A- the Supreme Being in the Muslim faith.
Girl/Female
Muslim/Islamic
Pure promise, fruit
MULTIPLE MYELOMA
MULTIPLE MYELOMA
MULTIPLE MYELOMA
MULTIPLE MYELOMA
MULTIPLE MYELOMA
v. t.
To redouble; to multiply; to repeat.
adv.
So as to multiply.
imp. & p. p.
of Multiply
a.
Manifold; multiple.
a.
Having many flues; as, a multiflue boiler. See Boiler.
n.
The number which is to be multiplied by another number called the multiplier. See Note under Multiplication.
p. pr. & vb. n.
of Multiply
v. i.
To increase amount of gold or silver by the arts of alchemy.
v. i.
To increase in extent and influence; to spread.
v. t.
To multiply; to make manifold.
n.
The number by which another number is multiplied; a multiplier.
n.
The multiplier.
v. t.
To add (any given number or quantity) to itself a certain number of times; to find the product of by multiplication; thus 7 multiplied by 8 produces the number 56; to multiply two numbers. See the Note under Multiplication.
n.
A quantity containing another quantity a number of times without a remainder.
a.
Containing more than once, or more than one; consisting of more than one; manifold; repeated many times; having several, or many, parts.
n.
Multiplied diversity.
n.
The number by which another number is multiplied. See the Note under Multiplication.
n.
One who, or that which, multiplies or increases number.
a.
Tending to multiply; having the power to multiply, or incease numbers.
v. t.
To multiply; to increase.